norfluoxetine has been researched along with Depressive Disorder in 23 studies
norfluoxetine: metabolite of fluoxetine; RN given refers to parent cpd without isomeric designation
Depressive Disorder: An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood disturbance is prominent and relatively persistent.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Platelet 3H-imipramine binding, serotonin (5-HT) uptake and 5-HT concentrations were studied in 14 hospitalized patients with depressive disorder following 6 weeks of treatment with a selective 5-HT uptake blocker, fluoxetine." | 7.68 | Effects of fluoxetine treatment of platelet 3H-imipramine binding, 5-HT uptake and 5-HT content in major depressive disorder. ( Asberg, M; Mårtensson, B; Montero, D; Siwers, B; Wgner, A, 1990) |
| "The relationship between plasma concentration, clinical outcome and side-effects was examined in 23 patients with major depressive disorder (DSM-III-R) treated with fluoxetine." | 5.07 | Relationship between antidepressant response and plasma concentrations of fluoxetine and norfluoxetine. ( Burrows, GD; Gupta, RK; Judd, FK; Norman, TR; Parker, G, 1993) |
| "In vivo 19fluorine nuclear magnetic resonance spectroscopy was used to measure the brain concentration of fluoxetine and norfluoxetine in five patients with obsessive-compulsive disorder and three with major depression." | 3.68 | Accumulation of fluoxetine and norfluoxetine in human brain during therapeutic administration. ( Clancy, K; Fava, M; Flood, JG; Gonzalez, RG; Guimaraes, AR; Pearlman, JD; Puopolo, PR; Renshaw, PF; Rosenbaum, JF, 1992) |
| "1) Thirty-four (34) out-patients with major depressive disorder as defined by Research Diagnostic Criteria were treated with fluoxetine in an open study." | 3.68 | The relationship between response to fluoxetine, plasma drug levels, imipramine binding to platelet membranes and whole-blood 5-HT. ( Griffiths, HW; Marshall, EF; Tyrer, SP, 1990) |
| "Platelet 3H-imipramine binding, serotonin (5-HT) uptake and 5-HT concentrations were studied in 14 hospitalized patients with depressive disorder following 6 weeks of treatment with a selective 5-HT uptake blocker, fluoxetine." | 3.68 | Effects of fluoxetine treatment of platelet 3H-imipramine binding, 5-HT uptake and 5-HT content in major depressive disorder. ( Asberg, M; Mårtensson, B; Montero, D; Siwers, B; Wgner, A, 1990) |
| "This study explored serum concentrations of fluoxetine and norfluoxetine in subjects treated under different dosing regimens." | 2.68 | Fluoxetine and norfluoxetine serum concentrations and clinical response in weekly versus daily dosing. ( Burke, WJ; Hendricks, SE; Jacques, D; McArthur-Campbell, D; Stull, T, 1996) |
| " With a few exceptions, the cumulative dosage of FLU and the AUC of FLU and NFLU were better predictors of the changes in awake and movement time in the PSG than single-sample concentrations of FLU and NFLU taken at the time of PSG assessment." | 1.29 | The effects of fluoxetine on the polysomnogram of depressed outpatients: a pilot study. ( Armitage, R; Battaglia, J; Cain, JW; Debus, JR; Grannemann, BD; Hendrickse, WA; Orsulak, PJ; Roffwarg, HP; Rush, AJ, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (8.70) | 18.7374 |
| 1990's | 19 (82.61) | 18.2507 |
| 2000's | 2 (8.70) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Epperson, CN | 1 |
| Jatlow, PI | 1 |
| Czarkowski, K | 1 |
| Anderson, GM | 1 |
| Kreider, MS | 1 |
| Bushnell, WD | 1 |
| Oakes, R | 1 |
| Wheadon, DE | 1 |
| el-Yazigi, A | 1 |
| Chaleby, K | 1 |
| Gad, A | 1 |
| Raines, DA | 1 |
| Hendrickse, WA | 1 |
| Roffwarg, HP | 1 |
| Grannemann, BD | 1 |
| Orsulak, PJ | 1 |
| Armitage, R | 1 |
| Cain, JW | 1 |
| Battaglia, J | 1 |
| Debus, JR | 1 |
| Rush, AJ | 1 |
| Schwartz, EM | 1 |
| Markovitz, PJ | 1 |
| Bergstrom, RF | 1 |
| Beasley, CM | 2 |
| Levy, NB | 1 |
| Blumenfield, M | 1 |
| Lemberger, L | 1 |
| Fichtner, CG | 1 |
| Jobe, TH | 1 |
| Braun, BG | 1 |
| Leinonen, E | 1 |
| Koponen, H | 1 |
| Lepola, U | 1 |
| Norman, TR | 1 |
| Gupta, RK | 1 |
| Burrows, GD | 1 |
| Parker, G | 1 |
| Judd, FK | 1 |
| Coplan, JD | 1 |
| Gorman, JM | 1 |
| Grey, P | 1 |
| Dominguez, RA | 1 |
| Kumar, AM | 1 |
| Cua, W | 1 |
| Burke, WJ | 1 |
| Hendricks, SE | 1 |
| McArthur-Campbell, D | 1 |
| Jacques, D | 1 |
| Stull, T | 1 |
| Amsterdam, JD | 1 |
| Fawcett, J | 1 |
| Quitkin, FM | 1 |
| Reimherr, FW | 1 |
| Rosenbaum, JF | 2 |
| Michelson, D | 1 |
| Hornig-Rohan, M | 1 |
| Mattes, JA | 1 |
| Lundmark, J | 1 |
| Reis, M | 1 |
| Bengtsson, F | 1 |
| Renshaw, PF | 1 |
| Guimaraes, AR | 1 |
| Fava, M | 1 |
| Pearlman, JD | 1 |
| Flood, JG | 1 |
| Puopolo, PR | 1 |
| Clancy, K | 1 |
| Gonzalez, RG | 1 |
| Keck, PE | 1 |
| McElroy, SL | 1 |
| Tyrer, SP | 1 |
| Marshall, EF | 1 |
| Griffiths, HW | 1 |
| Wgner, A | 1 |
| Montero, D | 1 |
| Mårtensson, B | 2 |
| Siwers, B | 1 |
| Asberg, M | 1 |
| Isenberg, KE | 1 |
| Nyberg, S | 1 |
| Toresson, G | 1 |
| Brodin, E | 1 |
| Bertilsson, L | 1 |
| Kelly, MW | 1 |
| Perry, PJ | 1 |
| Holstad, SG | 1 |
| Garvey, MJ | 1 |
1 review available for norfluoxetine and Depressive Disorder
| Article | Year |
|---|---|
The effects of renal and hepatic disease on the pharmacokinetics, renal tolerance, and risk-benefit profile of fluoxetine.
Topics: Adult; Aged; Clinical Trials as Topic; Depressive Disorder; Dose-Response Relationship, Drug; Drug A | 1993 |
6 trials available for norfluoxetine and Depressive Disorder
| Article | Year |
|---|---|
A double-blind, randomized study to provide safety information on switching fluoxetine-treated patients to paroxetine without an intervening washout period.
Topics: Adult; Depressive Disorder; Double-Blind Method; Drug Administration Schedule; Female; Fluoxetine; H | 1995 |
Steady-state kinetics of fluoxetine and amitriptyline in patients treated with a combination of these drugs as compared with those treated with amitriptyline alone.
Topics: Adolescent; Adult; Amitriptyline; Bipolar Disorder; Chromatography, High Pressure Liquid; Depression | 1995 |
Relationship between antidepressant response and plasma concentrations of fluoxetine and norfluoxetine.
Topics: Adult; Chromatography, High Pressure Liquid; Depressive Disorder; Female; Fluoxetine; Humans; Male; | 1993 |
Lack of change in fluoxetine and norfluoxetine kinetics when switching from fluoxetine to paroxetine.
Topics: Adult; Aged; Cytochrome P-450 CYP2D6 Inhibitors; Depressive Disorder; Double-Blind Method; Drug Inte | 1996 |
Fluoxetine and norfluoxetine serum concentrations and clinical response in weekly versus daily dosing.
Topics: Adult; Depressive Disorder; Drug Administration Schedule; Female; Fluoxetine; Humans; Male; Psychiat | 1996 |
Fluoxetine and norfluoxetine plasma concentrations in major depression: a multicenter study.
Topics: Adult; Depressive Disorder; Drug Administration Schedule; Female; Fluoxetine; Humans; Male; Prospect | 1997 |
16 other studies available for norfluoxetine and Depressive Disorder
| Article | Year |
|---|---|
Maternal fluoxetine treatment in the postpartum period: effects on platelet serotonin and plasma drug levels in breastfeeding mother-infant pairs.
Topics: Adult; Blood Platelets; Depressive Disorder; Female; Fluoxetine; Half-Life; Humans; Infant; Infant, | 2003 |
The effects of fluoxetine on the polysomnogram of depressed outpatients: a pilot study.
Topics: Adult; Depressive Disorder; Female; Fluoxetine; Humans; Male; Middle Aged; Pilot Projects; Polysomno | 1994 |
Fluoxetine responsivity mediated by serum levels, not dose.
Topics: Depressive Disorder; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Fluoxet | 1993 |
Possible therapeutic window for serotonin reuptake inhibitors.
Topics: Depressive Disorder; Dose-Response Relationship, Drug; Drug Administration Schedule; Fluoxetine; Hum | 1994 |
Delirium during fluoxetine treatment. A case report.
Topics: Aged; Delirium; Depressive Disorder; Dose-Response Relationship, Drug; Drug Interactions; Female; Fl | 1993 |
Detectable levels of fluoxetine metabolites after discontinuation: an unexpected serotonin syndrome.
Topics: Adult; Depressive Disorder; Drug Interactions; Female; Fluoxetine; Half-Life; Humans; Monoamine Oxid | 1993 |
Fluoxetine and onset of its therapeutic effect.
Topics: Affect; Depressive Disorder; Dose-Response Relationship, Drug; Female; Fluoxetine; Humans | 1993 |
Fluoxetine and norfluoxetine.
Topics: Depressive Disorder; Dose-Response Relationship, Drug; Drug Administration Schedule; Fluoxetine; Hum | 1998 |
Serum concentrations of fluoxetine in the clinical treatment setting.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antidepressive Agents, Second-Generation; Child; Chromat | 2001 |
Accumulation of fluoxetine and norfluoxetine in human brain during therapeutic administration.
Topics: Adult; Brain; Confidence Intervals; Depressive Disorder; Female; Fluorine; Fluoxetine; Humans; Magne | 1992 |
Ratio of plasma fluoxetine to norfluoxetine concentrations and associated sedation.
Topics: Adult; Bulimia; Depressive Disorder; Drug Administration Schedule; Female; Fluoxetine; Humans; Male; | 1992 |
The relationship between response to fluoxetine, plasma drug levels, imipramine binding to platelet membranes and whole-blood 5-HT.
Topics: Biomarkers; Biotransformation; Blood Platelets; Carrier Proteins; Cell Membrane; Depressive Disorder | 1990 |
Effects of fluoxetine treatment of platelet 3H-imipramine binding, 5-HT uptake and 5-HT content in major depressive disorder.
Topics: Adult; Aged; Blood Platelets; Carrier Proteins; Depressive Disorder; Female; Fluoxetine; Humans; Imi | 1990 |
Excretion of fluoxetine in human breast milk.
Topics: Adult; Breast Feeding; Depressive Disorder; Female; Fluoxetine; Humans; Infant, Newborn; Milk, Human | 1990 |
Fluoxetine treatment of depression. Clinical effects, drug concentrations and monoamine metabolites and N-terminally extended substance P in cerebrospinal fluid.
Topics: Adult; Aged; Depressive Disorder; Female; Fluoxetine; Glycols; Homovanillic Acid; Humans; Hydroxyind | 1989 |
Serum fluoxetine and norfluoxetine concentrations and antidepressant response.
Topics: Adult; Depressive Disorder; Dose-Response Relationship, Drug; Double-Blind Method; Female; Fluoxetin | 1989 |