Page last updated: 2024-11-07

norethindrone acetate and Osteoporosis

norethindrone acetate has been researched along with Osteoporosis in 11 studies

norethisterone acetate : A 3-oxo Delta(4)-steroid that is norethisterone in which the hydroxy group has been converted to its acetate ester.

Osteoporosis: Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis.

Research Excerpts

ExcerptRelevanceReference
"Norethindrone acetate (NETA) is a unique progestin that has both estrogenic and androgenic properties and is effective as an add-back regimen without estrogen supplementation."6.48The hormonal profile of norethindrone acetate: rationale for add-back therapy with gonadotropin-releasing hormone agonists in women with endometriosis. ( Chwalisz, K; Stanczyk, FZ; Surrey, E, 2012)
"Postmenopausal osteoporosis affects 25 to 50% of older women and increases the risk for vertebral, hip, and other fractures."3.76The menopause. ( Gambrell, RD, 1986)
"25 micrograms, oestrogens/gestagen alone or combined with 1,25(OH)2D3, and placebo."2.65Effect of 1,25-dihydroxy-vitamin D3 in itself or combined with hormone treatment in preventing postmenopausal osteoporosis. ( Christensen, MS; Christiansen, C; Hagen, C; Rødbro, P; Transbøl, I, 1981)
"Norethindrone acetate (NETA) is a unique progestin that has both estrogenic and androgenic properties and is effective as an add-back regimen without estrogen supplementation."2.48The hormonal profile of norethindrone acetate: rationale for add-back therapy with gonadotropin-releasing hormone agonists in women with endometriosis. ( Chwalisz, K; Stanczyk, FZ; Surrey, E, 2012)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19907 (63.64)18.7374
1990's2 (18.18)18.2507
2000's1 (9.09)29.6817
2010's1 (9.09)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chwalisz, K1
Surrey, E1
Stanczyk, FZ1
Christiansen, C6
Rødbro, P2
Christensen, MS1
Hagen, C1
Transbøl, I2
Jensen, GF1
Riggs, BL1
Bjarnason, NH1
Alexandersen, P1
Stevenson, JC1
Cust, MP1
Gangar, KF1
Hillard, TC1
Lees, B1
Whitehead, MI1
Löttge, M1
Spieler, W1
Seifert, B1
Hemp, O1
Riis, BJ2
Johansen, J1
Gambrell, RD1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Pilot Trial of 13-cis Retinoic Acid (Isotretinoin) for the Treatment of Men With Oligoasthenoteratozoospermia[NCT02061384]Phase 220 participants (Actual)Interventional2014-08-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Millions of Sperm Per Ejaculate

Millions of sperm per ejaculate in men treated with 13-cis retinoic acid (NCT02061384)
Timeframe: Up to 20-weeks

InterventionMillions of sperm per ejaculate (Median)
13-cis Retinoic Acid2.5
Calcitriol 0.25 mcg3.8

Reviews

4 reviews available for norethindrone acetate and Osteoporosis

ArticleYear
The hormonal profile of norethindrone acetate: rationale for add-back therapy with gonadotropin-releasing hormone agonists in women with endometriosis.
    Reproductive sciences (Thousand Oaks, Calif.), 2012, Volume: 19, Issue:6

    Topics: Bone Density; Endometriosis; Estrogens; Female; Gonadotropin-Releasing Hormone; Hot Flashes; Humans;

2012
Formation-stimulating regimens other than sodium fluoride.
    The American journal of medicine, 1993, Nov-30, Volume: 95, Issue:5A

    Topics: Anabolic Agents; Calcitriol; Diphosphonates; Growth Hormone; Humans; Insulin-Like Growth Factor I; N

1993
The menopause.
    Investigative radiology, 1986, Volume: 21, Issue:4

    Topics: Adult; Breast Neoplasms; Calcium; Clinical Trials as Topic; Coronary Disease; Estrogens; Female; Gal

1986
Post-menopausal bone loss: effects of oestrogens and progestogens. A review.
    Maturitas, 1986, Volume: 8, Issue:4

    Topics: Drug Therapy, Combination; Estradiol; Estrogens; Female; Humans; Norethindrone; Norethindrone Acetat

1986

Trials

6 trials available for norethindrone acetate and Osteoporosis

ArticleYear
Effect of 1,25-dihydroxy-vitamin D3 in itself or combined with hormone treatment in preventing postmenopausal osteoporosis.
    European journal of clinical investigation, 1981, Volume: 11, Issue:4

    Topics: Bone and Bones; Calcitriol; Calcium; Clinical Trials as Topic; Double-Blind Method; Drug Combination

1981
Treatment of post menopausal osteoporosis. A controlled therapeutic trial comparing oestrogen/gestagen, 1,25-dihydroxy-vitamin D3 and calcium.
    Clinical endocrinology, 1982, Volume: 16, Issue:5

    Topics: Aged; Bone and Bones; Calcitriol; Calcium; Clinical Trials as Topic; Double-Blind Method; Drug Combi

1982
Number of years since menopause: spontaneous bone loss is dependent but response to hormone replacement therapy is independent.
    Bone, 2002, Volume: 30, Issue:4

    Topics: Age Factors; Bone Density; Cross-Sectional Studies; Estradiol; Estrogen Replacement Therapy; Female;

2002
Effects of transdermal versus oral hormone replacement therapy on bone density in spine and proximal femur in postmenopausal women.
    Lancet (London, England), 1990, Aug-04, Volume: 336, Issue:8710

    Topics: Absorptiometry, Photon; Administration, Cutaneous; Administration, Oral; Bone Density; Drug Administ

1990
Continuous oestrogen-progestogen treatment and bone metabolism in post-menopausal women.
    Maturitas, 1988, Volume: 10, Issue:1

    Topics: Alkaline Phosphatase; Biochemical Phenomena; Biochemistry; Bone and Bones; Calcium; Calcium-Binding

1988
The menopause.
    Investigative radiology, 1986, Volume: 21, Issue:4

    Topics: Adult; Breast Neoplasms; Calcium; Clinical Trials as Topic; Coronary Disease; Estrogens; Female; Gal

1986

Other Studies

2 other studies available for norethindrone acetate and Osteoporosis

ArticleYear
Does postmenopausal bone loss respond to estrogen replacement therapy independent of bone loss rate?
    Calcified tissue international, 1983, Volume: 35, Issue:6

    Topics: Aged; Bone and Bones; Drug Therapy, Combination; Estradiol; Estradiol Congeners; Estriol; Female; Fo

1983
[Interdisciplinary diagnosis and therapy concepts in climacteric osteoporosis].
    Zentralblatt fur Gynakologie, 1989, Volume: 111, Issue:12

    Topics: Adult; Bone and Bones; Calcium; Chlormadinone Acetate; Climacteric; Combined Modality Therapy; Ethin

1989