norethindrone acetate and Bleeding Between Periods studies

norethisterone acetate : A 3-oxo Delta(4)-steroid that is norethisterone in which the hydroxy group has been converted to its acetate ester.

Research Excerpts

Excerpt	Relevance	Reference
"To evaluate the efficacy and tolerability of norethindrone acetate (NA) as single-agent hormonal therapy for suppression of endometriosis symptoms in adolescents and young adults."	7.78	Use of norethindrone acetate alone for postoperative suppression of endometriosis symptoms. ( Berry, KF; Kaser, DJ; Laufer, MR; Missmer, SA, 2012)
" The ultra-low dose of ethinyl estradiol did not impact scheduled bleeding or intensity of bleeding, but we observed a slight decline in amenorrhea and slight increase in unscheduled bleeding in obese women compared with other BMI categories."	5.22	Body mass index does not affect the efficacy or bleeding profile during use of an ultra-low-dose combined oral contraceptive. ( Archer, DF; Nakajima, ST; Pappadakis, J, 2016)
"This patient preference prospective study was designed to compare patients' satisfaction in women with endometriosis treated either by an extended-cycle oral contraception (OC) or by norethindrone acetate (NETA)."	3.88	Norethindrone acetate versus extended-cycle oral contraceptive (Seasonique ( Barra, F; Ferrero, S; Leone Roberti Maggiore, U; Scala, C; Venturini, PL, 2018)
"To evaluate the efficacy and tolerability of norethindrone acetate (NA) as single-agent hormonal therapy for suppression of endometriosis symptoms in adolescents and young adults."	3.78	Use of norethindrone acetate alone for postoperative suppression of endometriosis symptoms. ( Berry, KF; Kaser, DJ; Laufer, MR; Missmer, SA, 2012)
"New low-dose formulations of combination oral contraceptives (COCs) are safe and effective, but they may be associated with an increased risk of breakthrough bleeding."	2.73	Efficacy and safety of a new 24-day oral contraceptive regimen of norethindrone acetate 1 mg/ethinyl estradiol 20 micro g (Loestrin 24 Fe). ( Archer, DF; Ellman, H; Nakajima, ST, 2007)

Research

Studies (7)

Authors

Clinical Trials (2)

Trial Overview

Trial Outcomes

Median Duration of Withdrawal Bleeding, Cycle 12, MITT Population

Median Duration of Withdrawal Bleeding, Cycle 2, MITT Population

Median Duration of Withdrawal Bleeding, Cycle 6, MITT Population

Number of Intracyclic Bleeding (IB)/Spotting Days Cycle 13, MITT Population

Number of Intracyclic Bleeding (IB)/Spotting Days Cycle 2, MITT Population

Number of Intracyclic Bleeding (IB)/Spotting Days Cycle 6, MITT Population

Percentage of Subjects With Amenorrhea, Cycle 13, MITT Population

Percentage of Subjects With Amenorrhea, Cycle 2, MITT Population

Percentage of Subjects With Amenorrhea, Cycle 6, MITT Population

Percentage of Subjects With Withdrawal Bleeding (%), Cycle 13, MITT Population

Percentage of Subjects With Withdrawal Bleeding (%), Cycle 2, MITT Population

Percentage of Subjects With Withdrawal Bleeding (%), Cycle 6, MITT Population

Pregnancy Rate (Expressed as Pearl Index) in Women Aged 18 to 35, MITT Population,

Pregnancy Rate (Expressed as Pearl Index) in Women Aged 18-45, MITT Population

Total Number of Bleeding Days Per Cycle, Cycle 13, MITT Population

Total Number of Bleeding Days Per Cycle, Cycle 2, MITT Population

Total Number of Bleeding Days Per Cycle, Cycle 6, MITT Population

Trials

Other Studies

3 other studies available for norethindrone acetate and Bleeding Between Periods

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (28.57)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (28.57)	29.6817
2010's	3 (42.86)	24.3611
2020's	0 (0.00)	2.80

Trial	Phase	Enrollment	Study Type	Start Date	Status
Open-Label Study of the Safety and Efficacy of a Low Dose Oral Contraceptive Containing Norethindrone Acetate and Ethinyl Estradiol[NCT00391807]	Phase 3	1,683 participants (Actual)	Interventional	2006-11-30	Completed
A Multicenter, Randomized, Double-Blind, Double Dummy, Group-Comparative Trial to Compare the Effects of Livial® and Activelle ® on the Vaginal Bleeding Pattern, Vasomotor Complaints, Vaginal Atrophy, QoL and Sexual Function[NCT00431093]	Phase 4	570 participants (Actual)	Interventional	2002-11-30	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Body mass index does not affect the efficacy or bleeding profile during use of an ultra-low-dose combined oral contraceptive. Contraception, 2016, Volume: 93, Issue:1 Topics: Adolescent; Adult; Amenorrhea; Body Mass Index; Contraceptives, Oral, Combined; Contraceptives, Oral	2016
Efficacy and safety of a new 24-day oral contraceptive regimen of norethindrone acetate 1 mg/ethinyl estradiol 20 micro g (Loestrin 24 Fe). Contraception, 2007, Volume: 75, Issue:1 Topics: Adolescent; Adult; Contraceptives, Oral, Combined; Contraceptives, Oral, Synthetic; Dose-Response Re	2007
Tibolone and low-dose continuous combined hormone treatment: vaginal bleeding pattern, efficacy and tolerability. BJOG : an international journal of obstetrics and gynaecology, 2007, Volume: 114, Issue:12 Topics: Aged; Contraceptives, Oral, Synthetic; Double-Blind Method; Drug Therapy, Combination; Estradiol; Es	2007
[Emergency ambulatory treatment of dysfunctional metrorrhagia in adolescents]. Minerva ginecologica, 1989, Volume: 41, Issue:11 Topics: Adolescent; Ambulatory Care; Drug Combinations; Drug Evaluation; Emergencies; Ethinyl Estradiol; Fem	1989

Article	Year
Norethindrone acetate versus extended-cycle oral contraceptive (Seasonique European journal of obstetrics, gynecology, and reproductive biology, 2018, Volume: 222 Topics: Adult; Contraceptives, Oral, Synthetic; Drug Combinations; Endometriosis; Ethinyl Estradiol; Female;	2018
Use of norethindrone acetate alone for postoperative suppression of endometriosis symptoms. Journal of pediatric and adolescent gynecology, 2012, Volume: 25, Issue:2 Topics: Adolescent; Adult; Contraceptives, Oral, Synthetic; Endometriosis; Female; Humans; Metrorrhagia; Nor	2012
[Therapeutic potentials of treating uterine hemorrhages with norethisterone acetate]. Akusherstvo i ginekologiia, 1983, Volume: 22, Issue:1 Topics: Adolescent; Adult; Drug Evaluation; Female; Humans; Metrorrhagia; Middle Aged; Norethindrone; Noreth	1983

Authors	Studies
Scala, C	1
Leone Roberti Maggiore, U	1
Barra, F	1
Venturini, PL	1
Ferrero, S	1
Nakajima, ST	2
Pappadakis, J	1
Archer, DF	2
Kaser, DJ	1
Missmer, SA	1
Berry, KF	1
Laufer, MR	1
Ellman, H	1
Hammar, ML	1
van de Weijer, P	1
Franke, HR	1
Pornel, B	1
von Mauw, EM	1
Nijland, EA	1
Tokin, R	1
Dimov, I	1
Dzhebarov, S	1
Morini, A	1
Mossa, B	1
Roscetti, C	1
Florio, V	1