nordefrin has been researched along with Hypertension in 19 studies
Nordefrin: A norepinephrine derivative used as a vasoconstrictor agent.
Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The interactions of dopamine, reserpine and methyldopa on blood pressure of normal subjects and of those with essential hypertension were examined." | 9.04 | Interaction of dopamine, methyldopa and reserpine in the sympatho-adrenal system in essential hypertension. ( Abe, K; Aoyagi, H; Chiba, S; Irokawa, N; Kusaka, T; Miyazaki, S; Otsuka, Y; Saito, K; Sakurai, Y; Seino, M; Yasujima, M; Yoshinaga, K, 1976) |
| " The interactions of dopamine, reserpine and methyldopa on blood pressure of normal subjects and of those with essential hypertension were examined." | 5.04 | Interaction of dopamine, methyldopa and reserpine in the sympatho-adrenal system in essential hypertension. ( Abe, K; Aoyagi, H; Chiba, S; Irokawa, N; Kusaka, T; Miyazaki, S; Otsuka, Y; Saito, K; Sakurai, Y; Seino, M; Yasujima, M; Yoshinaga, K, 1976) |
| "A clinically significant interaction between epinephrine or levonordefrin with nonselective beta-adrenergic blocking agents, although apparently rare in the dental setting, is potentially serious and can lead to significant hypertension with a concomitant reflex bradycardia." | 4.86 | Beta-adrenergic blocking agents and dental vasoconstrictors. ( Giannakopoulos, H; Hersh, EV, 2010) |
| " The simultaneous application of alpha-methyldopa (2 g/day) in 13 patients with primary hypertension did not disturb the fluorimetric estimation of catecholamines." | 3.65 | [An improved trihydroxyindole method for the determination of urinary catecholamines]. ( Werner, U, 1975) |
| "Propranolol is a commonly used drug; of new and refilled prescriptions, it ranked no." | 1.27 | Hypertensive response to levonordefrin in a patient receiving propranolol: report of case. ( Mito, RS; Yagiela, JA, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (68.42) | 18.7374 |
| 1990's | 3 (15.79) | 18.2507 |
| 2000's | 2 (10.53) | 29.6817 |
| 2010's | 1 (5.26) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hersh, EV | 1 |
| Giannakopoulos, H | 1 |
| You, JS | 1 |
| Hu, SY | 1 |
| Xia, DS | 1 |
| Karas, M | 1 |
| Larochelle, P | 1 |
| LeBlanc, RA | 1 |
| Dubé, B | 1 |
| Nadeau, R | 1 |
| Champlain, Jd | 1 |
| Kunos, G | 1 |
| Farsang, C | 1 |
| Ramirez-Gonzales, MD | 1 |
| Ruffolo, RR | 1 |
| Yaden, EL | 1 |
| Waddell, JE | 1 |
| Jackman, GP | 1 |
| Oddie, CJ | 1 |
| Skews, H | 1 |
| Bobik, A | 1 |
| Niwa, M | 1 |
| Kawano, T | 1 |
| Fujita, Y | 1 |
| Maemura, S | 1 |
| Ozaki, M | 1 |
| El-Mas, MM | 1 |
| Abdel-Rahman, AA | 1 |
| Werner, U | 1 |
| van Zwieten, AP | 1 |
| Zandberg, P | 2 |
| de Jong, W | 2 |
| Versteeg, DH | 1 |
| Palkovits, M | 1 |
| Abe, K | 1 |
| Aoyagi, H | 1 |
| Yasujima, M | 1 |
| Miyazaki, S | 1 |
| Kusaka, T | 1 |
| Seino, M | 1 |
| Otsuka, Y | 1 |
| Irokawa, N | 1 |
| Chiba, S | 1 |
| Sakurai, Y | 1 |
| Saito, K | 1 |
| Yoshinaga, K | 1 |
| Henning, M | 1 |
| Finch, L | 1 |
| Hersom, A | 1 |
| Hicks, P | 1 |
| Goulet, JP | 2 |
| Pérusse, R | 2 |
| Turcotte, JY | 2 |
| Mito, RS | 1 |
| Yagiela, JA | 1 |
| Pearson, AC | 1 |
| Labovitz, AJ | 1 |
| Kern, MJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| 2%-Mepivacaine With Two Different Vasoconstrictors; 1:20.000 Levonordefrin or 1:100.000 Epinephrin for Local Anesthesia in Third Molar Surgery: A Comparative Randomized Clinical Trial[NCT02603198] | 30 participants (Anticipated) | Interventional | 2014-08-31 | Active, not recruiting | |||
| Safety of Local Dental Anesthesia in Patients With Cardiac Channelopathies[NCT03182777] | 31 participants (Actual) | Interventional | 2015-05-31 | Completed | |||
| Occurrence of Heart Arrhythmia During Restorative Dental Procedure Under Local Anesthesia , in Heart Failure Pacients. A Double-blind Study[NCT02228083] | 70 participants (Anticipated) | Interventional | 2014-09-30 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for nordefrin and Hypertension
| Article | Year |
|---|---|
Beta-adrenergic blocking agents and dental vasoconstrictors.
Topics: Adrenergic beta-Antagonists; Anesthesia, Dental; Anesthetics, Local; Bradycardia; Drug Interactions; | 2010 |
Beta-adrenergic blocking agents and dental vasoconstrictors.
Topics: Adrenergic beta-Antagonists; Anesthesia, Dental; Anesthetics, Local; Bradycardia; Drug Interactions; | 2010 |
Beta-adrenergic blocking agents and dental vasoconstrictors.
Topics: Adrenergic beta-Antagonists; Anesthesia, Dental; Anesthetics, Local; Bradycardia; Drug Interactions; | 2010 |
Beta-adrenergic blocking agents and dental vasoconstrictors.
Topics: Adrenergic beta-Antagonists; Anesthesia, Dental; Anesthetics, Local; Bradycardia; Drug Interactions; | 2010 |
Central sympathetic transmitters and hypertension.
Topics: Acetylcholine; Animals; Blood Pressure; Cardiac Output; Cats; Clonidine; Dihydroxyphenylalanine; Dog | 1975 |
Contraindications to vasoconstrictors in dentistry: Part III. Pharmacologic interactions.
Topics: Acute Disease; Adrenergic beta-Antagonists; Anesthesia, Dental; Anesthesia, Local; Antidepressive Ag | 1992 |
Contraindications to vasoconstrictors in dentistry: Part I. Cardiovascular diseases.
Topics: Anesthesia, Dental; Anesthesia, Local; Angina, Unstable; Arrhythmias, Cardiac; Cardiovascular Diseas | 1992 |
Contraindications to vasoconstrictors in dentistry: Part I. Cardiovascular diseases.
Topics: Anesthesia, Dental; Anesthesia, Local; Angina, Unstable; Arrhythmias, Cardiac; Cardiovascular Diseas | 1992 |
Contraindications to vasoconstrictors in dentistry: Part I. Cardiovascular diseases.
Topics: Anesthesia, Dental; Anesthesia, Local; Angina, Unstable; Arrhythmias, Cardiac; Cardiovascular Diseas | 1992 |
Contraindications to vasoconstrictors in dentistry: Part I. Cardiovascular diseases.
Topics: Anesthesia, Dental; Anesthesia, Local; Angina, Unstable; Arrhythmias, Cardiac; Cardiovascular Diseas | 1992 |
1 trial available for nordefrin and Hypertension
| Article | Year |
|---|---|
Interaction of dopamine, methyldopa and reserpine in the sympatho-adrenal system in essential hypertension.
Topics: Adult; Dopamine; Dose-Response Relationship, Drug; Drug Synergism; Humans; Hypertension; Methyldopa; | 1976 |
14 other studies available for nordefrin and Hypertension
| Article | Year |
|---|---|
[Further study on the indexes of auxiliary laboratory diagnosis in the syndrome of hyperactivity of liver-yang].
Topics: Adult; Diagnosis, Differential; Epinephrine; Female; Humans; Hypertension; Male; Medicine, Chinese T | 2002 |
Attenuation of autonomic nervous system functions in hypertensive patients at rest and during orthostatic stimulation.
Topics: Adolescent; Adult; Age Factors; Aged; Autonomic Nervous System; Blood Pressure; Electrocardiography; | 2008 |
beta-Endorphin: possible involvement in the antihypertensive effect of central alpha-receptor activation.
Topics: Adrenergic alpha-Agonists; Animals; Brain Stem; Clonidine; Disease Models, Animal; Endorphins; Hyper | 1981 |
Stereochemical requirements of alpha-2 adrenergic receptors.
Topics: Animals; Aorta; Blood Pressure; Dopamine; Guinea Pigs; Hypertension; Male; Molecular Conformation; N | 1982 |
High-performance liquid chromatographic determination of plasma catecholamines during alpha-methyldopa therapy.
Topics: Animals; Catecholamines; Chromatography, High Pressure Liquid; Epinephrine; Humans; Hypertension; Me | 1984 |
[Alpha-methyldopa and brain monoamines].
Topics: Animals; Antihypertensive Agents; Biotransformation; Brain; Catecholamines; Dihydroxyphenylalanine; | 1982 |
Ethanol selectively counteracts hypotension evoked by central I(1)-imidazoline but not alpha2-adrenergic receptor activation in spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Brain; Clonidine; Ethanol; Heart Rate; Hypertension; Imidazoline Receptors; | 1998 |
[An improved trihydroxyindole method for the determination of urinary catecholamines].
Topics: Chromatography, Ion Exchange; Copper; Epinephrine; Humans; Hydrogen-Ion Concentration; Hypertension; | 1975 |
Antihypertensive action of clonidine (Catapresan).
Topics: Animals; Blood Pressure; Bradycardia; Brain Stem; Cats; Clonidine; Depression, Chemical; Drug Evalua | 1977 |
Hypotensive response in spontaneously hypertensive rats following microinjection of alpha-methylnoradrenaline in the caudal brain-stem.
Topics: Animals; Blood Pressure; Heart Rate; Hypertension; Medulla Oblongata; Microinjections; Neural Pathwa | 1979 |
Brain-stem structures and catecholamines in the control of arterial blood pressure in the rat.
Topics: Animals; Blood Pressure; Brain Stem; Dose-Response Relationship, Drug; Epinephrine; Heart Rate; Hype | 1976 |
Studies on the hypotensive action of alpha-methyldopamine.
Topics: Animals; Blood Pressure; Cats; Deoxyepinephrine; Depression, Chemical; Desipramine; Dopamine; Drug I | 1975 |
Hypertensive response to levonordefrin in a patient receiving propranolol: report of case.
Topics: Adult; Anesthesia, Dental; Blood Pressure; Drug Interactions; Female; Humans; Hypertension; Mepivaca | 1988 |
Accelerated hypertension complicated by myocardial infarction after use of a local anesthetic/vasoconstrictor preparation.
Topics: Anesthetics, Local; Humans; Hypertension; Male; Mepivacaine; Middle Aged; Myocardial Infarction; Nor | 1987 |