nordefrin has been researched along with Bradycardia in 3 studies
Nordefrin: A norepinephrine derivative used as a vasoconstrictor agent.
Bradycardia: Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. They can be classified broadly into SINOATRIAL NODE dysfunction and ATRIOVENTRICULAR BLOCK.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A clinically significant interaction between epinephrine or levonordefrin with nonselective beta-adrenergic blocking agents, although apparently rare in the dental setting, is potentially serious and can lead to significant hypertension with a concomitant reflex bradycardia." | 4.86 | Beta-adrenergic blocking agents and dental vasoconstrictors. ( Giannakopoulos, H; Hersh, EV, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hersh, EV | 1 |
| Giannakopoulos, H | 1 |
| Li, SJ | 1 |
| Scanlon, MN | 1 |
| Járai, Z | 1 |
| Varga, K | 1 |
| Gantenberg, NS | 1 |
| Lazar-Wesley, E | 1 |
| Kunos, G | 1 |
| van Zwieten, AP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| 2%-Mepivacaine With Two Different Vasoconstrictors; 1:20.000 Levonordefrin or 1:100.000 Epinephrin for Local Anesthesia in Third Molar Surgery: A Comparative Randomized Clinical Trial[NCT02603198] | 30 participants (Anticipated) | Interventional | 2014-08-31 | Active, not recruiting | |||
| Safety of Local Dental Anesthesia in Patients With Cardiac Channelopathies[NCT03182777] | 31 participants (Actual) | Interventional | 2015-05-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for nordefrin and Bradycardia
| Article | Year |
|---|---|
Beta-adrenergic blocking agents and dental vasoconstrictors.
Topics: Adrenergic beta-Antagonists; Anesthesia, Dental; Anesthetics, Local; Bradycardia; Drug Interactions; | 2010 |
Beta-adrenergic blocking agents and dental vasoconstrictors.
Topics: Adrenergic beta-Antagonists; Anesthesia, Dental; Anesthetics, Local; Bradycardia; Drug Interactions; | 2010 |
Beta-adrenergic blocking agents and dental vasoconstrictors.
Topics: Adrenergic beta-Antagonists; Anesthesia, Dental; Anesthetics, Local; Bradycardia; Drug Interactions; | 2010 |
Beta-adrenergic blocking agents and dental vasoconstrictors.
Topics: Adrenergic beta-Antagonists; Anesthesia, Dental; Anesthetics, Local; Bradycardia; Drug Interactions; | 2010 |
2 other studies available for nordefrin and Bradycardia
| Article | Year |
|---|---|
alpha-2-Adrenergic activation of proopiomelanocortin-containing neurons in the arcuate nucleus causes opioid-mediated hypotension and bradycardia.
Topics: Adrenergic alpha-Agonists; Animals; Arcuate Nucleus of Hypothalamus; beta-Endorphin; Bradycardia; Hy | 1996 |
Antihypertensive action of clonidine (Catapresan).
Topics: Animals; Blood Pressure; Bradycardia; Brain Stem; Cats; Clonidine; Depression, Chemical; Drug Evalua | 1977 |