nordazepam has been researched along with Substance Withdrawal Syndrome in 13 studies
Nordazepam: An intermediate in the metabolism of DIAZEPAM to OXAZEPAM. It may have actions similar to those of diazepam.
nordazepam : A 1,4-benzodiazepinone having phenyl and chloro substituents at positions 5 and 7 respectively; it has anticonvulsant, anxiolytic, muscle relaxant and sedative properties but is used primarily in the treatment of anxiety.
Substance Withdrawal Syndrome: Physiological and psychological symptoms associated with withdrawal from the use of a drug after prolonged administration or habituation. The concept includes withdrawal from smoking or drinking, as well as withdrawal from an administered drug.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Thus, with long-term administration of diszepam, even in therapeutically accepted doses, withdrawal reactions can be encountered on abrupt termination." | 2.65 | Withdrawal reaction from long-term, low-dosage administration of diazepam. A double-blind, placebo-controlled case study. ( Greenblatt, DJ; Rickels, K; Schatz, NJ; Snyder, PJ; Winokur, A, 1980) |
| " ND and parent OX have similar pharmacokinetic profiles." | 1.29 | Pharmacokinetics of nordiazepam in physical dependence and precipitated abstinence in dogs. ( Martin, WR; Sloan, JW; Wala, EP, 1993) |
| " The mean elimination half-life of diazepam fell within the range observed in healthy persons after the ingestion of therapeutic doses (5), or it was only moderately prolonged (t1/2 49." | 1.28 | Diazepam loading in alcohol withdrawal: clinical pharmacokinetics. ( Heikkinen, H; Heinälä, P; Piepponen, T, 1990) |
| " Flumazenil caused dose-related increases in the NPAS scores of both diazepam- and nordiazepam-dependent dogs; the slopes of the two dose-response lines were not different." | 1.27 | Precipitation of abstinence in nordiazepam- and diazepam-dependent dogs. ( Martin, WR; McNicholas, LF; Sloan, JW; Wala, E, 1988) |
| " The chronic use of benzodiazepines for eight months or longer prior to substitution or withdrawal appears to place the patient at a higher risk of incurring withdrawal phenomena." | 1.27 | Severe withdrawal syndrome after substitution of a short-acting benzodiazepine for a long-acting benzodiazepine. ( Berwish, NJ; Bond, WS; Swift, B, 1985) |
| "Dogs, surgically implanted with a chronic gastric fistula, were chronically dosed with N-desmethyldiazepam (32 mg/kg/day) in four divided doses to attain N-desmethyldiazepam plasma levels comparable to those observed in dogs dependent on diazepam (60 mg/kg/day)." | 1.27 | N-desmethyldiazepam physical dependence in dogs. ( Martin, WR; McNicholas, LF; Pruitt, TA, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (61.54) | 18.7374 |
| 1990's | 5 (38.46) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Winokur, A | 2 |
| Rickels, K | 2 |
| Rhodes, PJ | 1 |
| Rhodes, RS | 1 |
| McCurdy, HH | 1 |
| Greenblatt, DJ | 1 |
| Snyder, PJ | 1 |
| Schatz, NJ | 1 |
| Jing, X | 1 |
| Wala, EP | 2 |
| Sloan, JW | 4 |
| Martin, WR | 4 |
| Miller, F | 1 |
| Nulsen, J | 1 |
| Wala, E | 2 |
| Dickey, KM | 1 |
| Dusci, LJ | 1 |
| Good, SM | 1 |
| Hall, RW | 1 |
| Ilett, KF | 1 |
| Heinälä, P | 1 |
| Piepponen, T | 1 |
| Heikkinen, H | 1 |
| Löscher, W | 1 |
| Hönack, D | 1 |
| Fassbender, CP | 1 |
| McNicholas, LF | 2 |
| Bond, WS | 1 |
| Berwish, NJ | 1 |
| Swift, B | 1 |
| Pruitt, TA | 1 |
2 trials available for nordazepam and Substance Withdrawal Syndrome
| Article | Year |
|---|---|
Withdrawal responses to abrupt discontinuation of desmethyldiazepam.
Topics: Acute Disease; Adult; Anxiety Disorders; Clinical Trials as Topic; Depression; Diazepam; Feeding and | 1984 |
Withdrawal reaction from long-term, low-dosage administration of diazepam. A double-blind, placebo-controlled case study.
Topics: Adult; Anxiety; Diazepam; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Male; Norda | 1980 |
11 other studies available for nordazepam and Substance Withdrawal Syndrome
| Article | Year |
|---|---|
Elimination kinetics and symptomatology of diazepam withdrawal in abusers.
Topics: Diazepam; Half-Life; Humans; Kinetics; Nordazepam; Substance Withdrawal Syndrome; Substance-Related | 1984 |
Flunitrazepam and nordiazepam slowly released from silastic capsules induce physical dependence in rat.
Topics: Animals; Anti-Anxiety Agents; Antidotes; Biological Availability; Delayed-Action Preparations; Diaze | 1995 |
Pharmacokinetics of nordiazepam in physical dependence and precipitated abstinence in dogs.
Topics: Administration, Oral; Animals; Blood Proteins; Diazepam; Dogs; Female; Flumazenil; Hydrolysis; Injec | 1993 |
Single case study. Diazepam (Valium) detoxification.
Topics: Adult; Diazepam; Dose-Response Relationship, Drug; Female; Humans; Metabolic Clearance Rate; Nordaze | 1979 |
Chronic administration of and dependence on halazepam, diazepam, and nordiazepam in the dog.
Topics: Administration, Oral; Animals; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Brain; Diaze | 1991 |
Excretion of diazepam and its metabolites in human milk during withdrawal from combination high dose diazepam and oxazepam.
Topics: Adult; Diazepam; Drug Combinations; Female; Humans; Infant; Milk, Human; Nordazepam; Oxazepam; Subst | 1990 |
Diazepam loading in alcohol withdrawal: clinical pharmacokinetics.
Topics: Administration, Oral; Adult; Diazepam; Ethanol; Half-Life; Humans; Male; Middle Aged; Nordazepam; Su | 1990 |
Physical dependence on diazepam in the dog: precipitation of different abstinence syndromes by the benzodiazepine receptor antagonists Ro 15-1788 and ZK 93426.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Carbolines; Diazepam; Dogs; Female; Flumazenil; Nord | 1989 |
Precipitation of abstinence in nordiazepam- and diazepam-dependent dogs.
Topics: Analysis of Variance; Animals; Diazepam; Dogs; Flumazenil; Nordazepam; Oxazepam; Pyrazoles; Seizures | 1988 |
Severe withdrawal syndrome after substitution of a short-acting benzodiazepine for a long-acting benzodiazepine.
Topics: Diazepam; Female; Half-Life; Humans; Middle Aged; Nordazepam; Oxazepam; Substance Withdrawal Syndrom | 1985 |
N-desmethyldiazepam physical dependence in dogs.
Topics: Analysis of Variance; Animals; Body Weight; Diazepam; Dogs; Drinking; Energy Intake; Female; Lorazep | 1985 |