nordazepam has been researched along with Status Epilepticus in 2 studies
Nordazepam: An intermediate in the metabolism of DIAZEPAM to OXAZEPAM. It may have actions similar to those of diazepam.
nordazepam : A 1,4-benzodiazepinone having phenyl and chloro substituents at positions 5 and 7 respectively; it has anticonvulsant, anxiolytic, muscle relaxant and sedative properties but is used primarily in the treatment of anxiety.
Status Epilepticus: A prolonged seizure or seizures repeated frequently enough to prevent recovery between episodes occurring over a period of 20-30 minutes. The most common subtype is generalized tonic-clonic status epilepticus, a potentially fatal condition associated with neuronal injury and respiratory and metabolic dysfunction. Nonconvulsive forms include petit mal status and complex partial status, which may manifest as behavioral disturbances. Simple partial status epilepticus consists of persistent motor, sensory, or autonomic seizures that do not impair cognition (see also EPILEPSIA PARTIALIS CONTINUA). Subclinical status epilepticus generally refers to seizures occurring in an unresponsive or comatose individual in the absence of overt signs of seizure activity. (From N Engl J Med 1998 Apr 2;338(14):970-6; Neurologia 1997 Dec;12 Suppl 6:25-30)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine whether repeat boluses of diazepam (DZP) lead to significant accumulation in the central nervous system and/or peripheral compartments, as repeat intravenous boluses of diazepam are commonly used in the treatment of status epilepticus (SE)." | 3.70 | Comparison of single- and repeated-dose pharmacokinetics of diazepam. ( Brown, S; Patsalos, PN; Shorvon, SD; Tong, X; Walker, MC, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Raisys, VA | 1 |
| Friel, PN | 1 |
| Graaff, PR | 1 |
| Opheim, KE | 1 |
| Wilensky, AJ | 1 |
| Walker, MC | 1 |
| Tong, X | 1 |
| Brown, S | 1 |
| Shorvon, SD | 1 |
| Patsalos, PN | 1 |
2 other studies available for nordazepam and Status Epilepticus
| Article | Year |
|---|---|
High-performance liquid chromatographic and gas-liquid chromatographic determination of diazepam and nordiazepam in plasma.
Topics: Adult; Chromatography, Gas; Chromatography, High Pressure Liquid; Diazepam; Humans; Male; Nordazepam | 1980 |
Comparison of single- and repeated-dose pharmacokinetics of diazepam.
Topics: Animals; Chromatography, High Pressure Liquid; Clinical Protocols; Diazepam; Dose-Response Relations | 1998 |