nordazepam has been researched along with Seizures in 14 studies
Nordazepam: An intermediate in the metabolism of DIAZEPAM to OXAZEPAM. It may have actions similar to those of diazepam.
nordazepam : A 1,4-benzodiazepinone having phenyl and chloro substituents at positions 5 and 7 respectively; it has anticonvulsant, anxiolytic, muscle relaxant and sedative properties but is used primarily in the treatment of anxiety.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
Excerpt | Relevance | Reference |
---|---|---|
"Spontaneous epileptic seizures in this model are known to be resistant to major antiepileptic drugs." | 5.40 | Low doses of ethanol markedly potentiate the anti-seizure effect of diazepam in a mouse model of difficult-to-treat focal seizures. ( Bankstahl, M; Gramer, M; Hausknecht, M; Klein, S; Löscher, W, 2014) |
"Diazepam, oxazepam, N-methyloxazepam, nitrazepam and N-desmethyldiazepam prevented seizures in mice produced by lidocaine, mepivacaine, and prilocaine, and in rats by lidocaine when administered IP five minutes before IP local anesthetic." | 3.66 | Structure activity relationships of selected benzodiazepines as anticonvulsants to local anesthetics. ( Coffman, WB; McFarland, SA; Meyer, EA; Mumford, R; Wynn, RL, 1980) |
"Spontaneous epileptic seizures in this model are known to be resistant to major antiepileptic drugs." | 1.40 | Low doses of ethanol markedly potentiate the anti-seizure effect of diazepam in a mouse model of difficult-to-treat focal seizures. ( Bankstahl, M; Gramer, M; Hausknecht, M; Klein, S; Löscher, W, 2014) |
" These results, when compared with human pharmacokinetic studies, allow a means of extrapolating effective monkey anticonvulsant doses to humans on a pharmacokinetic basis." | 1.28 | Pharmacokinetics of diazepam intramuscularly administered to rhesus monkeys. ( Corcoran, KD; Lukey, BJ; Solana, RP, 1991) |
" Flumazenil caused dose-related increases in the NPAS scores of both diazepam- and nordiazepam-dependent dogs; the slopes of the two dose-response lines were not different." | 1.27 | Precipitation of abstinence in nordiazepam- and diazepam-dependent dogs. ( Martin, WR; McNicholas, LF; Sloan, JW; Wala, E, 1988) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 11 (78.57) | 18.7374 |
1990's | 2 (14.29) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 1 (7.14) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Fatmi, AA | 1 |
Vaidya, NA | 1 |
Iturrian, WB | 1 |
Blanton, CD | 1 |
Lukovits, I | 1 |
Lopata, A | 1 |
Klein, S | 1 |
Bankstahl, M | 1 |
Gramer, M | 1 |
Hausknecht, M | 1 |
Löscher, W | 1 |
Kostowski, W | 1 |
Płaźnik, A | 1 |
Puciłowski, O | 1 |
Trzaskowska, E | 1 |
Lipińska, T | 1 |
Frey, HH | 2 |
Philippin, HP | 1 |
Scheuler, W | 1 |
Wynn, RL | 1 |
McFarland, SA | 1 |
Meyer, EA | 1 |
Coffman, WB | 1 |
Mumford, R | 1 |
Amano, K | 1 |
Takamatsu, J | 1 |
Ogata, A | 1 |
Katsuragi, S | 1 |
Miyazaki, C | 1 |
Deshimaru, M | 1 |
Sumiyoshi, S | 1 |
Miyakawa, T | 1 |
Golovenko, NIa | 1 |
Zin'kovskii, VG | 1 |
Langslet, A | 1 |
Meberg, A | 1 |
Bredesen, JE | 1 |
Lunde, PK | 1 |
Lukey, BJ | 1 |
Corcoran, KD | 1 |
Solana, RP | 1 |
Traversa, U | 1 |
de Angelis, L | 1 |
Della Loggia, R | 1 |
Bertolissi, M | 1 |
Nardini, G | 1 |
Vertua, R | 1 |
Scherkl, R | 1 |
McNicholas, LF | 1 |
Martin, WR | 1 |
Sloan, JW | 1 |
Wala, E | 1 |
File, SE | 1 |
Greenblatt, DJ | 1 |
Martin, IL | 1 |
Brown, C | 1 |
14 other studies available for nordazepam and Seizures
Article | Year |
---|---|
Synthesis of previously inaccessible quinazolines and 1,4-benzodiazepines as potential anticonvulsants.
Topics: Animals; Anticonvulsants; Benzodiazepines; Mice; Pentylenetetrazole; Quinazolines; Receptors, Cell S | 1984 |
Decomposition of pharmacological activity indices into mutually independent components using principal component analysis.
Topics: Animals; Anti-Infective Agents; Benzodiazepines; Hydroxyquinolines; Mathematics; Pharmacology; Rifam | 1980 |
Low doses of ethanol markedly potentiate the anti-seizure effect of diazepam in a mouse model of difficult-to-treat focal seizures.
Topics: Animals; Anticonvulsants; Brain; Diazepam; Disease Models, Animal; Drug Compounding; Drug Synergism; | 2014 |
Some behavioral effects of chlorodesmethyldiazepam and lorazepam.
Topics: Acoustic Stimulation; Aggression; Animals; Anti-Anxiety Agents; Behavior, Animal; Benzodiazepines; D | 1981 |
Development of tolerance to the anticonvulsant effect of diazepam in dogs.
Topics: Animals; Anticonvulsants; Diazepam; Dogs; Drug Tolerance; Electrocardiography; Electroencephalograph | 1984 |
Structure activity relationships of selected benzodiazepines as anticonvulsants to local anesthetics.
Topics: Anesthetics, Local; Animals; Anticonvulsants; Benzodiazepines; Diazepam; Lidocaine; Male; Mepivacain | 1980 |
Effect of dipotassium clorazepate on amygdaloid-kindling and comparison between amygdaloid- and hippocampal-kindled seizures in rats.
Topics: Amygdala; Animals; Anticonvulsants; Ataxia; Clorazepate Dipotassium; Conscious Sedation; Dose-Respon | 1999 |
[Analysis of the structure of the components of the convulsive action of corazole following administration of sulazepam and its metabolites to mice].
Topics: Animals; Anti-Anxiety Agents; Diazepam; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred C | 1976 |
Plasma concentrations of diazepam and N-desmethyldiazepam in newborn infants after intravenous, intramuscular, rectal and oral administration.
Topics: Administration, Oral; Diazepam; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Injectio | 1978 |
Pharmacokinetics of diazepam intramuscularly administered to rhesus monkeys.
Topics: Animals; Anticonvulsants; Blood Proteins; Diazepam; Hematocrit; Injections, Intramuscular; Macaca mu | 1991 |
Effects of caffeine and chlor-desmethyldiazepam on fighting behavior of mice with different reactivity baselines.
Topics: Aggression; Animals; Anti-Anxiety Agents; Benzodiazepines; Caffeine; Dextroamphetamine; Diazepam; El | 1985 |
Clorazepate, correlation between metabolism and anticonvulsant activity.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Brain; Clorazepate Dipotassium; Half-Life; Male; Mice | 1988 |
Precipitation of abstinence in nordiazepam- and diazepam-dependent dogs.
Topics: Analysis of Variance; Animals; Diazepam; Dogs; Flumazenil; Nordazepam; Oxazepam; Pyrazoles; Seizures | 1988 |
Long-lasting anticonvulsant effects of diazepam in different mouse strains: correlations with brain concentrations and receptor occupancy.
Topics: Animals; Anticonvulsants; Brain Chemistry; Diazepam; Mice; Mice, Inbred C3H; Nordazepam; Oxazepam; P | 1985 |