nordazepam has been researched along with Seizures in 14 studies
Nordazepam: An intermediate in the metabolism of DIAZEPAM to OXAZEPAM. It may have actions similar to those of diazepam.
nordazepam : A 1,4-benzodiazepinone having phenyl and chloro substituents at positions 5 and 7 respectively; it has anticonvulsant, anxiolytic, muscle relaxant and sedative properties but is used primarily in the treatment of anxiety.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Spontaneous epileptic seizures in this model are known to be resistant to major antiepileptic drugs." | 5.40 | Low doses of ethanol markedly potentiate the anti-seizure effect of diazepam in a mouse model of difficult-to-treat focal seizures. ( Bankstahl, M; Gramer, M; Hausknecht, M; Klein, S; Löscher, W, 2014) |
| "Diazepam, oxazepam, N-methyloxazepam, nitrazepam and N-desmethyldiazepam prevented seizures in mice produced by lidocaine, mepivacaine, and prilocaine, and in rats by lidocaine when administered IP five minutes before IP local anesthetic." | 3.66 | Structure activity relationships of selected benzodiazepines as anticonvulsants to local anesthetics. ( Coffman, WB; McFarland, SA; Meyer, EA; Mumford, R; Wynn, RL, 1980) |
| "Spontaneous epileptic seizures in this model are known to be resistant to major antiepileptic drugs." | 1.40 | Low doses of ethanol markedly potentiate the anti-seizure effect of diazepam in a mouse model of difficult-to-treat focal seizures. ( Bankstahl, M; Gramer, M; Hausknecht, M; Klein, S; Löscher, W, 2014) |
| " These results, when compared with human pharmacokinetic studies, allow a means of extrapolating effective monkey anticonvulsant doses to humans on a pharmacokinetic basis." | 1.28 | Pharmacokinetics of diazepam intramuscularly administered to rhesus monkeys. ( Corcoran, KD; Lukey, BJ; Solana, RP, 1991) |
| " Flumazenil caused dose-related increases in the NPAS scores of both diazepam- and nordiazepam-dependent dogs; the slopes of the two dose-response lines were not different." | 1.27 | Precipitation of abstinence in nordiazepam- and diazepam-dependent dogs. ( Martin, WR; McNicholas, LF; Sloan, JW; Wala, E, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (78.57) | 18.7374 |
| 1990's | 2 (14.29) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (7.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fatmi, AA | 1 |
| Vaidya, NA | 1 |
| Iturrian, WB | 1 |
| Blanton, CD | 1 |
| Lukovits, I | 1 |
| Lopata, A | 1 |
| Klein, S | 1 |
| Bankstahl, M | 1 |
| Gramer, M | 1 |
| Hausknecht, M | 1 |
| Löscher, W | 1 |
| Kostowski, W | 1 |
| Płaźnik, A | 1 |
| Puciłowski, O | 1 |
| Trzaskowska, E | 1 |
| Lipińska, T | 1 |
| Frey, HH | 2 |
| Philippin, HP | 1 |
| Scheuler, W | 1 |
| Wynn, RL | 1 |
| McFarland, SA | 1 |
| Meyer, EA | 1 |
| Coffman, WB | 1 |
| Mumford, R | 1 |
| Amano, K | 1 |
| Takamatsu, J | 1 |
| Ogata, A | 1 |
| Katsuragi, S | 1 |
| Miyazaki, C | 1 |
| Deshimaru, M | 1 |
| Sumiyoshi, S | 1 |
| Miyakawa, T | 1 |
| Golovenko, NIa | 1 |
| Zin'kovskii, VG | 1 |
| Langslet, A | 1 |
| Meberg, A | 1 |
| Bredesen, JE | 1 |
| Lunde, PK | 1 |
| Lukey, BJ | 1 |
| Corcoran, KD | 1 |
| Solana, RP | 1 |
| Traversa, U | 1 |
| de Angelis, L | 1 |
| Della Loggia, R | 1 |
| Bertolissi, M | 1 |
| Nardini, G | 1 |
| Vertua, R | 1 |
| Scherkl, R | 1 |
| McNicholas, LF | 1 |
| Martin, WR | 1 |
| Sloan, JW | 1 |
| Wala, E | 1 |
| File, SE | 1 |
| Greenblatt, DJ | 1 |
| Martin, IL | 1 |
| Brown, C | 1 |
14 other studies available for nordazepam and Seizures
| Article | Year |
|---|---|
Synthesis of previously inaccessible quinazolines and 1,4-benzodiazepines as potential anticonvulsants.
Topics: Animals; Anticonvulsants; Benzodiazepines; Mice; Pentylenetetrazole; Quinazolines; Receptors, Cell S | 1984 |
Decomposition of pharmacological activity indices into mutually independent components using principal component analysis.
Topics: Animals; Anti-Infective Agents; Benzodiazepines; Hydroxyquinolines; Mathematics; Pharmacology; Rifam | 1980 |
Low doses of ethanol markedly potentiate the anti-seizure effect of diazepam in a mouse model of difficult-to-treat focal seizures.
Topics: Animals; Anticonvulsants; Brain; Diazepam; Disease Models, Animal; Drug Compounding; Drug Synergism; | 2014 |
Some behavioral effects of chlorodesmethyldiazepam and lorazepam.
Topics: Acoustic Stimulation; Aggression; Animals; Anti-Anxiety Agents; Behavior, Animal; Benzodiazepines; D | 1981 |
Development of tolerance to the anticonvulsant effect of diazepam in dogs.
Topics: Animals; Anticonvulsants; Diazepam; Dogs; Drug Tolerance; Electrocardiography; Electroencephalograph | 1984 |
Structure activity relationships of selected benzodiazepines as anticonvulsants to local anesthetics.
Topics: Anesthetics, Local; Animals; Anticonvulsants; Benzodiazepines; Diazepam; Lidocaine; Male; Mepivacain | 1980 |
Effect of dipotassium clorazepate on amygdaloid-kindling and comparison between amygdaloid- and hippocampal-kindled seizures in rats.
Topics: Amygdala; Animals; Anticonvulsants; Ataxia; Clorazepate Dipotassium; Conscious Sedation; Dose-Respon | 1999 |
[Analysis of the structure of the components of the convulsive action of corazole following administration of sulazepam and its metabolites to mice].
Topics: Animals; Anti-Anxiety Agents; Diazepam; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred C | 1976 |
Plasma concentrations of diazepam and N-desmethyldiazepam in newborn infants after intravenous, intramuscular, rectal and oral administration.
Topics: Administration, Oral; Diazepam; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Injectio | 1978 |
Pharmacokinetics of diazepam intramuscularly administered to rhesus monkeys.
Topics: Animals; Anticonvulsants; Blood Proteins; Diazepam; Hematocrit; Injections, Intramuscular; Macaca mu | 1991 |
Effects of caffeine and chlor-desmethyldiazepam on fighting behavior of mice with different reactivity baselines.
Topics: Aggression; Animals; Anti-Anxiety Agents; Benzodiazepines; Caffeine; Dextroamphetamine; Diazepam; El | 1985 |
Clorazepate, correlation between metabolism and anticonvulsant activity.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Brain; Clorazepate Dipotassium; Half-Life; Male; Mice | 1988 |
Precipitation of abstinence in nordiazepam- and diazepam-dependent dogs.
Topics: Analysis of Variance; Animals; Diazepam; Dogs; Flumazenil; Nordazepam; Oxazepam; Pyrazoles; Seizures | 1988 |
Long-lasting anticonvulsant effects of diazepam in different mouse strains: correlations with brain concentrations and receptor occupancy.
Topics: Animals; Anticonvulsants; Brain Chemistry; Diazepam; Mice; Mice, Inbred C3H; Nordazepam; Oxazepam; P | 1985 |