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nordazepam and Seizures

nordazepam has been researched along with Seizures in 14 studies

Nordazepam: An intermediate in the metabolism of DIAZEPAM to OXAZEPAM. It may have actions similar to those of diazepam.
nordazepam : A 1,4-benzodiazepinone having phenyl and chloro substituents at positions 5 and 7 respectively; it has anticonvulsant, anxiolytic, muscle relaxant and sedative properties but is used primarily in the treatment of anxiety.

Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.

Research Excerpts

ExcerptRelevanceReference
"Spontaneous epileptic seizures in this model are known to be resistant to major antiepileptic drugs."5.40Low doses of ethanol markedly potentiate the anti-seizure effect of diazepam in a mouse model of difficult-to-treat focal seizures. ( Bankstahl, M; Gramer, M; Hausknecht, M; Klein, S; Löscher, W, 2014)
"Diazepam, oxazepam, N-methyloxazepam, nitrazepam and N-desmethyldiazepam prevented seizures in mice produced by lidocaine, mepivacaine, and prilocaine, and in rats by lidocaine when administered IP five minutes before IP local anesthetic."3.66Structure activity relationships of selected benzodiazepines as anticonvulsants to local anesthetics. ( Coffman, WB; McFarland, SA; Meyer, EA; Mumford, R; Wynn, RL, 1980)
"Spontaneous epileptic seizures in this model are known to be resistant to major antiepileptic drugs."1.40Low doses of ethanol markedly potentiate the anti-seizure effect of diazepam in a mouse model of difficult-to-treat focal seizures. ( Bankstahl, M; Gramer, M; Hausknecht, M; Klein, S; Löscher, W, 2014)
" These results, when compared with human pharmacokinetic studies, allow a means of extrapolating effective monkey anticonvulsant doses to humans on a pharmacokinetic basis."1.28Pharmacokinetics of diazepam intramuscularly administered to rhesus monkeys. ( Corcoran, KD; Lukey, BJ; Solana, RP, 1991)
" Flumazenil caused dose-related increases in the NPAS scores of both diazepam- and nordiazepam-dependent dogs; the slopes of the two dose-response lines were not different."1.27Precipitation of abstinence in nordiazepam- and diazepam-dependent dogs. ( Martin, WR; McNicholas, LF; Sloan, JW; Wala, E, 1988)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-199011 (78.57)18.7374
1990's2 (14.29)18.2507
2000's0 (0.00)29.6817
2010's1 (7.14)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fatmi, AA1
Vaidya, NA1
Iturrian, WB1
Blanton, CD1
Lukovits, I1
Lopata, A1
Klein, S1
Bankstahl, M1
Gramer, M1
Hausknecht, M1
Löscher, W1
Kostowski, W1
Płaźnik, A1
Puciłowski, O1
Trzaskowska, E1
Lipińska, T1
Frey, HH2
Philippin, HP1
Scheuler, W1
Wynn, RL1
McFarland, SA1
Meyer, EA1
Coffman, WB1
Mumford, R1
Amano, K1
Takamatsu, J1
Ogata, A1
Katsuragi, S1
Miyazaki, C1
Deshimaru, M1
Sumiyoshi, S1
Miyakawa, T1
Golovenko, NIa1
Zin'kovskii, VG1
Langslet, A1
Meberg, A1
Bredesen, JE1
Lunde, PK1
Lukey, BJ1
Corcoran, KD1
Solana, RP1
Traversa, U1
de Angelis, L1
Della Loggia, R1
Bertolissi, M1
Nardini, G1
Vertua, R1
Scherkl, R1
McNicholas, LF1
Martin, WR1
Sloan, JW1
Wala, E1
File, SE1
Greenblatt, DJ1
Martin, IL1
Brown, C1

Other Studies

14 other studies available for nordazepam and Seizures

ArticleYear
Synthesis of previously inaccessible quinazolines and 1,4-benzodiazepines as potential anticonvulsants.
    Journal of medicinal chemistry, 1984, Volume: 27, Issue:6

    Topics: Animals; Anticonvulsants; Benzodiazepines; Mice; Pentylenetetrazole; Quinazolines; Receptors, Cell S

1984
Decomposition of pharmacological activity indices into mutually independent components using principal component analysis.
    Journal of medicinal chemistry, 1980, Volume: 23, Issue:4

    Topics: Animals; Anti-Infective Agents; Benzodiazepines; Hydroxyquinolines; Mathematics; Pharmacology; Rifam

1980
Low doses of ethanol markedly potentiate the anti-seizure effect of diazepam in a mouse model of difficult-to-treat focal seizures.
    Epilepsy research, 2014, Volume: 108, Issue:10

    Topics: Animals; Anticonvulsants; Brain; Diazepam; Disease Models, Animal; Drug Compounding; Drug Synergism;

2014
Some behavioral effects of chlorodesmethyldiazepam and lorazepam.
    Polish journal of pharmacology and pharmacy, 1981, Volume: 33, Issue:6

    Topics: Acoustic Stimulation; Aggression; Animals; Anti-Anxiety Agents; Behavior, Animal; Benzodiazepines; D

1981
Development of tolerance to the anticonvulsant effect of diazepam in dogs.
    European journal of pharmacology, 1984, Sep-03, Volume: 104, Issue:1-2

    Topics: Animals; Anticonvulsants; Diazepam; Dogs; Drug Tolerance; Electrocardiography; Electroencephalograph

1984
Structure activity relationships of selected benzodiazepines as anticonvulsants to local anesthetics.
    Pharmacology and therapeutics in dentistry, 1980, Volume: 5, Issue:1-2

    Topics: Anesthetics, Local; Animals; Anticonvulsants; Benzodiazepines; Diazepam; Lidocaine; Male; Mepivacain

1980
Effect of dipotassium clorazepate on amygdaloid-kindling and comparison between amygdaloid- and hippocampal-kindled seizures in rats.
    European journal of pharmacology, 1999, Dec-03, Volume: 385, Issue:2-3

    Topics: Amygdala; Animals; Anticonvulsants; Ataxia; Clorazepate Dipotassium; Conscious Sedation; Dose-Respon

1999
[Analysis of the structure of the components of the convulsive action of corazole following administration of sulazepam and its metabolites to mice].
    Biulleten' eksperimental'noi biologii i meditsiny, 1976, Volume: 82, Issue:9

    Topics: Animals; Anti-Anxiety Agents; Diazepam; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred C

1976
Plasma concentrations of diazepam and N-desmethyldiazepam in newborn infants after intravenous, intramuscular, rectal and oral administration.
    Acta paediatrica Scandinavica, 1978, Volume: 67, Issue:6

    Topics: Administration, Oral; Diazepam; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Injectio

1978
Pharmacokinetics of diazepam intramuscularly administered to rhesus monkeys.
    Journal of pharmaceutical sciences, 1991, Volume: 80, Issue:10

    Topics: Animals; Anticonvulsants; Blood Proteins; Diazepam; Hematocrit; Injections, Intramuscular; Macaca mu

1991
Effects of caffeine and chlor-desmethyldiazepam on fighting behavior of mice with different reactivity baselines.
    Pharmacology, biochemistry, and behavior, 1985, Volume: 23, Issue:2

    Topics: Aggression; Animals; Anti-Anxiety Agents; Benzodiazepines; Caffeine; Dextroamphetamine; Diazepam; El

1985
Clorazepate, correlation between metabolism and anticonvulsant activity.
    European journal of pharmacology, 1988, Dec-13, Volume: 158, Issue:3

    Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Brain; Clorazepate Dipotassium; Half-Life; Male; Mice

1988
Precipitation of abstinence in nordiazepam- and diazepam-dependent dogs.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 245, Issue:1

    Topics: Analysis of Variance; Animals; Diazepam; Dogs; Flumazenil; Nordazepam; Oxazepam; Pyrazoles; Seizures

1988
Long-lasting anticonvulsant effects of diazepam in different mouse strains: correlations with brain concentrations and receptor occupancy.
    Psychopharmacology, 1985, Volume: 86, Issue:1-2

    Topics: Animals; Anticonvulsants; Brain Chemistry; Diazepam; Mice; Mice, Inbred C3H; Nordazepam; Oxazepam; P

1985