nordazepam has been researched along with Pregnancy in 13 studies
Nordazepam: An intermediate in the metabolism of DIAZEPAM to OXAZEPAM. It may have actions similar to those of diazepam.
nordazepam : A 1,4-benzodiazepinone having phenyl and chloro substituents at positions 5 and 7 respectively; it has anticonvulsant, anxiolytic, muscle relaxant and sedative properties but is used primarily in the treatment of anxiety.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The in vitro protein binding of diazepam and its major plasma metabolite, N-desmethyldiazepam (DMD), was measured in women at full term of pregnancy, in mixed cord plasma (fetal plasma), and in control subjects." | 3.66 | Differences in in vitro binding of diazepam and N-desmethyldiazepam to maternal and fetal plasma proteins at birth: relation to free fatty acid concentration and other parameters. ( Kuhnz, W; Nau, H, 1983) |
| "Nordazepam was found in higher concentrations in hair of newborns than in hair of mothers, which may suggest that it is cumulated in child's organism." | 1.39 | Diazepam and its metabolites in the mothers' and newborns' hair as a biomarker of prenatal exposure. ( Breborowicz, GH; Florek, E; Krzyscin, M; Kulza, M; Lechowicz, E; Markwitz, W; Mazela, J; Merritt, TA; Miechowicz, I; Piekoszewski, W; Senczuk-Przybylowska, M, 2013) |
| "Nordazepam with a lower solubility in milk fat showed M/P ratios which could be best explained by considering protein and fat concentrations together." | 1.28 | Studies on the excretion of diazepam and nordazepam into milk for the prediction of milk-to-plasma drug concentration ratios. ( Guentert, TW; Stebler, T, 1992) |
| "Pinazepam was administered orally as a single (10 mg) dose to 13 women, or in multiple doses of 5 mg daily to 12 women." | 1.27 | Placental transfer of pinazepam and its metabolite N-desmethyldiazepam in women at term. ( Arcidiacono, G; Cappelli, N; Cuoci, L; Fornaro, P; Guarneri, M; Moggi, G; Pacifici, GM; Placidi, GF, 1984) |
| "Nordiazepam (NDZ) was the only metabolite produced by guinea pigs in vivo." | 1.27 | Diazepam metabolism in the guinea pig materno-fetal model: effects of cigarette smoke. ( Ecobichon, DJ; Ungar, W, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (76.92) | 18.7374 |
| 1990's | 2 (15.38) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (7.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Senczuk-Przybylowska, M | 1 |
| Florek, E | 1 |
| Piekoszewski, W | 1 |
| Merritt, TA | 1 |
| Lechowicz, E | 1 |
| Mazela, J | 1 |
| Kulza, M | 1 |
| Breborowicz, GH | 1 |
| Krzyscin, M | 1 |
| Markwitz, W | 1 |
| Miechowicz, I | 1 |
| Pacifici, GM | 1 |
| Cuoci, L | 1 |
| Guarneri, M | 1 |
| Fornaro, P | 1 |
| Arcidiacono, G | 1 |
| Cappelli, N | 1 |
| Moggi, G | 1 |
| Placidi, GF | 1 |
| Kuhnz, W | 3 |
| Nau, H | 3 |
| Luck, W | 2 |
| Wegener, S | 1 |
| Picotti, GB | 1 |
| Corli, O | 1 |
| Galva, MD | 1 |
| Bondiolotti, GP | 1 |
| Carruba, MO | 1 |
| Pan, B | 1 |
| Lu, Y | 1 |
| Wang, D | 1 |
| Erkkola, R | 1 |
| Kanto, J | 2 |
| Kangas, L | 1 |
| Piiroinen, O | 1 |
| Rey, E | 1 |
| Turquais, JM | 1 |
| Olive, G | 1 |
| Langslet, A | 1 |
| Meberg, A | 1 |
| Bredesen, JE | 1 |
| Lunde, PK | 1 |
| Stebler, T | 1 |
| Guentert, TW | 1 |
| Ungar, W | 1 |
| Ecobichon, DJ | 1 |
| Scheinin, M | 1 |
2 trials available for nordazepam and Pregnancy
| Article | Year |
|---|---|
Effects of oral chlordemethyldiazepam on plasma adrenaline and noradrenaline and cardiovascular reactivity in preoperative patients.
Topics: Abortion, Induced; Adolescent; Adult; Anti-Anxiety Agents; Benzodiazepines; Blood Pressure; Diazepam | 1982 |
[Determination of diazepam concentration in maternal and fetal serum after intravenous administration during active phase of labor and its effects on neonates].
Topics: Adult; Apgar Score; Asphyxia Neonatorum; Diazepam; Female; Fetal Blood; Humans; Infant, Newborn; Inj | 1995 |
11 other studies available for nordazepam and Pregnancy
| Article | Year |
|---|---|
Diazepam and its metabolites in the mothers' and newborns' hair as a biomarker of prenatal exposure.
Topics: Biomarkers; Chromatography, Liquid; Diazepam; Female; Hair; Humans; Infant, Newborn; Maternal-Fetal | 2013 |
Placental transfer of pinazepam and its metabolite N-desmethyldiazepam in women at term.
Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Diazepam; Female; Humans; Labor, Obs | 1984 |
Differences in in vitro binding of diazepam and N-desmethyldiazepam to maternal and fetal plasma proteins at birth: relation to free fatty acid concentration and other parameters.
Topics: Adolescent; Adult; Blood Proteins; Diazepam; Fatty Acids, Nonesterified; Female; Fetal Blood; Humans | 1983 |
Decreased serum protein binding of diazepam and its major metabolite in the neonate during the first postnatal week relate to increased free fatty acid levels.
Topics: Adult; Bilirubin; Blood Proteins; Diazepam; Fatty Acids, Nonesterified; Female; Fetal Blood; Humans; | 1984 |
Serum protein binding of diazepam, desmethyldiazepam, furosemide, indomethacin, warfarin, and phenobarbital in human fetus, mother, and newborn infant.
Topics: Blood Proteins; Diazepam; Fatty Acids, Nonesterified; Female; Fetal Blood; Furosemide; Humans; Indom | 1983 |
Feto-maternal concentrations of diazepam and W-demethyldiazepam after intra-amniotic diazepam injection.
Topics: Adolescent; Adult; Amniotic Fluid; Brain Chemistry; Diazepam; Female; Fetal Blood; Humans; Injection | 1976 |
[Determination of dipotassium clorazepate in the plasma by gas chromatography (author's transl)].
Topics: Anti-Anxiety Agents; Chromatography, Gas; Clorazepate Dipotassium; Electrons; Female; Humans; Nordaz | 1978 |
Plasma concentrations of diazepam and N-desmethyldiazepam in newborn infants after intravenous, intramuscular, rectal and oral administration.
Topics: Administration, Oral; Diazepam; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Injectio | 1978 |
Studies on the excretion of diazepam and nordazepam into milk for the prediction of milk-to-plasma drug concentration ratios.
Topics: Animals; Diazepam; Diffusion; Fats; Female; Infusions, Intravenous; Jugular Veins; Milk, Human; Mode | 1992 |
Diazepam metabolism in the guinea pig materno-fetal model: effects of cigarette smoke.
Topics: Animals; Biotransformation; Dealkylation; Diazepam; Female; Guinea Pigs; Maternal-Fetal Exchange; Mi | 1986 |
Placental and blood-CSF transfer of orally administered diazepam in the same person.
Topics: Adult; Biotransformation; Diazepam; Female; Fetal Blood; Humans; Maternal-Fetal Exchange; Nordazepam | 1987 |