nordazepam has been researched along with Liver Diseases in 4 studies
Nordazepam: An intermediate in the metabolism of DIAZEPAM to OXAZEPAM. It may have actions similar to those of diazepam.
nordazepam : A 1,4-benzodiazepinone having phenyl and chloro substituents at positions 5 and 7 respectively; it has anticonvulsant, anxiolytic, muscle relaxant and sedative properties but is used primarily in the treatment of anxiety.
Liver Diseases: Pathological processes of the LIVER.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In the two patients, nordazepam accumulation (main active metabolite of clorazepam) was demonstrated as the cause of the coma." | 3.70 | Prolonged sedation requiring mechanical ventilation and continuous flumazenil infusion after routine doses of clorazepam for alcohol withdrawal syndrome. ( Alzieu, M; Becquemont, L; Delhotal Landes, B; Guglielminotti, J; Guidet, B; Maury, E; Offenstadt, G, 1999) |
| " administration the kinetics of total chlordesmethyldiazepam in patients with liver disease differed from those in controls: elimination half-life was almost twice that in controls (395 and 204 h), as a consequence of a marked reduction in total clearance (0." | 2.68 | Effects of liver disease on the pharmacokinetics of intravenous and oral chlordesmethyldiazepam. ( Bareggi, SR; Devis, G; Pirola, R; Potvin, P, 1995) |
| " The accumulation of DD after multiple dosage could be explained by the fact that it is formed faster from D than it is eliminated." | 2.64 | Disposition of diazepam and its major metabolite desmethyldiazepam in patients with liver disease. ( Antonin, KH; Bieck, PR; Brügel, H; Klotz, U, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (50.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kolenda, KD | 1 |
| Bareggi, SR | 1 |
| Pirola, R | 1 |
| Potvin, P | 1 |
| Devis, G | 1 |
| Guglielminotti, J | 1 |
| Maury, E | 1 |
| Alzieu, M | 1 |
| Delhotal Landes, B | 1 |
| Becquemont, L | 1 |
| Guidet, B | 1 |
| Offenstadt, G | 1 |
| Klotz, U | 1 |
| Antonin, KH | 1 |
| Brügel, H | 1 |
| Bieck, PR | 1 |
1 review available for nordazepam and Liver Diseases
| Article | Year |
|---|---|
[Drug catabolism and its significance for pharmacotherapy].
Topics: Biotransformation; Cytochrome P-450 Enzyme System; Diazepam; Digitoxin; Digoxin; Drug Interactions; | 1980 |
2 trials available for nordazepam and Liver Diseases
| Article | Year |
|---|---|
Effects of liver disease on the pharmacokinetics of intravenous and oral chlordesmethyldiazepam.
Topics: Administration, Oral; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Female; Fibrosis; Human | 1995 |
Disposition of diazepam and its major metabolite desmethyldiazepam in patients with liver disease.
Topics: Adult; Biological Availability; Biotransformation; Clinical Trials as Topic; Diazepam; Half-Life; He | 1977 |
1 other study available for nordazepam and Liver Diseases
| Article | Year |
|---|---|
Prolonged sedation requiring mechanical ventilation and continuous flumazenil infusion after routine doses of clorazepam for alcohol withdrawal syndrome.
Topics: Aged; Alcohol Withdrawal Seizures; Anticonvulsants; Antidotes; Bronchitis; Clorazepate Dipotassium; | 1999 |