nordazepam has been researched along with Liver Cirrhosis in 2 studies
Nordazepam: An intermediate in the metabolism of DIAZEPAM to OXAZEPAM. It may have actions similar to those of diazepam.
nordazepam : A 1,4-benzodiazepinone having phenyl and chloro substituents at positions 5 and 7 respectively; it has anticonvulsant, anxiolytic, muscle relaxant and sedative properties but is used primarily in the treatment of anxiety.
Liver Cirrhosis: Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The accumulation of DD after multiple dosage could be explained by the fact that it is formed faster from D than it is eliminated." | 2.64 | Disposition of diazepam and its major metabolite desmethyldiazepam in patients with liver disease. ( Antonin, KH; Bieck, PR; Brügel, H; Klotz, U, 1977) |
| " Plasma concentrations of DZ and its major metabolite desmethyldiazepam (DMDZ) were measured daily during the period of dosing and in the 7-day washout period that followed." | 1.27 | Repeated diazepam dosing in cirrhotic patients: cumulation and sedation. ( Eckardt, B; Greenblatt, DJ; Harmatz, JS; Ochs, HR; Shader, RI, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ochs, HR | 1 |
| Greenblatt, DJ | 1 |
| Eckardt, B | 1 |
| Harmatz, JS | 1 |
| Shader, RI | 1 |
| Klotz, U | 1 |
| Antonin, KH | 1 |
| Brügel, H | 1 |
| Bieck, PR | 1 |
1 trial available for nordazepam and Liver Cirrhosis
| Article | Year |
|---|---|
Disposition of diazepam and its major metabolite desmethyldiazepam in patients with liver disease.
Topics: Adult; Biological Availability; Biotransformation; Clinical Trials as Topic; Diazepam; Half-Life; He | 1977 |
1 other study available for nordazepam and Liver Cirrhosis
| Article | Year |
|---|---|
Repeated diazepam dosing in cirrhotic patients: cumulation and sedation.
Topics: Adult; Diazepam; Half-Life; Humans; Hypnotics and Sedatives; Kinetics; Liver Cirrhosis; Male; Middle | 1983 |