nordazepam has been researched along with Epilepsy in 9 studies
Nordazepam: An intermediate in the metabolism of DIAZEPAM to OXAZEPAM. It may have actions similar to those of diazepam.
nordazepam : A 1,4-benzodiazepinone having phenyl and chloro substituents at positions 5 and 7 respectively; it has anticonvulsant, anxiolytic, muscle relaxant and sedative properties but is used primarily in the treatment of anxiety.
Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The dominant patient was diagnosed with schizoaffective disorder and her non-dominant sister with paranoid schizophrenia." | 1.37 | Folie à deux: double case-report of shared delusions with a fatal outcome. ( Di Cosimo, D; Girardi, N; Kotzalidis, GD; Lazanio, S; Manfredi, G; Savoja, V; Talamo, A; Tatarelli, R; Vento, A, 2011) |
| " Newborns and premature infants can metabolize and eliminate diazepam, although the parent drug has a longer half-life and decreased rate of biotransformation to its primary metabolites than in older children and adults." | 1.27 | Pharmacokinetics of benzodiazepines and psychostimulants in children. ( Coffey, B; Greenblatt, DJ; Shader, RI, 1983) |
| " The elimination half-life was significantly shorter and the plasma clearance significantly higher in the patients than in the normal volunteers." | 1.26 | Pharmacokinetics of diazepam in epileptic patients and normal volunteers following intravenous administration. ( Dhillon, S; Richens, A, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (88.89) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Talamo, A | 1 |
| Vento, A | 1 |
| Savoja, V | 1 |
| Di Cosimo, D | 1 |
| Lazanio, S | 1 |
| Kotzalidis, GD | 1 |
| Manfredi, G | 1 |
| Girardi, N | 1 |
| Tatarelli, R | 1 |
| Coffey, B | 1 |
| Shader, RI | 1 |
| Greenblatt, DJ | 1 |
| Mimaki, T | 1 |
| Tagawa, T | 1 |
| Ono, J | 1 |
| Tanaka, J | 1 |
| Terada, H | 1 |
| Itoh, N | 1 |
| Yabuuchi, H | 1 |
| Dhillon, S | 1 |
| Richens, A | 1 |
| Wilensky, AJ | 1 |
| Levy, RH | 1 |
| Troupin, AS | 1 |
| Moretti-Ojemann, L | 1 |
| Rubio-Donnadieu, F | 1 |
| Gutiérrez, J | 1 |
| Flores, T | 1 |
| Dhar, AK | 1 |
| Kutt, H | 1 |
| Janicki, PK | 1 |
| Gumulka, SW | 1 |
| Rewekant, M | 1 |
| Pisarski, W | 1 |
| Jedrzejowska, H | 1 |
| De Domenico, P | 1 |
| Gallitto, G | 1 |
| Musolino, R | 1 |
| Bonanzinga, M | 1 |
| Troilo, G | 1 |
| Di Perri, R | 1 |
| Sacchi, C | 1 |
9 other studies available for nordazepam and Epilepsy
| Article | Year |
|---|---|
Folie à deux: double case-report of shared delusions with a fatal outcome.
Topics: Adult; Anticonvulsants; Antipsychotic Agents; Benzodiazepines; Clozapine; Combined Modality Therapy; | 2011 |
Pharmacokinetics of benzodiazepines and psychostimulants in children.
Topics: Adolescent; Adult; Anti-Anxiety Agents; Attention Deficit Disorder with Hyperactivity; Biotransforma | 1983 |
Antiepileptic effect and serum levels of clorazepate on children with refractory seizures.
Topics: Adolescent; Adult; Anti-Anxiety Agents; Anticonvulsants; Child; Child, Preschool; Clorazepate Dipota | 1984 |
Pharmacokinetics of diazepam in epileptic patients and normal volunteers following intravenous administration.
Topics: Adult; Diazepam; Epilepsy; Half-Life; Humans; Injections, Intravenous; Male; Nordazepam | 1981 |
Clorazepate kinetics in treated epileptics.
Topics: Adult; Anti-Anxiety Agents; Clorazepate Dipotassium; Epilepsy; Female; Humans; Kinetics; Male; Model | 1978 |
[Treatment of epileptic crisis with chlorazepate dipotassium. Clinical study of 48 patients with the determination of serum levels of nordiazepam].
Topics: Adolescent; Adult; Anti-Anxiety Agents; Child; Clorazepate Dipotassium; Epilepsy; Female; Humans; Ma | 1977 |
Monitoring diazepam and desmethyldiazepam concentrations in plasma by gas-liquid chromatography, with use of a nitrogen-sensitive detector.
Topics: Chromatography, Gas; Diazepam; Epilepsy; Humans; Microchemistry; Nitrogen; Nordazepam | 1979 |
Serum concentrations of diazepam and its metabolite desmethyldiazepam in epileptic patients after chronic diazepam treatment.
Topics: Adult; Aged; Diazepam; Epilepsy; Humans; Middle Aged; Nordazepam | 1986 |
[Epilepsy induced by penicillin in rabbits: comparative study of the anticonvulsant effects of diazepam and chlordesmethyldiazepam].
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Diazepam; Epilepsy; Male; Nordazepam | 1986 |