Page last updated: 2024-10-25

nordazepam and Epilepsy

nordazepam has been researched along with Epilepsy in 9 studies

Nordazepam: An intermediate in the metabolism of DIAZEPAM to OXAZEPAM. It may have actions similar to those of diazepam.
nordazepam : A 1,4-benzodiazepinone having phenyl and chloro substituents at positions 5 and 7 respectively; it has anticonvulsant, anxiolytic, muscle relaxant and sedative properties but is used primarily in the treatment of anxiety.

Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)

Research Excerpts

ExcerptRelevanceReference
"The dominant patient was diagnosed with schizoaffective disorder and her non-dominant sister with paranoid schizophrenia."1.37Folie à deux: double case-report of shared delusions with a fatal outcome. ( Di Cosimo, D; Girardi, N; Kotzalidis, GD; Lazanio, S; Manfredi, G; Savoja, V; Talamo, A; Tatarelli, R; Vento, A, 2011)
" Newborns and premature infants can metabolize and eliminate diazepam, although the parent drug has a longer half-life and decreased rate of biotransformation to its primary metabolites than in older children and adults."1.27Pharmacokinetics of benzodiazepines and psychostimulants in children. ( Coffey, B; Greenblatt, DJ; Shader, RI, 1983)
" The elimination half-life was significantly shorter and the plasma clearance significantly higher in the patients than in the normal volunteers."1.26Pharmacokinetics of diazepam in epileptic patients and normal volunteers following intravenous administration. ( Dhillon, S; Richens, A, 1981)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19908 (88.89)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (11.11)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Talamo, A1
Vento, A1
Savoja, V1
Di Cosimo, D1
Lazanio, S1
Kotzalidis, GD1
Manfredi, G1
Girardi, N1
Tatarelli, R1
Coffey, B1
Shader, RI1
Greenblatt, DJ1
Mimaki, T1
Tagawa, T1
Ono, J1
Tanaka, J1
Terada, H1
Itoh, N1
Yabuuchi, H1
Dhillon, S1
Richens, A1
Wilensky, AJ1
Levy, RH1
Troupin, AS1
Moretti-Ojemann, L1
Rubio-Donnadieu, F1
Gutiérrez, J1
Flores, T1
Dhar, AK1
Kutt, H1
Janicki, PK1
Gumulka, SW1
Rewekant, M1
Pisarski, W1
Jedrzejowska, H1
De Domenico, P1
Gallitto, G1
Musolino, R1
Bonanzinga, M1
Troilo, G1
Di Perri, R1
Sacchi, C1

Other Studies

9 other studies available for nordazepam and Epilepsy

ArticleYear
Folie à deux: double case-report of shared delusions with a fatal outcome.
    La Clinica terapeutica, 2011, Volume: 162, Issue:1

    Topics: Adult; Anticonvulsants; Antipsychotic Agents; Benzodiazepines; Clozapine; Combined Modality Therapy;

2011
Pharmacokinetics of benzodiazepines and psychostimulants in children.
    Journal of clinical psychopharmacology, 1983, Volume: 3, Issue:4

    Topics: Adolescent; Adult; Anti-Anxiety Agents; Attention Deficit Disorder with Hyperactivity; Biotransforma

1983
Antiepileptic effect and serum levels of clorazepate on children with refractory seizures.
    Brain & development, 1984, Volume: 6, Issue:6

    Topics: Adolescent; Adult; Anti-Anxiety Agents; Anticonvulsants; Child; Child, Preschool; Clorazepate Dipota

1984
Pharmacokinetics of diazepam in epileptic patients and normal volunteers following intravenous administration.
    British journal of clinical pharmacology, 1981, Volume: 12, Issue:6

    Topics: Adult; Diazepam; Epilepsy; Half-Life; Humans; Injections, Intravenous; Male; Nordazepam

1981
Clorazepate kinetics in treated epileptics.
    Clinical pharmacology and therapeutics, 1978, Volume: 24, Issue:1

    Topics: Adult; Anti-Anxiety Agents; Clorazepate Dipotassium; Epilepsy; Female; Humans; Kinetics; Male; Model

1978
[Treatment of epileptic crisis with chlorazepate dipotassium. Clinical study of 48 patients with the determination of serum levels of nordiazepam].
    Neurologia, neurocirugia, psiquiatria, 1977, Volume: 18, Issue:2-3 Suppl

    Topics: Adolescent; Adult; Anti-Anxiety Agents; Child; Clorazepate Dipotassium; Epilepsy; Female; Humans; Ma

1977
Monitoring diazepam and desmethyldiazepam concentrations in plasma by gas-liquid chromatography, with use of a nitrogen-sensitive detector.
    Clinical chemistry, 1979, Volume: 25, Issue:1

    Topics: Chromatography, Gas; Diazepam; Epilepsy; Humans; Microchemistry; Nitrogen; Nordazepam

1979
Serum concentrations of diazepam and its metabolite desmethyldiazepam in epileptic patients after chronic diazepam treatment.
    Acta neurologica, 1986, Volume: 8, Issue:4

    Topics: Adult; Aged; Diazepam; Epilepsy; Humans; Middle Aged; Nordazepam

1986
[Epilepsy induced by penicillin in rabbits: comparative study of the anticonvulsant effects of diazepam and chlordesmethyldiazepam].
    Bollettino chimico farmaceutico, 1986, Volume: 125, Issue:6

    Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Diazepam; Epilepsy; Male; Nordazepam

1986