nordazepam has been researched along with Chemical Dependence in 18 studies
Nordazepam: An intermediate in the metabolism of DIAZEPAM to OXAZEPAM. It may have actions similar to those of diazepam.
nordazepam : A 1,4-benzodiazepinone having phenyl and chloro substituents at positions 5 and 7 respectively; it has anticonvulsant, anxiolytic, muscle relaxant and sedative properties but is used primarily in the treatment of anxiety.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Thus, with long-term administration of diszepam, even in therapeutically accepted doses, withdrawal reactions can be encountered on abrupt termination." | 2.65 | Withdrawal reaction from long-term, low-dosage administration of diazepam. A double-blind, placebo-controlled case study. ( Greenblatt, DJ; Rickels, K; Schatz, NJ; Snyder, PJ; Winokur, A, 1980) |
| "Nitrazepam was detected most frequently (61 urine samples), but had not been prescribed to any of the patients in this study." | 1.30 | Benzodiazepine misuse by drug addicts. ( Garretty, DJ; Hay, AW; Raistrick, D; Wolff, K, 1997) |
| " ND and parent OX have similar pharmacokinetic profiles." | 1.29 | Pharmacokinetics of nordiazepam in physical dependence and precipitated abstinence in dogs. ( Martin, WR; Sloan, JW; Wala, EP, 1993) |
| " Flumazenil caused dose-related increases in the NPAS scores of both diazepam- and nordiazepam-dependent dogs; the slopes of the two dose-response lines were not different." | 1.27 | Precipitation of abstinence in nordiazepam- and diazepam-dependent dogs. ( Martin, WR; McNicholas, LF; Sloan, JW; Wala, E, 1988) |
| "Diazepam was used for relief of pain or muscle spasm, or anxiety and sleeplessness associated with these two symptoms, and was considered to be beneficial by 83% of the patients, although use of other drugs confounded this evaluation." | 1.26 | Long-term use of diazepam. ( Britt, RH; Conley, FK; Hollister, LE; Shuer, L, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (44.44) | 18.7374 |
| 1990's | 6 (33.33) | 18.2507 |
| 2000's | 2 (11.11) | 29.6817 |
| 2010's | 2 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Burch, HJ | 1 |
| Clarke, EJ | 1 |
| Hubbard, AM | 1 |
| Scott-Ham, M | 1 |
| Bertol, E | 1 |
| Mari, F | 1 |
| Boscolo Berto, R | 1 |
| Mannaioni, G | 1 |
| Vaiano, F | 1 |
| Favretto, D | 1 |
| Jones, AW | 1 |
| Holmgren, A | 1 |
| Holmgren, P | 1 |
| Harrison, M | 1 |
| Busto, U | 1 |
| Naranjo, CA | 1 |
| Kaplan, HL | 1 |
| Sellers, EM | 1 |
| Rhodes, PJ | 1 |
| Rhodes, RS | 1 |
| McCurdy, HH | 1 |
| Hollister, LE | 1 |
| Conley, FK | 1 |
| Britt, RH | 1 |
| Shuer, L | 1 |
| Winokur, A | 1 |
| Rickels, K | 1 |
| Greenblatt, DJ | 1 |
| Snyder, PJ | 1 |
| Schatz, NJ | 1 |
| Jing, X | 1 |
| Wala, EP | 3 |
| Sloan, JW | 5 |
| Martin, WR | 4 |
| Garretty, DJ | 1 |
| Wolff, K | 1 |
| Hay, AW | 1 |
| Raistrick, D | 1 |
| Smith-Kielland, A | 1 |
| Skuterud, B | 1 |
| Olsen, KM | 1 |
| Mørland, J | 1 |
| Miller, F | 1 |
| Nulsen, J | 1 |
| Wala, E | 2 |
| Dickey, KM | 1 |
| Dusci, LJ | 1 |
| Good, SM | 1 |
| Hall, RW | 1 |
| Ilett, KF | 1 |
| Löscher, W | 1 |
| Hönack, D | 1 |
| Fassbender, CP | 1 |
| Boisse, NR | 1 |
| Guarino, JJ | 1 |
| Samoriski, GM | 1 |
| McNicholas, LF | 1 |
2 trials available for nordazepam and Chemical Dependence
| Article | Year |
|---|---|
Withdrawal reaction from long-term, low-dosage administration of diazepam. A double-blind, placebo-controlled case study.
Topics: Adult; Anxiety; Diazepam; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Male; Norda | 1980 |
Urinary excretion of diazepam metabolites in healthy volunteers and drug users.
Topics: Adult; Anti-Anxiety Agents; Chromatography, Gas; Chromatography, High Pressure Liquid; Creatinine; D | 2001 |
16 other studies available for nordazepam and Chemical Dependence
| Article | Year |
|---|---|
Concentrations of drugs determined in blood samples collected from suspected drugged drivers in England and Wales.
Topics: Adolescent; Adult; Amphetamine; Automobile Driving; Central Nervous System Depressants; Chromatograp | 2013 |
A mixed MDPV and benzodiazepine intoxication in a chronic drug abuser: determination of MDPV metabolites by LC-HRMS and discussion of the case.
Topics: Adult; Alprazolam; Benzodiazepines; Benzodioxoles; Chlordiazepoxide; Chromatography, Liquid; Diazepa | 2014 |
High concentrations of diazepam and nordiazepam in blood of impaired drivers: association with age, gender and spectrum of other drugs present.
Topics: Adolescent; Adult; Age Distribution; Amphetamine; Anti-Anxiety Agents; Automobile Driving; Central N | 2004 |
Diazepam tapering in detoxification for high-dose benzodiazepine abuse.
Topics: Adult; Benzodiazepines; Diazepam; Dose-Response Relationship, Drug; Drug Administration Schedule; Fe | 1984 |
Elimination kinetics and symptomatology of diazepam withdrawal in abusers.
Topics: Diazepam; Half-Life; Humans; Kinetics; Nordazepam; Substance Withdrawal Syndrome; Substance-Related | 1984 |
Long-term use of diazepam.
Topics: Adult; Aged; Diazepam; Female; Humans; Kinetics; Male; Middle Aged; Muscle Cramp; Nordazepam; Pain; | 1981 |
Flunitrazepam and nordiazepam slowly released from silastic capsules induce physical dependence in rat.
Topics: Animals; Anti-Anxiety Agents; Antidotes; Biological Availability; Delayed-Action Preparations; Diaze | 1995 |
Pharmacokinetics of nordiazepam in physical dependence and precipitated abstinence in dogs.
Topics: Administration, Oral; Animals; Blood Proteins; Diazepam; Dogs; Female; Flumazenil; Hydrolysis; Injec | 1993 |
Benzodiazepine misuse by drug addicts.
Topics: Alcoholism; Benzodiazepines; Chromatography, High Pressure Liquid; Diazepam; Humans; Narcotics; Nitr | 1997 |
Single case study. Diazepam (Valium) detoxification.
Topics: Adult; Diazepam; Dose-Response Relationship, Drug; Female; Humans; Metabolic Clearance Rate; Nordaze | 1979 |
Chronic administration of and dependence on halazepam, diazepam, and nordiazepam in the dog.
Topics: Administration, Oral; Animals; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Brain; Diaze | 1991 |
Distribution of diazepam, nordiazepam, and oxazepam between brain extraneuronal space, brain tissue, plasma, and cerebrospinal fluid in diazepam and nordiazepam dependent dogs.
Topics: Animals; Brain; Diazepam; Dogs; Extracellular Space; Female; Nordazepam; Oxazepam; Substance-Related | 1991 |
Excretion of diazepam and its metabolites in human milk during withdrawal from combination high dose diazepam and oxazepam.
Topics: Adult; Diazepam; Drug Combinations; Female; Humans; Infant; Milk, Human; Nordazepam; Oxazepam; Subst | 1990 |
Physical dependence on diazepam in the dog: precipitation of different abstinence syndromes by the benzodiazepine receptor antagonists Ro 15-1788 and ZK 93426.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Carbolines; Diazepam; Dogs; Female; Flumazenil; Nord | 1989 |
Apparent lesser physical dependence potential of nor-diazepam compared to diazepam in the rat.
Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Male; Nordazepam; Rats; Rats, Inbred Strains; S | 1987 |
Precipitation of abstinence in nordiazepam- and diazepam-dependent dogs.
Topics: Analysis of Variance; Animals; Diazepam; Dogs; Flumazenil; Nordazepam; Oxazepam; Pyrazoles; Seizures | 1988 |