nordazepam has been researched along with Body Weight in 6 studies
Nordazepam: An intermediate in the metabolism of DIAZEPAM to OXAZEPAM. It may have actions similar to those of diazepam.
nordazepam : A 1,4-benzodiazepinone having phenyl and chloro substituents at positions 5 and 7 respectively; it has anticonvulsant, anxiolytic, muscle relaxant and sedative properties but is used primarily in the treatment of anxiety.
Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Changes in body weight (BW) in female rats treated for 5 weeks (wk) with weekly subcutaneous implantation of silastic capsules containing different benzodiazepines (BZs): diazepam (DZ) 90, 180, 360 and 540 mg wk-1; nordiazepam (ND) 600 mg wk-1; oxazepam (OX) 600 mg wk-1 and flunitrazepam (FN) 540 mg wk-1 and in male rats exposed to DZ (540 mg wk-1) were evaluated herein." | 3.70 | The effect of chronic benzodiazepines exposure on body weight in rats. ( Jing, X; Sloan, JW; Wala, EP, 1998) |
| " However, the distributions of elimination half-life (44." | 1.28 | A large-sample study of diazepam pharmacokinetics. ( Friedman, H; Greenblatt, DJ; Harmatz, JS; Locniskar, A; Shader, RI, 1989) |
| "Dogs, surgically implanted with a chronic gastric fistula, were chronically dosed with N-desmethyldiazepam (32 mg/kg/day) in four divided doses to attain N-desmethyldiazepam plasma levels comparable to those observed in dogs dependent on diazepam (60 mg/kg/day)." | 1.27 | N-desmethyldiazepam physical dependence in dogs. ( Martin, WR; McNicholas, LF; Pruitt, TA, 1985) |
| "The bioavailability of diazepam (I) in uncoated tablets in beagles was tested using tablets tested previously in humans." | 1.26 | Correlation of the bioavailability of diazepam from uncoated tablets in beagle dogs with its dissolution rate and bioavailability in humans. ( Aoyagi, N; Ejima, A; Kaniwa, N; Koibuchi, M; Nishida, Y; Ogata, H; Ogawa, Y; Shibazaki, T; Shimamoto, T; Uda, Y; Yashiki, T, 1982) |
| " The plasma half-life (t1/2), the elimination coefficient (Kbeta), the concentration (Css), and the apparent volume of distribution (Vbeta) were calculated at steady state, and the mean values +/- SEM were 53 +/- 6 h, 0." | 1.26 | Pharmacokinetics of N-desmethyldiazepam in healthy volunteers after single daily doses of dipotassium chlorazepate. ( Bertler, A; Lindgren, S; Malmgren, H; Post, C, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (83.33) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Abernethy, DR | 1 |
| Greenblatt, DJ | 2 |
| Divoll, M | 1 |
| Shader, RI | 2 |
| Ogata, H | 1 |
| Aoyagi, N | 1 |
| Kaniwa, N | 1 |
| Koibuchi, M | 1 |
| Shibazaki, T | 1 |
| Ejima, A | 1 |
| Shimamoto, T | 1 |
| Yashiki, T | 1 |
| Ogawa, Y | 1 |
| Uda, Y | 1 |
| Nishida, Y | 1 |
| Jing, X | 1 |
| Wala, EP | 1 |
| Sloan, JW | 1 |
| Post, C | 1 |
| Lindgren, S | 1 |
| Bertler, A | 1 |
| Malmgren, H | 1 |
| Harmatz, JS | 1 |
| Friedman, H | 1 |
| Locniskar, A | 1 |
| McNicholas, LF | 1 |
| Martin, WR | 1 |
| Pruitt, TA | 1 |
6 other studies available for nordazepam and Body Weight
| Article | Year |
|---|---|
Prolongation of drug half-life due to obesity: studies of desmethyldiazepam (clorazepate).
Topics: Adult; Aged; Body Weight; Clorazepate Dipotassium; Diazepam; Female; Half-Life; Humans; Male; Middle | 1982 |
Correlation of the bioavailability of diazepam from uncoated tablets in beagle dogs with its dissolution rate and bioavailability in humans.
Topics: Animals; Biological Availability; Body Weight; Diazepam; Dogs; Humans; Hydrogen-Ion Concentration; N | 1982 |
The effect of chronic benzodiazepines exposure on body weight in rats.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Body Weight; Diazepam; Dose-Response Relationshi | 1998 |
Pharmacokinetics of N-desmethyldiazepam in healthy volunteers after single daily doses of dipotassium chlorazepate.
Topics: Adult; Anti-Anxiety Agents; Body Weight; Clorazepate Dipotassium; Diazepam; Drug Interactions; Femal | 1977 |
A large-sample study of diazepam pharmacokinetics.
Topics: Adolescent; Adult; Body Weight; Chromatography, Gas; Diazepam; Half-Life; Humans; Male; Nordazepam | 1989 |
N-desmethyldiazepam physical dependence in dogs.
Topics: Analysis of Variance; Animals; Body Weight; Diazepam; Dogs; Drinking; Energy Intake; Female; Lorazep | 1985 |