norcocaine and Seizures

norcocaine has been researched along with Seizures* in 2 studies

Other Studies

2 other study(ies) available for norcocaine and Seizures

ArticleYear
Lethal toxicity from equimolar infusions of cocaine and cocaine metabolites in conscious and anesthetized rats.
    Anesthesia and analgesia, 1995, Volume: 81, Issue:5

    We compared the lethal toxicity of cocaine with that of three of its metabolites to determine the contribution of these metabolites to the lethal potential from cocaine infusion. Equimolar quantities of cocaine, norcocaine, benzoylecgonine, and ecgonine methyl ester were infused in conscious rats to determine onset of convulsions and respiratory arrest. In addition, the convulsive and respiratory toxicity for cocaine and norcocaine were evaluated in anesthetized rats and their circulatory toxicity in anesthetized and ventilated rats. Norcocaine infusion resulted in earlier onset of convulsions and respiratory arrest in conscious rats than cocaine and earlier onset of circulatory arrest. Plasma concentrations of norcocaine and cocaine were not different at these times. Benzoylecgonine and ecgonine methyl ester were less potent convulsants and respiratory depressants than norcocaine and cocaine, with ecgonine methyl ester more respiratory depressant than benzoylecgonine. Pentobarbital anesthesia enhanced the respiratory depression and suppressed or delayed the onset of convulsions from norcocaine and cocaine infusion. Prolonged infusion of cocaine to circulatory arrest resulted in benzoylecgonine concentrations approximately 60%, and norcocaine concentrations approximately 5%, of the cocaine concentration, but no detectable ecgonine methyl ester formation. We conclude that although norcocaine, ecgonine methyl ester, and benzoylecgonine administered separately have lethal potential in massive dosages, death from cocaine overdose primarily results from the parent compound and not from metabolite formation.

    Topics: Animals; Cocaine; Hemodynamics; Male; Narcotics; Rats; Rats, Sprague-Dawley; Respiration; Seizures; Structure-Activity Relationship

1995
Biological effects of cocaine derivatives I: Improved synthesis and pharmacological evaluation of norcocaine.
    Journal of pharmaceutical sciences, 1977, Volume: 66, Issue:1

    An improved synthesis of norcocaine, a metabolite of cocaine, is reported. Following intravenous administration to a rhesus monkey, respiratory effects were similar to those observed following cocaine treatment. In addition, clonic convulsions, hypothermia, and mydriasis resulted. Norcocaine could be responsible for part of the pharmacological activity of cocaine.

    Topics: Animals; Body Temperature; Cocaine; Haplorhini; Macaca mulatta; Male; Respiration; Seizures

1977