norcantharidin has been researched along with Carcinoma, Hepatocellular in 42 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (7.14) | 18.2507 |
| 2000's | 6 (14.29) | 29.6817 |
| 2010's | 24 (57.14) | 24.3611 |
| 2020's | 9 (21.43) | 2.80 |
| Authors | Studies |
|---|---|
| Bi, Y; Chen, T; Deng, M; Ding, Y; Tang, X; Xia, D; Yan, Z; Yang, K; Zhao, Y | 1 |
| Fu, S; Liu, Y; Ma, W; Wang, B; Wang, Y; Wen, Q; Wu, Z; Xiao, S; Xiong, K; Zhou, P | 1 |
| Dong, N; Gao, S; Gou, J; He, H; Liu, H; Liu, Z; Tang, X; Yang, L; Yin, T; Zhang, Y; Zhao, L; Zhou, N | 1 |
| El Gayar, AM; El-Magd, NFA; Yousef, EH | 1 |
| Feng, YP; Gou, JX; He, HB; Liu, BY; Liu, ZX; Tang, X; Wang, P; Wang, QQ; Wang, YJ; Yin, T; Zhang, Y | 1 |
| Ding, M; Ding, Z; Shi, S; Sun, L; Tang, M; Wang, Z; Xu, B; Zhang, H; Zhang, T | 1 |
| Hao, Y; Lei, M; Peng, J; Qian, Z; Shi, K; Wang, M; Xiao, Y; Xue, B; Yuan, L | 1 |
| Chen, X; Chi, J; Han, B; Jiang, Z; Liu, W; Peng, Y | 1 |
| Feng, Y; Liu, M; Tu, J; Wu, J; Zhang, J | 1 |
| Liang, L; Wang, Y; Zhao, L | 1 |
| Fu, S; Gao, B; Li, B; Liu, Y; Luo, J; Su, S; Yang, X | 1 |
| Han, T; Jiang, YP; Xin, HL; Yue, XQ; Zhang, QY | 1 |
| Chao, TI; Chen, KF; Chen, LJ; Chen, YL; Chu, PY; Hsiao, YJ; Hsieh, FS; Hung, MH; Shih, CT; Tsai, MH | 1 |
| Bao, Y; Gao, Y; Guo, Q; Hua, B; Jiang, S; Li, J; Li, W; Liu, R; Zheng, H | 1 |
| Chi, J; Han, B; Jiang, Z; Liu, W | 1 |
| Ding, X; Li, D; Wang, D; Wang, Z; Xu, W; Yang, C; Yang, Y; Zheng, Q | 1 |
| Chen, L; Chen, Y; Fan, J; Fu, S; Jiang, Y; Liu, J; Ni, X; Shan, X; Wu, J; Wu, M; Yang, B; Yang, L; Zhang, H | 1 |
| Hu, Y; Jiang, S; Li, M; Lv, H; Zhang, Z | 1 |
| Hou, J; Jiang, S; Ning, Q; Wang, J; Xia, X; Yang, L; Zhang, Z | 1 |
| Ge, M; Ji, LQ; Jiang, XR; Peng, JB; Wang, DS; Wang, Z; Xie, MH; Ying, Y | 1 |
| An, FY; Chen, XJ; Geng, GQ; Li, ZD; Liu, XS; Liu, YQ; Luo, LL; Sun, SB; Xie, XR; Zhang, XP | 1 |
| Gao, Y; Huang, X; Lu, S; Wang, X | 1 |
| Du, FY; Jiang, WJ; Lin, QY; Qi, QY; Song, WJ; Wei, Q | 1 |
| Guo, H; Guo, Y; Li, J; Li, X; Lu, B; Peng, R; Tian, Q; Wang, Y; Wu, M; Xiong, X; Zhang, H; Zhou, T | 1 |
| Pachuta-Stec, A; Szuster-Ciesielska, A | 1 |
| Li, G; Lin, L; Ren, J; Ye, T; Zhao, W | 1 |
| Gao, JQ; Han, M; Hu, Y; Liu, L; Liu, MC; Shuai, WP; Wang, XR | 1 |
| Fan, F; Sun, XF | 1 |
| Bei, YY; Hu, W; Hu, ZH; Wang, Q; Wang, WJ; Xu, JY; Zhang, L; Zhang, Q; Zhang, XN | 1 |
| Fan, ZZ; Gao, H; Han, XH; Li, XQ; Shao, SH; Sun, J; Sun, YN; Yin, PH | 1 |
| Bei, YY; Guan, M; Liu, Y; Zhang, Q; Zhang, XN; Zhou, Y; Zhu, QL | 1 |
| Chien, MH; Chiou, HL; Hsieh, MJ; Hsieh, YH; Yang, SF; Yeh, CB | 1 |
| Feng, L; Li, G; Liu, G; Lu, J; Ma, X; Qin, B; Wang, Y; Wu, Y; Ye, X; Zhang, G; Zhang, S; Zhao, Y | 1 |
| Chen, MF; Chow, KC; Huang, YF; Yang, YY; Yeh, CH | 1 |
| Chen, JC; Chen, YN; Hsu, SF; Hsu, SL; Tsauer, W; Wang, GS; Yin, SC | 1 |
| Chen, JC; Chen, YN; Cheng, CC; Hsu, SL; Tsauer, W | 1 |
| Hong, Z; Xiang, D; Zhang, L; Zhang, ZR | 1 |
| Fan, ZZ; Gao, H; Gu, W; Heng, P; Li, Q; Li, XQ; Liu, XH; Sun, J | 1 |
| Cui, J; Guo, W; Li, M; Xu, B; Yang, H | 1 |
| Fang, Y; Li, KQ; Tian, SL; Zhao, SW; Zhu, AT | 1 |
| Cheng, LY; Ha, XF; Mack, P | 1 |
| Cheng, LY; Mack, PO; Tang, WY; Yang, EB; Zhang, K | 1 |
42 other study(ies) available for norcantharidin and Carcinoma, Hepatocellular
| Article | Year |
|---|---|
Norcantharidin Nanostructured Lipid Carrier (NCTD-NLC) Suppresses the Viability of Human Hepatocellular Carcinoma HepG2 Cells and Accelerates the Apoptosis.
Topics: Animals; Apoptosis; Bridged Bicyclo Compounds, Heterocyclic; Carcinoma, Hepatocellular; Hep G2 Cells; Humans; Lipids; Liver Neoplasms; Mice; Mice, Nude; Rats | 2022 |
Intraperitoneal administration of thermosensitive hydrogel Co-loaded with norcantharidin nanoparticles and oxaliplatin inhibits malignant ascites of hepatocellular carcinoma.
Topics: Animals; Ascites; Bridged Bicyclo Compounds, Heterocyclic; Carcinoma, Hepatocellular; Cell Line, Tumor; Hydrogels; Liver Neoplasms; Mice; Nanoparticles; Oxaliplatin; Peritoneal Neoplasms | 2022 |
Norcantharidin liposome emulsion hybrid delivery system enhances PD-1/PD-L1 immunotherapy by agonizing the non-canonical NF-ÎşB pathway.
Topics: B7-H1 Antigen; Carcinoma, Hepatocellular; Cell Line, Tumor; Emulsions; Humans; Immunotherapy; Liposomes; Liver Neoplasms; NF-kappa B; Programmed Cell Death 1 Receptor | 2022 |
Norcantharidin potentiates sorafenib antitumor activity in hepatocellular carcinoma rat model through inhibiting IL-6/STAT3 pathway.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line, Tumor; Interleukin-6; Liver Neoplasms; Male; Rats; Sorafenib | 2023 |
Intratumoral injection of norcantharidin liposome emulsion hybrid delivery system amplifies the cancer-fighting effects of oral sorafenib against hepatocellular carcinoma.
Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Emulsions; Humans; Injections, Intralesional; Liposomes; Liver Neoplasms; Sorafenib | 2023 |
Norcantharidin-Encapsulated C60-Modified Nanomicelles: A Potential Approach to Mitigate Cytotoxicity in Renal Cells and Simultaneously Enhance Anti-Tumor Activity in Hepatocellular Carcinoma Cells.
Topics: Apoptosis; Bridged Bicyclo Compounds, Heterocyclic; Carcinoma, Hepatocellular; Cell Line, Tumor; Humans; Liver Neoplasms; Micelles; Reactive Oxygen Species | 2023 |
Intratumoral Injection of Norcantharidin-Loaded Poly(D,L-lactide)-b-Poly(ethylene glycol)-b-Poly(D,L-lactide) Thermosensitive Hydrogel for the Treatment of Primary Hepatocellular Carcinoma.
Topics: Bridged Bicyclo Compounds, Heterocyclic; Carcinoma, Hepatocellular; Humans; Hydrogels; Injections, Intralesional; Liver Neoplasms; Polyesters; Polyethylene Glycols | 2019 |
Studies on anti-hepatocarcinoma effect, pharmacokinetics and tissue distribution of carboxymethyl chitosan based norcantharidin conjugates.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Carcinoma, Hepatocellular; Cell Line, Tumor; Chitosan; Drug Carriers; Humans; Liver Neoplasms; Mice | 2019 |
Synergistic co-delivery of diacid metabolite of norcantharidin and ABT-737 based on folate-modified lipid bilayer-coated mesoporous silica nanoparticle against hepatic carcinoma.
Topics: Animals; Antineoplastic Agents; Biphenyl Compounds; Bridged Bicyclo Compounds, Heterocyclic; Carcinoma, Hepatocellular; Folic Acid; Lipid Bilayers; Liver; Liver Neoplasms; Mice; Nanoparticles; Nitrophenols; Piperazines; Silicon Dioxide; Sulfonamides | 2020 |
Treatment for Hepatocellular Carcinoma Is Enhanced When Norcantharidin Is Encapsulated in Exosomes Derived from Bone Marrow Mesenchymal Stem Cells.
Topics: Animals; Apoptosis; Bone Marrow; Bridged Bicyclo Compounds, Heterocyclic; Carcinoma, Hepatocellular; Cell Line; Cell Line, Tumor; Cell Proliferation; Exosomes; Hep G2 Cells; Hepatocytes; Humans; Liver Neoplasms; Male; Mesenchymal Stem Cells; Mice; Mice, Inbred BALB C; Mice, Nude | 2021 |
Intratumoral Administration of Thermosensitive Hydrogel Co-Loaded with Norcantharidin Nanoparticles and Doxorubicin for the Treatment of Hepatocellular Carcinoma.
Topics: Animals; Antineoplastic Agents; Body Temperature; Bridged Bicyclo Compounds, Heterocyclic; Carcinoma, Hepatocellular; Cell Line, Tumor; Delayed-Action Preparations; Doxorubicin; Drug Carriers; Drug Liberation; Hep G2 Cells; Humans; Hydrogels; Liver Neoplasms; Mice; Nanoparticles; Poloxamer | 2021 |
FAM46C is critical for the anti-proliferation and pro-apoptotic effects of norcantharidin in hepatocellular carcinoma cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Bridged Bicyclo Compounds, Heterocyclic; Carcinoma, Hepatocellular; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Humans; Liver Neoplasms; Male; Mice, Inbred C57BL; Nucleotidyltransferases; Polynucleotide Adenylyltransferase; Proteins; Signal Transduction | 2017 |
Protein phosphatase 5 promotes hepatocarcinogenesis through interaction with AMP-activated protein kinase.
Topics: AMP-Activated Protein Kinases; Animals; Antineoplastic Agents; Apoptosis; Bridged Bicyclo Compounds, Heterocyclic; Carcinogenesis; Carcinoma, Hepatocellular; Cell Line, Tumor; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; Gene Deletion; HEK293 Cells; Humans; Liver Neoplasms; Liver Neoplasms, Experimental; Mice, Nude; Neoplasm Proteins; Neoplasm Staging; Nuclear Proteins; Phosphoprotein Phosphatases; Protein Tyrosine Phosphatases, Non-Receptor; Random Allocation; Recombinant Fusion Proteins; RNA Interference; Survival Analysis; Tumor Burden | 2017 |
Norcantharidin inhibits IL-6-induced epithelial‑mesenchymal transition via the JAK2/STAT3/TWIST signaling pathway in hepatocellular carcinoma cells.
Topics: Antineoplastic Agents; Apoptosis; Biomarkers, Tumor; Bridged Bicyclo Compounds, Heterocyclic; Carcinoma, Hepatocellular; Cell Movement; Cell Proliferation; Epithelial-Mesenchymal Transition; Humans; Interleukin-6; Janus Kinase 2; Liver Neoplasms; Neoplasm Invasiveness; STAT3 Transcription Factor; Tumor Cells, Cultured; Twist-Related Protein 1 | 2017 |
Preparation and pharmacological evaluation of norcantharidin-conjugated carboxymethyl chitosan in mice bearing hepatocellular carcinoma.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Carcinoma, Hepatocellular; Chitosan; Drug Carriers; Liver Neoplasms, Experimental; Mice; Xenograft Model Antitumor Assays | 2017 |
Norcantharidin combined with Coix seed oil synergistically induces apoptosis and inhibits hepatocellular carcinoma growth by downregulating regulatory T cells accumulation.
Topics: Animals; Antineoplastic Agents; Apoptosis; Biomarkers; Bridged Bicyclo Compounds, Heterocyclic; Carcinoma, Hepatocellular; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cell Survival; Coix; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Humans; Immunophenotyping; Liver Neoplasms; Mice; Plant Oils; Seeds; T-Lymphocytes, Regulatory; Xenograft Model Antitumor Assays | 2017 |
Glycyrrhetinic Acid-Modified Norcantharidin Nanoparticles for Active Targeted Therapy of Hepatocellular Carcinoma.
Topics: Animals; Apoptosis; Bridged Bicyclo Compounds, Heterocyclic; Carcinoma, Hepatocellular; Cell Line, Tumor; Glycyrrhetinic Acid; Liver Neoplasms; Mice; Nanoparticles | 2018 |
Multifunctional self-assembled micelles of galactosamine-hyaluronic acid-vitamin E succinate for targeting delivery of norcantharidin to hepatic carcinoma.
Topics: alpha-Tocopherol; Animals; Antineoplastic Agents; Bridged Bicyclo Compounds, Heterocyclic; Carcinoma, Hepatocellular; Cell Proliferation; Dose-Response Relationship, Drug; Drug Delivery Systems; Drug Screening Assays, Antitumor; Female; Galactosamine; Hep G2 Cells; Humans; Hyaluronic Acid; Liver Neoplasms; Liver Neoplasms, Experimental; MCF-7 Cells; Mice; Mice, Inbred BALB C; Mice, Nude; Micelles; Molecular Structure; Structure-Activity Relationship | 2018 |
Promising positive liver targeting delivery system based on arabinogalactan-anchored polymeric micelles of norcantharidin.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Carcinoma, Hepatocellular; Drug Delivery Systems; Galactans; Hep G2 Cells; Humans; Liver; Liver Neoplasms; Male; Mice; Mice, Nude; Micelles; Xenograft Model Antitumor Assays | 2018 |
In-vivo anti-tumor activity of a novel poloxamer-based thermosensitive in situ gel for sustained delivery of norcantharidin.
Topics: Animals; Antineoplastic Agents; Bridged Bicyclo Compounds, Heterocyclic; Carcinoma, Hepatocellular; Cell Line, Tumor; Delayed-Action Preparations; Female; Gels; Humans; Injections; Liver Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Poloxamer; Temperature; Vascular Endothelial Growth Factor A | 2019 |
Norcantharidin combined with diamminedichloroplatinum inhibits tumor growth and cancerometastasis of hepatic carcinoma in murine.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Bridged Bicyclo Compounds, Heterocyclic; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cisplatin; Disease Models, Animal; Drug Synergism; Female; Humans; Liver Neoplasms; Lung Neoplasms; Mice; Mice, Inbred BALB C; Neovascularization, Pathologic; Treatment Outcome | 2018 |
Cantharidin exerts anti-hepatocellular carcinoma by miR-214 modulating macrophage polarization.
Topics: Animals; Antineoplastic Agents; beta Catenin; Bridged Bicyclo Compounds, Heterocyclic; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Gene Expression Regulation, Neoplastic; Interleukin-10; Interleukin-12; Macrophages; Male; Mice; MicroRNAs; Tumor Microenvironment | 2014 |
Synthesis, interaction with DNA and antiproliferative activities of two novel Cu(II) complexes with norcantharidin and benzimidazole derivatives.
Topics: Animals; Antineoplastic Agents; Benzimidazoles; Bridged Bicyclo Compounds, Heterocyclic; Carcinoma, Hepatocellular; Cattle; Cell Line, Tumor; Cell Proliferation; Coordination Complexes; Copper; Crystallography, X-Ray; DNA; Humans; Intercalating Agents; Liver Neoplasms; Models, Molecular; Serum Albumin, Bovine | 2015 |
Atg5 siRNA inhibits autophagy and enhances norcantharidin-induced apoptosis in hepatocellular carcinoma.
Topics: Antineoplastic Agents; Autophagy; Autophagy-Related Protein 5; Blotting, Western; Bridged Bicyclo Compounds, Heterocyclic; Carcinoma, Hepatocellular; Fluorescent Antibody Technique; Gene Knockdown Techniques; Hep G2 Cells; Humans; Liver Neoplasms; Membrane Potential, Mitochondrial; Microtubule-Associated Proteins; Polymerase Chain Reaction; Reactive Oxygen Species; RNA, Small Interfering; Transfection | 2015 |
New Norcantharidin Analogs: Synthesis and Anticancer Activity.
Topics: Antineoplastic Agents; Bridged Bicyclo Compounds, Heterocyclic; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Design; Hepatic Stellate Cells; Humans; Inhibitory Concentration 50; Liver Neoplasms; Molecular Structure; Structure-Activity Relationship; Time Factors | 2015 |
Norcantharidin combined with ABT-737 for hepatocellular carcinoma: Therapeutic effects and molecular mechanisms.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Biphenyl Compounds; Bridged Bicyclo Compounds, Heterocyclic; Carcinoma, Hepatocellular; Cell Proliferation; Cytochromes c; Dose-Response Relationship, Drug; Hep G2 Cells; Humans; Liver Neoplasms; Myeloid Cell Leukemia Sequence 1 Protein; Nitrophenols; Piperazines; Sulfonamides; Time Factors | 2016 |
Folate receptor-targeted liposomes loaded with a diacid metabolite of norcantharidin enhance antitumor potency for H22 hepatocellular carcinoma both in vitro and in vivo.
Topics: Animals; Apoptosis; Bridged Bicyclo Compounds, Heterocyclic; Carcinoma, Hepatocellular; Cell Proliferation; Chromatography, Liquid; Folate Receptor 1; Folic Acid; Half-Life; Humans; In Vitro Techniques; Liposomes; Liver Neoplasms; Male; Mice; Particle Size; Polyethylene Glycols; Tissue Distribution | 2016 |
[Synthesis and anticancer activity of norcantharidin-galactose derivatives].
Topics: Animals; Antineoplastic Agents; Bridged Bicyclo Compounds, Heterocyclic; Carcinoma, Hepatocellular; Cell Line, Tumor; Drug Delivery Systems; Female; Galactose; Humans; Liver Neoplasms; Male; Mice; Neoplasm Transplantation; Prodrugs | 2008 |
Norcantharidin-associated galactosylated chitosan nanoparticles for hepatocyte-targeted delivery.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Carcinoma, Hepatocellular; Cell Line, Tumor; Chitosan; Drug Carriers; Galactose; Liver Neoplasms; Mice; Nanoparticles | 2010 |
[Norcantharidin induces apoptosis in SMMC-7721 cells via the c-Jun-NH2-terminal kinase signaling pathways].
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Bridged Bicyclo Compounds, Heterocyclic; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Flow Cytometry; Humans; JNK Mitogen-Activated Protein Kinases; Liver Neoplasms; Signal Transduction; Time Factors | 2010 |
N-trimethyl chitosan nanoparticle-encapsulated lactosyl-norcantharidin for liver cancer therapy with high targeting efficacy.
Topics: Animals; Antineoplastic Agents; Apoptosis; Bridged Bicyclo Compounds, Heterocyclic; Carcinoma, Hepatocellular; Chitosan; Drug Delivery Systems; Hep G2 Cells; Humans; Liver; Liver Neoplasms; Male; Mice; Nanoparticles | 2012 |
Antimetastatic effects of norcantharidin on hepatocellular carcinoma by transcriptional inhibition of MMP-9 through modulation of NF-kB activity.
Topics: Bridged Bicyclo Compounds, Heterocyclic; Butadienes; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cell Survival; Hepatocytes; Humans; Liver Neoplasms; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Neoplasm Invasiveness; Neoplasm Metastasis; NF-kappa B; Nitriles; Phosphatidylinositol 3-Kinases; Plasminogen Activator Inhibitor 1; Proto-Oncogene Proteins c-akt; Signal Transduction; Tissue Inhibitor of Metalloproteinase-1; Transcription, Genetic; Urokinase-Type Plasminogen Activator; Wound Healing | 2012 |
Norcantharidin enhances ABT-737-induced apoptosis in hepatocellular carcinoma cells by transcriptional repression of Mcl-1.
Topics: Antineoplastic Agents; Apoptosis; Biphenyl Compounds; Bridged Bicyclo Compounds, Heterocyclic; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Liver Neoplasms; Myeloid Cell Leukemia Sequence 1 Protein; Nitrophenols; Piperazines; Sulfonamides; Transcription, Genetic | 2012 |
Induction of apoptosis in human Hep3B hepatoma cells by norcantharidin through a p53 independent pathway via TRAIL/DR5 signal transduction.
Topics: Antibodies, Neoplasm; Antibodies, Neutralizing; Apoptosis; Bridged Bicyclo Compounds, Heterocyclic; Carcinoma, Hepatocellular; Caspase 10; Caspase 3; Caspase Inhibitors; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; DNA Fragmentation; Humans; Immunohistochemistry; Liver Neoplasms; Receptors, TNF-Related Apoptosis-Inducing Ligand; Signal Transduction; TNF-Related Apoptosis-Inducing Ligand; Tumor Suppressor Protein p53 | 2012 |
Effector mechanisms of norcantharidin-induced mitotic arrest and apoptosis in human hepatoma cells.
Topics: Annexin A5; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; bcl-Associated Death Protein; Blotting, Western; Bridged Bicyclo Compounds, Heterocyclic; Carcinoma, Hepatocellular; Carrier Proteins; Caspase Inhibitors; Caspases; Cell Cycle; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Humans; Liver Neoplasms; Microfilament Proteins; Mitosis; Muscle Proteins; Protein Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2002 |
Norcantharidin-induced apoptosis is via the extracellular signal-regulated kinase and c-Jun-NH2-terminal kinase signaling pathways in human hepatoma HepG2 cells.
Topics: Apoptosis; Bridged Bicyclo Compounds, Heterocyclic; Carcinoma, Hepatocellular; Cell Line, Tumor; Enzyme Activation; Enzyme Inhibitors; Humans; JNK Mitogen-Activated Protein Kinases; Liver Neoplasms; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases | 2003 |
[Studies on the liver targeting of norcantharindin microemulsion].
Topics: Animals; Antineoplastic Agents; Area Under Curve; Bridged Bicyclo Compounds, Heterocyclic; Carcinoma, Hepatocellular; Cell Line, Tumor; Cells, Cultured; Drug Delivery Systems; Emulsions; Female; Humans; Injections, Intravenous; Liver; Liver Neoplasms; Male; Mice; Particle Size; Tissue Distribution | 2004 |
[Effects of interventional therapy with norcantharidin microsphere on hepatoma in rats and its mechanism].
Topics: Alginates; Animals; Apoptosis; Bridged Bicyclo Compounds, Heterocyclic; Carcinoma, Hepatocellular; Cell Proliferation; Glucuronic Acid; Hexuronic Acids; Liver Neoplasms; Liver Neoplasms, Experimental; Microspheres; Random Allocation; Rats | 2006 |
Anticancer activity and mechanisms of norcantharidin-Nd3II on hepatoma.
Topics: Animals; Antineoplastic Agents; Blotting, Western; Bridged Bicyclo Compounds, Heterocyclic; Carcinoma, Hepatocellular; CDC2 Protein Kinase; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cyclin B; Cyclin B1; Drug Screening Assays, Antitumor; Flow Cytometry; Humans; In Vitro Techniques; Liver Neoplasms; Male; Mice; Mice, Inbred ICR; Neodymium; Neoplasm Transplantation; Organometallic Compounds; Proto-Oncogene Proteins c-bcl-2; Structure-Activity Relationship | 2007 |
[Studies on anti-tumor agents. I: Synthesis and anti-cancer activity of amino acid derivatives of norcantharidin].
Topics: Animals; Antineoplastic Agents; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Carcinoma, Hepatocellular; Humans; Liver Neoplasms; Tumor Cells, Cultured | 1993 |
Efficacy of intra-arterial norcantharidin in suppressing tumour 14C-labelled glucose oxidative metabolism in rat Morris hepatoma.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Bridged Bicyclo Compounds, Heterocyclic; Carbon Radioisotopes; Carcinoma, Hepatocellular; Doxorubicin; Drug Evaluation, Preclinical; Glucose; Hepatic Artery; Infusions, Intra-Arterial; Ligation; Liver Neoplasms, Experimental; Male; Oxidation-Reduction; Rats; Rats, Inbred BUF | 1996 |
Norcantharidin inhibits growth of human HepG2 cell-transplanted tumor in nude mice and prolongs host survival.
Topics: Animals; Antineoplastic Agents; Body Weight; Bridged Bicyclo Compounds, Heterocyclic; Carcinoma, Hepatocellular; Doxorubicin; Humans; Liver Neoplasms; Mice; Mice, Nude; Mitomycin; Neoplasm Transplantation; Survival Analysis; Tumor Cells, Cultured | 1997 |