norbuprenorphine has been researched along with Pregnancy in 16 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (25.00) | 29.6817 |
| 2010's | 10 (62.50) | 24.3611 |
| 2020's | 2 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Berquist, MD; Brents, LK; Coward, LU; Gorman, GS; Parks, BJ; Salazar, P; Tobacyk, J | 1 |
| Bastian, JR; Caritis, SN; Chaphekar, N; Chen, H; Shaik, IH; Venkataramanan, R; Zhang, H; Zhao, W | 1 |
| Bhatt, DK; Gao, C; Han, LW; Liao, MZ; Mao, Q; Neradugomma, NK; Phillips, BR; Prasad, B; Shen, DD | 1 |
| Alund, AW; Brents, LK; Cabanlong, CV; Caperton, CO; Fantegrossi, WE; Griffin, BA; Martins, BS; Moran, JH; Owens, SM; Patton, AL; Russell, LN; Urquhart, KR; Wilson, CD; Zita, MD | 1 |
| Brown, S; Carmical, J; Kyle, AR; Pryor, J; Shah, D | 1 |
| Marin, SJ; McMillin, GA | 1 |
| Barnes, AJ; Huestis, MA; Jansson, LM; Scheidweiler, KB; Swortwood, MJ | 1 |
| Liao, MZ; Mao, Q; Neradugomma, NK | 1 |
| Concheiro, M; Huestis, MA; Shakleya, DM | 1 |
| Concheiro, M; Huestis, MA; Johnson, RE; Jones, H; Shakleya, DM | 1 |
| Ahmed, MS; Fokina, VM; Hankins, GV; Nanovskaya, TN; Patrikeeva, SL; Zharikova, OL | 1 |
| Choo, R; Concheiro, M; Huestis, MA; Johnson, RE; Jones, HE | 1 |
| Bartu, AE; Doherty, DA; Gower, S; Hackett, LP; Hamilton, D; Ilett, KF | 1 |
| Huestis, MA; Murphy, CM | 1 |
| Averin, O; Choo, RE; Goodwin, RS; Huestis, MA; Jasinski, DR; Johnson, RE; Jones, HE; Schroeder, JR; Wilkins, DG | 1 |
| Huestis, MA; Kacinko, SL; Shakleya, DM | 1 |
2 trial(s) available for norbuprenorphine and Pregnancy
| Article | Year |
|---|---|
Preliminary buprenorphine sublingual tablet pharmacokinetic data in plasma, oral fluid, and sweat during treatment of opioid-dependent pregnant women.
Topics: Area Under Curve; Buprenorphine; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Narcotic Antagonists; Opioid-Related Disorders; Postpartum Period; Pregnancy; Saliva; Sweat | 2011 |
Buprenorphine and norbuprenorphine in hair of pregnant women and their infants after controlled buprenorphine administration.
Topics: Adult; Buprenorphine; Chromatography, Liquid; Female; Hair; Heroin Dependence; Humans; Infant; Infant, Newborn; Pregnancy; Pregnancy Complications; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tandem Mass Spectrometry; Tissue Distribution | 2007 |
14 other study(ies) available for norbuprenorphine and Pregnancy
| Article | Year |
|---|---|
Interaction between buprenorphine and norbuprenorphine in neonatal opioid withdrawal syndrome.
Topics: Analgesics, Opioid; Animals; Buprenorphine; Female; Humans; Infant, Newborn; Male; Neonatal Abstinence Syndrome; Opioid-Related Disorders; Pregnancy; Rats; Rats, Long-Evans; Receptors, Opioid, mu | 2023 |
Pregnancy Alters CYP- and UGT-Mediated Metabolism of Buprenorphine.
Topics: Adult; Buprenorphine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Female; Glucuronosyltransferase; Humans; Longitudinal Studies; Narcotic Antagonists; Opiate Substitution Treatment; Opioid-Related Disorders; Postpartum Period; Pregnancy; Pregnancy Trimesters; Young Adult | 2020 |
Pregnancy Increases Norbuprenorphine Clearance in Mice by Induction of Hepatic Glucuronidation.
Topics: Animals; Buprenorphine; Female; Glucuronosyltransferase; Inactivation, Metabolic; Liver; Mice; Microsomes, Liver; Pregnancy | 2018 |
In Utero Exposure to Norbuprenorphine, a Major Metabolite of Buprenorphine, Induces Fetal Opioid Dependence and Leads to Neonatal Opioid Withdrawal Syndrome.
Topics: Animals; Animals, Newborn; Buprenorphine; Female; Fetus; Opioid-Related Disorders; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Risk; Substance Withdrawal Syndrome | 2019 |
UHPLC-MS/MS quantification of buprenorphine, norbuprenorphine, methadone, and glucuronide conjugates in umbilical cord plasma.
Topics: Blood Chemical Analysis; Blood Specimen Collection; Buprenorphine; Chromatography, High Pressure Liquid; Female; Fetal Blood; Glucuronides; Humans; Infant, Newborn; Methadone; Phospholipids; Pregnancy; Reproducibility of Results; Sensitivity and Specificity; Solid Phase Extraction; Tandem Mass Spectrometry | 2015 |
Quantitation of Total Buprenorphine and Norbuprenorphine in Meconium by LC-MS/MS.
Topics: Analgesics, Opioid; Buprenorphine; Chromatography, Liquid; Female; Humans; Infant, Newborn; Meconium; Opioid-Related Disorders; Pregnancy; Tandem Mass Spectrometry | 2016 |
Simultaneous quantification of buprenorphine, naloxone and phase I and II metabolites in plasma and breastmilk by liquid chromatography-tandem mass spectrometry.
Topics: Buprenorphine; Chromatography, Liquid; Female; Glucuronides; Humans; Infant, Newborn; Metabolic Detoxication, Phase I; Metabolic Detoxication, Phase II; Methadone; Milk, Human; Naloxone; Narcotic Antagonists; Pregnancy; Solid Phase Extraction; Tandem Mass Spectrometry | 2016 |
Buprenorphine, Norbuprenorphine, R-Methadone, and S-Methadone Upregulate BCRP/ABCG2 Expression by Activating Aryl Hydrocarbon Receptor in Human Placental Trophoblasts.
Topics: ATP Binding Cassette Transporter, Subfamily G, Member 2; Buprenorphine; Female; Gene Knockdown Techniques; Humans; Ligands; Methadone; Placenta; Pregnancy; Promoter Regions, Genetic; Receptors, Aryl Hydrocarbon; RNA, Messenger; Transcription, Genetic; Trophoblasts; Up-Regulation | 2017 |
Simultaneous quantification of buprenorphine, norbuprenorphine, buprenorphine-glucuronide and norbuprenorphine-glucuronide in human umbilical cord by liquid chromatography tandem mass spectrometry.
Topics: Buprenorphine; Chromatography, Liquid; Female; Forensic Toxicology; Glucuronides; Humans; Narcotic Antagonists; Opioid-Related Disorders; Pregnancy; Tandem Mass Spectrometry; Umbilical Cord | 2009 |
Confirmatory analysis of buprenorphine, norbuprenorphine, and glucuronide metabolites in plasma by LCMSMS. Application to umbilical cord plasma from buprenorphine-maintained pregnant women.
Topics: Buprenorphine; Chromatography, Liquid; Female; Fetal Blood; Glucuronides; Humans; Linear Models; Narcotic Antagonists; Opioid-Related Disorders; Pregnancy; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry | 2010 |
Transplacental transfer and metabolism of buprenorphine in preterm human placenta.
Topics: Antibodies, Monoclonal; Aromatase; Aryl Hydrocarbon Hydroxylases; Biotransformation; Buprenorphine; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C8; Cytochrome P-450 Enzyme System; Female; Gestational Age; Humans; In Vitro Techniques; Microsomes; Oxidoreductases, N-Demethylating; Perfusion; Placenta; Pregnancy | 2011 |
Estimated dose exposure of the neonate to buprenorphine and its metabolite norbuprenorphine via breastmilk during maternal buprenorphine substitution treatment.
Topics: Adult; Analgesics, Opioid; Apgar Score; Australia; Breast Feeding; Buprenorphine; Chromatography, Liquid; Female; Humans; Infant Welfare; Infant, Newborn; Male; Mass Spectrometry; Milk, Human; Opiate Substitution Treatment; Pregnancy; Prenatal Exposure Delayed Effects; Surveys and Questionnaires; Treatment Outcome | 2012 |
Liquid chromatographic/electrospray ionization tandem mass spectrometric analysis for the quantification of buprenorphine, norbuprenorphine, buprenorphine-3-beta-D-glucuronide and norbuprenorphine-3-beta-D-glucuronide in human plasma.
Topics: Buprenorphine; Chromatography, High Pressure Liquid; Female; Humans; Narcotic Antagonists; Pregnancy; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization | 2005 |
Validation and application of a method for the determination of buprenorphine, norbuprenorphine, and their glucuronide conjugates in human meconium.
Topics: Buprenorphine; Calibration; Chromatography, Liquid; Female; Glucuronides; Humans; Infant; Meconium; Mothers; Opioid-Related Disorders; Pregnancy; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry | 2008 |