Page last updated: 2024-10-25

nonivamide and Acute Pain

nonivamide has been researched along with Acute Pain in 1 studies

nonivamide: has effect on sensory neurons
nonivamide : A capsaicinoid that is the carboxamide resulting from the formal condensation of the amino group of 4-hydroxy-3-methoxybenzylamine with the carboxy group of nonanoic acid. It is the active ingredient in many pepper sprays.

Acute Pain: Intensely discomforting, distressful, or agonizing sensation associated with trauma or disease, with well-defined location, character, and timing.

Research Excerpts

ExcerptRelevanceReference
"Until now, nonivamide/nicoboxil ointment has not been tested in a randomized trial for the treatment of acute non-specific low back pain."9.22Efficacy and safety of nicoboxil/nonivamide ointment for the treatment of acute pain in the low back - A randomized, controlled trial. ( Gaubitz, M; Holm, C; Pisternick-Ruf, W; Richter, E; Schiffer, T; Weiser, T, 2016)
"Until now, nonivamide/nicoboxil ointment has not been tested in a randomized trial for the treatment of acute non-specific low back pain."5.22Efficacy and safety of nicoboxil/nonivamide ointment for the treatment of acute pain in the low back - A randomized, controlled trial. ( Gaubitz, M; Holm, C; Pisternick-Ruf, W; Richter, E; Schiffer, T; Weiser, T, 2016)

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Gaubitz, M1
Schiffer, T1
Holm, C1
Richter, E1
Pisternick-Ruf, W1
Weiser, T1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Multi-centre, Double-blind, Randomised, Parallel Group Study to Assess the Efficacy and Safety of Multiple Doses of Topically Applied Hyperemisation-inducing Ointment (2cm Ointment Line Per Application; up to 3 Times Daily for up to 4 Days) Containing 2[NCT01708915]Phase 3805 participants (Actual)Interventional2012-10-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Difference Between Baseline Pain Intensity and Average Pain Intensity on the Last Individual Treatment Day

Average pain intensity was assessed in the evening of days 1, 2, 3 and 4 on a 11-point numerical rating scale ranging from 0 (no pain) to 10 (worst pain possible). The last individual treatment day is the last day with diary-recorded ointment application. Means were adjusted for centre effect and baseline value. (NCT01708915)
Timeframe: Baseline and 1 to 4 days

Interventionunits on a scale (Least Squares Mean)
Placebo-1.884
Nicoboxil-2.371
Nonivamide-3.074
Nicoboxil/Nonivamide-3.540

Pain Intensity Difference (PID) Between Pre-dose Baseline and 4 Hours After First Application

Pain intensity was assessed on a 11-point numerical rating scale ranging from 0 (no pain) to 10 (worst pain possible) at pre-dose baseline and 0.5, 1, 2, 3 and 4 hours after first ointment application. Means were adjusted for centre effect and baseline value. (NCT01708915)
Timeframe: Baseline and 4 hours after first ointment application

Interventionunits on a scale (Least Squares Mean)
Placebo-0.650
Nicoboxil-0.968
Nonivamide-1.641
Nicoboxil/Nonivamide-1.699

Pain Intensity Difference (PID) Between Pre-dose Baseline and 8hours After First Application

Pain intensity (PI) was assessed on a 11-point numerical rating scale ranging from 0 (no pain) to 10 (worst pain possible) at pre-dose baseline and 0.5, 1, 2, 3, 4, 6 and 8 hours after first ointment application. Means were adjusted for centre effect and baseline value. (NCT01708915)
Timeframe: Baseline and 8 hours after first ointment application

Interventionunits on a scale (Least Squares Mean)
Placebo-1.049
Nicoboxil-1.428
Nonivamide-2.252
Nicoboxil/Nonivamide-2.410

Patient Assessment of Efficacy on the Last Individual Treatment Day

Patient assessment of efficacy was assessed on a 4-point verbal rating scale (VRS, 0 = 'poor', 1 = 'fair', 2 = 'good', 3 = 'very good' relief of the patients' low back pain) in the evening of days 1, 2, 3 and 4. The last individual treatment day is the last day with diary-recorded ointment application (NCT01708915)
Timeframe: 1 to 4 days

,,,
Interventionparticipants (Number)
Very goodGoodFairPoorMissing
Nicoboxil196720941
Nicoboxil/Nonivamide508820422
Nonivamide348527520
Placebo947221251

Trials

1 trial available for nonivamide and Acute Pain

ArticleYear
Efficacy and safety of nicoboxil/nonivamide ointment for the treatment of acute pain in the low back - A randomized, controlled trial.
    European journal of pain (London, England), 2016, Volume: 20, Issue:2

    Topics: Acute Pain; Adolescent; Adult; Aged; Capsaicin; Double-Blind Method; Drug Combinations; Female; Huma

2016