non-ovlon and Metrorrhagia

Platelet aggregation during steroidal treatment of dysfunctional uterine hemorrhages in the climacteric was studied. Non-ovlon, containing .05 mg of ethinyl estradiol and 1 mg of norethisterone acetate, and Norcolut, containing 5 mg of norethisterone, were used as sex steroids. The study included 60 women, aged 40-53 years, with dysfunctional hemorrhages. The control group consisted of 20 healthy women in the same age group. Upon admission, all patients were complaining of uterine hemorrhages and general weakness. In most cases, the hemorrhages were of an acyclical nature. In 3 months, 5 of the 20 women taking Non-ovlon developed the clinical symptoms of thrombophilia. In 3 of the 5 patients, symptoms of thrombophlebitis were observed. Hormonal therapy for these patients was terminated and they were treated with anticoagulants and antiaggregants. Norcolut caused no clinical symptons of thrombophilia. Results were confirmed by platelet determinations and aggregatograms. Comparison of clinical and laboratory data suggests a direct correlation between platelet hyperactivity and the genesis of the aforementioned complications of combined estrogen/gestagen preparations. Results contribute to a better understanding of the disorders occurring during the intake of sex steroids in the climacteric.

Topics: Adult; Chlormadinone Acetate; Climacteric; Contraceptives, Oral, Combined; Drug Combinations; Estradiol Congeners; Female; Humans; Metrorrhagia; Middle Aged; Norethindrone; Platelet Aggregation; Progesterone Congeners