nomifensine has been researched along with Xerostomia in 8 studies
Nomifensine: An isoquinoline derivative that prevents dopamine reuptake into synaptosomes. The maleate was formerly used in the treatment of depression. It was withdrawn worldwide in 1986 due to the risk of acute hemolytic anemia with intravascular hemolysis resulting from its use. In some cases, renal failure also developed. (From Martindale, The Extra Pharmacopoeia, 30th ed, p266)
nomifensine : An N-methylated tetrahydroisoquinoline carrying phenyl and amino substituents at positions C-4 and C-8, respectively.
Xerostomia: Decreased salivary flow.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Side effects include sleep disturbance, restlessness, and nausea; rare adverse reactions are in keeping with other antidepressants." | 3.75 | A review of the clinical safety and tolerability of nomifensine. ( Stonier, PD, 1984) |
| "Nomifensine was at least as effective as imipramine in reducing depressive symptoms at average doses of 150 mg/day." | 2.65 | Multicenter double-blind comparison of nomifensine and imipramine for efficacy and safety in depressed outpatients. ( Abrahams, LM; Bremner, JD; Crupie, JE; McCawley, A; Proctor, RC; Sathananthan, GL, 1984) |
| "The nomifensine-treated depressed patients showed significant improvement over the placebo depressed patients early in and throughout treatment." | 2.65 | Nomifensine in geriatric inpatients: a placebo-controlled study. ( Jansen, W; Siegfried, K, 1984) |
| " The findings suggest a more favorable side effect profile for nomifensine, which was associated with a lower frequency of sedating and anticholinergic effects than was seen in the imipramine group." | 2.65 | A double-blind comparative evaluation of the efficacy and safety of nomifensine, imipramine, and placebo in depressed geriatric outpatients. ( Feighner, JP; Hendrickson, G; Merideth, CH, 1984) |
| " Side effect information was collected at each visit." | 2.65 | An overview of side effects and long-term experience with nomifensine from United States clinical trials. ( Hardiman, S; Nash, RJ; Yakabow, AL, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bremner, JD | 1 |
| Abrahams, LM | 1 |
| Crupie, JE | 1 |
| McCawley, A | 1 |
| Proctor, RC | 1 |
| Sathananthan, GL | 1 |
| Fann, WE | 1 |
| Lyle, FA | 1 |
| Higginbotham, W | 1 |
| Jansen, W | 1 |
| Siegfried, K | 1 |
| Cohn, JB | 1 |
| Varga, L | 1 |
| Lyford, A | 1 |
| Merideth, CH | 1 |
| Feighner, JP | 1 |
| Hendrickson, G | 1 |
| Stonier, PD | 1 |
| Yakabow, AL | 1 |
| Hardiman, S | 1 |
| Nash, RJ | 1 |
| Pepper, GA | 1 |
1 review available for nomifensine and Xerostomia
| Article | Year |
|---|---|
A review of the clinical safety and tolerability of nomifensine.
Topics: Adult; Akathisia, Drug-Induced; Animals; Antidepressive Agents; Cardiovascular System; Clinical Tria | 1984 |
7 trials available for nomifensine and Xerostomia
| Article | Year |
|---|---|
Multicenter double-blind comparison of nomifensine and imipramine for efficacy and safety in depressed outpatients.
Topics: Adolescent; Adult; Aged; Ambulatory Care; Clinical Trials as Topic; Depressive Disorder; Double-Blin | 1984 |
Nomifensine vs. imipramine in depressed inpatients.
Topics: Adult; Akathisia, Drug-Induced; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; | 1984 |
Nomifensine in geriatric inpatients: a placebo-controlled study.
Topics: Aged; Clinical Trials as Topic; Cognition Disorders; Depressive Disorder; Double-Blind Method; Fatig | 1984 |
A two-center double-blind study of nomifensine, imipramine, and placebo in depressed geriatric outpatients.
Topics: Aged; Akathisia, Drug-Induced; Ambulatory Care; Clinical Trials as Topic; Depressive Disorder; Doubl | 1984 |
A double-blind comparative evaluation of the efficacy and safety of nomifensine, imipramine, and placebo in depressed geriatric outpatients.
Topics: Aged; Akathisia, Drug-Induced; Ambulatory Care; Clinical Trials as Topic; Depressive Disorder; Doubl | 1984 |
A review of the clinical safety and tolerability of nomifensine.
Topics: Adult; Akathisia, Drug-Induced; Animals; Antidepressive Agents; Cardiovascular System; Clinical Tria | 1984 |
An overview of side effects and long-term experience with nomifensine from United States clinical trials.
Topics: Adult; Akathisia, Drug-Induced; Clinical Trials as Topic; Depressive Disorder; Dizziness; Headache; | 1984 |
1 other study available for nomifensine and Xerostomia
| Article | Year |
|---|---|
Nomifensine (Merital): a second generation antidepressant.
Topics: Akathisia, Drug-Induced; Antidepressive Agents; Constipation; Depression; Headache; Humans; Kinetics | 1986 |