nomifensine has been researched along with Seizures in 11 studies
Nomifensine: An isoquinoline derivative that prevents dopamine reuptake into synaptosomes. The maleate was formerly used in the treatment of depression. It was withdrawn worldwide in 1986 due to the risk of acute hemolytic anemia with intravascular hemolysis resulting from its use. In some cases, renal failure also developed. (From Martindale, The Extra Pharmacopoeia, 30th ed, p266)
nomifensine : An N-methylated tetrahydroisoquinoline carrying phenyl and amino substituents at positions C-4 and C-8, respectively.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Four cases of convulsive seizures occurring during treatment with nomifensine have been notified to the Committee on the Safety of Medicines of the United Kingdom, and 22 cases have been reported from other countries." | 7.67 | Nomifensine and convulsive seizures. ( Edwards, JG; Glen-Bott, M, 1987) |
| "An In Vivo model is presented to determine the effects of alpha methyl-para-tyrosine methyl ester (MPT), fusaric acid (FA), and haloperidol on nomifensine-induced seizures." | 7.67 | Delay of nomifensine-induced seizures by fusaric acid, alpha-methyltyrosine and haloperidol. ( Huff, MR; Johnson, WE; Meadows, GG, 1986) |
| "Four cases of convulsive seizures occurring during treatment with nomifensine have been notified to the Committee on the Safety of Medicines of the United Kingdom, and 22 cases have been reported from other countries." | 3.67 | Nomifensine and convulsive seizures. ( Edwards, JG; Glen-Bott, M, 1987) |
| "An In Vivo model is presented to determine the effects of alpha methyl-para-tyrosine methyl ester (MPT), fusaric acid (FA), and haloperidol on nomifensine-induced seizures." | 3.67 | Delay of nomifensine-induced seizures by fusaric acid, alpha-methyltyrosine and haloperidol. ( Huff, MR; Johnson, WE; Meadows, GG, 1986) |
| "Nomifensine was withdrawn from markets worldwide because of reports of serious hypersensitivity reactions, especially hemolytic anemia, and marketing of bupropion in the United States was delayed after seizures occurred in bulimic patients in clinical trials." | 2.37 | Adverse reactions to five new antidepressants. ( Hayes, PE; Kristoff, CA, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (90.91) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (9.09) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rudorfer, MV | 1 |
| Golden, RN | 2 |
| Potter, WZ | 1 |
| Trimble, MR | 2 |
| Gillman, MA | 1 |
| Sandyk, R | 1 |
| Huff, MR | 2 |
| Johnson, WE | 2 |
| Meadows, GG | 2 |
| Sato, T | 1 |
| Kitayama, S | 1 |
| Morita, K | 1 |
| Ikeda, T | 1 |
| Dohi, T | 1 |
| Sato, M | 1 |
| Hikasa, N | 1 |
| Otsuki, S | 1 |
| Meldrum, BS | 1 |
| Anlezark, G | 1 |
| Brown, TM | 1 |
| Miller, H | 1 |
| Evans, DL | 1 |
| Hayes, PE | 1 |
| Kristoff, CA | 1 |
| Edwards, JG | 1 |
| Glen-Bott, M | 1 |
4 reviews available for nomifensine and Seizures
| Article | Year |
|---|---|
Second-generation antidepressants.
Topics: Alprazolam; Amoxapine; Antidepressive Agents; Benzodiazepines; Bupropion; Citalopram; Clinical Trial | 1984 |
Epilepsy, antidepressants, and the role of nomifensine.
Topics: Adult; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Clinical Trials as Topic; Double-Bl | 1984 |
The new antidepressants.
Topics: Alprazolam; Amoxapine; Antidepressive Agents; Fluoxetine; Maprotiline; Nomifensine; Seizures; Trazod | 1988 |
Adverse reactions to five new antidepressants.
Topics: Acute Kidney Injury; Amoxapine; Animals; Antidepressive Agents; Bupropion; Cardiovascular Diseases; | 1986 |
2 trials available for nomifensine and Seizures
| Article | Year |
|---|---|
Second-generation antidepressants.
Topics: Alprazolam; Amoxapine; Antidepressive Agents; Benzodiazepines; Bupropion; Citalopram; Clinical Trial | 1984 |
Epilepsy, antidepressants, and the role of nomifensine.
Topics: Adult; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Clinical Trials as Topic; Double-Bl | 1984 |
7 other studies available for nomifensine and Seizures
| Article | Year |
|---|---|
Nomifensine exacerbates depression and seizures in an epileptic patient.
Topics: Depression; Female; Humans; Isoquinolines; Middle Aged; Nomifensine; Seizures | 1984 |
Delay of nomifensine induced convulsions by pyridoxine HCl.
Topics: Animals; Isoquinolines; Male; Nomifensine; Pyridoxine; Rats; Seizures; Time Factors | 1980 |
Changes in seizure susceptibility to local anesthetics by repeated administration of cocaine and nomifensine but not GBR12935: possible involvement of noradrenergic system.
Topics: Anesthetics, Local; Animals; Cocaine; Male; Mice; Mice, Inbred ICR; Nomifensine; Norepinephrine; Pip | 2000 |
[Effects of nomifensine and imipramine on amygdaloid kindled convulsion--inhibitory effects of dopamine on epileptic seizure (author's transl)].
Topics: Amygdala; Animals; Cats; Dopamine; Electric Stimulation; Imipramine; Isoquinolines; Nomifensine; Sei | 1978 |
Effect of nomifensine on brain amines and epilepsy in photosensitive baboons.
Topics: Amines; Animals; Brain Chemistry; Clomipramine; Dose-Response Relationship, Drug; Imipramine; Isoqui | 1977 |
Nomifensine and convulsive seizures.
Topics: Aged; Female; Humans; Middle Aged; Nomifensine; Seizures | 1987 |
Delay of nomifensine-induced seizures by fusaric acid, alpha-methyltyrosine and haloperidol.
Topics: Animals; Brain; Dopamine; Fusaric Acid; Haloperidol; Male; Methyltyrosines; Nomifensine; Norepinephr | 1986 |