nomifensine has been researched along with Pituitary Neoplasms in 41 studies
Nomifensine: An isoquinoline derivative that prevents dopamine reuptake into synaptosomes. The maleate was formerly used in the treatment of depression. It was withdrawn worldwide in 1986 due to the risk of acute hemolytic anemia with intravascular hemolysis resulting from its use. In some cases, renal failure also developed. (From Martindale, The Extra Pharmacopoeia, 30th ed, p266)
nomifensine : An N-methylated tetrahydroisoquinoline carrying phenyl and amino substituents at positions C-4 and C-8, respectively.
Pituitary Neoplasms: Neoplasms which arise from or metastasize to the PITUITARY GLAND. The majority of pituitary neoplasms are adenomas, which are divided into non-secreting and secreting forms. Hormone producing forms are further classified by the type of hormone they secrete. Pituitary adenomas may also be characterized by their staining properties (see ADENOMA, BASOPHIL; ADENOMA, ACIDOPHIL; and ADENOMA, CHROMOPHOBE). Pituitary tumors may compress adjacent structures, including the HYPOTHALAMUS, several CRANIAL NERVES, and the OPTIC CHIASM. Chiasmal compression may result in bitemporal HEMIANOPSIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A group of 17 hyperprolactinemic women was given 200 mg of nomifensine orally to evaluate its diagnostic potential to discriminate between tumors and nontumorous hyperprolactinemia." | 7.66 | Nomifensine test does not differentiate hyperprolactinemia associated with and without radiologic abnormalities in the sella turcica. ( Ablanedo, J; Canales, ES; Cano, C; Zárate, A, 1981) |
| "To verify the diagnostic capacity of some dynamic tests of the prolactin (Prl) secretion, the findings obtained by high-resolution computed tomography (CT) were compared with results obtained from tests using nomifensine (NOM) domperidone (DOM) and thyrotrophin-releasing hormone (TRH) in 72 patients with pathological hyperprolactinaemia." | 3.67 | Comparison between pituitary computed tomographic findings and tests of hypothalamo-pituitary function in 72 patients with hyperprolactinaemia. ( Bianchi, SD; Camanni, F; Ciccarelli, E; Gatti, G; Ghigo, E; Massara, F; Molinatti, GM; Müller, EE, 1986) |
| " Twenty-six women diagnosed by dynamic tests and radiologic examination as having PRL-secreting adenoma were treated surgically (15) or with bromocriptine (11) and their condition was evaluated one to three years later by TRH, nomifensine, and domperidone tests." | 3.67 | Prolactin secretion after surgery or bromocriptine treatment of prolactinoma. ( D'Antona, N; Danero, S; De Leo, V; Genazzani, AR; Petraglia, F; Sardelli, S, 1987) |
| "A group of 17 hyperprolactinemic women was given 200 mg of nomifensine orally to evaluate its diagnostic potential to discriminate between tumors and nontumorous hyperprolactinemia." | 3.66 | Nomifensine test does not differentiate hyperprolactinemia associated with and without radiologic abnormalities in the sella turcica. ( Ablanedo, J; Canales, ES; Cano, C; Zárate, A, 1981) |
| "Nomifensine failed to suppress the serum PRL in all subjects and PRL responses to TRH and insulin-induced hypoglycemia were impaired in all patients, irrespective of the origin of hyperprolactinemia." | 1.27 | Nomifensine, TRH and insulin-induced hypoglycemia tests in the diagnosis of prolactinomas. ( Fachinetti, A; Fachinetti, P; Iannotta, F; Pinotti, G; Usellini, L, 1983) |
| "The normality of the GH-ACTH-secreting pituitary tumors and hypothalamic tumor responses to TRH is one more factor in differentiating these from prolactinomas." | 1.27 | Evidence of abnormal dopaminergic control of prolactin in patients with hypothalamic and pituitary tumors. ( Almoguera, I; Cabranes, JA; Charro, AL; del Olmo, J; Pablos, I; Prensa, A, 1986) |
| "Domperidone did not increase PRL in about a third of acromegalic patients, while TRH increased PRL in the all normoprolactinemic acromegalic patients." | 1.27 | Disturbed prolactin responses to dopamine-related substances in patients with acromegaly and hyperprolactinemia. ( Ibayashi, H; Ikuyama, S; Karashima, T; Kato, K; Muta, K; Sekiya, K, 1985) |
| "Nomifensine has recently been proposed as a dynamic test to discriminate tumoral from functional hyperprolactinaemia." | 1.26 | Some critical considerations on the use of the nomifensine test in the hyperprolactinaemic syndrome. ( Aliffi, A; D'Agata, R; Gulizia, S; Mongioì, A; Vicari, E; Volpicelli, D, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 41 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ferrari, C | 4 |
| Romussi, M | 1 |
| Benco, R | 2 |
| Rampini, P | 3 |
| Mailland, F | 1 |
| De Leo, V | 8 |
| D'Ambrogio, G | 1 |
| De Leo, M | 2 |
| Franchi, F | 2 |
| Inaudi, P | 1 |
| La Rosa, R | 1 |
| D'Antona, N | 3 |
| Genazzani, AR | 10 |
| Camanni, F | 8 |
| Ghigo, E | 2 |
| Ciccarelli, E | 2 |
| Massara, F | 6 |
| Campagnoli, C | 1 |
| Molinatti, G | 1 |
| Müller, EE | 12 |
| Iannotta, F | 1 |
| Fachinetti, P | 1 |
| Fachinetti, A | 1 |
| Pinotti, G | 1 |
| Usellini, L | 1 |
| Cavagnini, F | 1 |
| Martinez-Campos, A | 1 |
| Maraschini, C | 1 |
| Giovannini, P | 1 |
| Novelli, A | 2 |
| Cocchi, D | 6 |
| Ganzetti, I | 1 |
| Giusti, M | 1 |
| Mazzocchi, G | 2 |
| Mignone, D | 1 |
| Tarditi, W | 1 |
| Contessini, M | 1 |
| Bessarione, D | 1 |
| Giordano, G | 1 |
| Danero, S | 2 |
| Ricci, MG | 1 |
| La Marca, S | 2 |
| Urbani, TM | 2 |
| Pieroni, ML | 1 |
| Minuto, F | 1 |
| Barbarino, A | 2 |
| Baviera, G | 1 |
| De Marinis, L | 2 |
| Leonardi, R | 1 |
| Bernasconi, D | 1 |
| Menini, E | 2 |
| Maira, G | 2 |
| Anile, C | 2 |
| Picciolini, E | 1 |
| Belforte, L | 1 |
| Casanueva, F | 1 |
| Locatelli, V | 1 |
| Flauto, C | 1 |
| Zambotti, F | 1 |
| Bestetti, G | 1 |
| Rossi, GL | 2 |
| Müller, E | 1 |
| Caldara, R | 3 |
| Scarduelli, C | 1 |
| Crosignani, PG | 3 |
| Canales, ES | 1 |
| Cano, C | 1 |
| Ablanedo, J | 1 |
| Zárate, A | 1 |
| Murru, S | 2 |
| De Gennes, JL | 1 |
| Turpin, G | 1 |
| Heshmati, HM | 1 |
| Carayon, A | 1 |
| Dallabonzana, D | 1 |
| Spelta, B | 1 |
| Botalla, L | 1 |
| Oppizzi, G | 1 |
| Silvestrini, F | 1 |
| Chiodini, PG | 1 |
| Liuzzi, A | 1 |
| Pontiroli, AE | 2 |
| Loda, G | 1 |
| Roggia, A | 1 |
| Scagliola, P | 1 |
| Falsetti, L | 2 |
| Massafra, C | 1 |
| Venturi, C | 1 |
| Iodice, M | 1 |
| Lombardi, G | 1 |
| Tommaselli, A | 1 |
| Rossi, R | 1 |
| Annunziato, L | 1 |
| Minozzi, M | 1 |
| Abraham, G | 1 |
| Picciotti, MC | 1 |
| Malinverni, A | 2 |
| Barattini, B | 1 |
| Telloli, P | 1 |
| Molinatti, GM | 4 |
| Moriondo, P | 1 |
| Travaglini, P | 1 |
| Nissim, M | 1 |
| Faglia, G | 1 |
| D'Agata, R | 1 |
| Aliffi, A | 1 |
| Vicari, E | 1 |
| Volpicelli, D | 1 |
| Mongioì, A | 1 |
| Gulizia, S | 1 |
| Kamoi, K | 1 |
| Tchuchida, I | 1 |
| Sato, H | 1 |
| Tanaka, R | 1 |
| Ishiguro, T | 1 |
| Kaneko, K | 1 |
| Iwasaki, Y | 1 |
| Shibata, A | 1 |
| Gullo, D | 1 |
| Carmina, E | 1 |
| Mogavero, G | 1 |
| Perino, A | 1 |
| Venezia, R | 1 |
| Barbieri, C | 1 |
| Mattei, AM | 1 |
| Rocchetti, M | 1 |
| Genazzani, A | 1 |
| Takeda, R | 1 |
| Minagawa, F | 1 |
| Nakabayashi, H | 1 |
| Cabranes, JA | 1 |
| Almoguera, I | 1 |
| del Olmo, J | 1 |
| Prensa, A | 1 |
| Pablos, I | 1 |
| Charro, AL | 1 |
| Bianchi, SD | 1 |
| Gatti, G | 1 |
| Petraglia, F | 1 |
| Sardelli, S | 1 |
| Aguirre Sánchez-Covisa, M | 1 |
| Ruiz-Valdepeñas, MP | 1 |
| Larrodera, L | 1 |
| Jaunsolo, MA | 1 |
| Hawkins, FG | 1 |
| Mancini, A | 1 |
| D'Amico, C | 1 |
| Passeri, M | 1 |
| Sambo, P | 1 |
| Vertosick, FT | 1 |
| Peñalva, A | 1 |
| Torpia, R | 1 |
| Sekiya, K | 1 |
| Karashima, T | 1 |
| Ikuyama, S | 1 |
| Muta, K | 1 |
| Kato, K | 1 |
| Ibayashi, H | 1 |
1 review available for nomifensine and Pituitary Neoplasms
| Article | Year |
|---|---|
[Differential diagnosis of hyperprolactinemia].
Topics: Adenoma; Bromocriptine; Diagnosis, Differential; Humans; Hyperprolactinemia; Levodopa; Nomifensine; | 1986 |
1 trial available for nomifensine and Pituitary Neoplasms
| Article | Year |
|---|---|
The effect of nomifensine on thyroid-stimulating hormone (TSH) in normal and hyperprolactinemic subjects.
Topics: Adult; Female; Humans; Isoquinolines; Male; Nomifensine; Pituitary Neoplasms; Placebos; Prolactin; T | 1983 |
39 other studies available for nomifensine and Pituitary Neoplasms
| Article | Year |
|---|---|
Effect of dihydroergocristine administration on serum prolactin and growth hormone levels in normal, hyperprolactinaemic, and acromegalic subjects: further evidence for pituitary dopamine deficiency in these conditions.
Topics: Acromegaly; Adenoma; Adolescent; Adult; Amenorrhea; Dihydroergotoxine; Dopamine; Female; Growth Horm | 1983 |
[Hyperprolactinemia in chronic renal insufficiency: an interesting model of hypothalamo-hypophyseal dysfunction].
Topics: Adult; Bromocriptine; Domperidone; Female; Humans; Hypothalamo-Hypophyseal System; Kidney Failure, C | 1983 |
Defective regulation of prolactin secretion after successful removal of prolactinomas.
Topics: Adenoma; Adult; Domperidone; Female; Humans; Male; Nomifensine; Pituitary Neoplasms; Pregnancy; Prol | 1983 |
Nomifensine, TRH and insulin-induced hypoglycemia tests in the diagnosis of prolactinomas.
Topics: Adolescent; Adult; Blood Glucose; Child; Female; Humans; Insulin; Isoquinolines; Male; Middle Aged; | 1983 |
Dynamic testing of prolactin and growth hormone secretion in patients with neuroendocrine disorders.
Topics: Acromegaly; Adolescent; Adult; Aged; Brain; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Domperidone; Fem | 1984 |
Nomifensine in hyperprolactinemic states.
Topics: Humans; Isoquinolines; Nomifensine; Pituitary Neoplasms; Prolactin; Thyrotropin-Releasing Hormone | 1984 |
In vivo supersensitivity of the anterior pituitary of old female rats to dopaminergic inhibition of prolactin secretion.
Topics: Adenoma; Animals; Bromocriptine; Dopamine Antagonists; Female; Isoquinolines; Kinetics; Nomifensine; | 1984 |
[Various aspects of dopaminergic function in patients with prolactin-secreting hypophyseal adenoma].
Topics: Adenoma; Adult; Amenorrhea; Carbidopa; Dopamine; Female; Humans; Levodopa; Nomifensine; Pituitary Ne | 1983 |
Multicentric experience on the acute effect of nomifensine in hyperprolactinemic women.
Topics: Adolescent; Adult; Female; Humans; Isoquinolines; Nomifensine; Pituitary Neoplasms; Postpartum Perio | 1984 |
A new pharmacological approach to the diagnosis of hyperprolactinaemic states: the nomifensine test.
Topics: Adult; Female; Follicle Stimulating Hormone; Humans; Isoquinolines; Luteinizing Hormone; Male; Menst | 1980 |
Defective central nervous system dopaminergic function in rats with estrogen-induced pituitary tumors, as assessed by plasma prolactin concentrations.
Topics: Animals; Brain; Bromocriptine; Domperidone; Dopamine; Estradiol; Female; Hypothalamus; Median Eminen | 1982 |
Functional characterization of hypothalamic hyperprolactinemia.
Topics: Adult; Aged; Carbidopa; Child; Dopamine; Female; Humans; Hypothalamic Diseases; Levodopa; Male; Meni | 1982 |
Nomifensine test does not differentiate hyperprolactinemia associated with and without radiologic abnormalities in the sella turcica.
Topics: Adenoma; Adult; Diagnosis, Differential; Female; Humans; Hyperprolactinemia; Nomifensine; Pituitary | 1981 |
Dynamic tests of prolactin secretion in hyperprolactinemic states: carbidopa-L-dopa and indirectly acting dopamine agonists.
Topics: Adenoma; Adult; Carbidopa; Dopamine; Female; Humans; Kinetics; Levodopa; Methylphenidate; Nomifensin | 1982 |
[Progress in the hormonal detection of pituitary prolactin adenoma].
Topics: Adenoma; Bromocriptine; Domperidone; Humans; Metoclopramide; Nomifensine; Pituitary Neoplasms; Prola | 1982 |
Effects of nomifensine on growth hormone and prolactin secretion in normal subjects and in pathological hyperprolactinemia.
Topics: Adult; Analysis of Variance; Dopamine; Female; Growth Hormone; Humans; Isoquinolines; Nomifensine; P | 1982 |
Benserazide and nomifensine in the diagnosis of prolactin-secreting pituitary adenomas.
Topics: Adenoma; Benserazide; Female; Humans; Hydrazines; Isoquinolines; Nomifensine; Pituitary Neoplasms; P | 1982 |
[Indirect dopamine agonists and direct dopamine antagonists in the diagnosis of hyperprolactinemia].
Topics: Adenoma; Adult; Domperidone; False Negative Reactions; False Positive Reactions; Female; Humans; Iso | 1982 |
Agreement of prolactin response to cimetidine and nomifensine in patients with prolactin-secreting tumors and idiopathic hyperprolactinemia.
Topics: Adolescent; Adult; Cimetidine; Female; Guanidines; Humans; Isoquinolines; Male; Nomifensine; Pituita | 1982 |
Use of bromocriptine as a diagnostic and therapeutic tool in hyperprolactinemic states.
Topics: Adenoma; Adolescent; Adult; Amenorrhea; Bromocriptine; Child; Female; Galactorrhea; Humans; Lactatio | 1982 |
Failure of nomifensine administration to discriminate between tumorous and nontumorous hyperprolactinemia.
Topics: Adenoma; Adolescent; Adult; Amenorrhea; Diagnosis, Differential; Female; Galactorrhea; Humans; Isoqu | 1980 |
Tests of prolactin secretion in the diagnosis of hyperprolactinemic states: nomifensine and domperidone.
Topics: Adenoma; Adult; Benzimidazoles; Domperidone; Female; Humans; Isoquinolines; Male; Menstruation; Midd | 1981 |
Evaluation of two inhibitory tests (nomifensine and L-dopa + carbidopa) for the diagnosis of hyperprolactinaemic states.
Topics: Adenoma; Adolescent; Adult; Carbidopa; Diagnosis, Differential; Female; Humans; Isoquinolines; Levod | 1980 |
Some critical considerations on the use of the nomifensine test in the hyperprolactinaemic syndrome.
Topics: Adenoma; Adolescent; Adult; Clinical Laboratory Techniques; Diagnosis, Differential; Female; Humans; | 1981 |
Comparison of the responses in the nomifensine test with hyperprolactinemia due to prolactin-secreting pituitary tumors and nonprolactin-secreting hypothalamic tumors.
Topics: Adenoma; Adult; Female; Humans; Hypothalamic Neoplasms; Isoquinolines; Male; Middle Aged; Nomifensin | 1981 |
Nomifensine in the diagnosis of hyperprolactinemia.
Topics: Adenoma; Adolescent; Adult; Female; Humans; Isoquinolines; Nomifensine; Pituitary Neoplasms; Prolact | 1981 |
Prolactin responsiveness to nomifensine in patients with hyperprolactinemia of tumorous or uncertain etiology.
Topics: Adolescent; Adult; Female; Humans; Isoquinolines; Male; Middle Aged; Nomifensine; Pituitary Neoplasm | 1980 |
Effect of central nervous system dopaminergic activation on prolactin secretion in man: evidence for a common central defect in hyperprolactinemic patients with and without radiological signs of pituitary tumors.
Topics: Adolescent; Adult; Carbidopa; Female; Humans; Kinetics; Levodopa; Nomifensine; Pituitary Neoplasms; | 1980 |
Biochemical diagnosis of prolactinoma.
Topics: Adenoma; Female; Humans; Nomifensine; Paraneoplastic Endocrine Syndromes; Pituitary Gland, Anterior; | 1979 |
Nomifensine: diagnostic test in hyperprolactinemic states.
Topics: Adenoma; Female; Humans; Isoquinolines; Lactation; Nomifensine; Pituitary Neoplasms; Postpartum Peri | 1978 |
Evidence of abnormal dopaminergic control of prolactin in patients with hypothalamic and pituitary tumors.
Topics: Adrenocorticotropic Hormone; Domperidone; Female; Growth Hormone; Humans; Hypothalamic Neoplasms; Ma | 1986 |
Comparison between pituitary computed tomographic findings and tests of hypothalamo-pituitary function in 72 patients with hyperprolactinaemia.
Topics: Adenoma; Adolescent; Adult; Domperidone; Female; Humans; Hyperprolactinemia; Hypothalamo-Hypophyseal | 1986 |
Prolactin secretion after surgery or bromocriptine treatment of prolactinoma.
Topics: Adenoma; Adult; Bromocriptine; Domperidone; Female; Humans; Hypophysectomy; Nomifensine; Pituitary N | 1987 |
[The metoclopramide and nomifensine tests in the diagnosis of prolactinomas].
Topics: Diagnosis, Differential; Female; Humans; Hyperprolactinemia; Male; Metoclopramide; Nomifensine; Pitu | 1986 |
Prolactin dynamics in patients with non-secretin tumours of the hypothalamic-pituitary region.
Topics: Adenoma; Adenoma, Chromophobe; Adolescent; Adult; Craniopharyngioma; Female; Follicle Stimulating Ho | 1985 |
Role of defective dopaminergic inhibition of prolactin secretion in the pathogenesis of prolactinoma.
Topics: Autoantibodies; Carbidopa; Dopamine; Female; Humans; Hypothalamo-Hypophyseal System; Levodopa; Metoc | 1985 |
Persistence of a defective tuberoinfundibular dopaminergic function in rats after long-term removal of oestrogen treatment. An in vivo study.
Topics: Adenoma; Animals; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Domperidone; Estradiol; Female; Hypothalam | 1985 |
Disturbed prolactin responses to dopamine-related substances in patients with acromegaly and hyperprolactinemia.
Topics: Acromegaly; Adult; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Domperidone; Female; Humans; Male; Middle | 1985 |
More on nomifensine.
Topics: Adenoma; Female; Humans; Hyperprolactinemia; Nomifensine; Pituitary Neoplasms | 1985 |