nomifensine has been researched along with Nerve Degeneration in 5 studies
Nomifensine: An isoquinoline derivative that prevents dopamine reuptake into synaptosomes. The maleate was formerly used in the treatment of depression. It was withdrawn worldwide in 1986 due to the risk of acute hemolytic anemia with intravascular hemolysis resulting from its use. In some cases, renal failure also developed. (From Martindale, The Extra Pharmacopoeia, 30th ed, p266)
nomifensine : An N-methylated tetrahydroisoquinoline carrying phenyl and amino substituents at positions C-4 and C-8, respectively.
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Excerpt | Relevance | Reference |
|---|---|---|
| " It is known that dopamine (DA) enhances this toxic effect." | 1.35 | Endogenous dopamine enhances the neurotoxicity of 3-nitropropionic acid in the striatum through the increase of mitochondrial respiratory inhibition and free radicals production. ( Cano, J; de Pablos, RM; Herrera, AJ; Machado, A; Navarro, A; Santiago, M; Tomás-Camardiel, M; Villarán, RF, 2008) |
| " Neuronal degeneration was observed in the substantia nigra pars compacta (SN), ventral tegmental area (VTA) and retrorubral field (RRF) of only animals dosed in the low temperature environment." | 1.30 | Systemic administration of MPTP induces thalamic neuronal degeneration in mice. ( Ali, SF; Freyaldenhoven, TE; Schmued, LC, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| McKinley, ET | 1 |
| Baranowski, TC | 1 |
| Blavo, DO | 1 |
| Cato, C | 1 |
| Doan, TN | 1 |
| Rubinstein, AL | 1 |
| Villarán, RF | 1 |
| Tomás-Camardiel, M | 1 |
| de Pablos, RM | 1 |
| Santiago, M | 1 |
| Herrera, AJ | 1 |
| Navarro, A | 1 |
| Machado, A | 1 |
| Cano, J | 1 |
| Florio, T | 1 |
| Di Loreto, S | 1 |
| Cerrito, F | 1 |
| Scarnati, E | 1 |
| Freyaldenhoven, TE | 1 |
| Ali, SF | 1 |
| Schmued, LC | 1 |
| Eidelberg, E | 1 |
| Nguyen, LH | 1 |
| Polich, R | 1 |
| Walden, JG | 1 |
5 other studies available for nomifensine and Nerve Degeneration
| Article | Year |
|---|---|
Neuroprotection of MPTP-induced toxicity in zebrafish dopaminergic neurons.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Dopamine; Dopamine Plasma Membrane Tra | 2005 |
Endogenous dopamine enhances the neurotoxicity of 3-nitropropionic acid in the striatum through the increase of mitochondrial respiratory inhibition and free radicals production.
Topics: alpha-Methyltyrosine; Animals; Apoptosis; Astrocytes; Cell Respiration; Corpus Striatum; Dopamine; D | 2008 |
Influence of prelimbic and sensorimotor cortices on striatal neurons in the rat: electrophysiological evidence for converging inputs and the effects of 6-OHDA-induced degeneration of the substantia nigra.
Topics: Animals; Cerebral Cortex; Corpus Striatum; Dopamine; Electric Stimulation; Limbic System; Male; Moto | 1993 |
Systemic administration of MPTP induces thalamic neuronal degeneration in mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Dizocilpine Maleate; Dopamine Agents; Male; M | 1997 |
Transsynaptic degeneration of motoneurones caudal to spinal cord lesions.
Topics: Animals; Colchicine; Male; Motor Neurons; Muscimol; Nerve Degeneration; Nomifensine; Rats; Rats, Inb | 1989 |