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nomifensine and Kidney Failure, Chronic

nomifensine has been researched along with Kidney Failure, Chronic in 2 studies

Nomifensine: An isoquinoline derivative that prevents dopamine reuptake into synaptosomes. The maleate was formerly used in the treatment of depression. It was withdrawn worldwide in 1986 due to the risk of acute hemolytic anemia with intravascular hemolysis resulting from its use. In some cases, renal failure also developed. (From Martindale, The Extra Pharmacopoeia, 30th ed, p266)
nomifensine : An N-methylated tetrahydroisoquinoline carrying phenyl and amino substituents at positions C-4 and C-8, respectively.

Kidney Failure, Chronic: The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.

Research Excerpts

ExcerptRelevanceReference
" Plasma levels of nomifensine were examined using a radioimmunological determination method and pharmacokinetic parameters were calculated by computer program."2.64Pharmacokinetics of nomifensine in impaired renal function. ( Heptner, W; Lameire, N; Munche, M; Ringoir, S; Taeuber, K, 1977)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19902 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
De Leo, V1
D'Ambrogio, G1
De Leo, M1
Franchi, F1
Inaudi, P1
La Rosa, R1
D'Antona, N1
Genazzani, AR1
Ringoir, S1
Lameire, N1
Munche, M1
Heptner, W1
Taeuber, K1

Trials

1 trial available for nomifensine and Kidney Failure, Chronic

ArticleYear
Pharmacokinetics of nomifensine in impaired renal function.
    British journal of clinical pharmacology, 1977, Volume: 4Suppl 2

    Topics: Clinical Trials as Topic; Glomerular Filtration Rate; Half-Life; Humans; Isoquinolines; Kidney Failu

1977

Other Studies

1 other study available for nomifensine and Kidney Failure, Chronic

ArticleYear
[Hyperprolactinemia in chronic renal insufficiency: an interesting model of hypothalamo-hypophyseal dysfunction].
    Bollettino della Societa italiana di biologia sperimentale, 1983, Aug-30, Volume: 59, Issue:8

    Topics: Adult; Bromocriptine; Domperidone; Female; Humans; Hypothalamo-Hypophyseal System; Kidney Failure, C

1983