nomifensine has been researched along with Hepatic Encephalopathy in 1 studies
Nomifensine: An isoquinoline derivative that prevents dopamine reuptake into synaptosomes. The maleate was formerly used in the treatment of depression. It was withdrawn worldwide in 1986 due to the risk of acute hemolytic anemia with intravascular hemolysis resulting from its use. In some cases, renal failure also developed. (From Martindale, The Extra Pharmacopoeia, 30th ed, p266)
nomifensine : An N-methylated tetrahydroisoquinoline carrying phenyl and amino substituents at positions C-4 and C-8, respectively.
Hepatic Encephalopathy: A syndrome characterized by central nervous system dysfunction in association with LIVER FAILURE, including portal-systemic shunts. Clinical features include lethargy and CONFUSION (frequently progressing to COMA); ASTERIXIS; NYSTAGMUS, PATHOLOGIC; brisk oculovestibular reflexes; decorticate and decerebrate posturing; MUSCLE SPASTICITY; and bilateral extensor plantar reflexes (see REFLEX, BABINSKI). ELECTROENCEPHALOGRAPHY may demonstrate triphasic waves. (From Adams et al., Principles of Neurology, 6th ed, pp1117-20; Plum & Posner, Diagnosis of Stupor and Coma, 3rd ed, p222-5)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In order to investigate whether the variations in prolactin (PRL) secretion found in patients with liver cirrhosis are related to the derangement of neurotransmitter metabolism, serum PRL levels were measured in 8 patients with hepatic encephalopathy (a condition where neurotransmission is severely deranged), in 10 patients with liver cirrhosis but without encephalopathy and in 10 control subjects under control conditions and in response to nomifensine, levodopa and synthetic TRH administration." | 7.67 | Failure of nomifensine to reduce serum prolactin levels in patients with hepatic encephalopathy. ( Alagna, S; Anania, V; Chiandussi, L; Deplano, A; Langer, M; Masala, A; Rovasio, PP, 1985) |
| "In order to investigate whether the variations in prolactin (PRL) secretion found in patients with liver cirrhosis are related to the derangement of neurotransmitter metabolism, serum PRL levels were measured in 8 patients with hepatic encephalopathy (a condition where neurotransmission is severely deranged), in 10 patients with liver cirrhosis but without encephalopathy and in 10 control subjects under control conditions and in response to nomifensine, levodopa and synthetic TRH administration." | 3.67 | Failure of nomifensine to reduce serum prolactin levels in patients with hepatic encephalopathy. ( Alagna, S; Anania, V; Chiandussi, L; Deplano, A; Langer, M; Masala, A; Rovasio, PP, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Masala, A | 1 |
| Alagna, S | 1 |
| Rovasio, PP | 1 |
| Deplano, A | 1 |
| Anania, V | 1 |
| Chiandussi, L | 1 |
| Langer, M | 1 |
1 other study available for nomifensine and Hepatic Encephalopathy
| Article | Year |
|---|---|
Failure of nomifensine to reduce serum prolactin levels in patients with hepatic encephalopathy.
Topics: Adult; Estrogens; Hepatic Encephalopathy; Humans; Isoquinolines; Levodopa; Liver Cirrhosis; Male; Mi | 1985 |