nomifensine has been researched along with Encephalopathy, Hepatic in 1 studies
Nomifensine: An isoquinoline derivative that prevents dopamine reuptake into synaptosomes. The maleate was formerly used in the treatment of depression. It was withdrawn worldwide in 1986 due to the risk of acute hemolytic anemia with intravascular hemolysis resulting from its use. In some cases, renal failure also developed. (From Martindale, The Extra Pharmacopoeia, 30th ed, p266)
nomifensine : An N-methylated tetrahydroisoquinoline carrying phenyl and amino substituents at positions C-4 and C-8, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In order to investigate whether the variations in prolactin (PRL) secretion found in patients with liver cirrhosis are related to the derangement of neurotransmitter metabolism, serum PRL levels were measured in 8 patients with hepatic encephalopathy (a condition where neurotransmission is severely deranged), in 10 patients with liver cirrhosis but without encephalopathy and in 10 control subjects under control conditions and in response to nomifensine, levodopa and synthetic TRH administration." | 7.67 | Failure of nomifensine to reduce serum prolactin levels in patients with hepatic encephalopathy. ( Alagna, S; Anania, V; Chiandussi, L; Deplano, A; Langer, M; Masala, A; Rovasio, PP, 1985) |
| "In order to investigate whether the variations in prolactin (PRL) secretion found in patients with liver cirrhosis are related to the derangement of neurotransmitter metabolism, serum PRL levels were measured in 8 patients with hepatic encephalopathy (a condition where neurotransmission is severely deranged), in 10 patients with liver cirrhosis but without encephalopathy and in 10 control subjects under control conditions and in response to nomifensine, levodopa and synthetic TRH administration." | 3.67 | Failure of nomifensine to reduce serum prolactin levels in patients with hepatic encephalopathy. ( Alagna, S; Anania, V; Chiandussi, L; Deplano, A; Langer, M; Masala, A; Rovasio, PP, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Masala, A | 1 |
| Alagna, S | 1 |
| Rovasio, PP | 1 |
| Deplano, A | 1 |
| Anania, V | 1 |
| Chiandussi, L | 1 |
| Langer, M | 1 |
1 other study available for nomifensine and Encephalopathy, Hepatic
| Article | Year |
|---|---|
Failure of nomifensine to reduce serum prolactin levels in patients with hepatic encephalopathy.
Topics: Adult; Estrogens; Hepatic Encephalopathy; Humans; Isoquinolines; Levodopa; Liver Cirrhosis; Male; Mi | 1985 |