nomifensine has been researched along with Dyskinesia Syndromes in 4 studies
Nomifensine: An isoquinoline derivative that prevents dopamine reuptake into synaptosomes. The maleate was formerly used in the treatment of depression. It was withdrawn worldwide in 1986 due to the risk of acute hemolytic anemia with intravascular hemolysis resulting from its use. In some cases, renal failure also developed. (From Martindale, The Extra Pharmacopoeia, 30th ed, p266)
nomifensine : An N-methylated tetrahydroisoquinoline carrying phenyl and amino substituents at positions C-4 and C-8, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "These mice provide a valid model of Parkinson's disease and are a resource for the investigation of pathogenesis and therapeutics." | 1.35 | Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease. ( Beal, MF; Bogdanov, M; Burke, RE; Geghman, K; Jackson-Lewis, V; Li, C; Li, Y; Liu, W; Oo, TF; Przedborski, S; Tang, Y; Wang, L; Zhou, C, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, Y | 1 |
| Liu, W | 1 |
| Oo, TF | 1 |
| Wang, L | 1 |
| Tang, Y | 1 |
| Jackson-Lewis, V | 1 |
| Zhou, C | 1 |
| Geghman, K | 1 |
| Bogdanov, M | 1 |
| Przedborski, S | 1 |
| Beal, MF | 1 |
| Burke, RE | 1 |
| Li, C | 1 |
| Campbell, JM | 1 |
| Gilmore, DP | 1 |
| Russell, D | 1 |
| Growney, CA | 1 |
| Favor, G | 1 |
| Kennedy, AK | 1 |
| Davies, RW | 1 |
| Payne, AP | 1 |
| Stone, TW | 1 |
| Schultz, W | 1 |
| Scarnati, E | 1 |
| Sundström, E | 1 |
| Romo, R | 1 |
| Mihatsch, W | 1 |
| Russ, H | 1 |
| Przuntek, H | 1 |
4 other studies available for nomifensine and Dyskinesia Syndromes
| Article | Year |
|---|---|
Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease.
Topics: Age Factors; Animals; Antiparkinson Agents; Apomorphine; Brain; Chromosomes, Artificial, Bacterial; | 2009 |
Pharmacological analysis of extracellular dopamine and metabolites in the striatum of conscious as/agu rats, mutants with locomotor disorder.
Topics: Amphetamine; Animals; Clorgyline; Corpus Striatum; Dopamine; Dopamine Agents; Dopamine Uptake Inhibi | 2000 |
Protection against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism by the catecholamine uptake inhibitor nomifensine: behavioral analysis in monkeys with partial striatal dopamine depletions.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Catecholamines; Female; Macaca fascicularis; | 1989 |
Intracerebroventricular administration of 1-methyl-4-phenylpyridinium ion in mice: effects of simultaneously administered nomifensine, deprenyl, and 1-t-butyl-4,4-diphenylpiperidine.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Brain; Catecholamines; Caudate Nucleus; Dose-Response Relation | 1988 |