nomifensine has been researched along with Depression in 45 studies
Nomifensine: An isoquinoline derivative that prevents dopamine reuptake into synaptosomes. The maleate was formerly used in the treatment of depression. It was withdrawn worldwide in 1986 due to the risk of acute hemolytic anemia with intravascular hemolysis resulting from its use. In some cases, renal failure also developed. (From Martindale, The Extra Pharmacopoeia, 30th ed, p266)
nomifensine : An N-methylated tetrahydroisoquinoline carrying phenyl and amino substituents at positions C-4 and C-8, respectively.
Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The dosage schedule was a flexible one, with a daily dose range from 50-200 mg for nomifensine and 50-225 mg for amitriptyline." | 6.64 | Dopaminergic agonist nomifensine compared with amitriptyline: a double-blind clinical trial in acute primary depressions. ( Daigle, L; Grof, P; Mahutte, G; Saxena, B, 1977) |
| " Three double-blind placebo-controlled trials with nomifensine are reviewed; one in neurotic depression, one in psychotic depression and one in geriatric patients showing depressive symptoms." | 5.04 | Comparison of nomifensine and placebo. ( Taeuber, K, 1977) |
| " Nomifensine, an isoquinoline dopaminergic agonist, was investigated in a randomized double-blind group comparison with imipramine, in 40 out-patients with depression." | 5.04 | Controlled randomized group comparison of nomifensine and imipramine in depressive illness. ( Forrest, A; Hewett, A; Nicholson, P, 1977) |
| "A double-blind study comparing the effects of nomifensine and nortriptyline, which was carried out exclusively on outpatients with retarded depressions, showed nomifensine to have a distinctive antidepressive and activating effect." | 5.04 | Differences in effect between nomifensine and nortriptyline. ( Gammel, G; Pöldinger, W, 1978) |
| "3." | 3.74 | A review of controlled studies with nomifensine, performed outside the UK. ( Habermann, W, 1977) |
| "Nomifensine is a widely used antidepressant agent with few side-effects but haemolytic anaemia with acute renal failure has been reported with both intermittent therapeutic dosage and self-inflicted overdose." | 1.27 | Intravascular haemolysis and acute renal failure induced by nomifensine. ( Briggs, JD; Dominiczak, AF; Fulton, JD; Junor, BJ; Lucie, NP, 1986) |
| "Nomifensine is a tetrahydoisoquinoline antidepressant which is chemically unrelated to the tricyclic or tetracyclic antidepressants, the monoamine oxidase inhibitors or the recently introduced agents." | 1.26 | Nomifensine: A review of its pharmacological properties and therapeutic efficacy in depressive illness. ( Avery, GS; Brogden, RN; Heel, RC; Speight, TM, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 40 (88.89) | 18.7374 |
| 1990's | 1 (2.22) | 18.2507 |
| 2000's | 2 (4.44) | 29.6817 |
| 2010's | 2 (4.44) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Esumi, S | 1 |
| Kawaski, Y | 1 |
| Nakamoto, A | 1 |
| Sagara, H | 1 |
| Gomita, Y | 1 |
| Kitamura, Y | 1 |
| Sendo, T | 1 |
| Getachew, B | 1 |
| Hauser, SR | 1 |
| Taylor, RE | 1 |
| Tizabi, Y | 1 |
| Yamada, J | 1 |
| Sugimoto, Y | 1 |
| Yamada, S | 1 |
| Basso, AM | 1 |
| Gallagher, KB | 1 |
| Bratcher, NA | 1 |
| Brioni, JD | 1 |
| Moreland, RB | 1 |
| Hsieh, GC | 1 |
| Drescher, K | 1 |
| Fox, GB | 1 |
| Decker, MW | 1 |
| Rueter, LE | 1 |
| Nawishy, S | 1 |
| Hathway, N | 1 |
| Turner, P | 1 |
| Katona, C | 1 |
| Piacentini, F | 1 |
| Prati, R | 1 |
| Prosdocimo, M | 1 |
| Leonard, BE | 1 |
| Montgomery, SA | 1 |
| Gillman, MA | 1 |
| Sandyk, R | 1 |
| Freed, E | 1 |
| Haq, SM | 1 |
| Buhrich, N | 1 |
| De Maio, D | 1 |
| Sesso, M | 1 |
| Levi Minzi, A | 1 |
| Caponeri, MA | 1 |
| Mellado, C | 1 |
| Bonicalzi, M | 1 |
| Bergener, M | 1 |
| Hesse, C | 1 |
| Nash, RJ | 1 |
| Hernando, F | 1 |
| Fuentes, JA | 1 |
| Roques, BP | 1 |
| Ruiz-Gayo, M | 1 |
| Vohra, JK | 1 |
| Burrows, GD | 2 |
| McIntyre, I | 1 |
| Davies, B | 2 |
| Wittenborn, JR | 1 |
| Van Scheyen, JD | 1 |
| Van Praag, HM | 1 |
| Korf, J | 1 |
| Taeuber, K | 1 |
| Forrest, A | 1 |
| Hewett, A | 1 |
| Nicholson, P | 1 |
| Grof, P | 1 |
| Saxena, B | 1 |
| Daigle, L | 1 |
| Mahutte, G | 1 |
| Habermann, W | 1 |
| Spencer, PS | 1 |
| Pöldinger, W | 1 |
| Gammel, G | 1 |
| Amin, MM | 2 |
| Ban, TA | 2 |
| Lehmann, HE | 1 |
| Pecknold, JC | 1 |
| Coudray, JP | 1 |
| Dufour, H | 1 |
| Garello, JL | 1 |
| Mollo, Y | 1 |
| Pascal, F | 1 |
| Poisson, D | 1 |
| Scotto, JC | 1 |
| Simart, G | 1 |
| Sormani, J | 1 |
| Tourame, G | 1 |
| McCawley, A | 1 |
| Woggon, B | 1 |
| Angst, J | 1 |
| Fleckenstein, G | 1 |
| Brogden, RN | 1 |
| Heel, RC | 1 |
| Speight, TM | 1 |
| Avery, GS | 1 |
| Molcan, J | 1 |
| Caplová, T | 1 |
| Rakús, A | 1 |
| Strecko, A | 1 |
| Vinar, O | 1 |
| Náhunek, K | 1 |
| Rysánek, R | 1 |
| Svestka, J | 1 |
| Cesková, E | 1 |
| Misurec, J | 1 |
| Buresová, A | 1 |
| Vohra, J | 1 |
| Dumovic, P | 1 |
| Scoggins, BA | 1 |
| Spriet, A | 1 |
| Beiler, D | 1 |
| Dechorgnat, J | 1 |
| Chigot, CD | 1 |
| Rössner, M | 1 |
| Simon, P | 1 |
| Fulton, JD | 1 |
| Briggs, JD | 1 |
| Dominiczak, AF | 1 |
| Junor, BJ | 1 |
| Lucie, NP | 1 |
| Guliamov, MG | 1 |
| Cunha, UV | 1 |
| Woodliff, HJ | 1 |
| Wallace, PF | 1 |
| Pepper, GA | 1 |
4 reviews available for nomifensine and Depression
| Article | Year |
|---|---|
Pharmacological properties of some "second generation" antidepressant drugs.
Topics: Animals; Antidepressive Agents; Brompheniramine; Depression; Electroconvulsive Therapy; Humans; Mian | 1980 |
Maprotiline, nomifensine, mianserin, zimelidine: a review of antidepressant efficacy in in-patients.
Topics: Antidepressive Agents; Brompheniramine; Clinical Trials as Topic; Depression; Humans; Maprotiline; M | 1980 |
A review of controlled studies with nomifensine, performed outside the UK.
Topics: Adult; Aged; Amitriptyline; Clinical Trials as Topic; Depression; Double-Blind Method; Doxepin; Drug | 1977 |
Review of the pharmacology of existing antidepressants.
Topics: Amphetamine; Animals; Antidepressive Agents; Brain; Catecholamines; Depression; Humans; Imipramine; | 1977 |
14 trials available for nomifensine and Depression
| Article | Year |
|---|---|
Maprotiline, nomifensine, mianserin, zimelidine: a review of antidepressant efficacy in in-patients.
Topics: Antidepressive Agents; Brompheniramine; Clinical Trials as Topic; Depression; Humans; Maprotiline; M | 1980 |
Contrasts in antidepressant medications.
Topics: Adult; Clinical Trials as Topic; Depression; Double-Blind Method; Drug Evaluation; Female; Humans; I | 1977 |
Controlled study comparing nomifensine and clomipramine in unipolar depression, using the probenecid technique.
Topics: Adult; Clinical Trials as Topic; Clomipramine; Depression; Dibenzazepines; Double-Blind Method; Fema | 1977 |
Comparison of nomifensine and placebo.
Topics: Adjustment Disorders; Affective Disorders, Psychotic; Aged; Clinical Trials as Topic; Depression; Do | 1977 |
Controlled randomized group comparison of nomifensine and imipramine in depressive illness.
Topics: Adult; Clinical Trials as Topic; Depression; Double-Blind Method; Drug Evaluation; Female; Humans; I | 1977 |
Dopaminergic agonist nomifensine compared with amitriptyline: a double-blind clinical trial in acute primary depressions.
Topics: Adult; Aged; Amitriptyline; Clinical Trials as Topic; Depression; Double-Blind Method; Drug Evaluati | 1977 |
A review of controlled studies with nomifensine, performed outside the UK.
Topics: Adult; Aged; Amitriptyline; Clinical Trials as Topic; Depression; Double-Blind Method; Doxepin; Drug | 1977 |
Differences in effect between nomifensine and nortriptyline.
Topics: Adult; Clinical Trials as Topic; Depression; Double-Blind Method; Female; Humans; Isoquinolines; Mal | 1978 |
Nomifensin in the treatment of depression: a report on the Canadian part of a transcultural study.
Topics: Adjustment Disorders; Adult; Canada; Clinical Trials as Topic; Cross-Cultural Comparison; Depression | 1978 |
Nomifensin in the treatment of depression: a standard-controlled clinical study.
Topics: Adult; Clinical Trials as Topic; Depression; Double-Blind Method; Female; Humans; Imipramine; Isoqui | 1978 |
[A double-blind nomifensine-nortriptyline trial in ambulatory patients conducted by psychiatrists in private practice: results and comments].
Topics: Adolescent; Adult; Aged; Antidepressive Agents; Clinical Trials as Topic; Depression; Double-Blind M | 1978 |
A double-blind evaluation of nomifensine and imipramine in depressed outpatients.
Topics: Adolescent; Adult; Aged; Clinical Trials as Topic; Depression; Double-Blind Method; Humans; Imiprami | 1979 |
Comparative efficacy of nomifensine and imipramine.
Topics: Clinical Trials as Topic; Depression; Double-Blind Method; Humans; Imipramine; Isoquinolines; Middle | 1979 |
[Alival in general practice. Report on a field study].
Topics: Clinical Trials as Topic; Depression; Family Practice; Female; Humans; Isoquinolines; Male; Nomifens | 1979 |
29 other studies available for nomifensine and Depression
| Article | Year |
|---|---|
Differential effects of nomifensine and imipramine on motivated behavior in the runway model of intracranial self-stimulation.
Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Behavior, Animal; Depression; Dopamine | 2013 |
Alcohol-induced depressive-like behavior is associated with cortical norepinephrine reduction.
Topics: Animals; Depression; Ethanol; Female; Frontal Lobe; Hippocampus; Imipramine; Neurotransmitter Uptake | 2010 |
Involvement of dopamine receptors in the anti-immobility effects of dopamine re-uptake inhibitors in the forced swimming test.
Topics: Animals; Benzazepines; Bupropion; Depression; Dopamine Antagonists; Dopamine Uptake Inhibitors; Dose | 2004 |
Antidepressant-like effect of D(2/3) receptor-, but not D(4) receptor-activation in the rat forced swim test.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models, | 2005 |
Interactions of anticonvulsant drugs with mianserin and nomifensine.
Topics: Adult; Anticonvulsants; Depression; Dibenzazepines; Drug Interactions; Humans; Isoquinolines; Mianse | 1981 |
Paranoid symptoms after nomifensine.
Topics: Adult; Depression; Goiter; Humans; Isoquinolines; Male; Nomifensine; Paranoid Disorders | 1982 |
[Use of antidepressive drugs in rehabilitation].
Topics: Depression; Female; Hemiplegia; Humans; Isoquinolines; Male; Nomifensine; Sleep Wake Disorders | 1983 |
Nomifensine exacerbates depression and seizures in an epileptic patient.
Topics: Depression; Female; Humans; Isoquinolines; Middle Aged; Nomifensine; Seizures | 1984 |
Increased sexual function with nomifensine.
Topics: Depression; Female; Humans; Isoquinolines; Libido; Male; Middle Aged; Nomifensine | 1983 |
Tolerance of daily single compared to space dose of merital.
Topics: Adult; Depression; Drug Administration Schedule; Drug Tolerance; Female; Humans; Isoquinolines; Male | 1980 |
Evaluation of the clinical efficacy of single daily doses of antidepressants.
Topics: Adult; Amitriptyline; Antidepressive Agents; Depression; Drug Administration Schedule; Half-Life; Hu | 1980 |
A biological concept for diagnosis, treatment and therapy control of endogenous psychoses.
Topics: Age Factors; Aged; Antidepressive Agents; Benzodiazepines; Depression; Humans; Maprotiline; Nomifens | 1980 |
Overview of nomifensine maleate antidepressant studies in the U.S.
Topics: Depression; Double-Blind Method; Drug Evaluation; Female; Humans; Isoquinolines; Male; Nomifensine | 1980 |
The CCKB receptor antagonist, L-365,260, elicits antidepressant-type effects in the forced-swim test in mice.
Topics: Amino Acid Sequence; Animals; Antidepressive Agents; Benzodiazepinones; Cholecystokinin; Depression; | 1994 |
[Antidepressive agents are turning more practical].
Topics: Depression; Humans; Isoquinolines; Neurotransmitter Agents; Nomifensine | 1978 |
Cardiovascular effects of nomifensine.
Topics: Adolescent; Adult; Depression; Drug Evaluation; Female; Heart; Hemodynamics; Humans; Isoquinolines; | 1978 |
Nomifensine: A review of its pharmacological properties and therapeutic efficacy in depressive illness.
Topics: Animals; Biogenic Amines; Brain; Depression; Epilepsy; Evaluation Studies as Topic; Humans; Imiprami | 1979 |
[Treatment of depressive conditions with nomifensine].
Topics: Adjustment Disorders; Depression; Humans; Isoquinolines; Nomifensine | 1979 |
Clinical experience with nomifensine.
Topics: Adolescent; Adult; Aged; Depression; Female; Humans; Isoquinolines; Male; Middle Aged; Nomifensine; | 1979 |
Nomifensin in the treatment of endogenous depressions. Clinical experience and EEG findings.
Topics: Depression; Electroencephalography; Humans; Isoquinolines; Nomifensine | 1979 |
[Results of a predictive trial of the response to nomifensine in ambulatory patients].
Topics: Adjustment Disorders; Adult; Aged; Ambulatory Care; Antidepressive Agents; Depression; Female; Human | 1978 |
Do nomifensine and low-dose flupenthixol differ from other antidepressive drugs?
Topics: Antidepressive Agents; Depression; Flupenthixol; Humans; Isoquinolines; Nomifensine; Thioxanthenes | 1978 |
Cardiological effects of nomifensine, a new antidepressant.
Topics: Action Potentials; Adolescent; Adult; Animals; Atrial Function; Depression; Electrocardiography; Fem | 1978 |
[Methodology of a cooperative study of response predictors in ambulatory depressive syndrome treated with nomifensine].
Topics: Ambulatory Care; Antidepressive Agents; Depression; Humans; Isoquinolines; Medical Records; Nomifens | 1978 |
Intravascular haemolysis and acute renal failure induced by nomifensine.
Topics: Acute Kidney Injury; Anemia, Hemolytic, Autoimmune; Depression; Female; Humans; Middle Aged; Nomifen | 1986 |
[Comparative evaluation of the therapeutic efficacy of the antidepressants adepren, linamiphen and emovit].
Topics: Adjustment Disorders; Adolescent; Adult; Aminoquinolines; Antidepressive Agents; Bipolar Disorder; D | 1986 |
Antidepressants: their uses in nonpsychiatric disorders of aging.
Topics: Affective Symptoms; Aged; Antidepressive Agents; Chronic Disease; Colonic Diseases, Functional; Depr | 1986 |
Haemolytic anaemia caused by nomifensine.
Topics: Anemia, Hemolytic; Depression; Female; Humans; Middle Aged; Nomifensine | 1986 |
Nomifensine (Merital): a second generation antidepressant.
Topics: Akathisia, Drug-Induced; Antidepressive Agents; Constipation; Depression; Headache; Humans; Kinetics | 1986 |