nomifensine has been researched along with Chemical and Drug Induced Liver Injury in 16 studies
Nomifensine: An isoquinoline derivative that prevents dopamine reuptake into synaptosomes. The maleate was formerly used in the treatment of depression. It was withdrawn worldwide in 1986 due to the risk of acute hemolytic anemia with intravascular hemolysis resulting from its use. In some cases, renal failure also developed. (From Martindale, The Extra Pharmacopoeia, 30th ed, p266)
nomifensine : An N-methylated tetrahydroisoquinoline carrying phenyl and amino substituents at positions C-4 and C-8, respectively.
Chemical and Drug Induced Liver Injury: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The granulomas were located both in the portal tract and the liver parenchyma, and contained eosinophils and a few polynuclear giant cells." | 5.27 | [Granulomatous hepatitis caused by nomifensine]. ( Kummer, H; Marti, F; Wegmann, W, 1985) |
| " We proposed a systematic classification scheme using FDA-approved drug labeling to assess the DILI potential of drugs, which yielded a benchmark dataset with 287 drugs representing a wide range of therapeutic categories and daily dosage amounts." | 1.37 | FDA-approved drug labeling for the study of drug-induced liver injury. ( Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V, 2011) |
| " An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential toxic effects early in the drug development process and aid in avoiding such problems." | 1.36 | Developing structure-activity relationships for the prediction of hepatotoxicity. ( Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ, 2010) |
| "The granulomas were located both in the portal tract and the liver parenchyma, and contained eosinophils and a few polynuclear giant cells." | 1.27 | [Granulomatous hepatitis caused by nomifensine]. ( Kummer, H; Marti, F; Wegmann, W, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (56.25) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 7 (43.75) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Greene, N | 1 |
| Fisk, L | 1 |
| Naven, RT | 1 |
| Note, RR | 1 |
| Patel, ML | 1 |
| Pelletier, DJ | 1 |
| Ekins, S | 1 |
| Williams, AJ | 1 |
| Xu, JJ | 1 |
| Chen, M | 2 |
| Vijay, V | 1 |
| Shi, Q | 2 |
| Liu, Z | 2 |
| Fang, H | 2 |
| Tong, W | 3 |
| Dawson, S | 1 |
| Stahl, S | 2 |
| Paul, N | 1 |
| Barber, J | 1 |
| Kenna, JG | 2 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Warner, DJ | 1 |
| Chen, H | 1 |
| Cantin, LD | 1 |
| Walker, CL | 1 |
| Noeske, T | 1 |
| Suzuki, A | 1 |
| Thakkar, S | 1 |
| Yu, K | 1 |
| Hu, C | 1 |
| Vaz, FG | 1 |
| Singh, R | 1 |
| Nuruzzaman, M | 1 |
| Judd, FK | 1 |
| Holwill, BJ | 1 |
| Norman, TR | 2 |
| Wälti, M | 1 |
| Neftel, K | 1 |
| Cohen, M | 1 |
| de Weck, AL | 1 |
| Perisić, M | 1 |
| Zarski, JP | 1 |
| Aubert, H | 1 |
| Rachail, M | 1 |
| Dankbaar, H | 1 |
| Mudde, AH | 1 |
| Thomsen, F | 1 |
| Jensen, HC | 1 |
| Thomsen, P | 1 |
| Brandes, JW | 1 |
| Körst, HA | 1 |
| Littmann, KP | 1 |
| Burrows, GD | 1 |
| Dennerstein, L | 1 |
| Davies, BM | 1 |
| Kummer, H | 1 |
| Marti, F | 1 |
| Wegmann, W | 1 |
2 reviews available for nomifensine and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr | 2016 |
Antidepressant therapy: benefits and risks in perspective.
Topics: Cardiovascular Diseases; Chemical and Drug Induced Liver Injury; Depressive Disorder; Dibenzazepines | 1985 |
14 other studies available for nomifensine and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Des | 2011 |
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2012 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2012 |
Hepatitis induced by nomifensine.
Topics: Aged; Chemical and Drug Induced Liver Injury; Female; Humans; Isoquinolines; Liver; Nomifensine | 1984 |
Liver impairment associated with nomifensine.
Topics: Adult; Chemical and Drug Induced Liver Injury; Female; Humans; Isoquinolines; Jaundice; Liver Functi | 1983 |
[Demonstration of drug-specific IgE and IgG antibodies using RIA: clinical importance as shown with nomifensin (Alival)].
Topics: Alveolitis, Extrinsic Allergic; Anemia, Hemolytic; Antibody Formation; Antibody Specificity; Chemica | 1983 |
[Hepatic toxicity of new antidepressive drugs. Apropos of a case].
Topics: Acute Disease; Chemical and Drug Induced Liver Injury; Dibenzazepines; Female; Humans; Isoquinolines | 1983 |
[Fever and liver function disorders caused by nomifensine (Alival)].
Topics: Adult; Chemical and Drug Induced Liver Injury; Female; Fever; Humans; Isoquinolines; Liver Function | 1980 |
[Liver damage after nomifensine (Alival)].
Topics: Adult; Chemical and Drug Induced Liver Injury; Female; Humans; Isoquinolines; Nomifensine | 1981 |
[Jaundice following nomifensine].
Topics: Chemical and Drug Induced Liver Injury; Cholestasis; Depressive Disorder; Female; Humans; Isoquinoli | 1980 |
[Granulomatous hepatitis caused by nomifensine].
Topics: Aged; Biopsy; Chemical and Drug Induced Liver Injury; Female; Granuloma; Humans; Liver; Liver Diseas | 1985 |