nomifensine has been researched along with Aura in 4 studies
Nomifensine: An isoquinoline derivative that prevents dopamine reuptake into synaptosomes. The maleate was formerly used in the treatment of depression. It was withdrawn worldwide in 1986 due to the risk of acute hemolytic anemia with intravascular hemolysis resulting from its use. In some cases, renal failure also developed. (From Martindale, The Extra Pharmacopoeia, 30th ed, p266)
nomifensine : An N-methylated tetrahydroisoquinoline carrying phenyl and amino substituents at positions C-4 and C-8, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Forty-two patients with depression and epilepsy were entered into an antidepressant trial of amitriptyline, nomifensine and placebo." | 5.05 | The treatment of depression in patients with epilepsy. A double-blind trial. ( Robertson, MM; Trimble, MR, 1985) |
| " Side effects include sleep disturbance, restlessness, and nausea; rare adverse reactions are in keeping with other antidepressants." | 3.75 | A review of the clinical safety and tolerability of nomifensine. ( Stonier, PD, 1984) |
| "Nomifensine is a tetrahydoisoquinoline antidepressant which is chemically unrelated to the tricyclic or tetracyclic antidepressants, the monoamine oxidase inhibitors or the recently introduced agents." | 1.26 | Nomifensine: A review of its pharmacological properties and therapeutic efficacy in depressive illness. ( Avery, GS; Brogden, RN; Heel, RC; Speight, TM, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Trimble, MR | 2 |
| Stonier, PD | 1 |
| Brogden, RN | 1 |
| Heel, RC | 1 |
| Speight, TM | 1 |
| Avery, GS | 1 |
| Robertson, MM | 1 |
2 reviews available for nomifensine and Aura
| Article | Year |
|---|---|
Epilepsy, antidepressants, and the role of nomifensine.
Topics: Adult; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Clinical Trials as Topic; Double-Bl | 1984 |
A review of the clinical safety and tolerability of nomifensine.
Topics: Adult; Akathisia, Drug-Induced; Animals; Antidepressive Agents; Cardiovascular System; Clinical Tria | 1984 |
3 trials available for nomifensine and Aura
| Article | Year |
|---|---|
Epilepsy, antidepressants, and the role of nomifensine.
Topics: Adult; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Clinical Trials as Topic; Double-Bl | 1984 |
A review of the clinical safety and tolerability of nomifensine.
Topics: Adult; Akathisia, Drug-Induced; Animals; Antidepressive Agents; Cardiovascular System; Clinical Tria | 1984 |
The treatment of depression in patients with epilepsy. A double-blind trial.
Topics: Adolescent; Adult; Aged; Amitriptyline; Clinical Trials as Topic; Depressive Disorder; Double-Blind | 1985 |
1 other study available for nomifensine and Aura
| Article | Year |
|---|---|
Nomifensine: A review of its pharmacological properties and therapeutic efficacy in depressive illness.
Topics: Animals; Biogenic Amines; Brain; Depression; Epilepsy; Evaluation Studies as Topic; Humans; Imiprami | 1979 |