Page last updated: 2024-11-01

nomifensine and Aging

nomifensine has been researched along with Aging in 12 studies

Nomifensine: An isoquinoline derivative that prevents dopamine reuptake into synaptosomes. The maleate was formerly used in the treatment of depression. It was withdrawn worldwide in 1986 due to the risk of acute hemolytic anemia with intravascular hemolysis resulting from its use. In some cases, renal failure also developed. (From Martindale, The Extra Pharmacopoeia, 30th ed, p266)
nomifensine : An N-methylated tetrahydroisoquinoline carrying phenyl and amino substituents at positions C-4 and C-8, respectively.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"Nomifensine treatment significantly increased TH enzyme amount in substantia nigra (39."1.30Chronic inhibition of the high-affinity dopamine uptake system increases oxidative damage to proteins in the aged rat substantia nigra. ( Cano, J; Machado, A; Rodríguez-Gómez, JA; Romero-Ramos, M; Venero, JL, 1997)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19903 (25.00)18.7374
1990's5 (41.67)18.2507
2000's2 (16.67)29.6817
2010's2 (16.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Walker, QD1
Morris, SE1
Arrant, AE1
Nagel, JM1
Parylak, S1
Zhou, G1
Caster, JM1
Kuhn, CM1
Oyama, G1
Yoshimi, K1
Natori, S1
Chikaoka, Y1
Ren, YR1
Funayama, M1
Shimo, Y1
Takahashi, R1
Nakazato, T1
Kitazawa, S1
Hattori, N1
Stanford, JA1
Vorontsova, E1
Surgener, SP1
Gerhardt, GA4
Fowler, SC1
Cassel, JC1
Lazaris, A1
Birthelmer, A1
Jackisch, R1
Polleri, A1
Nappi, G1
Murialdo, G1
Sances, G1
Masturzo, P1
Savoldi, F1
Romero-Ramos, M1
Rodríguez-Gómez, JA1
Venero, JL1
Cano, J1
Machado, A1
Lin, AM1
Bickford, PC1
Palmer, MR1
Cline, EJ1
Hebert, MA2
Bolanos, CA1
Glatt, SJ1
Jackson, D1
Marshall, JF1
Altar, CA1
Hilakivi, LA1
Hilakivi, I1
Ahtee, L1
Haikala, H1
Attila, M1

Other Studies

12 other studies available for nomifensine and Aging

ArticleYear
Dopamine uptake inhibitors but not dopamine releasers induce greater increases in motor behavior and extracellular dopamine in adolescent rats than in adult male rats.
    The Journal of pharmacology and experimental therapeutics, 2010, Volume: 335, Issue:1

    Topics: Aging; Amphetamines; Animals; Behavior, Animal; Brain Chemistry; Dopamine; Dopamine Uptake Inhibitor

2010
Impaired in vivo dopamine release in parkin knockout mice.
    Brain research, 2010, Sep-17, Volume: 1352

    Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Body Weight; Corpus Striatum; Dopamine; Homovanillic

2010
Aged Fischer 344 rats exhibit altered locomotion in the absence of decreased locomotor activity: exacerbation by nomifensine.
    Neuroscience letters, 2002, Nov-29, Volume: 333, Issue:3

    Topics: 3,4-Dihydroxyphenylacetic Acid; Age Factors; Aging; Analysis of Variance; Animals; Corpus Striatum;

2002
Spatial reference- (not working- or procedural-) memory performance of aged rats in the water maze predicts the magnitude of sulpiride-induced facilitation of acetylcholine release by striatal slices.
    Neurobiology of aging, 2007, Volume: 28, Issue:8

    Topics: Acetylcholine; Age Factors; Aging; Animals; Behavior, Animal; Cholinesterase Inhibitors; Corpus Stri

2007
Neuroendocrinological signs of central neurotransmission disorders.
    Cephalalgia : an international journal of headache, 1983, Volume: 3 Suppl 1

    Topics: Aging; Central Nervous System Diseases; Endocrine System Diseases; Headache; Humans; Levodopa; Neuro

1983
Chronic inhibition of the high-affinity dopamine uptake system increases oxidative damage to proteins in the aged rat substantia nigra.
    Free radical biology & medicine, 1997, Volume: 23, Issue:1

    Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Blotting, Western; Dopamine; Dopamine Uptake Inhibit

1997
Effects of ethanol and nomifensine on NE clearance in the cerebellum of young and aged Fischer 344 rats.
    Brain research, 1997, May-09, Volume: 756, Issue:1-2

    Topics: Aging; Animals; Central Nervous System Depressants; Cerebellum; Electrochemistry; Ethanol; Male; Nom

1997
Normal and drug-induced locomotor behavior in aging: comparison to evoked DA release and tissue content in fischer 344 rats.
    Brain research, 1998, Jun-22, Volume: 797, Issue:1

    Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic Uptake Inhibitors; Aging; Animals; Brain Chemistry; Chrom

1998
Subsensitivity to dopaminergic drugs in periadolescent rats: a behavioral and neurochemical analysis.
    Brain research. Developmental brain research, 1998, Nov-01, Volume: 111, Issue:1

    Topics: Acetylcholine; Aging; Amphetamine; Animals; Apomorphine; Behavior, Animal; Cocaine; Corpus Striatum;

1998
Age-related changes in the capacity, rate, and modulation of dopamine uptake within the striatum and nucleus accumbens of Fischer 344 rats: an in vivo electrochemical study.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 288, Issue:2

    Topics: Adrenergic Uptake Inhibitors; Aging; Animals; Citalopram; Corpus Striatum; Desipramine; Dopamine; Do

1999
Striatal dopamine uptake and swim performance of the aged rat.
    Brain research, 1986, Jul-30, Volume: 379, Issue:1

    Topics: Aging; Animals; Bupropion; Corpus Striatum; Desipramine; Dopamine; Dopamine Antagonists; Male; Motor

1986
Effect of neonatal nomifensine exposure on adult behavior and brain monoamines in rats.
    Journal of neural transmission, 1987, Volume: 70, Issue:1-2

    Topics: Aging; Alcohol Drinking; Animals; Animals, Newborn; Behavior, Animal; Biogenic Amines; Brain; Male;

1987