nomifensine has been researched along with Aging in 12 studies
Nomifensine: An isoquinoline derivative that prevents dopamine reuptake into synaptosomes. The maleate was formerly used in the treatment of depression. It was withdrawn worldwide in 1986 due to the risk of acute hemolytic anemia with intravascular hemolysis resulting from its use. In some cases, renal failure also developed. (From Martindale, The Extra Pharmacopoeia, 30th ed, p266)
nomifensine : An N-methylated tetrahydroisoquinoline carrying phenyl and amino substituents at positions C-4 and C-8, respectively.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Nomifensine treatment significantly increased TH enzyme amount in substantia nigra (39." | 1.30 | Chronic inhibition of the high-affinity dopamine uptake system increases oxidative damage to proteins in the aged rat substantia nigra. ( Cano, J; Machado, A; Rodríguez-Gómez, JA; Romero-Ramos, M; Venero, JL, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (25.00) | 18.7374 |
| 1990's | 5 (41.67) | 18.2507 |
| 2000's | 2 (16.67) | 29.6817 |
| 2010's | 2 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Walker, QD | 1 |
| Morris, SE | 1 |
| Arrant, AE | 1 |
| Nagel, JM | 1 |
| Parylak, S | 1 |
| Zhou, G | 1 |
| Caster, JM | 1 |
| Kuhn, CM | 1 |
| Oyama, G | 1 |
| Yoshimi, K | 1 |
| Natori, S | 1 |
| Chikaoka, Y | 1 |
| Ren, YR | 1 |
| Funayama, M | 1 |
| Shimo, Y | 1 |
| Takahashi, R | 1 |
| Nakazato, T | 1 |
| Kitazawa, S | 1 |
| Hattori, N | 1 |
| Stanford, JA | 1 |
| Vorontsova, E | 1 |
| Surgener, SP | 1 |
| Gerhardt, GA | 4 |
| Fowler, SC | 1 |
| Cassel, JC | 1 |
| Lazaris, A | 1 |
| Birthelmer, A | 1 |
| Jackisch, R | 1 |
| Polleri, A | 1 |
| Nappi, G | 1 |
| Murialdo, G | 1 |
| Sances, G | 1 |
| Masturzo, P | 1 |
| Savoldi, F | 1 |
| Romero-Ramos, M | 1 |
| Rodríguez-Gómez, JA | 1 |
| Venero, JL | 1 |
| Cano, J | 1 |
| Machado, A | 1 |
| Lin, AM | 1 |
| Bickford, PC | 1 |
| Palmer, MR | 1 |
| Cline, EJ | 1 |
| Hebert, MA | 2 |
| Bolanos, CA | 1 |
| Glatt, SJ | 1 |
| Jackson, D | 1 |
| Marshall, JF | 1 |
| Altar, CA | 1 |
| Hilakivi, LA | 1 |
| Hilakivi, I | 1 |
| Ahtee, L | 1 |
| Haikala, H | 1 |
| Attila, M | 1 |
12 other studies available for nomifensine and Aging
| Article | Year |
|---|---|
Dopamine uptake inhibitors but not dopamine releasers induce greater increases in motor behavior and extracellular dopamine in adolescent rats than in adult male rats.
Topics: Aging; Amphetamines; Animals; Behavior, Animal; Brain Chemistry; Dopamine; Dopamine Uptake Inhibitor | 2010 |
Impaired in vivo dopamine release in parkin knockout mice.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Body Weight; Corpus Striatum; Dopamine; Homovanillic | 2010 |
Aged Fischer 344 rats exhibit altered locomotion in the absence of decreased locomotor activity: exacerbation by nomifensine.
Topics: 3,4-Dihydroxyphenylacetic Acid; Age Factors; Aging; Analysis of Variance; Animals; Corpus Striatum; | 2002 |
Spatial reference- (not working- or procedural-) memory performance of aged rats in the water maze predicts the magnitude of sulpiride-induced facilitation of acetylcholine release by striatal slices.
Topics: Acetylcholine; Age Factors; Aging; Animals; Behavior, Animal; Cholinesterase Inhibitors; Corpus Stri | 2007 |
Neuroendocrinological signs of central neurotransmission disorders.
Topics: Aging; Central Nervous System Diseases; Endocrine System Diseases; Headache; Humans; Levodopa; Neuro | 1983 |
Chronic inhibition of the high-affinity dopamine uptake system increases oxidative damage to proteins in the aged rat substantia nigra.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Blotting, Western; Dopamine; Dopamine Uptake Inhibit | 1997 |
Effects of ethanol and nomifensine on NE clearance in the cerebellum of young and aged Fischer 344 rats.
Topics: Aging; Animals; Central Nervous System Depressants; Cerebellum; Electrochemistry; Ethanol; Male; Nom | 1997 |
Normal and drug-induced locomotor behavior in aging: comparison to evoked DA release and tissue content in fischer 344 rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic Uptake Inhibitors; Aging; Animals; Brain Chemistry; Chrom | 1998 |
Subsensitivity to dopaminergic drugs in periadolescent rats: a behavioral and neurochemical analysis.
Topics: Acetylcholine; Aging; Amphetamine; Animals; Apomorphine; Behavior, Animal; Cocaine; Corpus Striatum; | 1998 |
Age-related changes in the capacity, rate, and modulation of dopamine uptake within the striatum and nucleus accumbens of Fischer 344 rats: an in vivo electrochemical study.
Topics: Adrenergic Uptake Inhibitors; Aging; Animals; Citalopram; Corpus Striatum; Desipramine; Dopamine; Do | 1999 |
Striatal dopamine uptake and swim performance of the aged rat.
Topics: Aging; Animals; Bupropion; Corpus Striatum; Desipramine; Dopamine; Dopamine Antagonists; Male; Motor | 1986 |
Effect of neonatal nomifensine exposure on adult behavior and brain monoamines in rats.
Topics: Aging; Alcohol Drinking; Animals; Animals, Newborn; Behavior, Animal; Biogenic Amines; Brain; Male; | 1987 |