nomifensine has been researched along with Acromegaly in 4 studies
Nomifensine: An isoquinoline derivative that prevents dopamine reuptake into synaptosomes. The maleate was formerly used in the treatment of depression. It was withdrawn worldwide in 1986 due to the risk of acute hemolytic anemia with intravascular hemolysis resulting from its use. In some cases, renal failure also developed. (From Martindale, The Extra Pharmacopoeia, 30th ed, p266)
nomifensine : An N-methylated tetrahydroisoquinoline carrying phenyl and amino substituents at positions C-4 and C-8, respectively.
Acromegaly: A condition caused by prolonged exposure to excessive HUMAN GROWTH HORMONE in adults. It is characterized by bony enlargement of the FACE; lower jaw (PROGNATHISM); hands; FEET; HEAD; and THORAX. The most common etiology is a GROWTH HORMONE-SECRETING PITUITARY ADENOMA. (From Joynt, Clinical Neurology, 1992, Ch36, pp79-80)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Nomifensine, an inhibitor of endogenous catecholamine re-uptake, did not affect the growth hormone (GH) or prolactin levels in patients with acromegaly or hyperprolactinaemia." | 7.65 | Effects of nomifensine, an inhibitor of endogenous catecholamine re-uptake, in acromegaly, in hyperprolactinaemia, and against stimulated prolactin release in man. ( Cook, DB; Dewar, JH; Evered, DC; Gomez-Pan, A; Hall, R; Hildyard, A; Mora, B; Scanlon, MF; Weightman, DR, 1977) |
| " Nomifensine, an inhibitor of endogenous catecholamine re-uptake, did not affect the growth hormone (GH) or prolactin levels in patients with acromegaly or hyperprolactinaemia." | 3.65 | Effects of nomifensine, an inhibitor of endogenous catecholamine re-uptake, in acromegaly, in hyperprolactinaemia, and against stimulated prolactin release in man. ( Cook, DB; Dewar, JH; Evered, DC; Gomez-Pan, A; Hall, R; Hildyard, A; Mora, B; Scanlon, MF; Weightman, DR, 1977) |
| "Domperidone did not increase PRL in about a third of acromegalic patients, while TRH increased PRL in the all normoprolactinemic acromegalic patients." | 1.27 | Disturbed prolactin responses to dopamine-related substances in patients with acromegaly and hyperprolactinemia. ( Ibayashi, H; Ikuyama, S; Karashima, T; Kato, K; Muta, K; Sekiya, K, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ferrari, C | 1 |
| Romussi, M | 1 |
| Benco, R | 1 |
| Rampini, P | 1 |
| Mailland, F | 1 |
| Müller, EE | 1 |
| Cavagnini, F | 1 |
| Martinez-Campos, A | 1 |
| Maraschini, C | 1 |
| Giovannini, P | 1 |
| Novelli, A | 1 |
| De Leo, V | 1 |
| Scanlon, MF | 1 |
| Gomez-Pan, A | 1 |
| Mora, B | 1 |
| Cook, DB | 1 |
| Dewar, JH | 1 |
| Hildyard, A | 1 |
| Weightman, DR | 1 |
| Evered, DC | 1 |
| Hall, R | 1 |
| Sekiya, K | 1 |
| Karashima, T | 1 |
| Ikuyama, S | 1 |
| Muta, K | 1 |
| Kato, K | 1 |
| Ibayashi, H | 1 |
4 other studies available for nomifensine and Acromegaly
| Article | Year |
|---|---|
Effect of dihydroergocristine administration on serum prolactin and growth hormone levels in normal, hyperprolactinaemic, and acromegalic subjects: further evidence for pituitary dopamine deficiency in these conditions.
Topics: Acromegaly; Adenoma; Adolescent; Adult; Amenorrhea; Dihydroergotoxine; Dopamine; Female; Growth Horm | 1983 |
Dynamic testing of prolactin and growth hormone secretion in patients with neuroendocrine disorders.
Topics: Acromegaly; Adolescent; Adult; Aged; Brain; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Domperidone; Fem | 1984 |
Effects of nomifensine, an inhibitor of endogenous catecholamine re-uptake, in acromegaly, in hyperprolactinaemia, and against stimulated prolactin release in man.
Topics: Acromegaly; Adult; Female; Humans; Isoquinolines; Male; Nomifensine; Prolactin; Tyrosine | 1977 |
Disturbed prolactin responses to dopamine-related substances in patients with acromegaly and hyperprolactinemia.
Topics: Acromegaly; Adult; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Domperidone; Female; Humans; Male; Middle | 1985 |