nogalamycin and Body-Weight

Mice bearing the P388/S or P388/ADR (doxorubicin-resistant) leukemia were treated with menogaril or mitoxantrone. Both drugs were highly effective against P388/S but were ineffective against the doxorubicin-resistant subline, indicating cross-resistance. These observations may be of use in the design of clinical trials with these drugs.

Topics: Animals; Antineoplastic Agents; Body Weight; Cell Line; Daunorubicin; Doxorubicin; Drug Resistance; Leukemia P388; Life Expectancy; Menogaril; Mice; Mice, Inbred Strains; Mitoxantrone; Nogalamycin

Nogalamycin (1) has been modified by changes at C-10 and C-7 and in the dimethylamino group to prepare an extensive series of analogues. The chemistry involved in the modifications and structure--activity relationships among these nogalamycin analogues are discussed, as well as comparisons with previously reported compounds 1, 7-con-O-methylnogarol (2), and disnogamycin (11).

Topics: Animals; Body Weight; Chemical Phenomena; Chemistry; Daunorubicin; Leukemia L1210; Leukemia P388; Mice; Nogalamycin; Structure-Activity Relationship

Topics: Anemia, Macrocytic; Animals; Body Weight; Dose-Response Relationship, Drug; Female; Heart; Heart Failure; Lethal Dose 50; Male; Myocardium; Naphthacenes; Nogalamycin; Organ Size; Rabbits; Time Factors