nodularin and Chemical-and-Drug-Induced-Liver-Injury

nodularin has been researched along with Chemical-and-Drug-Induced-Liver-Injury* in 3 studies

Reviews

1 review(s) available for nodularin and Chemical-and-Drug-Induced-Liver-Injury

Article	Year
Cyanobacterial toxins--occurrence, biosynthesis and impact on human affairs. Molecular nutrition & food research, 2006, Volume: 50, Issue:1 Mass developments of cyanobacteria ("blue-green algae") in lakes and brackish waters have repeatedly led to serious concerns due to their frequent association with toxins. Among these are the widespread hepatotoxins microcystin (MC) and nodularin (NOD). Here, we give an overview about the ecostrategies of the diverse toxin-producing species and about the genes and enzymes that are involved in the biosynthesis of the cyclic peptides. We further summarize current knowledge about toxicological mechanisms of MC and NOD, including protein phosphatase inhibition, oxidative stress and their tumor-promoting capabilities. One biotransformation pathway for MC is described. Mechanisms of cyanobacterial neurotoxins (anatoxin-a, homanatoxin-a, and anatoxin-a(s)) are briefly explained. We highlight selected cases of human fatalities related to the toxins. A special focus is given to evident cases of contamination of food supplements with cyanobacterial toxins, and to the necessary precautions. Topics: Animals; Bacterial Toxins; Carcinogens; Chemical and Drug Induced Liver Injury; Cyanobacteria; Cyanobacteria Toxins; Dietary Supplements; Ecosystem; Food Contamination; Humans; Marine Toxins; Microcystins; Oxidative Stress; Peptides, Cyclic; Phosphoprotein Phosphatases; Tropanes	2006

Article

Year

Cyanobacterial toxins--occurrence, biosynthesis and impact on human affairs.

Molecular nutrition & food research, 2006, Volume: 50, Issue:1

Mass developments of cyanobacteria ("blue-green algae") in lakes and brackish waters have repeatedly led to serious concerns due to their frequent association with toxins. Among these are the widespread hepatotoxins microcystin (MC) and nodularin (NOD). Here, we give an overview about the ecostrategies of the diverse toxin-producing species and about the genes and enzymes that are involved in the biosynthesis of the cyclic peptides. We further summarize current knowledge about toxicological mechanisms of MC and NOD, including protein phosphatase inhibition, oxidative stress and their tumor-promoting capabilities. One biotransformation pathway for MC is described. Mechanisms of cyanobacterial neurotoxins (anatoxin-a, homanatoxin-a, and anatoxin-a(s)) are briefly explained. We highlight selected cases of human fatalities related to the toxins. A special focus is given to evident cases of contamination of food supplements with cyanobacterial toxins, and to the necessary precautions.

Topics: Animals; Bacterial Toxins; Carcinogens; Chemical and Drug Induced Liver Injury; Cyanobacteria; Cyanobacteria Toxins; Dietary Supplements; Ecosystem; Food Contamination; Humans; Marine Toxins; Microcystins; Oxidative Stress; Peptides, Cyclic; Phosphoprotein Phosphatases; Tropanes

2006

Other Studies

2 other study(ies) available for nodularin and Chemical-and-Drug-Induced-Liver-Injury

Article	Year
Lymphoid depletion in two dogs with nodularin intoxication. The Veterinary record, 2011, Jul-02, Volume: 169, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Dog Diseases; Dogs; Fatal Outcome; Immunohistochemistry; Kidney Diseases; Lymphoid Tissue; Peptides, Cyclic	2011
Synthesis and organotropism of 3H-dihydro derivatives of the cyanobacterial peptide hepatotoxin nodularin. Toxicon : official journal of the International Society on Toxinology, 2003, Volume: 41, Issue:2 Tritium-labelled dihydro derivatives of the cyanobacterial peptide hepatotoxin nodularin were prepared by reduction with sodium boro[3H]hydride. The optimised reaction gave two dihydronodularin stereoisomers which were purified by high-performance liquid chromatography with a mobile phase of methanol-0.7% sodium sulfate (6:4) and a C(18) stationary phase. The specific activities of the stereoisomers were 1780-1807 dis min(-1) ng(-1). The radiolabelled dihydronodularins were tested for stability and used for toxicokinetic studies in mice. Liver was the main site of toxin accumulation. Topics: Animals; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Cyanobacteria; Cyanobacteria Toxins; Female; Isotope Labeling; Liver; Marine Toxins; Mice; Mice, Inbred BALB C; Peptides, Cyclic; Stereoisomerism; Tritium	2003

Article

Year

Lymphoid depletion in two dogs with nodularin intoxication.

The Veterinary record, 2011, Jul-02, Volume: 169, Issue:1

Topics: Animals; Chemical and Drug Induced Liver Injury; Dog Diseases; Dogs; Fatal Outcome; Immunohistochemistry; Kidney Diseases; Lymphoid Tissue; Peptides, Cyclic

2011

Synthesis and organotropism of 3H-dihydro derivatives of the cyanobacterial peptide hepatotoxin nodularin.

Toxicon : official journal of the International Society on Toxinology, 2003, Volume: 41, Issue:2

Tritium-labelled dihydro derivatives of the cyanobacterial peptide hepatotoxin nodularin were prepared by reduction with sodium boro[3H]hydride. The optimised reaction gave two dihydronodularin stereoisomers which were purified by high-performance liquid chromatography with a mobile phase of methanol-0.7% sodium sulfate (6:4) and a C(18) stationary phase. The specific activities of the stereoisomers were 1780-1807 dis min(-1) ng(-1). The radiolabelled dihydronodularins were tested for stability and used for toxicokinetic studies in mice. Liver was the main site of toxin accumulation.

Topics: Animals; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Cyanobacteria; Cyanobacteria Toxins; Female; Isotope Labeling; Liver; Marine Toxins; Mice; Mice, Inbred BALB C; Peptides, Cyclic; Stereoisomerism; Tritium

2003