Page last updated: 2024-10-31

nocodazole and Polyploid

nocodazole has been researched along with Polyploid in 55 studies

Research Excerpts

ExcerptRelevanceReference
"Nocodazole in a dose of 100 ng/ml was used to induce polyploidization in a breast cancer cell line MDA-MB-231 cells."7.78[Sensitivity to chemotherapeutic drugs of polyploid tumor cells induced by a spindle poison nocodazole]. ( Hao, J; Liu, GY; Wang, DH; Xu, YF; Yu, J; Yuan, BB, 2012)
"The proportions of aneuploid/polyploid versus euploid cells formed after treatment with spindle poisons like nocodazole are of course dependent on the relative survival of cells with numerical chromosome aberrations."7.70Induction of polyploidy and apoptosis after exposure to high concentrations of the spindle poison nocodazole. ( Cundari, E; Cunha, M; Decordier, I; Geleyns, K; Kirsch-Volders, M; Verdoodt, B, 1999)
" We show in this report that treatment of only M phase-arrested mouse cells, with the protein kinase inhibitor staurosporine, induced polyploidy."7.69A brief staurosporine treatment of mitotic cells triggers premature exit from mitosis and polyploid cell formation. ( Bradbury, EM; Guo, XW; Hall, LL; Teplitz, RL; Th'ng, JP, 1996)
"Eupatorin likely has additional targets since eupatorin treatment of pre-mitotic cells causes spindle anomalies triggering a transient M phase delay followed by impaired cytokinesis and polyploidy."5.38The flavonoid eupatorin inactivates the mitotic checkpoint leading to polyploidy and apoptosis. ( Jaakkola, K; Kallio, L; Kallio, MJ; Kukkonen-Macchi, A; Mäki-Jouppila, J; Pouwels, J; Salmela, AL; Toivonen, P; Waris, S, 2012)
"Inverse relation of apoptosis and polyploidy induction by paclitaxel or nocodazole in BL."3.81Apoptosis resistance, mitotic catastrophe, and loss of ploidy control in Burkitt lymphoma. ( Chumduri, C; Daniel, PT; Gillissen, B; Milojkovic, A; Müller, A; Overkamp, T; Pott, C; Richter, A, 2015)
"Nocodazole induced a relatively synchronized polyploidization in Dami cells."3.78[mTOR/p70s6k signaling pathway is involved in megakaryocyte polyploidization]. ( Lin, D; Ma, DC; Sun, YH; Tao, SY; Yu, HY, 2012)
"Nocodazole in a dose of 100 ng/ml was used to induce polyploidization in a breast cancer cell line MDA-MB-231 cells."3.78[Sensitivity to chemotherapeutic drugs of polyploid tumor cells induced by a spindle poison nocodazole]. ( Hao, J; Liu, GY; Wang, DH; Xu, YF; Yu, J; Yuan, BB, 2012)
" In this study, we examined mechanisms of hyperploid formation in glioma cells by treatment with nocodazole, which activates spindle assembly checkpoint by inhibiting microtubule polymerization."3.71Mechanism of hyperploid cell formation induced by microtubule inhibiting drug in glioma cell lines. ( Inagaki, M; Nitta, M; Saya, H; Tada, M; Tsuiki, H; Ushio, Y, 2001)
"The proportions of aneuploid/polyploid versus euploid cells formed after treatment with spindle poisons like nocodazole are of course dependent on the relative survival of cells with numerical chromosome aberrations."3.70Induction of polyploidy and apoptosis after exposure to high concentrations of the spindle poison nocodazole. ( Cundari, E; Cunha, M; Decordier, I; Geleyns, K; Kirsch-Volders, M; Verdoodt, B, 1999)
" The aim was to visualize the events leading to aneuploidy directly during anaphase, analyse the induction of aneuploidy during this mitotic stage and compare the frequencies of chromosome malsegregation observed in ana-telophases with the estimated malsegregation obtained in binucleate cells after a short cytochalasin B treatment."3.70Differences in malsegregation rates obtained by scoring ana-telophases or binucleate cells. ( Cimini, D; Degrassi, F; Tanzarella, C, 1999)
" We show in this report that treatment of only M phase-arrested mouse cells, with the protein kinase inhibitor staurosporine, induced polyploidy."3.69A brief staurosporine treatment of mitotic cells triggers premature exit from mitosis and polyploid cell formation. ( Bradbury, EM; Guo, XW; Hall, LL; Teplitz, RL; Th'ng, JP, 1996)
" Polyploidization of UT-7 cells was induced by the microtubule-depolymerizing agent, nocodazole, and 12-O-tetradecanoylphorbol-13-acetate (TPA), but the effect was much more striking with nocodazole."3.69Polyploidization and functional maturation are two distinct processes during megakaryocytic differentiation: involvement of cyclin-dependent kinase inhibitor p21 in polyploidization. ( Furukawa, Y; Iwase, S; Kikuchi, J; Kitagawa, M; Kitagawa, S; Komatsu, N; Miura, Y; Nakamura, M; Terui, Y, 1997)
"It is well known that aneuploidy can have adverse effects on human health such as pregnancy wastage, birth defects and the development of human tumours."2.44Survival of aneuploid, micronucleated and/or polyploid cells: crosstalk between ploidy control and apoptosis. ( Cundari, E; Decordier, I; Kirsch-Volders, M, 2008)
"Eupatorin likely has additional targets since eupatorin treatment of pre-mitotic cells causes spindle anomalies triggering a transient M phase delay followed by impaired cytokinesis and polyploidy."1.38The flavonoid eupatorin inactivates the mitotic checkpoint leading to polyploidy and apoptosis. ( Jaakkola, K; Kallio, L; Kallio, MJ; Kukkonen-Macchi, A; Mäki-Jouppila, J; Pouwels, J; Salmela, AL; Toivonen, P; Waris, S, 2012)
"The amount of polyploidy cells was increased following mitotic slippage."1.37High LET radiation enhances nocodazole Induced cell death in HeLa cells through mitotic catastrophe and apoptosis. ( Dai, Z; Furusawa, Y; Jin, X; Li, P; Li, Q; Liu, X; Matsumoto, Y; Zhou, L, 2011)
"Interestingly, induction of polyploidy was completely prevented by modest overexpression of the NAD+ regenerating enzyme, nicotinamide phosphoribosyltransferase (Nampt)."1.36Polyploidy impairs human aortic endothelial cell function and is prevented by nicotinamide phosphoribosyltransferase. ( Borradaile, NM; Pickering, JG, 2010)
"However, polyploidy may also render cancer cells more vulnerable to chemotherapy."1.36Small-molecule inducer of cancer cell polyploidy promotes apoptosis or senescence: Implications for therapy. ( Deo, D; Heimbrook, DC; Higgins, B; Kolinsky, K; Liu, JJ; Tovar, C; Vassilev, LT, 2010)
"Here we demonstrated that Pim-1-induced polyploidy develops in a passage-dependent manner in culture consistent with a stochastic mode of progression."1.33Chromosomal instability induced by Pim-1 is passage-dependent and associated with dysregulation of cyclin B1. ( Abdulkadir, SA; Kim, J; Roh, M; Song, C, 2005)
"Tetraploidy can result in cancer-associated aneuploidy."1.33Apoptosis regulation in tetraploid cancer cells. ( Casares, N; Castedo, M; Coquelle, A; Dessen, P; Garrido, C; Kauffmann, A; Kroemer, G; Lazar, V; Modjtahedi, N; Mouhamad, S; Pequignot, MO; Schmitt, E; Vainchenker, W; Valent, A; Vitale, I; Vivet, S; Zitvogel, L, 2006)
"Previous studies have shown that polyploid cells are unstable and lose chromosomes randomly to give aneuploidy."1.31Flavopiridol, a cyclin-dependent kinase inhibitor, prevents spindle inhibitor-induced endoreduplication in human cancer cells. ( Li, X; Motwani, M; Schwartz, GK, 2000)
"Mature megakaryocyte-like polyploid cells were detected at day 5-7 of treatment with nocodazole."1.31The involvement of human-nuc gene in polyploidization of K562 cell line. ( Aglietta, M; Bréchot, C; Bruno, S; Cavalloni, G; Danè, A; Lamas, E; Piacibello, W, 2000)

Research

Studies (55)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's11 (20.00)18.2507
2000's35 (63.64)29.6817
2010's9 (16.36)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chumduri, C1
Gillissen, B1
Richter, A2
Milojkovic, A1
Overkamp, T1
Müller, A1
Pott, C1
Daniel, PT1
Zhang, Z1
Hou, SQ1
He, J1
Gu, T1
Yin, Y1
Shen, WH1
Rakotomalala, L1
Studach, L1
Wang, WH1
Gregori, G1
Hullinger, RL1
Andrisani, O1
Ma, D1
Yu, H1
Lin, D2
Sun, Y1
Liu, L1
Liu, Y1
Dai, B1
Chen, W2
Cao, J1
Medendorp, K1
van Groningen, JJ1
Vreede, L1
Hetterschijt, L1
Brugmans, L1
van den Hurk, WH1
van Kessel, AG1
Borradaile, NM1
Pickering, JG1
Tovar, C1
Higgins, B1
Deo, D1
Kolinsky, K1
Liu, JJ1
Heimbrook, DC1
Vassilev, LT1
Tsuchiya, M1
Katagiri, N1
Kuroda, T1
Kishimoto, H1
Nishimura, K1
Kumazawa, T1
Iwasaki, N1
Kimura, K1
Yanagisawa, J1
Li, P1
Zhou, L1
Dai, Z1
Jin, X1
Liu, X2
Matsumoto, Y1
Furusawa, Y1
Li, Q2
Salmela, AL1
Pouwels, J1
Kukkonen-Macchi, A1
Waris, S1
Toivonen, P1
Jaakkola, K1
Mäki-Jouppila, J1
Kallio, L1
Kallio, MJ1
Yu, HY1
Ma, DC1
Sun, YH1
Tao, SY1
Hao, J1
Yuan, BB1
Xu, YF1
Yu, J1
Liu, GY1
Wang, DH1
Hauf, S1
Cole, RW1
LaTerra, S1
Zimmer, C1
Schnapp, G1
Walter, R1
Heckel, A1
van Meel, J1
Rieder, CL1
Peters, JM1
Dridi, W1
Fetni, R1
Lavoie, J1
Poupon, MF1
Drouin, R1
Baek, KH4
Shin, HJ3
Yoo, JK1
Cho, JH1
Choi, YH1
Sung, YC2
McKeon, F4
Lee, CW4
Smirnova, IS1
Iakovleva, TK1
Aksenov, ND2
Yih, LH1
Lee, TC1
Jeon, AH1
Park, MT1
Lee, SJ1
Kang, CM1
Lee, HS1
Yoo, SH1
Chung, DH1
Patel, D1
Incassati, A1
Wang, N1
McCance, DJ1
Neliudova, AM1
Brichkina, AI1
Rukhlova, MP1
Pospelova, TV1
Kim, KT1
Ongusaha, PP1
Hong, YK1
Kurdistani, SK1
Nakamura, M2
Lu, KP1
Lee, SW1
Jeong, SJ2
Park, JW1
Kim, CM2
Roh, M1
Song, C1
Kim, J1
Abdulkadir, SA1
Nishiyama, A1
Dey, A1
Miyazaki, J1
Ozato, K1
Castedo, M1
Coquelle, A1
Vivet, S1
Vitale, I1
Kauffmann, A1
Dessen, P1
Pequignot, MO1
Casares, N1
Valent, A1
Mouhamad, S1
Schmitt, E1
Modjtahedi, N1
Vainchenker, W2
Zitvogel, L1
Lazar, V1
Garrido, C1
Kroemer, G1
Stavropoulou, V1
Vasquez, V1
Cereser, B1
Freda, E1
Masucci, MG1
Hau, PM2
Siu, WY1
Wong, N1
Lai, PB1
Poon, RY2
Inoue, T1
Hiratsuka, M1
Osaki, M1
Yamada, H1
Kishimoto, I1
Yamaguchi, S1
Nakano, S1
Katoh, M1
Ito, H1
Oshimura, M1
Grove, LE1
Ghosh, RN1
Aylon, Y1
Michael, D1
Shmueli, A1
Yabuta, N1
Nojima, H1
Oren, M1
Leao, M1
Anderton, E1
Wade, M1
Meekings, K1
Allday, MJ1
Dikovskaya, D1
Schiffmann, D1
Newton, IP1
Oakley, A1
Kroboth, K1
Sansom, O1
Jamieson, TJ1
Meniel, V1
Clarke, A1
Näthke, IS1
Qi, W1
Martinez, JD1
Ha, GH1
Kim, HS1
Decordier, I2
Cundari, E3
Kirsch-Volders, M4
Chan, YW1
On, KF1
Chan, WM1
Wong, W1
Siu, HO1
van der Loo, B1
Hong, Y1
Hancock, V1
Martin, JF1
Erusalimsky, JD1
Everett, CA1
Searle, JB1
Hall, LL1
Th'ng, JP1
Guo, XW1
Teplitz, RL1
Bradbury, EM1
Andreassen, PR1
Martineau, SN1
Margolis, RL1
Kikuchi, J1
Furukawa, Y1
Iwase, S1
Terui, Y1
Kitagawa, S1
Kitagawa, M1
Komatsu, N1
Miura, Y1
Elhajouji, A2
Cunha, M2
Hong, FD1
Chen, J1
Donovan, S1
Schneider, N1
Nisen, PD1
Casenghi, M1
Mangiacasale, R1
Tuynder, M1
Caillet-Fauquet, P1
Lavia, P1
Mousset, S1
Verdoodt, B1
Geleyns, K1
Cimini, D1
Tanzarella, C1
Degrassi, F1
Khan, SH1
Moritsugu, J1
Wahl, GM1
Motwani, M1
Li, X1
Schwartz, GK1
Gandarillas, A1
Davies, D1
Blanchard, JM1
Cavalloni, G1
Danè, A1
Piacibello, W1
Bruno, S1
Lamas, E1
Bréchot, C1
Aglietta, M1
Roy, L1
Coullin, P1
Vitrat, N1
Hellio, R1
Debili, N1
Weinstein, J1
Bernheim, A1
Tsuiki, H2
Nitta, M2
Tada, M1
Inagaki, M1
Ushio, Y2
Saya, H2
Damiens, E1
Baratte, B1
Marie, D1
Eisenbrand, G1
Meijer, L1
Arima, Y1
Harada, K1
Nishizaki, T1
Sasaki, K1
Mimori, T1
Mayer, VW1
Goin, CJ1
Arras, CA1
Taylor-Mayer, RE1

Reviews

1 review available for nocodazole and Polyploid

ArticleYear
Survival of aneuploid, micronucleated and/or polyploid cells: crosstalk between ploidy control and apoptosis.
    Mutation research, 2008, Mar-12, Volume: 651, Issue:1-2

    Topics: Aneuploidy; Animals; Apoptosis; Cell Survival; Humans; Micronuclei, Chromosome-Defective; Models, Bi

2008

Other Studies

54 other studies available for nocodazole and Polyploid

ArticleYear
Apoptosis resistance, mitotic catastrophe, and loss of ploidy control in Burkitt lymphoma.
    Journal of molecular medicine (Berlin, Germany), 2015, Volume: 93, Issue:5

    Topics: Animals; Apoptosis; Burkitt Lymphoma; Caspase Inhibitors; Caspases; Cell Line; DNA Fragmentation; Fl

2015
PTEN regulates PLK1 and controls chromosomal stability during cell division.
    Cell cycle (Georgetown, Tex.), 2016, Sep-16, Volume: 15, Issue:18

    Topics: Animals; Cell Cycle Proteins; Cell Division; Chromosomal Instability; Enzyme Activation; Enzyme Stab

2016
Hepatitis B virus X protein increases the Cdt1-to-geminin ratio inducing DNA re-replication and polyploidy.
    The Journal of biological chemistry, 2008, Oct-17, Volume: 283, Issue:42

    Topics: Animals; Cell Cycle Proteins; Cell Line; DNA; DNA-Binding Proteins; Flow Cytometry; Geminin; Hepatoc

2008
S6K1 is involved in polyploidization through its phosphorylation at Thr421/Ser424.
    Journal of cellular physiology, 2009, Volume: 219, Issue:1

    Topics: Adaptor Proteins, Signal Transducing; Androstadienes; Animals; Antineoplastic Agents; Carcinogens; C

2009
The renal cell carcinoma-associated oncogenic fusion protein PRCCTFE3 provokes p21 WAF1/CIP1-mediated cell cycle delay.
    Experimental cell research, 2009, Aug-15, Volume: 315, Issue:14

    Topics: Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Carcinoma, Renal Cell; Cell Cycle; Cell

2009
Polyploidy impairs human aortic endothelial cell function and is prevented by nicotinamide phosphoribosyltransferase.
    American journal of physiology. Cell physiology, 2010, Volume: 298, Issue:1

    Topics: Aging; Aorta; Atherosclerosis; Cell Cycle; Cell Division; Cytokines; Endothelium, Vascular; Extracel

2010
Small-molecule inducer of cancer cell polyploidy promotes apoptosis or senescence: Implications for therapy.
    Cell cycle (Georgetown, Tex.), 2010, Aug-15, Volume: 9, Issue:16

    Topics: Antineoplastic Agents; Apoptosis; Benzodiazepines; Cell Line, Tumor; Cellular Senescence; Humans; Mi

2010
Critical role of the nucleolus in activation of the p53-dependent postmitotic checkpoint.
    Biochemical and biophysical research communications, 2011, Apr-08, Volume: 407, Issue:2

    Topics: Acetylation; Active Transport, Cell Nucleus; Cell Line, Tumor; Cell Nucleolus; DNA-Binding Proteins;

2011
High LET radiation enhances nocodazole Induced cell death in HeLa cells through mitotic catastrophe and apoptosis.
    Journal of radiation research, 2011, Volume: 52, Issue:4

    Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Death; Cell Line, Tumor; DNA Damage; HeLa Cells;

2011
The flavonoid eupatorin inactivates the mitotic checkpoint leading to polyploidy and apoptosis.
    Experimental cell research, 2012, Mar-10, Volume: 318, Issue:5

    Topics: Antimitotic Agents; Apoptosis; Aurora Kinase B; Aurora Kinases; Cell Culture Techniques; Cell Prolif

2012
[mTOR/p70s6k signaling pathway is involved in megakaryocyte polyploidization].
    Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 2012, Volume: 28, Issue:1

    Topics: Cell Cycle; Humans; Megakaryocytes; Nocodazole; Phosphorylation; Polyploidy; Ribosomal Protein S6 Ki

2012
[Sensitivity to chemotherapeutic drugs of polyploid tumor cells induced by a spindle poison nocodazole].
    Zhonghua zhong liu za zhi [Chinese journal of oncology], 2012, Volume: 34, Issue:6

    Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Breast Neoplasms; Cell Line, Tu

2012
The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint.
    The Journal of cell biology, 2003, Apr-28, Volume: 161, Issue:2

    Topics: Anaphase; Aneugens; Animals; Aurora Kinase B; Aurora Kinases; Cell Cycle Proteins; Chromosome Segreg

2003
The dominant-negative effect of p53 mutants and p21 induction in tetraploid G1 arrest depends on the type of p53 mutation and the nature of the stimulus.
    Cancer genetics and cytogenetics, 2003, Volume: 143, Issue:1

    Topics: Cyclin-Dependent Kinase Inhibitor p21; Cyclins; G1 Phase; Genes, p53; Humans; Mutation; Nocodazole;

2003
p53 deficiency and defective mitotic checkpoint in proliferating T lymphocytes increase chromosomal instability through aberrant exit from mitotic arrest.
    Journal of leukocyte biology, 2003, Volume: 73, Issue:6

    Topics: Animals; Cell Cycle Proteins; Cells, Cultured; Chromosomes; DNA; Female; Humans; Jurkat Cells; Kinet

2003
[Delayed biological consequences induced by gamma-radiation in human tumorigenic diploid line SK-UT-1B].
    Tsitologiia, 2003, Volume: 45, Issue:4

    Topics: Antineoplastic Agents; Cell Cycle; Cell Line, Tumor; Chromosomes; Gamma Rays; Gene Rearrangement; Hu

2003
Induction of C-anaphase and diplochromosome through dysregulation of spindle assembly checkpoint by sodium arsenite in human fibroblasts.
    Cancer research, 2003, Oct-15, Volume: 63, Issue:20

    Topics: Anaphase; Anaphase-Promoting Complex-Cyclosome; Arsenites; Calcium-Binding Proteins; Cdc20 Proteins;

2003
Dual roles of human BubR1, a mitotic checkpoint kinase, in the monitoring of chromosomal instability.
    Cancer cell, 2003, Volume: 4, Issue:6

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Apoptosis; Caspases; Cell Cycle Proteins; Chromosoma

2003
Human papillomavirus type 16 E6 and E7 cause polyploidy in human keratinocytes and up-regulation of G2-M-phase proteins.
    Cancer research, 2004, Feb-15, Volume: 64, Issue:4

    Topics: Cell Cycle Proteins; Cell Line; G2 Phase; Gene Expression Regulation; Humans; Keratinocytes; Mitosis

2004
[Antiproliferative effect of bcl-2 gene does not concern the control of mitotic events].
    Tsitologiia, 2004, Volume: 46, Issue:3

    Topics: Adenovirus E1A Proteins; Animals; Antineoplastic Agents; Apoptosis; Cell Division; Cell Line, Transf

2004
Function of Drg1/Rit42 in p53-dependent mitotic spindle checkpoint.
    The Journal of biological chemistry, 2004, Sep-10, Volume: 279, Issue:37

    Topics: Adenoviridae; Antineoplastic Agents; Blotting, Western; Cell Cycle; Cell Cycle Proteins; Cell Line,

2004
Caspases-dependent cleavage of mitotic checkpoint proteins in response to microtubule inhibitor.
    Oncology research, 2005, Volume: 15, Issue:3

    Topics: Apoptosis; Caspase Inhibitors; Caspases; Cell Cycle Proteins; Cloning, Molecular; Enzyme Inhibitors;

2005
Chromosomal instability induced by Pim-1 is passage-dependent and associated with dysregulation of cyclin B1.
    The Journal of biological chemistry, 2005, Dec-09, Volume: 280, Issue:49

    Topics: Animals; Cattle; CDC2 Protein Kinase; Cell Cycle; Cell Division; Cell Line, Tumor; Chromosomes, Huma

2005
Brd4 is required for recovery from antimicrotubule drug-induced mitotic arrest: preservation of acetylated chromatin.
    Molecular biology of the cell, 2006, Volume: 17, Issue:2

    Topics: Acetylation; Animals; Apoptosis; CDC2 Protein Kinase; Cell Proliferation; Chromatin; Chromosome Segr

2006
Apoptosis regulation in tetraploid cancer cells.
    The EMBO journal, 2006, Jun-07, Volume: 25, Issue:11

    Topics: Animals; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Cell Line, Tumor; Cisplatin;

2006
TPPII promotes genetic instability by allowing the escape from apoptosis of cells with activated mitotic checkpoints.
    Biochemical and biophysical research communications, 2006, Jul-28, Volume: 346, Issue:2

    Topics: Aminopeptidases; Apoptosis; Apoptosis Regulatory Proteins; Cell Cycle; Cell Line; Cell Line, Transfo

2006
Polyploidization increases the sensitivity to DNA-damaging agents in mammalian cells.
    FEBS letters, 2006, Aug-21, Volume: 580, Issue:19

    Topics: Cells, Cultured; Centrosome; DNA; DNA Damage; Histones; Humans; Nocodazole; Phosphorylation; Polyplo

2006
SIRT2, a tubulin deacetylase, acts to block the entry to chromosome condensation in response to mitotic stress.
    Oncogene, 2007, Feb-15, Volume: 26, Issue:7

    Topics: Cell Line, Tumor; Chromosomal Instability; Chromosomes, Human; Glioma; Histone Deacetylase Inhibitor

2007
Quantitative characterization of mitosis-blocked tetraploid cells using high content analysis.
    Assay and drug development technologies, 2006, Volume: 4, Issue:4

    Topics: Antineoplastic Agents; Cell Cycle Proteins; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; Cell

2006
A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization.
    Genes & development, 2006, Oct-01, Volume: 20, Issue:19

    Topics: Animals; Cell Cycle; Cell Cycle Proteins; Cell Line; Cell Line, Tumor; Cells, Cultured; Centrosome;

2006
Epstein-barr virus-induced resistance to drugs that activate the mitotic spindle assembly checkpoint in Burkitt's lymphoma cells.
    Journal of virology, 2007, Volume: 81, Issue:1

    Topics: Antineoplastic Agents; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Burkitt Lymphoma; Cell

2007
Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis.
    The Journal of cell biology, 2007, Jan-15, Volume: 176, Issue:2

    Topics: Adenomatous Polyposis Coli Protein; Animals; Apoptosis; beta Catenin; Caspase 3; Cell Cycle Proteins

2007
Overexpression of 14-3-3gamma causes polyploidization in H322 lung cancer cells.
    Molecular carcinogenesis, 2007, Volume: 46, Issue:10

    Topics: 14-3-3 Proteins; Cell Cycle; DNA Replication; Humans; Lung Neoplasms; Mitotic Index; Nocodazole; Pol

2007
p53 activation in response to mitotic spindle damage requires signaling via BubR1-mediated phosphorylation.
    Cancer research, 2007, Aug-01, Volume: 67, Issue:15

    Topics: Antineoplastic Agents; Cell Cycle; Chromosomal Instability; Colonic Neoplasms; Fluorescent Antibody

2007
The kinetics of p53 activation versus cyclin E accumulation underlies the relationship between the spindle-assembly checkpoint and the postmitotic checkpoint.
    The Journal of biological chemistry, 2008, Jun-06, Volume: 283, Issue:23

    Topics: Calcium-Binding Proteins; CDC2 Protein Kinase; Cell Cycle Proteins; Chromosomal Instability; Chromos

2008
Antimicrotubule agents induce polyploidization of human leukaemic cell lines with megakaryocytic features.
    European journal of clinical investigation, 1993, Volume: 23, Issue:10

    Topics: Cell Division; Colchicine; Demecolcine; DNA; Flow Cytometry; Humans; Leukemia; Lumicolchicines; Mega

1993
Pattern and frequency of nocodazole induced meiotic nondisjunction in oocytes of mice carrying the 'tobacco mouse' metacentric Rb(16.17)7Bnr.
    Genetical research, 1995, Volume: 66, Issue:1

    Topics: Anaphase; Animals; Antineoplastic Agents; Cells, Cultured; Centromere; Chromosomes; Dose-Response Re

1995
A brief staurosporine treatment of mitotic cells triggers premature exit from mitosis and polyploid cell formation.
    Cancer research, 1996, Aug-01, Volume: 56, Issue:15

    Topics: Alkaloids; Animals; Antineoplastic Agents; CDC2 Protein Kinase; DNA, Neoplasm; Enzyme Inhibitors; G1

1996
Chemical induction of mitotic checkpoint override in mammalian cells results in aneuploidy following a transient tetraploid state.
    Mutation research, 1996, Volume: 372, Issue:2

    Topics: 2-Aminopurine; Aneuploidy; Animals; Cell Cycle; CHO Cells; Cricetinae; Cytochalasin B; Diketopiperaz

1996
Polyploidization and functional maturation are two distinct processes during megakaryocytic differentiation: involvement of cyclin-dependent kinase inhibitor p21 in polyploidization.
    Blood, 1997, Jun-01, Volume: 89, Issue:11

    Topics: Carcinogens; Cell Differentiation; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; HL-60 Cells; Huma

1997
Spindle poisons can induce polyploidy by mitotic slippage and micronucleate mononucleates in the cytokinesis-block assay.
    Mutagenesis, 1998, Volume: 13, Issue:2

    Topics: Benzimidazoles; Carbamates; Colchicine; Female; Humans; Leukocyte Count; Leukocytes, Mononuclear; Ma

1998
Taxol, vincristine or nocodazole induces lethality in G1-checkpoint-defective human astrocytoma U373MG cells by triggering hyperploid progression.
    Carcinogenesis, 1999, Volume: 20, Issue:7

    Topics: Astrocytoma; Cell Cycle; Cell Cycle Proteins; Cell Death; Cell Division; Cyclin-Dependent Kinase Inh

1999
p53-independent apoptosis and p53-dependent block of DNA rereplication following mitotic spindle inhibition in human cells.
    Experimental cell research, 1999, Aug-01, Volume: 250, Issue:2

    Topics: Apoptosis; Cell Cycle; Cell Cycle Proteins; Centromere; Chromosome Segregation; Cyclin B; Cyclin B1;

1999
Induction of polyploidy and apoptosis after exposure to high concentrations of the spindle poison nocodazole.
    Mutagenesis, 1999, Volume: 14, Issue:5

    Topics: Adult; Antineoplastic Agents; Apoptosis; Cell Survival; Cells, Cultured; Demecolcine; Dose-Response

1999
Differences in malsegregation rates obtained by scoring ana-telophases or binucleate cells.
    Mutagenesis, 1999, Volume: 14, Issue:6

    Topics: Anaphase; Aneuploidy; Cell Nucleus; Cells, Cultured; Chromosomes, Human, Pair 11; Chromosomes, Human

1999
Differential requirement for p19ARF in the p53-dependent arrest induced by DNA damage, microtubule disruption, and ribonucleotide depletion.
    Proceedings of the National Academy of Sciences of the United States of America, 2000, Mar-28, Volume: 97, Issue:7

    Topics: Animals; Blotting, Western; Cells, Cultured; DNA Damage; Mice; Mice, Knockout; Microtubules; Nocodaz

2000
Flavopiridol, a cyclin-dependent kinase inhibitor, prevents spindle inhibitor-induced endoreduplication in human cancer cells.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2000, Volume: 6, Issue:3

    Topics: Antineoplastic Agents; CDC2 Protein Kinase; CDC2-CDC28 Kinases; Cyclin B; Cyclin B1; Cyclin E; Cycli

2000
Normal and c-Myc-promoted human keratinocyte differentiation both occur via a novel cell cycle involving cellular growth and endoreplication.
    Oncogene, 2000, Jul-06, Volume: 19, Issue:29

    Topics: Cell Cycle; Cell Differentiation; Cell Division; Cell Size; Cells, Cultured; DNA; DNA Replication; H

2000
The involvement of human-nuc gene in polyploidization of K562 cell line.
    Experimental hematology, 2000, Volume: 28, Issue:12

    Topics: Apoptosis; Cell Differentiation; DNA; Flow Cytometry; Gene Expression; Humans; K562 Cells; Megakaryo

2000
Asymmetrical segregation of chromosomes with a normal metaphase/anaphase checkpoint in polyploid megakaryocytes.
    Blood, 2001, Apr-15, Volume: 97, Issue:8

    Topics: Anaphase; Cdc20 Proteins; Cell Cycle Proteins; Cells, Cultured; Chromosomes, Human; Cyclin B; Cyclin

2001
Mechanism of hyperploid cell formation induced by microtubule inhibiting drug in glioma cell lines.
    Oncogene, 2001, Jan-25, Volume: 20, Issue:4

    Topics: CDC2 Protein Kinase; Glioma; Humans; Microtubules; Mitosis; Mitotic Index; Nocodazole; Polyploidy; S

2001
Anti-mitotic properties of indirubin-3'-monoxime, a CDK/GSK-3 inhibitor: induction of endoreplication following prophase arrest.
    Oncogene, 2001, Jun-28, Volume: 20, Issue:29

    Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Calcium-Calmodulin-Dependent Protein Kinases; CD

2001
Hyperploidy induced by drugs that inhibit formation of microtubule promotes chromosome instability.
    Genes to cells : devoted to molecular & cellular mechanisms, 2002, Volume: 7, Issue:2

    Topics: Antineoplastic Agents; Chromosomes; Glioma; Humans; Microtubules; Nocodazole; Polyploidy; Tumor Cell

2002
Comparison of chemically induced chromosome loss in a diploid, triploid, and tetraploid strain of Saccharomyces cerevisiae.
    Mutation research, 1992, May-01, Volume: 279, Issue:1

    Topics: Acetates; Chromosomes, Fungal; Diploidy; Ethyl Methanesulfonate; Hydroxyurea; Mutagens; Nocodazole;

1992