nocodazole has been researched along with Polyploid in 55 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Nocodazole in a dose of 100 ng/ml was used to induce polyploidization in a breast cancer cell line MDA-MB-231 cells." | 7.78 | [Sensitivity to chemotherapeutic drugs of polyploid tumor cells induced by a spindle poison nocodazole]. ( Hao, J; Liu, GY; Wang, DH; Xu, YF; Yu, J; Yuan, BB, 2012) |
| "The proportions of aneuploid/polyploid versus euploid cells formed after treatment with spindle poisons like nocodazole are of course dependent on the relative survival of cells with numerical chromosome aberrations." | 7.70 | Induction of polyploidy and apoptosis after exposure to high concentrations of the spindle poison nocodazole. ( Cundari, E; Cunha, M; Decordier, I; Geleyns, K; Kirsch-Volders, M; Verdoodt, B, 1999) |
| " We show in this report that treatment of only M phase-arrested mouse cells, with the protein kinase inhibitor staurosporine, induced polyploidy." | 7.69 | A brief staurosporine treatment of mitotic cells triggers premature exit from mitosis and polyploid cell formation. ( Bradbury, EM; Guo, XW; Hall, LL; Teplitz, RL; Th'ng, JP, 1996) |
| "Eupatorin likely has additional targets since eupatorin treatment of pre-mitotic cells causes spindle anomalies triggering a transient M phase delay followed by impaired cytokinesis and polyploidy." | 5.38 | The flavonoid eupatorin inactivates the mitotic checkpoint leading to polyploidy and apoptosis. ( Jaakkola, K; Kallio, L; Kallio, MJ; Kukkonen-Macchi, A; Mäki-Jouppila, J; Pouwels, J; Salmela, AL; Toivonen, P; Waris, S, 2012) |
| "Inverse relation of apoptosis and polyploidy induction by paclitaxel or nocodazole in BL." | 3.81 | Apoptosis resistance, mitotic catastrophe, and loss of ploidy control in Burkitt lymphoma. ( Chumduri, C; Daniel, PT; Gillissen, B; Milojkovic, A; Müller, A; Overkamp, T; Pott, C; Richter, A, 2015) |
| "Nocodazole induced a relatively synchronized polyploidization in Dami cells." | 3.78 | [mTOR/p70s6k signaling pathway is involved in megakaryocyte polyploidization]. ( Lin, D; Ma, DC; Sun, YH; Tao, SY; Yu, HY, 2012) |
| "Nocodazole in a dose of 100 ng/ml was used to induce polyploidization in a breast cancer cell line MDA-MB-231 cells." | 3.78 | [Sensitivity to chemotherapeutic drugs of polyploid tumor cells induced by a spindle poison nocodazole]. ( Hao, J; Liu, GY; Wang, DH; Xu, YF; Yu, J; Yuan, BB, 2012) |
| " In this study, we examined mechanisms of hyperploid formation in glioma cells by treatment with nocodazole, which activates spindle assembly checkpoint by inhibiting microtubule polymerization." | 3.71 | Mechanism of hyperploid cell formation induced by microtubule inhibiting drug in glioma cell lines. ( Inagaki, M; Nitta, M; Saya, H; Tada, M; Tsuiki, H; Ushio, Y, 2001) |
| "The proportions of aneuploid/polyploid versus euploid cells formed after treatment with spindle poisons like nocodazole are of course dependent on the relative survival of cells with numerical chromosome aberrations." | 3.70 | Induction of polyploidy and apoptosis after exposure to high concentrations of the spindle poison nocodazole. ( Cundari, E; Cunha, M; Decordier, I; Geleyns, K; Kirsch-Volders, M; Verdoodt, B, 1999) |
| " The aim was to visualize the events leading to aneuploidy directly during anaphase, analyse the induction of aneuploidy during this mitotic stage and compare the frequencies of chromosome malsegregation observed in ana-telophases with the estimated malsegregation obtained in binucleate cells after a short cytochalasin B treatment." | 3.70 | Differences in malsegregation rates obtained by scoring ana-telophases or binucleate cells. ( Cimini, D; Degrassi, F; Tanzarella, C, 1999) |
| " We show in this report that treatment of only M phase-arrested mouse cells, with the protein kinase inhibitor staurosporine, induced polyploidy." | 3.69 | A brief staurosporine treatment of mitotic cells triggers premature exit from mitosis and polyploid cell formation. ( Bradbury, EM; Guo, XW; Hall, LL; Teplitz, RL; Th'ng, JP, 1996) |
| " Polyploidization of UT-7 cells was induced by the microtubule-depolymerizing agent, nocodazole, and 12-O-tetradecanoylphorbol-13-acetate (TPA), but the effect was much more striking with nocodazole." | 3.69 | Polyploidization and functional maturation are two distinct processes during megakaryocytic differentiation: involvement of cyclin-dependent kinase inhibitor p21 in polyploidization. ( Furukawa, Y; Iwase, S; Kikuchi, J; Kitagawa, M; Kitagawa, S; Komatsu, N; Miura, Y; Nakamura, M; Terui, Y, 1997) |
| "It is well known that aneuploidy can have adverse effects on human health such as pregnancy wastage, birth defects and the development of human tumours." | 2.44 | Survival of aneuploid, micronucleated and/or polyploid cells: crosstalk between ploidy control and apoptosis. ( Cundari, E; Decordier, I; Kirsch-Volders, M, 2008) |
| "Eupatorin likely has additional targets since eupatorin treatment of pre-mitotic cells causes spindle anomalies triggering a transient M phase delay followed by impaired cytokinesis and polyploidy." | 1.38 | The flavonoid eupatorin inactivates the mitotic checkpoint leading to polyploidy and apoptosis. ( Jaakkola, K; Kallio, L; Kallio, MJ; Kukkonen-Macchi, A; Mäki-Jouppila, J; Pouwels, J; Salmela, AL; Toivonen, P; Waris, S, 2012) |
| "The amount of polyploidy cells was increased following mitotic slippage." | 1.37 | High LET radiation enhances nocodazole Induced cell death in HeLa cells through mitotic catastrophe and apoptosis. ( Dai, Z; Furusawa, Y; Jin, X; Li, P; Li, Q; Liu, X; Matsumoto, Y; Zhou, L, 2011) |
| "Interestingly, induction of polyploidy was completely prevented by modest overexpression of the NAD+ regenerating enzyme, nicotinamide phosphoribosyltransferase (Nampt)." | 1.36 | Polyploidy impairs human aortic endothelial cell function and is prevented by nicotinamide phosphoribosyltransferase. ( Borradaile, NM; Pickering, JG, 2010) |
| "However, polyploidy may also render cancer cells more vulnerable to chemotherapy." | 1.36 | Small-molecule inducer of cancer cell polyploidy promotes apoptosis or senescence: Implications for therapy. ( Deo, D; Heimbrook, DC; Higgins, B; Kolinsky, K; Liu, JJ; Tovar, C; Vassilev, LT, 2010) |
| "Here we demonstrated that Pim-1-induced polyploidy develops in a passage-dependent manner in culture consistent with a stochastic mode of progression." | 1.33 | Chromosomal instability induced by Pim-1 is passage-dependent and associated with dysregulation of cyclin B1. ( Abdulkadir, SA; Kim, J; Roh, M; Song, C, 2005) |
| "Tetraploidy can result in cancer-associated aneuploidy." | 1.33 | Apoptosis regulation in tetraploid cancer cells. ( Casares, N; Castedo, M; Coquelle, A; Dessen, P; Garrido, C; Kauffmann, A; Kroemer, G; Lazar, V; Modjtahedi, N; Mouhamad, S; Pequignot, MO; Schmitt, E; Vainchenker, W; Valent, A; Vitale, I; Vivet, S; Zitvogel, L, 2006) |
| "Previous studies have shown that polyploid cells are unstable and lose chromosomes randomly to give aneuploidy." | 1.31 | Flavopiridol, a cyclin-dependent kinase inhibitor, prevents spindle inhibitor-induced endoreduplication in human cancer cells. ( Li, X; Motwani, M; Schwartz, GK, 2000) |
| "Mature megakaryocyte-like polyploid cells were detected at day 5-7 of treatment with nocodazole." | 1.31 | The involvement of human-nuc gene in polyploidization of K562 cell line. ( Aglietta, M; Bréchot, C; Bruno, S; Cavalloni, G; Danè, A; Lamas, E; Piacibello, W, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 11 (20.00) | 18.2507 |
| 2000's | 35 (63.64) | 29.6817 |
| 2010's | 9 (16.36) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chumduri, C | 1 |
| Gillissen, B | 1 |
| Richter, A | 2 |
| Milojkovic, A | 1 |
| Overkamp, T | 1 |
| Müller, A | 1 |
| Pott, C | 1 |
| Daniel, PT | 1 |
| Zhang, Z | 1 |
| Hou, SQ | 1 |
| He, J | 1 |
| Gu, T | 1 |
| Yin, Y | 1 |
| Shen, WH | 1 |
| Rakotomalala, L | 1 |
| Studach, L | 1 |
| Wang, WH | 1 |
| Gregori, G | 1 |
| Hullinger, RL | 1 |
| Andrisani, O | 1 |
| Ma, D | 1 |
| Yu, H | 1 |
| Lin, D | 2 |
| Sun, Y | 1 |
| Liu, L | 1 |
| Liu, Y | 1 |
| Dai, B | 1 |
| Chen, W | 2 |
| Cao, J | 1 |
| Medendorp, K | 1 |
| van Groningen, JJ | 1 |
| Vreede, L | 1 |
| Hetterschijt, L | 1 |
| Brugmans, L | 1 |
| van den Hurk, WH | 1 |
| van Kessel, AG | 1 |
| Borradaile, NM | 1 |
| Pickering, JG | 1 |
| Tovar, C | 1 |
| Higgins, B | 1 |
| Deo, D | 1 |
| Kolinsky, K | 1 |
| Liu, JJ | 1 |
| Heimbrook, DC | 1 |
| Vassilev, LT | 1 |
| Tsuchiya, M | 1 |
| Katagiri, N | 1 |
| Kuroda, T | 1 |
| Kishimoto, H | 1 |
| Nishimura, K | 1 |
| Kumazawa, T | 1 |
| Iwasaki, N | 1 |
| Kimura, K | 1 |
| Yanagisawa, J | 1 |
| Li, P | 1 |
| Zhou, L | 1 |
| Dai, Z | 1 |
| Jin, X | 1 |
| Liu, X | 2 |
| Matsumoto, Y | 1 |
| Furusawa, Y | 1 |
| Li, Q | 2 |
| Salmela, AL | 1 |
| Pouwels, J | 1 |
| Kukkonen-Macchi, A | 1 |
| Waris, S | 1 |
| Toivonen, P | 1 |
| Jaakkola, K | 1 |
| Mäki-Jouppila, J | 1 |
| Kallio, L | 1 |
| Kallio, MJ | 1 |
| Yu, HY | 1 |
| Ma, DC | 1 |
| Sun, YH | 1 |
| Tao, SY | 1 |
| Hao, J | 1 |
| Yuan, BB | 1 |
| Xu, YF | 1 |
| Yu, J | 1 |
| Liu, GY | 1 |
| Wang, DH | 1 |
| Hauf, S | 1 |
| Cole, RW | 1 |
| LaTerra, S | 1 |
| Zimmer, C | 1 |
| Schnapp, G | 1 |
| Walter, R | 1 |
| Heckel, A | 1 |
| van Meel, J | 1 |
| Rieder, CL | 1 |
| Peters, JM | 1 |
| Dridi, W | 1 |
| Fetni, R | 1 |
| Lavoie, J | 1 |
| Poupon, MF | 1 |
| Drouin, R | 1 |
| Baek, KH | 4 |
| Shin, HJ | 3 |
| Yoo, JK | 1 |
| Cho, JH | 1 |
| Choi, YH | 1 |
| Sung, YC | 2 |
| McKeon, F | 4 |
| Lee, CW | 4 |
| Smirnova, IS | 1 |
| Iakovleva, TK | 1 |
| Aksenov, ND | 2 |
| Yih, LH | 1 |
| Lee, TC | 1 |
| Jeon, AH | 1 |
| Park, MT | 1 |
| Lee, SJ | 1 |
| Kang, CM | 1 |
| Lee, HS | 1 |
| Yoo, SH | 1 |
| Chung, DH | 1 |
| Patel, D | 1 |
| Incassati, A | 1 |
| Wang, N | 1 |
| McCance, DJ | 1 |
| Neliudova, AM | 1 |
| Brichkina, AI | 1 |
| Rukhlova, MP | 1 |
| Pospelova, TV | 1 |
| Kim, KT | 1 |
| Ongusaha, PP | 1 |
| Hong, YK | 1 |
| Kurdistani, SK | 1 |
| Nakamura, M | 2 |
| Lu, KP | 1 |
| Lee, SW | 1 |
| Jeong, SJ | 2 |
| Park, JW | 1 |
| Kim, CM | 2 |
| Roh, M | 1 |
| Song, C | 1 |
| Kim, J | 1 |
| Abdulkadir, SA | 1 |
| Nishiyama, A | 1 |
| Dey, A | 1 |
| Miyazaki, J | 1 |
| Ozato, K | 1 |
| Castedo, M | 1 |
| Coquelle, A | 1 |
| Vivet, S | 1 |
| Vitale, I | 1 |
| Kauffmann, A | 1 |
| Dessen, P | 1 |
| Pequignot, MO | 1 |
| Casares, N | 1 |
| Valent, A | 1 |
| Mouhamad, S | 1 |
| Schmitt, E | 1 |
| Modjtahedi, N | 1 |
| Vainchenker, W | 2 |
| Zitvogel, L | 1 |
| Lazar, V | 1 |
| Garrido, C | 1 |
| Kroemer, G | 1 |
| Stavropoulou, V | 1 |
| Vasquez, V | 1 |
| Cereser, B | 1 |
| Freda, E | 1 |
| Masucci, MG | 1 |
| Hau, PM | 2 |
| Siu, WY | 1 |
| Wong, N | 1 |
| Lai, PB | 1 |
| Poon, RY | 2 |
| Inoue, T | 1 |
| Hiratsuka, M | 1 |
| Osaki, M | 1 |
| Yamada, H | 1 |
| Kishimoto, I | 1 |
| Yamaguchi, S | 1 |
| Nakano, S | 1 |
| Katoh, M | 1 |
| Ito, H | 1 |
| Oshimura, M | 1 |
| Grove, LE | 1 |
| Ghosh, RN | 1 |
| Aylon, Y | 1 |
| Michael, D | 1 |
| Shmueli, A | 1 |
| Yabuta, N | 1 |
| Nojima, H | 1 |
| Oren, M | 1 |
| Leao, M | 1 |
| Anderton, E | 1 |
| Wade, M | 1 |
| Meekings, K | 1 |
| Allday, MJ | 1 |
| Dikovskaya, D | 1 |
| Schiffmann, D | 1 |
| Newton, IP | 1 |
| Oakley, A | 1 |
| Kroboth, K | 1 |
| Sansom, O | 1 |
| Jamieson, TJ | 1 |
| Meniel, V | 1 |
| Clarke, A | 1 |
| Näthke, IS | 1 |
| Qi, W | 1 |
| Martinez, JD | 1 |
| Ha, GH | 1 |
| Kim, HS | 1 |
| Decordier, I | 2 |
| Cundari, E | 3 |
| Kirsch-Volders, M | 4 |
| Chan, YW | 1 |
| On, KF | 1 |
| Chan, WM | 1 |
| Wong, W | 1 |
| Siu, HO | 1 |
| van der Loo, B | 1 |
| Hong, Y | 1 |
| Hancock, V | 1 |
| Martin, JF | 1 |
| Erusalimsky, JD | 1 |
| Everett, CA | 1 |
| Searle, JB | 1 |
| Hall, LL | 1 |
| Th'ng, JP | 1 |
| Guo, XW | 1 |
| Teplitz, RL | 1 |
| Bradbury, EM | 1 |
| Andreassen, PR | 1 |
| Martineau, SN | 1 |
| Margolis, RL | 1 |
| Kikuchi, J | 1 |
| Furukawa, Y | 1 |
| Iwase, S | 1 |
| Terui, Y | 1 |
| Kitagawa, S | 1 |
| Kitagawa, M | 1 |
| Komatsu, N | 1 |
| Miura, Y | 1 |
| Elhajouji, A | 2 |
| Cunha, M | 2 |
| Hong, FD | 1 |
| Chen, J | 1 |
| Donovan, S | 1 |
| Schneider, N | 1 |
| Nisen, PD | 1 |
| Casenghi, M | 1 |
| Mangiacasale, R | 1 |
| Tuynder, M | 1 |
| Caillet-Fauquet, P | 1 |
| Lavia, P | 1 |
| Mousset, S | 1 |
| Verdoodt, B | 1 |
| Geleyns, K | 1 |
| Cimini, D | 1 |
| Tanzarella, C | 1 |
| Degrassi, F | 1 |
| Khan, SH | 1 |
| Moritsugu, J | 1 |
| Wahl, GM | 1 |
| Motwani, M | 1 |
| Li, X | 1 |
| Schwartz, GK | 1 |
| Gandarillas, A | 1 |
| Davies, D | 1 |
| Blanchard, JM | 1 |
| Cavalloni, G | 1 |
| Danè, A | 1 |
| Piacibello, W | 1 |
| Bruno, S | 1 |
| Lamas, E | 1 |
| Bréchot, C | 1 |
| Aglietta, M | 1 |
| Roy, L | 1 |
| Coullin, P | 1 |
| Vitrat, N | 1 |
| Hellio, R | 1 |
| Debili, N | 1 |
| Weinstein, J | 1 |
| Bernheim, A | 1 |
| Tsuiki, H | 2 |
| Nitta, M | 2 |
| Tada, M | 1 |
| Inagaki, M | 1 |
| Ushio, Y | 2 |
| Saya, H | 2 |
| Damiens, E | 1 |
| Baratte, B | 1 |
| Marie, D | 1 |
| Eisenbrand, G | 1 |
| Meijer, L | 1 |
| Arima, Y | 1 |
| Harada, K | 1 |
| Nishizaki, T | 1 |
| Sasaki, K | 1 |
| Mimori, T | 1 |
| Mayer, VW | 1 |
| Goin, CJ | 1 |
| Arras, CA | 1 |
| Taylor-Mayer, RE | 1 |
1 review available for nocodazole and Polyploid
| Article | Year |
|---|---|
Survival of aneuploid, micronucleated and/or polyploid cells: crosstalk between ploidy control and apoptosis.
Topics: Aneuploidy; Animals; Apoptosis; Cell Survival; Humans; Micronuclei, Chromosome-Defective; Models, Bi | 2008 |
54 other studies available for nocodazole and Polyploid
| Article | Year |
|---|---|
Apoptosis resistance, mitotic catastrophe, and loss of ploidy control in Burkitt lymphoma.
Topics: Animals; Apoptosis; Burkitt Lymphoma; Caspase Inhibitors; Caspases; Cell Line; DNA Fragmentation; Fl | 2015 |
PTEN regulates PLK1 and controls chromosomal stability during cell division.
Topics: Animals; Cell Cycle Proteins; Cell Division; Chromosomal Instability; Enzyme Activation; Enzyme Stab | 2016 |
Hepatitis B virus X protein increases the Cdt1-to-geminin ratio inducing DNA re-replication and polyploidy.
Topics: Animals; Cell Cycle Proteins; Cell Line; DNA; DNA-Binding Proteins; Flow Cytometry; Geminin; Hepatoc | 2008 |
S6K1 is involved in polyploidization through its phosphorylation at Thr421/Ser424.
Topics: Adaptor Proteins, Signal Transducing; Androstadienes; Animals; Antineoplastic Agents; Carcinogens; C | 2009 |
The renal cell carcinoma-associated oncogenic fusion protein PRCCTFE3 provokes p21 WAF1/CIP1-mediated cell cycle delay.
Topics: Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Carcinoma, Renal Cell; Cell Cycle; Cell | 2009 |
Polyploidy impairs human aortic endothelial cell function and is prevented by nicotinamide phosphoribosyltransferase.
Topics: Aging; Aorta; Atherosclerosis; Cell Cycle; Cell Division; Cytokines; Endothelium, Vascular; Extracel | 2010 |
Small-molecule inducer of cancer cell polyploidy promotes apoptosis or senescence: Implications for therapy.
Topics: Antineoplastic Agents; Apoptosis; Benzodiazepines; Cell Line, Tumor; Cellular Senescence; Humans; Mi | 2010 |
Critical role of the nucleolus in activation of the p53-dependent postmitotic checkpoint.
Topics: Acetylation; Active Transport, Cell Nucleus; Cell Line, Tumor; Cell Nucleolus; DNA-Binding Proteins; | 2011 |
High LET radiation enhances nocodazole Induced cell death in HeLa cells through mitotic catastrophe and apoptosis.
Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Death; Cell Line, Tumor; DNA Damage; HeLa Cells; | 2011 |
The flavonoid eupatorin inactivates the mitotic checkpoint leading to polyploidy and apoptosis.
Topics: Antimitotic Agents; Apoptosis; Aurora Kinase B; Aurora Kinases; Cell Culture Techniques; Cell Prolif | 2012 |
[mTOR/p70s6k signaling pathway is involved in megakaryocyte polyploidization].
Topics: Cell Cycle; Humans; Megakaryocytes; Nocodazole; Phosphorylation; Polyploidy; Ribosomal Protein S6 Ki | 2012 |
[Sensitivity to chemotherapeutic drugs of polyploid tumor cells induced by a spindle poison nocodazole].
Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Breast Neoplasms; Cell Line, Tu | 2012 |
The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint.
Topics: Anaphase; Aneugens; Animals; Aurora Kinase B; Aurora Kinases; Cell Cycle Proteins; Chromosome Segreg | 2003 |
The dominant-negative effect of p53 mutants and p21 induction in tetraploid G1 arrest depends on the type of p53 mutation and the nature of the stimulus.
Topics: Cyclin-Dependent Kinase Inhibitor p21; Cyclins; G1 Phase; Genes, p53; Humans; Mutation; Nocodazole; | 2003 |
p53 deficiency and defective mitotic checkpoint in proliferating T lymphocytes increase chromosomal instability through aberrant exit from mitotic arrest.
Topics: Animals; Cell Cycle Proteins; Cells, Cultured; Chromosomes; DNA; Female; Humans; Jurkat Cells; Kinet | 2003 |
[Delayed biological consequences induced by gamma-radiation in human tumorigenic diploid line SK-UT-1B].
Topics: Antineoplastic Agents; Cell Cycle; Cell Line, Tumor; Chromosomes; Gamma Rays; Gene Rearrangement; Hu | 2003 |
Induction of C-anaphase and diplochromosome through dysregulation of spindle assembly checkpoint by sodium arsenite in human fibroblasts.
Topics: Anaphase; Anaphase-Promoting Complex-Cyclosome; Arsenites; Calcium-Binding Proteins; Cdc20 Proteins; | 2003 |
Dual roles of human BubR1, a mitotic checkpoint kinase, in the monitoring of chromosomal instability.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Apoptosis; Caspases; Cell Cycle Proteins; Chromosoma | 2003 |
Human papillomavirus type 16 E6 and E7 cause polyploidy in human keratinocytes and up-regulation of G2-M-phase proteins.
Topics: Cell Cycle Proteins; Cell Line; G2 Phase; Gene Expression Regulation; Humans; Keratinocytes; Mitosis | 2004 |
[Antiproliferative effect of bcl-2 gene does not concern the control of mitotic events].
Topics: Adenovirus E1A Proteins; Animals; Antineoplastic Agents; Apoptosis; Cell Division; Cell Line, Transf | 2004 |
Function of Drg1/Rit42 in p53-dependent mitotic spindle checkpoint.
Topics: Adenoviridae; Antineoplastic Agents; Blotting, Western; Cell Cycle; Cell Cycle Proteins; Cell Line, | 2004 |
Caspases-dependent cleavage of mitotic checkpoint proteins in response to microtubule inhibitor.
Topics: Apoptosis; Caspase Inhibitors; Caspases; Cell Cycle Proteins; Cloning, Molecular; Enzyme Inhibitors; | 2005 |
Chromosomal instability induced by Pim-1 is passage-dependent and associated with dysregulation of cyclin B1.
Topics: Animals; Cattle; CDC2 Protein Kinase; Cell Cycle; Cell Division; Cell Line, Tumor; Chromosomes, Huma | 2005 |
Brd4 is required for recovery from antimicrotubule drug-induced mitotic arrest: preservation of acetylated chromatin.
Topics: Acetylation; Animals; Apoptosis; CDC2 Protein Kinase; Cell Proliferation; Chromatin; Chromosome Segr | 2006 |
Apoptosis regulation in tetraploid cancer cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Cell Line, Tumor; Cisplatin; | 2006 |
TPPII promotes genetic instability by allowing the escape from apoptosis of cells with activated mitotic checkpoints.
Topics: Aminopeptidases; Apoptosis; Apoptosis Regulatory Proteins; Cell Cycle; Cell Line; Cell Line, Transfo | 2006 |
Polyploidization increases the sensitivity to DNA-damaging agents in mammalian cells.
Topics: Cells, Cultured; Centrosome; DNA; DNA Damage; Histones; Humans; Nocodazole; Phosphorylation; Polyplo | 2006 |
SIRT2, a tubulin deacetylase, acts to block the entry to chromosome condensation in response to mitotic stress.
Topics: Cell Line, Tumor; Chromosomal Instability; Chromosomes, Human; Glioma; Histone Deacetylase Inhibitor | 2007 |
Quantitative characterization of mitosis-blocked tetraploid cells using high content analysis.
Topics: Antineoplastic Agents; Cell Cycle Proteins; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; Cell | 2006 |
A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization.
Topics: Animals; Cell Cycle; Cell Cycle Proteins; Cell Line; Cell Line, Tumor; Cells, Cultured; Centrosome; | 2006 |
Epstein-barr virus-induced resistance to drugs that activate the mitotic spindle assembly checkpoint in Burkitt's lymphoma cells.
Topics: Antineoplastic Agents; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Burkitt Lymphoma; Cell | 2007 |
Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis.
Topics: Adenomatous Polyposis Coli Protein; Animals; Apoptosis; beta Catenin; Caspase 3; Cell Cycle Proteins | 2007 |
Overexpression of 14-3-3gamma causes polyploidization in H322 lung cancer cells.
Topics: 14-3-3 Proteins; Cell Cycle; DNA Replication; Humans; Lung Neoplasms; Mitotic Index; Nocodazole; Pol | 2007 |
p53 activation in response to mitotic spindle damage requires signaling via BubR1-mediated phosphorylation.
Topics: Antineoplastic Agents; Cell Cycle; Chromosomal Instability; Colonic Neoplasms; Fluorescent Antibody | 2007 |
The kinetics of p53 activation versus cyclin E accumulation underlies the relationship between the spindle-assembly checkpoint and the postmitotic checkpoint.
Topics: Calcium-Binding Proteins; CDC2 Protein Kinase; Cell Cycle Proteins; Chromosomal Instability; Chromos | 2008 |
Antimicrotubule agents induce polyploidization of human leukaemic cell lines with megakaryocytic features.
Topics: Cell Division; Colchicine; Demecolcine; DNA; Flow Cytometry; Humans; Leukemia; Lumicolchicines; Mega | 1993 |
Pattern and frequency of nocodazole induced meiotic nondisjunction in oocytes of mice carrying the 'tobacco mouse' metacentric Rb(16.17)7Bnr.
Topics: Anaphase; Animals; Antineoplastic Agents; Cells, Cultured; Centromere; Chromosomes; Dose-Response Re | 1995 |
A brief staurosporine treatment of mitotic cells triggers premature exit from mitosis and polyploid cell formation.
Topics: Alkaloids; Animals; Antineoplastic Agents; CDC2 Protein Kinase; DNA, Neoplasm; Enzyme Inhibitors; G1 | 1996 |
Chemical induction of mitotic checkpoint override in mammalian cells results in aneuploidy following a transient tetraploid state.
Topics: 2-Aminopurine; Aneuploidy; Animals; Cell Cycle; CHO Cells; Cricetinae; Cytochalasin B; Diketopiperaz | 1996 |
Polyploidization and functional maturation are two distinct processes during megakaryocytic differentiation: involvement of cyclin-dependent kinase inhibitor p21 in polyploidization.
Topics: Carcinogens; Cell Differentiation; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; HL-60 Cells; Huma | 1997 |
Spindle poisons can induce polyploidy by mitotic slippage and micronucleate mononucleates in the cytokinesis-block assay.
Topics: Benzimidazoles; Carbamates; Colchicine; Female; Humans; Leukocyte Count; Leukocytes, Mononuclear; Ma | 1998 |
Taxol, vincristine or nocodazole induces lethality in G1-checkpoint-defective human astrocytoma U373MG cells by triggering hyperploid progression.
Topics: Astrocytoma; Cell Cycle; Cell Cycle Proteins; Cell Death; Cell Division; Cyclin-Dependent Kinase Inh | 1999 |
p53-independent apoptosis and p53-dependent block of DNA rereplication following mitotic spindle inhibition in human cells.
Topics: Apoptosis; Cell Cycle; Cell Cycle Proteins; Centromere; Chromosome Segregation; Cyclin B; Cyclin B1; | 1999 |
Induction of polyploidy and apoptosis after exposure to high concentrations of the spindle poison nocodazole.
Topics: Adult; Antineoplastic Agents; Apoptosis; Cell Survival; Cells, Cultured; Demecolcine; Dose-Response | 1999 |
Differences in malsegregation rates obtained by scoring ana-telophases or binucleate cells.
Topics: Anaphase; Aneuploidy; Cell Nucleus; Cells, Cultured; Chromosomes, Human, Pair 11; Chromosomes, Human | 1999 |
Differential requirement for p19ARF in the p53-dependent arrest induced by DNA damage, microtubule disruption, and ribonucleotide depletion.
Topics: Animals; Blotting, Western; Cells, Cultured; DNA Damage; Mice; Mice, Knockout; Microtubules; Nocodaz | 2000 |
Flavopiridol, a cyclin-dependent kinase inhibitor, prevents spindle inhibitor-induced endoreduplication in human cancer cells.
Topics: Antineoplastic Agents; CDC2 Protein Kinase; CDC2-CDC28 Kinases; Cyclin B; Cyclin B1; Cyclin E; Cycli | 2000 |
Normal and c-Myc-promoted human keratinocyte differentiation both occur via a novel cell cycle involving cellular growth and endoreplication.
Topics: Cell Cycle; Cell Differentiation; Cell Division; Cell Size; Cells, Cultured; DNA; DNA Replication; H | 2000 |
The involvement of human-nuc gene in polyploidization of K562 cell line.
Topics: Apoptosis; Cell Differentiation; DNA; Flow Cytometry; Gene Expression; Humans; K562 Cells; Megakaryo | 2000 |
Asymmetrical segregation of chromosomes with a normal metaphase/anaphase checkpoint in polyploid megakaryocytes.
Topics: Anaphase; Cdc20 Proteins; Cell Cycle Proteins; Cells, Cultured; Chromosomes, Human; Cyclin B; Cyclin | 2001 |
Mechanism of hyperploid cell formation induced by microtubule inhibiting drug in glioma cell lines.
Topics: CDC2 Protein Kinase; Glioma; Humans; Microtubules; Mitosis; Mitotic Index; Nocodazole; Polyploidy; S | 2001 |
Anti-mitotic properties of indirubin-3'-monoxime, a CDK/GSK-3 inhibitor: induction of endoreplication following prophase arrest.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Calcium-Calmodulin-Dependent Protein Kinases; CD | 2001 |
Hyperploidy induced by drugs that inhibit formation of microtubule promotes chromosome instability.
Topics: Antineoplastic Agents; Chromosomes; Glioma; Humans; Microtubules; Nocodazole; Polyploidy; Tumor Cell | 2002 |
Comparison of chemically induced chromosome loss in a diploid, triploid, and tetraploid strain of Saccharomyces cerevisiae.
Topics: Acetates; Chromosomes, Fungal; Diploidy; Ethyl Methanesulfonate; Hydroxyurea; Mutagens; Nocodazole; | 1992 |