nocodazole has been researched along with Neoplasms in 44 studies
Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Currently, cancer and its progression to metastasis result in a large number of deaths." | 2.61 | Multi-target compounds acting in cancer progression: Focus on thiosemicarbazone, thiazole and thiazolidinone analogues. ( de Lima Ferreira, LP; de Melo Rêgo, MJB; de Moraes Gomes, PAT; de Siqueira, LRP; Leite, ACL, 2019) |
| "Anticancer agents are critical for the cancer treatment, but side effects and the drug resistance associated with the currently used anticancer agents create an urgent need to explore novel drugs with low side effects and high efficacy." | 2.61 | 1,2,3-Triazole-containing hybrids as potential anticancer agents: Current developments, action mechanisms and structure-activity relationships. ( Liu, Y; Xu, Z; Zhao, SJ, 2019) |
| "Hybrid anticancer drugs are of great therapeutic interests since they can potentially overcome most of the pharmacokinetic drawbacks encountered with conventional anticancer drugs." | 2.55 | Recent advances (2015-2016) in anticancer hybrids. ( Kerru, N; Koorbanally, N; Kumar, V; Raj, R; Singh, P, 2017) |
| "MTAs demonstrate anticancer activity either as microtubule-stabilizing agents (paclitaxel) or microtubule-destabilizing agents (nocodazole)." | 1.91 | Not all benzimidazole derivatives are microtubule destabilizing agents. ( Kim, T; Nimse, SB; Park, SJ; Song, IH; Song, KS; Yeom, GS, 2023) |
| "Chemotherapy and targeted agent anti-cancer efficacy is largely dependent on the proliferative state of tumours, as exemplified by agents that target DNA synthesis/replication or mitosis." | 1.62 | Quantifying cell cycle-dependent drug sensitivities in cancer using a high throughput synchronisation and screening approach. ( Carnevalli, LS; Dunlop, CR; Fernández, SBQ; Jodrell, DI; Johnson, TI; Kottmann, D; Lau, A; Minteer, CJ; Richards, FM; Wallez, Y, 2021) |
| "We further show that MPS1-inhibited tetraploid cells promote mitotic catastrophe executed by the intrinsic pathway of apoptosis, as indicated by the loss of mitochondrial potential, the release of the pro-apoptotic cytochrome c from mitochondria, and the activation of caspases." | 1.43 | Whole-genome duplication increases tumor cell sensitivity to MPS1 inhibition. ( Abrieu, A; Castedo, M; Chibon, F; Jemaà, M; Kroemer, G; Lissa, D; Lledo, G; Manic, G; Morin, N; Reynes, C; Sistigu, A; Vitale, I, 2016) |
| "Noscapine has since been discovered to arrest cells at mitosis, albeit with moderately weak activity." | 1.42 | Progress Toward the Development of Noscapine and Derivatives as Anticancer Agents. ( Capuano, B; DeBono, A; Scammells, PJ, 2015) |
| "Unexpectedly, tetraploidization is also under the control of a cell-extrinsic mechanism determined by the immune system." | 1.39 | Immunological control of cell cycle aberrations for the avoidance of oncogenesis: the case of tetraploidy. ( Castedo, M; Galluzzi, L; Kroemer, G; Senovilla, L, 2013) |
| "Treatment of nocodazole-synchronized cells with JNJ-7706621 was able to override mitotic arrest by preventing spindle checkpoint signaling, resulting in failure of chromosome alignment and segregation." | 1.38 | Growth suppression and mitotic defect induced by JNJ-7706621, an inhibitor of cyclin-dependent kinases and aurora kinases. ( Hara, A; Kawai, G; Kimura, M; Matsuhashi, A; Nagano, A; Ohno, T; Okano, Y; Saio, M; Saitou, M; Shimizu, K; Takigami, I; Yamada, K, 2012) |
| "However, polyploidy may also render cancer cells more vulnerable to chemotherapy." | 1.36 | Small-molecule inducer of cancer cell polyploidy promotes apoptosis or senescence: Implications for therapy. ( Deo, D; Heimbrook, DC; Higgins, B; Kolinsky, K; Liu, JJ; Tovar, C; Vassilev, LT, 2010) |
| "Quercetin is a flavonoid with anticancer properties." | 1.36 | The flavonoid quercetin transiently inhibits the activity of taxol and nocodazole through interference with the cell cycle. ( Fadlalla, K; Samuel, T; Turner, T; Yehualaeshet, TE, 2010) |
| "Many cancer-treating compounds used in chemotherapies, the so-called antimitotics, target the mitotic spindle." | 1.36 | Adapt or die: how eukaryotic cells respond to prolonged activation of the spindle assembly checkpoint. ( Galati, E; Piatti, S; Rossio, V, 2010) |
| "When cancer cells spread away from the primary tumor, they often follow the trajectories of lymphatic vessels, nerves, white matter tracts, or other heterogeneous structures in tissues." | 1.35 | Spontaneous migration of cancer cells under conditions of mechanical confinement. ( Irimia, D; Toner, M, 2009) |
| "Upon nocodazole treatment, GNE redistributes to the cytoplasm suggesting that GNE may act as a nucleocytoplasmic shuttling protein." | 1.33 | Localization of UDP-GlcNAc 2-epimerase/ManAc kinase (GNE) in the Golgi complex and the nucleus of mammalian cells. ( Amsili, S; Argov, Z; Hinderlich, S; Horstkorte, R; Krause, S; Lochmüller, H; Mitrani-Rosenbaum, S; Wiendl, H, 2005) |
| "Tetraploidy can result in cancer-associated aneuploidy." | 1.33 | Apoptosis regulation in tetraploid cancer cells. ( Casares, N; Castedo, M; Coquelle, A; Dessen, P; Garrido, C; Kauffmann, A; Kroemer, G; Lazar, V; Modjtahedi, N; Mouhamad, S; Pequignot, MO; Schmitt, E; Vainchenker, W; Valent, A; Vitale, I; Vivet, S; Zitvogel, L, 2006) |
| "In most colorectal cancers, and probably in many other cancer types, a chromosomal instability (CIN) leading to an abnormal chromosome number (aneuploidy) is observed." | 1.30 | Mutations of mitotic checkpoint genes in human cancers. ( Cahill, DP; Kinzler, KW; Lengauer, C; Markowitz, SD; Riggins, GJ; Vogelstein, B; Willson, JK; Yu, J, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (4.55) | 18.2507 |
| 2000's | 12 (27.27) | 29.6817 |
| 2010's | 27 (61.36) | 24.3611 |
| 2020's | 3 (6.82) | 2.80 |
| Authors | Studies |
|---|---|
| Diamandis, P | 1 |
| Wildenhain, J | 1 |
| Clarke, ID | 1 |
| Sacher, AG | 1 |
| Graham, J | 1 |
| Bellows, DS | 1 |
| Ling, EK | 1 |
| Ward, RJ | 1 |
| Jamieson, LG | 1 |
| Tyers, M | 1 |
| Dirks, PB | 1 |
| Kamal, A | 1 |
| Reddy, MK | 1 |
| Shaik, TB | 1 |
| Srikanth, YV | 1 |
| Reddy, VS | 1 |
| Kumar, GB | 1 |
| Kalivendi, SV | 1 |
| Reddy, MV | 1 |
| Mallireddigari, MR | 1 |
| Pallela, VR | 1 |
| Cosenza, SC | 1 |
| Billa, VK | 1 |
| Akula, B | 1 |
| Subbaiah, DR | 1 |
| Bharathi, EV | 1 |
| Padgaonkar, A | 1 |
| Lv, H | 1 |
| Gallo, JM | 1 |
| Reddy, EP | 1 |
| DeBono, A | 1 |
| Capuano, B | 1 |
| Scammells, PJ | 1 |
| Lin, R | 1 |
| Elf, S | 1 |
| Shan, C | 1 |
| Kang, HB | 1 |
| Ji, Q | 1 |
| Zhou, L | 1 |
| Hitosugi, T | 1 |
| Zhang, L | 1 |
| Zhang, S | 1 |
| Seo, JH | 1 |
| Xie, J | 1 |
| Tucker, M | 1 |
| Gu, TL | 1 |
| Sudderth, J | 1 |
| Jiang, L | 1 |
| Mitsche, M | 1 |
| DeBerardinis, RJ | 1 |
| Wu, S | 1 |
| Li, Y | 1 |
| Mao, H | 1 |
| Chen, PR | 1 |
| Wang, D | 1 |
| Chen, GZ | 1 |
| Hurwitz, SJ | 1 |
| Lonial, S | 1 |
| Arellano, ML | 1 |
| Khoury, HJ | 1 |
| Khuri, FR | 1 |
| Lee, BH | 1 |
| Lei, Q | 1 |
| Brat, DJ | 1 |
| Ye, K | 1 |
| Boggon, TJ | 1 |
| He, C | 1 |
| Kang, S | 1 |
| Fan, J | 1 |
| Chen, J | 1 |
| Srivastava, V | 1 |
| Lee, H | 2 |
| Banu, S | 1 |
| Bollu, R | 1 |
| Bantu, R | 1 |
| Nagarapu, L | 1 |
| Polepalli, S | 1 |
| Jain, N | 1 |
| Vangala, R | 1 |
| Manga, V | 1 |
| Kerru, N | 1 |
| Singh, P | 1 |
| Koorbanally, N | 1 |
| Raj, R | 1 |
| Kumar, V | 1 |
| de Siqueira, LRP | 1 |
| de Moraes Gomes, PAT | 1 |
| de Lima Ferreira, LP | 1 |
| de Melo Rêgo, MJB | 1 |
| Leite, ACL | 1 |
| Lin, MS | 1 |
| Hong, TM | 1 |
| Chou, TH | 1 |
| Yang, SC | 1 |
| Chung, WC | 1 |
| Weng, CW | 1 |
| Tsai, ML | 1 |
| Cheng, TR | 1 |
| Chen, JJW | 1 |
| Lee, TC | 1 |
| Wong, CH | 1 |
| Chein, RJ | 1 |
| Yang, PC | 1 |
| Xu, Z | 1 |
| Zhao, SJ | 1 |
| Liu, Y | 1 |
| Song, IH | 1 |
| Park, SJ | 1 |
| Yeom, GS | 1 |
| Song, KS | 1 |
| Kim, T | 1 |
| Nimse, SB | 1 |
| Marquis, C | 1 |
| Fonseca, CL | 1 |
| Queen, KA | 1 |
| Wood, L | 1 |
| Vandal, SE | 1 |
| Malaby, HLH | 1 |
| Clayton, JE | 1 |
| Stumpff, J | 1 |
| Johnson, TI | 1 |
| Minteer, CJ | 1 |
| Kottmann, D | 1 |
| Dunlop, CR | 1 |
| Fernández, SBQ | 1 |
| Carnevalli, LS | 1 |
| Wallez, Y | 1 |
| Lau, A | 1 |
| Richards, FM | 1 |
| Jodrell, DI | 1 |
| Marks, DH | 1 |
| Thomas, R | 1 |
| Chin, Y | 1 |
| Shah, R | 1 |
| Khoo, C | 1 |
| Benezra, R | 1 |
| DeHart, DN | 1 |
| Lemasters, JJ | 2 |
| Maldonado, EN | 2 |
| Werwein, E | 1 |
| Cibis, H | 1 |
| Hess, D | 1 |
| Klempnauer, KH | 1 |
| Senovilla, L | 1 |
| Galluzzi, L | 1 |
| Castedo, M | 3 |
| Kroemer, G | 3 |
| Kuang, Y | 1 |
| Long, MJ | 1 |
| Zhou, J | 1 |
| Shi, J | 1 |
| Gao, Y | 1 |
| Xu, C | 1 |
| Hedstrom, L | 1 |
| Xu, B | 1 |
| Shuda, M | 1 |
| Velásquez, C | 1 |
| Cheng, E | 1 |
| Cordek, DG | 1 |
| Kwun, HJ | 1 |
| Chang, Y | 1 |
| Moore, PS | 1 |
| Moore, P | 1 |
| Viegas, J | 1 |
| Galán-Cobo, A | 1 |
| Ramírez-Lorca, R | 1 |
| Serna, A | 1 |
| Echevarría, M | 1 |
| Jemaà, M | 1 |
| Manic, G | 1 |
| Lledo, G | 1 |
| Lissa, D | 1 |
| Reynes, C | 1 |
| Morin, N | 1 |
| Chibon, F | 1 |
| Sistigu, A | 1 |
| Vitale, I | 2 |
| Abrieu, A | 1 |
| Stuart, HC | 1 |
| Jia, Z | 1 |
| Messenberg, A | 1 |
| Joshi, B | 1 |
| Underhill, TM | 1 |
| Moukhles, H | 1 |
| Nabi, IR | 1 |
| Li, M | 1 |
| Fang, X | 1 |
| Wei, Z | 1 |
| York, JP | 1 |
| Zhang, P | 1 |
| Tsui, M | 1 |
| Xie, T | 1 |
| Orth, JD | 1 |
| Carpenter, AE | 1 |
| Rudnicki, S | 1 |
| Kim, S | 1 |
| Shamu, CE | 1 |
| Mitchison, TJ | 1 |
| Irimia, D | 1 |
| Toner, M | 1 |
| Tovar, C | 1 |
| Higgins, B | 1 |
| Deo, D | 1 |
| Kolinsky, K | 1 |
| Liu, JJ | 1 |
| Heimbrook, DC | 1 |
| Vassilev, LT | 1 |
| Samuel, T | 1 |
| Fadlalla, K | 1 |
| Turner, T | 1 |
| Yehualaeshet, TE | 1 |
| Jeon, J | 1 |
| Ryu, YS | 1 |
| Jeong, JE | 1 |
| Shin, S | 1 |
| Zhang, T | 1 |
| Kang, SW | 1 |
| Hong, JH | 1 |
| Hur, GM | 1 |
| Rossio, V | 1 |
| Galati, E | 1 |
| Piatti, S | 1 |
| Patnaik, J | 1 |
| Mullins, MR | 1 |
| Park, H | 1 |
| Hong, S | 2 |
| Matsuhashi, A | 1 |
| Ohno, T | 1 |
| Kimura, M | 1 |
| Hara, A | 1 |
| Saio, M | 1 |
| Nagano, A | 1 |
| Kawai, G | 1 |
| Saitou, M | 1 |
| Takigami, I | 1 |
| Yamada, K | 1 |
| Okano, Y | 1 |
| Shimizu, K | 1 |
| Lee, CG | 1 |
| Park, GY | 1 |
| Han, YK | 1 |
| Lee, JH | 1 |
| Chun, SH | 1 |
| Park, HY | 1 |
| Lim, KH | 1 |
| Kim, EG | 1 |
| Choi, YJ | 1 |
| Yang, K | 1 |
| Lee, CW | 1 |
| Xu, K | 1 |
| Ludueña, RF | 1 |
| Krause, S | 1 |
| Hinderlich, S | 1 |
| Amsili, S | 1 |
| Horstkorte, R | 1 |
| Wiendl, H | 1 |
| Argov, Z | 1 |
| Mitrani-Rosenbaum, S | 1 |
| Lochmüller, H | 1 |
| Dowling, M | 1 |
| Voong, KR | 2 |
| Kim, M | 2 |
| Keutmann, MK | 1 |
| Harris, E | 1 |
| Kao, GD | 2 |
| Seeber, S | 1 |
| Issinger, OG | 1 |
| Holm, T | 1 |
| Kristensen, LP | 1 |
| Guerra, B | 1 |
| Coquelle, A | 1 |
| Vivet, S | 1 |
| Kauffmann, A | 1 |
| Dessen, P | 1 |
| Pequignot, MO | 1 |
| Casares, N | 1 |
| Valent, A | 1 |
| Mouhamad, S | 1 |
| Schmitt, E | 1 |
| Modjtahedi, N | 1 |
| Vainchenker, W | 1 |
| Zitvogel, L | 1 |
| Lazar, V | 1 |
| Garrido, C | 1 |
| Liao, J | 1 |
| Dowling, ML | 1 |
| Parker, SE | 1 |
| Wang, S | 1 |
| El-Deiry, WS | 1 |
| Cahill, DP | 1 |
| Lengauer, C | 1 |
| Yu, J | 1 |
| Riggins, GJ | 1 |
| Willson, JK | 1 |
| Markowitz, SD | 1 |
| Kinzler, KW | 1 |
| Vogelstein, B | 1 |
| Larsen, CJ | 1 |
5 reviews available for nocodazole and Neoplasms
| Article | Year |
|---|---|
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
Topics: AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Humans; Lipogenesis; Neoplasms; | 2015 |
Recent advances (2015-2016) in anticancer hybrids.
Topics: Animals; Antineoplastic Agents; Drug Design; Humans; Neoplasms; Structure-Activity Relationship | 2017 |
Multi-target compounds acting in cancer progression: Focus on thiosemicarbazone, thiazole and thiazolidinone analogues.
Topics: Animals; Antineoplastic Agents; Cell Cycle Proteins; Disease Progression; Drug Delivery Systems; Dru | 2019 |
1,2,3-Triazole-containing hybrids as potential anticancer agents: Current developments, action mechanisms and structure-activity relationships.
Topics: Antineoplastic Agents; Humans; Molecular Structure; Neoplasms; Structure-Activity Relationship; Tria | 2019 |
[The RASSF1 (Ras association domain family protein 1) gene. Category: tumor suppressor gene].
Topics: Animals; Apoptosis; Cell Cycle; Chromosomes, Human, Pair 3; DNA Methylation; Drug Resistance; Epigen | 2005 |
39 other studies available for nocodazole and Neoplasms
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutic | 2007 |
Synthesis of terphenyl benzimidazoles as tubulin polymerization inhibitors.
Topics: Benzimidazoles; Blotting, Western; Cell Cycle; Cell Proliferation; Drug Screening Assays, Antitumor; | 2012 |
Design, synthesis, and biological evaluation of (E)-N-aryl-2-arylethenesulfonamide analogues as potent and orally bioavailable microtubule-targeted anticancer agents.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Biological Availability; Blood-Brain Barrier; | 2013 |
Progress Toward the Development of Noscapine and Derivatives as Anticancer Agents.
Topics: Antineoplastic Agents; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Neoplasms; Noscap | 2015 |
Synthesis and bio-evaluation of novel quinolino-stilbene derivatives as potential anticancer agents.
Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Drug Screening Assays, Antitumor; Hu | 2015 |
Design, synthesis and docking studies of novel 1,2-dihydro-4-hydroxy-2-oxoquinoline-3-carboxamide derivatives as a potential anti-proliferative agents.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Humans; Molecular Docking Simulation; N | 2017 |
4(1H)-quinolone derivatives overcome acquired resistance to anti-microtubule agents by targeting the colchicine site of β-tubulin.
Topics: Antineoplastic Agents; Apoptosis; Binding Sites; Cell Proliferation; Colchicine; Drug Resistance, Ne | 2019 |
Not all benzimidazole derivatives are microtubule destabilizing agents.
Topics: Antineoplastic Agents; Benzimidazoles; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, | 2023 |
Chromosomally unstable tumor cells specifically require KIF18A for proliferation.
Topics: Cell Cycle Checkpoints; Cell Death; Cell Line, Tumor; Cell Proliferation; Centrosome; Chromosomal In | 2021 |
Quantifying cell cycle-dependent drug sensitivities in cancer using a high throughput synchronisation and screening approach.
Topics: Cell Culture Techniques; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Deoxycytid | 2021 |
Mad2 Overexpression Uncovers a Critical Role for TRIP13 in Mitotic Exit.
Topics: Animals; ATPases Associated with Diverse Cellular Activities; Base Sequence; Cell Cycle Checkpoints; | 2017 |
Erastin-Like Anti-Warburg Agents Prevent Mitochondrial Depolarization Induced by Free Tubulin and Decrease Lactate Formation in Cancer Cells.
Topics: Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Energy Metabol | 2018 |
Activation of the oncogenic transcription factor B-Myb via multisite phosphorylation and prolyl cis/trans isomerization.
Topics: Carcinogenesis; Cell Cycle; Cell Cycle Proteins; Cyclin-Dependent Kinases; Gene Expression Regulatio | 2019 |
Immunological control of cell cycle aberrations for the avoidance of oncogenesis: the case of tetraploidy.
Topics: Animals; Calreticulin; Cell Cycle; Cell Transformation, Neoplastic; Chromosome Aberrations; DNA; End | 2013 |
Prion-like nanofibrils of small molecules (PriSM) selectively inhibit cancer cells by impeding cytoskeleton dynamics.
Topics: Antineoplastic Agents; Apoptosis; Cytoskeleton; Endocytosis; Glioblastoma; HeLa Cells; Hep G2 Cells; | 2014 |
CDK1 substitutes for mTOR kinase to activate mitotic cap-dependent protein translation.
Topics: Adaptor Proteins, Signal Transducing; Antigens, Polyomavirus Transforming; CDC2 Protein Kinase; Cell | 2015 |
QnAs with Patrick Moore.
Topics: Cell Division; Herpesvirus 8, Human; Humans; Merkel cell polyomavirus; Mitosis; Neoplasms; Nocodazol | 2015 |
Overexpression of AQP3 Modifies the Cell Cycle and the Proliferation Rate of Mammalian Cells in Culture.
Topics: Animals; Aquaporin 3; Cell Cycle Checkpoints; Cell Division; G2 Phase; Gene Expression Regulation, N | 2015 |
Whole-genome duplication increases tumor cell sensitivity to MPS1 inhibition.
Topics: Apoptosis; Cell Cycle Proteins; Cell Line, Tumor; Cell Survival; Diploidy; HCT116 Cells; Humans; Imm | 2016 |
Localized Rho GTPase activation regulates RNA dynamics and compartmentalization in tumor cell protrusions.
Topics: Animals; Antineoplastic Agents; Cell Line; Dogs; Enzyme Activation; Fluorescence Resonance Energy Tr | 2008 |
Loss of spindle assembly checkpoint-mediated inhibition of Cdc20 promotes tumorigenesis in mice.
Topics: Amino Acid Sequence; Aneuploidy; Animals; Cdc20 Proteins; Cell Cycle Proteins; Cells, Cultured; Chro | 2009 |
An intermittent live cell imaging screen for siRNA enhancers and suppressors of a kinesin-5 inhibitor.
Topics: Genome, Human; Green Fluorescent Proteins; HeLa Cells; Humans; Image Processing, Computer-Assisted; | 2009 |
Spontaneous migration of cancer cells under conditions of mechanical confinement.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Humans; Microfluidics; Microscopy, Phase-Con | 2009 |
Small-molecule inducer of cancer cell polyploidy promotes apoptosis or senescence: Implications for therapy.
Topics: Antineoplastic Agents; Apoptosis; Benzodiazepines; Cell Line, Tumor; Cellular Senescence; Humans; Mi | 2010 |
The flavonoid quercetin transiently inhibits the activity of taxol and nocodazole through interference with the cell cycle.
Topics: Antineoplastic Agents, Phytogenic; Cell Adhesion; Cell Cycle; Cell Line, Tumor; Cell Proliferation; | 2010 |
Disruption of microtubules sensitizes the DNA damage-induced apoptosis through inhibiting nuclear factor κB (NF-κB) DNA-binding activity.
Topics: Animals; Antibiotics, Antineoplastic; Apoptosis; Caspases; Cell Line; Colchicine; DNA; DNA Damage; D | 2010 |
Adapt or die: how eukaryotic cells respond to prolonged activation of the spindle assembly checkpoint.
Topics: Adaptation, Physiological; Aneuploidy; Antimitotic Agents; Cell Cycle Proteins; Eukaryotic Cells; Fu | 2010 |
Free tubulin modulates mitochondrial membrane potential in cancer cells.
Topics: Adenosine Triphosphate; Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Membrane; Colchic | 2010 |
Nocodazole is a high-affinity ligand for the cancer-related kinases ABL, c-KIT, BRAF, and MEK.
Topics: Antineoplastic Agents; Humans; Mitogen-Activated Protein Kinase Kinases; Models, Molecular; Neoplasm | 2012 |
Growth suppression and mitotic defect induced by JNJ-7706621, an inhibitor of cyclin-dependent kinases and aurora kinases.
Topics: Animals; Antineoplastic Agents; Aurora Kinase A; Aurora Kinase B; Aurora Kinases; Bone Neoplasms; Ce | 2012 |
Roles of 14-3-3η in mitotic progression and its potential use as a therapeutic target for cancers.
Topics: 14-3-3 Proteins; Aneuploidy; Apoptosis; Caspase 9; Cell Division; Forkhead Box Protein O3; Forkhead | 2013 |
Characterization of nuclear betaII-tubulin in tumor cells: a possible novel target for taxol.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Nucleolus; Cell Nucleus; Colchicine; Dim | 2002 |
Localization of UDP-GlcNAc 2-epimerase/ManAc kinase (GNE) in the Golgi complex and the nucleus of mammalian cells.
Topics: Active Transport, Cell Nucleus; Animals; Antineoplastic Agents; Brefeldin A; Cell Compartmentation; | 2005 |
Mitotic spindle checkpoint inactivation by trichostatin a defines a mechanism for increasing cancer cell killing by microtubule-disrupting agents.
Topics: Antineoplastic Agents; Cell Cycle; Cell Cycle Proteins; Cell Survival; Centrosome; Drug Therapy, Com | 2005 |
Validation of protein kinase CK2 as oncological target.
Topics: Apoptosis; Casein Kinase II; Catalytic Domain; Cell Transformation, Neoplastic; Flow Cytometry; HCT1 | 2005 |
Apoptosis regulation in tetraploid cancer cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Cell Line, Tumor; Cisplatin; | 2006 |
TRAIL inactivates the mitotic checkpoint and potentiates death induced by microtubule-targeting agents in human cancer cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Caspase 3; Drug Evaluation, Preclinical; | 2008 |
Mutations of mitotic checkpoint genes in human cancers.
Topics: Amino Acid Sequence; Aneuploidy; Antineoplastic Agents; Cell Cycle; Cloning, Molecular; Colorectal N | 1998 |
[Have they discovered the origins of aneuploidy in tumors?].
Topics: Aneuploidy; Antineoplastic Agents; Humans; Microsatellite Repeats; Microtubules; Mitosis; Mitotic In | 1998 |