nocodazole has been researched along with Chromosomal Instability in 21 studies
Chromosomal Instability: An increased tendency to acquire CHROMOSOME ABERRATIONS when various processes involved in chromosome replication, repair, or segregation are dysfunctional.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Here, we report that EBNA2 can compromise mitotic spindle checkpoint (MSC) induced by the spindle inhibitor nocodazole and cause chromosomal instability (CIN) in HEp-2, U2-OS and BJAB cells." | 3.75 | Epstein-Barr virus nuclear antigen 2 disrupts mitotic checkpoint and causes chromosomal instability. ( Chen, JY; Chou, SF; Hsu, WB; Lai, CC; Lee, FY; Lin, CS; Pan, SH; Tai, CC; Tien, HF; Wang, WB, 2009) |
| "In contrast, tetraploid metaphases were found following pharmacological inhibition of Chk1 kinase, suggesting the involvement of the ATR/Chk1 pathway in the G2 arrest of binucleated cells." | 1.43 | Tetraploid cells produced by absence of substrate adhesion during cytokinesis are limited in their proliferation and enter senescence after DNA replication. ( Ascenzi, S; Cundari, E; De Santis Puzzonia, M; Degrassi, F; Gonzalez, L, 2016) |
| "Aneuploidy is a key process in tumorigenesis." | 1.33 | FAT10 plays a role in the regulation of chromosomal stability. ( Chong, SS; Jeang, KT; Kan, A; Kon, OL; Lee, CG; Leong, SH; Ooi, LL; Ren, J, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 12 (57.14) | 29.6817 |
| 2010's | 8 (38.10) | 24.3611 |
| 2020's | 1 (4.76) | 2.80 |
| Authors | Studies |
|---|---|
| Marquis, C | 1 |
| Fonseca, CL | 1 |
| Queen, KA | 1 |
| Wood, L | 1 |
| Vandal, SE | 1 |
| Malaby, HLH | 1 |
| Clayton, JE | 1 |
| Stumpff, J | 1 |
| Skowyra, A | 1 |
| Allan, LA | 1 |
| Saurin, AT | 1 |
| Clarke, PR | 1 |
| Santibáñez, M | 1 |
| Gallardo, D | 1 |
| Morales, F | 1 |
| López, A | 1 |
| Prada, D | 1 |
| Mendoza, J | 1 |
| Castro, C | 1 |
| de León, DC | 1 |
| Oñate, LF | 1 |
| Perez, D | 1 |
| Mohar, A | 1 |
| Herrera, LA | 1 |
| De Santis Puzzonia, M | 1 |
| Gonzalez, L | 1 |
| Ascenzi, S | 1 |
| Cundari, E | 1 |
| Degrassi, F | 1 |
| Zhang, Z | 1 |
| Hou, SQ | 1 |
| He, J | 1 |
| Gu, T | 1 |
| Yin, Y | 1 |
| Shen, WH | 1 |
| Rajasekaran, SA | 1 |
| Christiansen, JJ | 1 |
| Schmid, I | 1 |
| Oshima, E | 1 |
| Ryazantsev, S | 1 |
| Sakamoto, K | 1 |
| Weinstein, J | 1 |
| Rao, NP | 1 |
| Rajasekaran, AK | 1 |
| Pan, SH | 1 |
| Tai, CC | 1 |
| Lin, CS | 1 |
| Hsu, WB | 1 |
| Chou, SF | 1 |
| Lai, CC | 1 |
| Chen, JY | 1 |
| Tien, HF | 1 |
| Lee, FY | 1 |
| Wang, WB | 1 |
| DeMoe, JH | 1 |
| Santaguida, S | 1 |
| Daum, JR | 1 |
| Musacchio, A | 1 |
| Gorbsky, GJ | 1 |
| Li, M | 1 |
| Fang, X | 1 |
| Wei, Z | 1 |
| York, JP | 1 |
| Zhang, P | 1 |
| Hu, L | 1 |
| Liu, X | 2 |
| Chervona, Y | 1 |
| Yang, F | 1 |
| Tang, MS | 1 |
| Darzynkiewicz, Z | 1 |
| Dai, W | 1 |
| Kawashima, S | 1 |
| Nakabayashi, Y | 1 |
| Matsubara, K | 1 |
| Sano, N | 1 |
| Enomoto, T | 1 |
| Tanaka, K | 1 |
| Seki, M | 1 |
| Horikoshi, M | 1 |
| Zhang, Y | 1 |
| van Deursen, J | 1 |
| Galardy, PJ | 1 |
| Zheng, H | 1 |
| Qu, CK | 1 |
| Shin, HJ | 1 |
| Baek, KH | 2 |
| Jeon, AH | 1 |
| Park, MT | 1 |
| Lee, SJ | 1 |
| Kang, CM | 1 |
| Lee, HS | 1 |
| Yoo, SH | 1 |
| Chung, DH | 1 |
| Sung, YC | 1 |
| McKeon, F | 2 |
| Lee, CW | 2 |
| Ren, J | 1 |
| Kan, A | 1 |
| Leong, SH | 1 |
| Ooi, LL | 1 |
| Jeang, KT | 1 |
| Chong, SS | 1 |
| Kon, OL | 1 |
| Lee, CG | 1 |
| Stavropoulou, V | 1 |
| Vasquez, V | 1 |
| Cereser, B | 1 |
| Freda, E | 1 |
| Masucci, MG | 1 |
| Leng, M | 1 |
| Chan, DW | 1 |
| Luo, H | 1 |
| Zhu, C | 1 |
| Qin, J | 1 |
| Wang, Y | 1 |
| Inoue, T | 1 |
| Hiratsuka, M | 1 |
| Osaki, M | 1 |
| Yamada, H | 1 |
| Kishimoto, I | 1 |
| Yamaguchi, S | 1 |
| Nakano, S | 1 |
| Katoh, M | 1 |
| Ito, H | 1 |
| Oshimura, M | 1 |
| Montpetit, B | 1 |
| Hazbun, TR | 1 |
| Fields, S | 1 |
| Hieter, P | 1 |
| Ha, GH | 1 |
| Kim, HS | 1 |
| Jeong, SJ | 1 |
| Kim, CM | 1 |
| Chan, YW | 1 |
| On, KF | 1 |
| Chan, WM | 1 |
| Wong, W | 1 |
| Siu, HO | 1 |
| Hau, PM | 1 |
| Poon, RY | 1 |
21 other studies available for nocodazole and Chromosomal Instability
| Article | Year |
|---|---|
Chromosomally unstable tumor cells specifically require KIF18A for proliferation.
Topics: Cell Cycle Checkpoints; Cell Death; Cell Line, Tumor; Cell Proliferation; Centrosome; Chromosomal In | 2021 |
USP9X Limits Mitotic Checkpoint Complex Turnover to Strengthen the Spindle Assembly Checkpoint and Guard against Chromosomal Instability.
Topics: Anaphase-Promoting Complex-Cyclosome; Apc11 Subunit, Anaphase-Promoting Complex-Cyclosome; Cdc20 Pro | 2018 |
The MAD1 1673 G → A polymorphism alters the function of the mitotic spindle assembly checkpoint and is associated with a worse response to induction chemotherapy and sensitivity to treatment in patients with advanced epithelial ovarian cancer.
Topics: Biomarkers, Pharmacological; Calcium-Binding Proteins; Carcinoma, Ovarian Epithelial; Cell Cycle Pro | 2013 |
Tetraploid cells produced by absence of substrate adhesion during cytokinesis are limited in their proliferation and enter senescence after DNA replication.
Topics: Ataxia Telangiectasia Mutated Proteins; Camptothecin; Cell Line; Cell Proliferation; Cellular Senesc | 2016 |
PTEN regulates PLK1 and controls chromosomal stability during cell division.
Topics: Animals; Cell Cycle Proteins; Cell Division; Chromosomal Instability; Enzyme Activation; Enzyme Stab | 2016 |
Prostate-specific membrane antigen associates with anaphase-promoting complex and induces chromosomal instability.
Topics: Anaphase-Promoting Complex-Cyclosome; Animals; Cell Cycle; Cell Line, Tumor; Centrosome; Chromosomal | 2008 |
Epstein-Barr virus nuclear antigen 2 disrupts mitotic checkpoint and causes chromosomal instability.
Topics: Animals; Calcium-Binding Proteins; Cell Cycle Proteins; Cell Line, Tumor; Cell Transformation, Neopl | 2009 |
A high throughput, whole cell screen for small molecule inhibitors of the mitotic spindle checkpoint identifies OM137, a novel Aurora kinase inhibitor.
Topics: Aurora Kinases; Cell Division; Chromosomal Instability; Chromosomes, Human; Enzyme Inhibitors; HeLa | 2009 |
Loss of spindle assembly checkpoint-mediated inhibition of Cdc20 promotes tumorigenesis in mice.
Topics: Amino Acid Sequence; Aneuploidy; Animals; Cdc20 Proteins; Cell Cycle Proteins; Cells, Cultured; Chro | 2009 |
Chromium induces chromosomal instability, which is partly due to deregulation of BubR1 and Emi1, two APC/C inhibitors.
Topics: Adenomatous Polyposis Coli Protein; Antineoplastic Agents; Cell Cycle Proteins; Cell Division; Chrom | 2011 |
Global analysis of core histones reveals nucleosomal surfaces required for chromosome bi-orientation.
Topics: Amino Acid Sequence; Benomyl; Centromere; Chromosomal Instability; Chromosome Segregation; Chromosom | 2011 |
Overexpression of ubiquitin specific protease 44 (USP44) induces chromosomal instability and is frequently observed in human T-cell leukemia.
Topics: Aneuploidy; Animals; Chromosomal Instability; Chromosome Segregation; Cyclin B; Endopeptidases; Huma | 2011 |
Protein tyrosine phosphatase Shp2 (Ptpn11) plays an important role in maintenance of chromosome stability.
Topics: Chromosomal Instability; HeLa Cells; Humans; Microscopy, Confocal; Mitosis; Nocodazole; Phosphorylat | 2012 |
Dual roles of human BubR1, a mitotic checkpoint kinase, in the monitoring of chromosomal instability.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Apoptosis; Caspases; Cell Cycle Proteins; Chromosoma | 2003 |
FAT10 plays a role in the regulation of chromosomal stability.
Topics: Aneuploidy; Apoptosis; Blotting, Western; Calcium-Binding Proteins; Cell Cycle; Cell Cycle Proteins; | 2006 |
TPPII promotes genetic instability by allowing the escape from apoptosis of cells with activated mitotic checkpoints.
Topics: Aminopeptidases; Apoptosis; Apoptosis Regulatory Proteins; Cell Cycle; Cell Line; Cell Line, Transfo | 2006 |
MPS1-dependent mitotic BLM phosphorylation is important for chromosome stability.
Topics: Adenosine Triphosphatases; Animals; Antineoplastic Agents; Bloom Syndrome; Cell Cycle Proteins; Chro | 2006 |
SIRT2, a tubulin deacetylase, acts to block the entry to chromosome condensation in response to mitotic stress.
Topics: Cell Line, Tumor; Chromosomal Instability; Chromosomes, Human; Glioma; Histone Deacetylase Inhibitor | 2007 |
Sumoylation of the budding yeast kinetochore protein Ndc10 is required for Ndc10 spindle localization and regulation of anaphase spindle elongation.
Topics: Anaphase; Benomyl; Chromosomal Instability; DNA-Binding Proteins; Fungal Proteins; Kinetochores; Lys | 2006 |
p53 activation in response to mitotic spindle damage requires signaling via BubR1-mediated phosphorylation.
Topics: Antineoplastic Agents; Cell Cycle; Chromosomal Instability; Colonic Neoplasms; Fluorescent Antibody | 2007 |
The kinetics of p53 activation versus cyclin E accumulation underlies the relationship between the spindle-assembly checkpoint and the postmitotic checkpoint.
Topics: Calcium-Binding Proteins; CDC2 Protein Kinase; Cell Cycle Proteins; Chromosomal Instability; Chromos | 2008 |