nocodazole has been researched along with Breast Neoplasms in 31 studies
Breast Neoplasms: Tumors or cancer of the human BREAST.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Nocodazole in a dose of 100 ng/ml was used to induce polyploidization in a breast cancer cell line MDA-MB-231 cells." | 7.78 | [Sensitivity to chemotherapeutic drugs of polyploid tumor cells induced by a spindle poison nocodazole]. ( Hao, J; Liu, GY; Wang, DH; Xu, YF; Yu, J; Yuan, BB, 2012) |
| " Here we report our finding that treatment of MCF-7 human breast cancer cells with nocodazole, a prototypic microtubule inhibitor, results in strong up-regulation of cyclin B1 and Cdc2 levels, and their increases are required for the development of mitotic prometaphase arrest and characteristic phenotypes." | 7.77 | Role of cyclin B1/Cdc2 up-regulation in the development of mitotic prometaphase arrest in human breast cancer cells treated with nocodazole. ( Choi, HJ; Fukui, M; Zhu, BT, 2011) |
| " In the present study we show that, in human breast cancer cells, chemical inhibition of Bone morphogenetic proteins (BMPs), but not Transforming Growth Factor-β (TGF-β), abrogates the mitotic arrest induced by nocodazole." | 3.78 | Bone morphogenetic protein (BMP) signaling regulates mitotic checkpoint protein levels in human breast cancer cells. ( Kang, J; Liu, N; Song, C; Yan, H; Zhu, S, 2012) |
| "Nocodazole in a dose of 100 ng/ml was used to induce polyploidization in a breast cancer cell line MDA-MB-231 cells." | 3.78 | [Sensitivity to chemotherapeutic drugs of polyploid tumor cells induced by a spindle poison nocodazole]. ( Hao, J; Liu, GY; Wang, DH; Xu, YF; Yu, J; Yuan, BB, 2012) |
| " Here we report our finding that treatment of MCF-7 human breast cancer cells with nocodazole, a prototypic microtubule inhibitor, results in strong up-regulation of cyclin B1 and Cdc2 levels, and their increases are required for the development of mitotic prometaphase arrest and characteristic phenotypes." | 3.77 | Role of cyclin B1/Cdc2 up-regulation in the development of mitotic prometaphase arrest in human breast cancer cells treated with nocodazole. ( Choi, HJ; Fukui, M; Zhu, BT, 2011) |
| " After treatment with 1 microM nocodazole, seven of ten breast cancer lines (type A cells) arrested in mitosis, whereas the other three (type B cells) did not." | 3.71 | G(1) and G(2) cell-cycle arrest following microtubule depolymerization in human breast cancer cells. ( Blajeski, AL; Kaufmann, SH; Kottke, TJ; Phan, VA, 2002) |
| " In the present study, we demonstrated that microtubule-binding agents (MBAs) taxol and colchicine induced immediate early gene (c-jun and ATF3) expression, cell cycle arrest, and apoptosis in the human breast cancer cell line MCF-7." | 3.70 | Differential regulation of mitogen-activated protein kinases by microtubule-binding agents in human breast cancer cells. ( Hagen, K; Kong, AN; Mandlekar, S; Roninson, IB; Shtil, AA; Tan, TH; Walter, RJ; Yu, R, 1999) |
| "Depletion of BNIP-2 in MDA-MB-231 breast cancer cells decreases RhoA activity and promotes cell migration." | 1.56 | BNIP-2 retards breast cancer cell migration by coupling microtubule-mediated GEF-H1 and RhoA activation. ( Chew, TW; Chin, JFL; Low, BC; Ong, HT; Pan, M; Wong, DCP; Xiao, J, 2020) |
| "Cancer metastasis involves the dissemination of cancer cells from the primary tumour site and is responsible for the majority of solid tumour-related mortality." | 1.40 | Mechanistic adaptability of cancer cells strongly affects anti-migratory drug efficacy. ( Kurniawan, NA; Lim, CT; Sun, W, 2014) |
| "Microinjection of the ANK peptide in breast cancer cell line overexpressing SNCG (MCF7-SNCG) exhibited a similar cell killing response by nocodazole as in the SNCG-negative MCF7 cells." | 1.34 | Synuclein-gamma targeting peptide inhibitor that enhances sensitivity of breast cancer cells to antimicrotubule drugs. ( Forman-Kay, JD; Jia, Z; Liu, J; Marsh, JA; Singh, VK; Uversky, VN; Zhou, Y, 2007) |
| " We found that DFMO administration to MCF-10A cells increased EGF-R mRNA and protein levels in a dose-response fashion, while HER-2neu expression was not affected." | 1.31 | Effect of alpha-difluoromethyl-ornithine on the expression and function of the epidermal growth factor receptor in human breast epithelial cells in culture. ( Demers, L; Manni, A; Mauger, D; Trout, D; Verderame, MF; Washington, S, 2001) |
| "We have shown that several breast cancer cell lines (MDA-MB-453, BT474, MDA-MB-361, and SKBR3), which overexpress the ErbB2 receptor tyrosine kinase, contain constitutively tyrosine phosphorylated Shc." | 1.30 | Shc dominant negative disrupts cell cycle progression in both G0-G1 and G2-M of ErbB2-positive breast cancer cells. ( Frackelton, AR; Ravichandran, KS; Stevenson, LE, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (25.81) | 18.2507 |
| 2000's | 9 (29.03) | 29.6817 |
| 2010's | 13 (41.94) | 24.3611 |
| 2020's | 1 (3.23) | 2.80 |
| Authors | Studies |
|---|---|
| Punganuru, SR | 1 |
| Madala, HR | 1 |
| Venugopal, SN | 1 |
| Samala, R | 1 |
| Mikelis, C | 1 |
| Srivenugopal, KS | 1 |
| Mandalapu, D | 1 |
| Saini, KS | 1 |
| Gupta, S | 1 |
| Sharma, V | 1 |
| Yaseen Malik, M | 1 |
| Chaturvedi, S | 1 |
| Bala, V | 1 |
| Thakur, S | 1 |
| Maikhuri, JP | 1 |
| Wahajuddin, M | 1 |
| Konwar, R | 1 |
| Gupta, G | 1 |
| Sharma, VL | 1 |
| Meegan, MJ | 1 |
| Nathwani, S | 1 |
| Twamley, B | 1 |
| Zisterer, DM | 1 |
| O'Boyle, NM | 1 |
| Pan, M | 1 |
| Chew, TW | 1 |
| Wong, DCP | 1 |
| Xiao, J | 1 |
| Ong, HT | 1 |
| Chin, JFL | 1 |
| Low, BC | 1 |
| Zuo, D | 1 |
| Jiang, X | 1 |
| Han, M | 1 |
| Shen, J | 1 |
| Lang, B | 1 |
| Guan, Q | 1 |
| Bai, Z | 1 |
| Han, C | 1 |
| Li, Z | 1 |
| Zhang, W | 1 |
| Wu, Y | 1 |
| Kent, IA | 1 |
| Zhang, Q | 1 |
| Katiyar, A | 1 |
| Li, Y | 1 |
| Pathak, S | 1 |
| Dickinson, RB | 1 |
| Lele, TP | 1 |
| Stone, A | 1 |
| Cowley, MJ | 1 |
| Valdes-Mora, F | 1 |
| McCloy, RA | 1 |
| Sergio, CM | 1 |
| Gallego-Ortega, D | 1 |
| Caldon, CE | 1 |
| Ormandy, CJ | 1 |
| Biankin, AV | 1 |
| Gee, JM | 1 |
| Nicholson, RI | 1 |
| Print, CG | 1 |
| Clark, SJ | 1 |
| Musgrove, EA | 1 |
| Sun, W | 1 |
| Lim, CT | 1 |
| Kurniawan, NA | 1 |
| Sánchez-Pérez, T | 1 |
| Ortiz-Ferrón, G | 1 |
| López-Rivas, A | 1 |
| Nikkhah, M | 1 |
| Strobl, JS | 1 |
| De Vita, R | 1 |
| Agah, M | 2 |
| Choi, HJ | 1 |
| Fukui, M | 1 |
| Zhu, BT | 1 |
| Yan, H | 1 |
| Zhu, S | 1 |
| Song, C | 1 |
| Liu, N | 1 |
| Kang, J | 1 |
| Hao, J | 1 |
| Yuan, BB | 1 |
| Xu, YF | 1 |
| Yu, J | 1 |
| Liu, GY | 1 |
| Wang, DH | 1 |
| Srinivasaraghavan, V | 1 |
| Strobl, J | 1 |
| Wang, Q | 1 |
| Moyret-Lalle, C | 1 |
| Couzon, F | 1 |
| Surbiguet-Clippe, C | 1 |
| Saurin, JC | 1 |
| Lorca, T | 1 |
| Navarro, C | 1 |
| Puisieux, A | 1 |
| Lee, EA | 1 |
| Keutmann, MK | 1 |
| Dowling, ML | 1 |
| Harris, E | 1 |
| Chan, G | 1 |
| Kao, GD | 1 |
| Marx, KA | 1 |
| Zhou, T | 1 |
| Montrone, A | 1 |
| McIntosh, D | 1 |
| Braunhut, SJ | 1 |
| Singh, VK | 1 |
| Zhou, Y | 1 |
| Marsh, JA | 1 |
| Uversky, VN | 1 |
| Forman-Kay, JD | 1 |
| Liu, J | 1 |
| Jia, Z | 1 |
| Martin, KJ | 1 |
| Vassallo, CD | 1 |
| Teicher, BA | 1 |
| Kaddurah-Daouk, R | 1 |
| Wang, SC | 1 |
| Lin, SH | 1 |
| Su, LK | 1 |
| Hung, MC | 1 |
| Anderson, HJ | 1 |
| de Jong, G | 1 |
| Vincent, I | 1 |
| Roberge, M | 1 |
| Srivastava, RK | 1 |
| Srivastava, AR | 1 |
| Korsmeyer, SJ | 1 |
| Nesterova, M | 1 |
| Cho-Chung, YS | 1 |
| Longo, DL | 1 |
| Gupta, M | 1 |
| Fan, S | 1 |
| Zhan, Q | 1 |
| Kohn, KW | 1 |
| O'Connor, PM | 1 |
| Pommier, Y | 1 |
| Shtil, AA | 1 |
| Mandlekar, S | 1 |
| Yu, R | 1 |
| Walter, RJ | 1 |
| Hagen, K | 1 |
| Tan, TH | 1 |
| Roninson, IB | 1 |
| Kong, AN | 1 |
| Stevenson, LE | 1 |
| Ravichandran, KS | 1 |
| Frackelton, AR | 1 |
| Berditchevski, F | 1 |
| Odintsova, E | 1 |
| Khan, QA | 2 |
| Dipple, A | 2 |
| Sterin, M | 1 |
| Cohen, JS | 1 |
| Mardor, Y | 1 |
| Berman, E | 1 |
| Ringel, I | 1 |
| Manni, A | 1 |
| Trout, D | 1 |
| Verderame, MF | 1 |
| Washington, S | 1 |
| Mauger, D | 1 |
| Demers, L | 1 |
| Anderson, LM | 1 |
| Blajeski, AL | 1 |
| Phan, VA | 1 |
| Kottke, TJ | 1 |
| Kaufmann, SH | 1 |
31 other studies available for nocodazole and Breast Neoplasms
| Article | Year |
|---|---|
Design and synthesis of a C7-aryl piperlongumine derivative with potent antimicrotubule and mutant p53-reactivating properties.
Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Chemistry Techniqu | 2016 |
Synthesis and biological evaluation of some novel triazole hybrids of curcumin mimics and their selective anticancer activity against breast and prostate cancer cell lines.
Topics: Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Breast Neoplasms; Cell Cycle Checkpoin | 2016 |
Piperlongumine (piplartine) and analogues: Antiproliferative microtubule-destabilising agents.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Survival; Dioxolanes; Female; Humans; MCF-7 Cells; Mic | 2017 |
BNIP-2 retards breast cancer cell migration by coupling microtubule-mediated GEF-H1 and RhoA activation.
Topics: Breast Neoplasms; Carrier Proteins; Cell Movement; Female; Humans; Microtubules; Nocodazole; Rho Gua | 2020 |
Methyl 5-[(1H-indol-3-yl)selanyl]-1H-benzoimidazol-2-ylcarbamate (M-24), a novel tubulin inhibitor, causes G2/M arrest and cell apoptosis by disrupting tubulin polymerization in human cervical and breast cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Caspases; Female; G2 Phase Cell Cycle Checkpoint | 2017 |
Apical cell protrusions cause vertical deformation of the soft cancer nucleus.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Nucleus; Cytochalasin D; Cytoskeleton; Female; Heterocyclic | 2019 |
BCL-2 hypermethylation is a potential biomarker of sensitivity to antimitotic chemotherapy in endocrine-resistant breast cancer.
Topics: Antimitotic Agents; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis | 2013 |
Mechanistic adaptability of cancer cells strongly affects anti-migratory drug efficacy.
Topics: Amides; Antineoplastic Agents; Breast Neoplasms; Cell Movement; Cytochalasin D; Dipeptides; Extracel | 2014 |
Mitotic arrest and JNK-induced proteasomal degradation of FLIP and Mcl-1 are key events in the sensitization of breast tumor cells to TRAIL by antimicrotubule agents.
Topics: Apoptosis; Breast Neoplasms; CASP8 and FADD-Like Apoptosis Regulating Protein; Cell Line, Tumor; Flo | 2010 |
The cytoskeletal organization of breast carcinoma and fibroblast cells inside three dimensional (3-D) isotropic silicon microstructures.
Topics: Breast Neoplasms; Cell Culture Techniques; Cell Line; Cytoskeleton; Elastic Modulus; Equipment Desig | 2010 |
Role of cyclin B1/Cdc2 up-regulation in the development of mitotic prometaphase arrest in human breast cancer cells treated with nocodazole.
Topics: Antineoplastic Agents; Blotting, Western; Breast Neoplasms; CDC2 Protein Kinase; Cell Line, Tumor; C | 2011 |
Bone morphogenetic protein (BMP) signaling regulates mitotic checkpoint protein levels in human breast cancer cells.
Topics: Activins; Benzamides; Bone Morphogenetic Proteins; Breast Neoplasms; Calcium-Binding Proteins; Cell | 2012 |
[Sensitivity to chemotherapeutic drugs of polyploid tumor cells induced by a spindle poison nocodazole].
Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Breast Neoplasms; Cell Line, Tu | 2012 |
Bioimpedance rise in response to histone deacetylase inhibitor is a marker of mammary cancer cells within a mixed culture of normal breast cells.
Topics: Biomarkers, Tumor; Biosensing Techniques; Breast; Breast Neoplasms; Cell Line, Tumor; Cell Separatio | 2012 |
Alterations of anaphase-promoting complex genes in human colon cancer cells.
Topics: Anaphase-Promoting Complex-Cyclosome; Antineoplastic Agents; Apc3 Subunit, Anaphase-Promoting Comple | 2003 |
Inactivation of the mitotic checkpoint as a determinant of the efficacy of microtubule-targeted drugs in killing human cancer cells.
Topics: Antineoplastic Agents, Phytogenic; Breast Neoplasms; CDC2 Protein Kinase; Cell Cycle Proteins; Cell | 2004 |
A comparative study of the cytoskeleton binding drugs nocodazole and taxol with a mammalian cell quartz crystal microbalance biosensor: different dynamic responses and energy dissipation effects.
Topics: Animals; Aorta; Biosensing Techniques; Breast Neoplasms; Cattle; Cell Culture Techniques; Cell Line; | 2007 |
Synuclein-gamma targeting peptide inhibitor that enhances sensitivity of breast cancer cells to antimicrotubule drugs.
Topics: Amino Acid Sequence; Animals; Ankyrins; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; C | 2007 |
Microtubule stabilization and potentiation of taxol activity by the creatine analog cyclocreatine.
Topics: Adenocarcinoma; Antineoplastic Agents; Breast Neoplasms; Colony-Forming Units Assay; Creatinine; Dru | 1995 |
Changes in BRCA2 expression during progression of the cell cycle.
Topics: Blotting, Northern; BRCA2 Protein; Breast; Breast Neoplasms; Cell Cycle; Cell Line; Electrophoresis, | 1997 |
Flow cytometry of mitotic cells.
Topics: Antibodies, Monoclonal; Antibody Specificity; Antigens; Breast Neoplasms; Carcinoma; Cell Separation | 1998 |
Involvement of microtubules in the regulation of Bcl2 phosphorylation and apoptosis through cyclic AMP-dependent protein kinase.
Topics: Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Breast Neoplasms; Caspase 3; Caspases; | 1998 |
Inactivation of p53 increases the cytotoxicity of camptothecin in human colon HCT116 and breast MCF-7 cancer cells.
Topics: Adenocarcinoma; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Camptothecin; Colonic Neoplasms | 1997 |
Differential regulation of mitogen-activated protein kinases by microtubule-binding agents in human breast cancer cells.
Topics: Apoptosis; Breast Neoplasms; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cell Cycle; Colc | 1999 |
Shc dominant negative disrupts cell cycle progression in both G0-G1 and G2-M of ErbB2-positive breast cancer cells.
Topics: Breast; Breast Neoplasms; Cell Cycle; Epithelial Cells; Female; G1 Phase; G2 Phase; Humans; Mitosis; | 1999 |
Characterization of integrin-tetraspanin adhesion complexes: role of tetraspanins in integrin signaling.
Topics: Actins; Antigens, CD; Breast Neoplasms; Cell Adhesion; Cell Adhesion Molecules; Culture Media, Serum | 1999 |
Diverse chemical carcinogens fail to induce G(1) arrest in MCF-7 cells.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Acetoxyacetylaminofluorene; Alkylating Agents; B | 2000 |
Levels of phospholipid metabolites in breast cancer cells treated with antimitotic drugs: a 31P-magnetic resonance spectroscopy study.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Cycle; Cell Division; Cell Membrane; Collagen; Doxorub | 2001 |
Effect of alpha-difluoromethyl-ornithine on the expression and function of the epidermal growth factor receptor in human breast epithelial cells in culture.
Topics: Antineoplastic Agents; Blotting, Northern; Blotting, Western; Breast Neoplasms; Cell Line; Dose-Resp | 2001 |
Protease inhibitor-induced stabilization of p21(waf1/cip1) and cell-cycle arrest in chemical carcinogen-exposed mammary and lung cells.
Topics: Animals; Antineoplastic Agents; Blotting, Western; Breast Neoplasms; Carcinogens; Cell Cycle; Chryse | 2002 |
G(1) and G(2) cell-cycle arrest following microtubule depolymerization in human breast cancer cells.
Topics: Breast Neoplasms; Colchicine; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Dose-Response Relation | 2002 |