nocodazole has been researched along with Aneuploid in 59 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "M to agents that induce aneuploidy, we noted that nocodazole, which strongly induces aneuploidy when yeast cells are treated in yeast extract-peptone-dextrose (YEPD) medium, had no effect when a synthetic complete (SC) medium was used." | 7.67 | Effect of treatment medium on induction of aneuploidy by nocodazole in Saccharomyces cerevisiae. ( Goin, CJ; Mayer, VW; Taylor-Mayer, RE, 1988) |
| "Nocodazole and ethyl acetate have previously been shown to be potent inducers of aneuploidy in Saccharomyces cerevisiae." | 7.67 | Aneuploidy induced by nocodazole or ethyl acetate is suppressed by dimethyl sulfoxide. ( Goin, CJ; Mayer, VW, 1987) |
| " Reduced bioavailability of nocodazole to the target cells due to its poor water solubility may contribute to this difference." | 5.33 | Aneuploidy in mouse metaphase II oocytes exposed in vivo and in vitro in preantral follicle culture to nocodazole. ( Betzendahl, I; Cortvrindt, R; Eichenlaub-Ritter, U; Pacchierotti, F; Ranaldi, R; Smitz, J; Sun, F, 2005) |
| "We have shown that it induces aneuploidy in the yeast Saccharomyces cerevisiae at very low concentrations." | 5.27 | Induction of aneuploidy by oncodazole (nocodazole), an anti-tubulin agent, and acetone. ( Mayer, VW; Scheel, I; Zimmermann, FK, 1984) |
| " Nocodazole-mediated aneuploidy was increased in p53-defective (p53Mut) cells; however, it was not increased in p53 wild-type (p53WT) cells." | 3.75 | Heat shock factor 1-mediated aneuploidy requires a defective function of p53. ( Bae, S; Kim, EH; Kim, J; Lee, JS; Lee, YJ; Lee, YS, 2009) |
| " The aim was to visualize the events leading to aneuploidy directly during anaphase, analyse the induction of aneuploidy during this mitotic stage and compare the frequencies of chromosome malsegregation observed in ana-telophases with the estimated malsegregation obtained in binucleate cells after a short cytochalasin B treatment." | 3.70 | Differences in malsegregation rates obtained by scoring ana-telophases or binucleate cells. ( Cimini, D; Degrassi, F; Tanzarella, C, 1999) |
| "The utility of Chinese hamsters as a test species for aneuploidy analysis was studied using four chemicals--vincristine, methyl 2-benzimidazole carbamate (MBC), nocodazole, and cyclophosphamide." | 3.68 | The feasibility of using Chinese hamsters as an animal model for aneuploidy. ( Arras, CA; Jones, RL; Lavappa, KS; Lee, JK; Sheu, CW, 1990) |
| "M to agents that induce aneuploidy, we noted that nocodazole, which strongly induces aneuploidy when yeast cells are treated in yeast extract-peptone-dextrose (YEPD) medium, had no effect when a synthetic complete (SC) medium was used." | 3.67 | Effect of treatment medium on induction of aneuploidy by nocodazole in Saccharomyces cerevisiae. ( Goin, CJ; Mayer, VW; Taylor-Mayer, RE, 1988) |
| "Nocodazole, ethyl acetate, acetone and methyl ethyl ketone all are known to induce aneuploidy." | 3.67 | Effects of chemical combinations on the induction of aneuploidy in Saccharomyces cerevisiae. ( Goin, CJ; Mayer, VW, 1987) |
| "Nocodazole and ethyl acetate have previously been shown to be potent inducers of aneuploidy in Saccharomyces cerevisiae." | 3.67 | Aneuploidy induced by nocodazole or ethyl acetate is suppressed by dimethyl sulfoxide. ( Goin, CJ; Mayer, VW, 1987) |
| "Depending on their p53-status polyploid cells may eventually arrest, die or continue cycling." | 2.44 | Survival of aneuploid, micronucleated and/or polyploid cells: crosstalk between ploidy control and apoptosis. ( Cundari, E; Decordier, I; Kirsch-Volders, M, 2008) |
| "Aneuploidy is the leading genetic abnormality causing early miscarriage and pregnancy failure in humans." | 1.72 | Evaluation of the Spindle Assembly Checkpoint Integrity in Mouse Oocytes. ( Aboelenain, M; Blengini, CS; Schindler, K, 2022) |
| "Despite aneuploidy's correlation with aging, we find that aged proliferating muscle stem cells display robust SAC activity without elevated aneuploidy." | 1.42 | The Spindle Assembly Checkpoint Safeguards Genomic Integrity of Skeletal Muscle Satellite Cells. ( Abou-Khalil, R; Brack, AS; Kollu, S; Shen, C, 2015) |
| "Nocodazole-treated oocytes did not display increased DNA damage signals that were marked by γH2A." | 1.40 | Effects of DNA damage and short-term spindle disruption on oocyte meiotic maturation. ( Jiang, ZZ; Luo, YB; Ma, JY; Qi, ST; Schatten, H; Sun, QY; Wang, ZB; Wang, ZW; Zhang, GL; Zhang, T, 2014) |
| "Embryonic aneuploidy occurs when chromosome aberrations are present in gametes or early embryos." | 1.37 | Spindle assembly checkpoint regulates mitotic cell cycle progression during preimplantation embryo development. ( Ge, ZJ; Hou, Y; Li, M; Ma, J; Multi, S; Ouyang, YC; Schatten, H; Sun, QY; Wang, ZB; Wei, L; Wei, Y; Yang, CR; Zhang, CH; Zhang, QH, 2011) |
| "Many cancer-treating compounds used in chemotherapies, the so-called antimitotics, target the mitotic spindle." | 1.36 | Adapt or die: how eukaryotic cells respond to prolonged activation of the spindle assembly checkpoint. ( Galati, E; Piatti, S; Rossio, V, 2010) |
| "The possible risk of aneuploidy induction by the cancer chemotherapeutic drugs amsacrine (AMSA) and nocodazole (NOC) was investigated in male mice." | 1.35 | The chemotherapeutic agents nocodazole and amsacrine cause meiotic delay and non-disjunction in spermatocytes of mice. ( Adler, ID; Attia, SM; Badary, OA; Hamada, FM; Hrabé de Angelis, M, 2008) |
| "The 8;21 chromosomal translocation occurs in 15% to 40% of patients with the FAB M2 subtype of acute myeloid leukemia (AML)." | 1.34 | A leukemia fusion protein attenuates the spindle checkpoint and promotes aneuploidy. ( Biggs, JR; Boyapati, A; Le Beau, MM; Peterson, LF; Yan, M; Zhang, DE, 2007) |
| "Aneuploidy is a key process in tumorigenesis." | 1.33 | FAT10 plays a role in the regulation of chromosomal stability. ( Chong, SS; Jeang, KT; Kan, A; Kon, OL; Lee, CG; Leong, SH; Ooi, LL; Ren, J, 2006) |
| "Our results suggest that elimination of aneuploid cells does occur." | 1.31 | Elimination of micronucleated cells by apoptosis after treatment with inhibitors of microtubules. ( Cundari, E; Decordier, I; Dillen, L; Kirsch-Volders, M, 2002) |
| "This pattern of chromosomal aberrations is consistent with a mechanism involving the impairment of chromosome segregation fidelity during mitotic cell division." | 1.31 | Centrosome amplification and instability occurs exclusively in aneuploid, but not in diploid colorectal cancer cell lines, and correlates with numerical chromosomal aberrations. ( Auer, G; Difilippantonio, MJ; Ghadimi, BM; Jauho, A; Neumann, T; Ried, T; Sackett, DL; Schröck, E, 2000) |
| " But since it is obvious from dose-response curves where the inflection point/threshold lies, it appears that the model might be picking up some irregularities (possibly due to experimental variability in the dose-response curve at concentrations greater than the threshold)." | 1.30 | Indication for thresholds of chromosome non-disjunction versus chromosome lagging induced by spindle inhibitors in vitro in human lymphocytes. ( Elhajouji, A; Kirsch-Volders, M; Tibaldi, F, 1997) |
| "In most colorectal cancers, and probably in many other cancer types, a chromosomal instability (CIN) leading to an abnormal chromosome number (aneuploidy) is observed." | 1.30 | Mutations of mitotic checkpoint genes in human cancers. ( Cahill, DP; Kinzler, KW; Lengauer, C; Markowitz, SD; Riggins, GJ; Vogelstein, B; Willson, JK; Yu, J, 1998) |
| "Despite the fact that aneuploidy is a major genetic cause of human morbidity and mortality, antimutagenicity studies have used predominantly short-term tests that detect gene mutations, chromosomal aberrations, and micronuclei." | 1.29 | Utility of a test for chromosomal malsegregation in Saccharomyces cerevisiae strain D61.M for the detection of antianeugens: test of the model combination of chlorophyllin and nocodazole. ( Brockman, HE; Mayer, VW; Verma, A, 1996) |
| "Detailed dose-response data for two reference aneugens, vincristine and nocodazole, have been derived for the mouse bone marrow micronucleus assay." | 1.28 | Micronucleus morphology as a means to distinguish aneugens and clastogens in the mouse bone marrow micronucleus assay. ( Ashby, J; Tinwell, H, 1991) |
| "The state of aneuploidy test methodology was appraised by the U." | 1.28 | Reevaluation of the 9 compounds reported conclusive positive in yeast Saccharomyces cerevisiae aneuploidy test systems by the Gene-Tox Program using strain D61.M of Saccharomyces cerevisiae. ( Albertini, S, 1991) |
| "The occurrence of aneuploidy can be measured in several assays." | 1.28 | The mouse bone marrow micronucleus assay can be used to distinguish aneugens from clastogens. ( Kirsch-Volders, M; Vanderkerken, K; Vanparys, P; Verschaeve, L, 1989) |
| "Nocodazole was administered either to maturing preovulatory oocytes or to normally ovulated eggs at one of the following stages: (1) the time of sperm entry, (2) early pronuclear stage, (3) pronuclear DNA synthesis, (4) prior to first cleavage division, (5) early 2-cell stage, or (6) prior to the second cleavage division." | 1.28 | Chromosome malsegregation and embryonic lethality induced by treatment of normally ovulated mouse oocytes with nocodazole. ( Bishop, JB; Cain, KT; Foxworth, LB; Generoso, WM; Hughes, LA; Katoh, M; Mitchell, TJ, 1989) |
| "When nocodazole was dissolved in 1-methyl-2-pyrrolidinone as a concentrated stock solution, a potentiation effect occurred even at low concentrations of the solvent." | 1.27 | Investigations of aneuploidy-inducing chemical combinations in Saccharomyces cerevisiae. ( Goin, CJ; Mayer, VW, 1988) |
| "4 chemicals reported to induce aneuploidy in mammalian cells were used in a flexion assay." | 1.27 | Chromosome flexion: potential for assessing the state of spindle assembly. ( Correll, AT; Ford, JH, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (16.95) | 18.7374 |
| 1990's | 13 (22.03) | 18.2507 |
| 2000's | 19 (32.20) | 29.6817 |
| 2010's | 15 (25.42) | 24.3611 |
| 2020's | 2 (3.39) | 2.80 |
| Authors | Studies |
|---|---|
| Aboelenain, M | 1 |
| Schindler, K | 1 |
| Blengini, CS | 1 |
| Endo, Y | 1 |
| Saeki, K | 1 |
| Watanabe, M | 1 |
| Miyajima-Magara, N | 1 |
| Igarashi, M | 1 |
| Mochizuki, M | 1 |
| Nishimura, R | 1 |
| Sugano, S | 1 |
| Sasaki, N | 1 |
| Nakagawa, T | 1 |
| Worrall, JT | 1 |
| Tamura, N | 1 |
| Mazzagatti, A | 1 |
| Shaikh, N | 1 |
| van Lingen, T | 1 |
| Bakker, B | 1 |
| Spierings, DCJ | 1 |
| Vladimirou, E | 1 |
| Foijer, F | 1 |
| McClelland, SE | 1 |
| Cho, JG | 1 |
| Choi, JS | 1 |
| Lee, JH | 2 |
| Cho, MG | 1 |
| Kim, HS | 1 |
| Noh, HD | 1 |
| Lim, KH | 2 |
| Park, B | 1 |
| Kim, JO | 1 |
| Park, SG | 1 |
| Zhang, T | 1 |
| Zhang, GL | 1 |
| Ma, JY | 1 |
| Qi, ST | 2 |
| Wang, ZB | 3 |
| Wang, ZW | 1 |
| Luo, YB | 1 |
| Jiang, ZZ | 1 |
| Schatten, H | 3 |
| Sun, QY | 4 |
| Yun, Y | 1 |
| Holt, JE | 1 |
| Lane, SI | 1 |
| McLaughlin, EA | 1 |
| Merriman, JA | 1 |
| Jones, KT | 1 |
| Kollu, S | 1 |
| Abou-Khalil, R | 1 |
| Shen, C | 1 |
| Brack, AS | 1 |
| Dai, X | 1 |
| Zhang, M | 1 |
| Lu, Y | 1 |
| Miao, Y | 1 |
| Zhou, C | 1 |
| Xiong, B | 2 |
| Li, S | 1 |
| Ai, JS | 1 |
| Yin, S | 1 |
| Ouyang, YC | 3 |
| Sun, SC | 1 |
| Chen, DY | 1 |
| Schliekelman, M | 1 |
| Cowley, DO | 1 |
| O'Quinn, R | 1 |
| Oliver, TG | 1 |
| Lu, L | 1 |
| Salmon, ED | 2 |
| Van Dyke, T | 1 |
| Li, M | 2 |
| Fang, X | 1 |
| Wei, Z | 1 |
| York, JP | 1 |
| Zhang, P | 1 |
| Duncan, FE | 1 |
| Chiang, T | 1 |
| Schultz, RM | 1 |
| Lampson, MA | 1 |
| Kim, EH | 1 |
| Lee, YJ | 1 |
| Bae, S | 1 |
| Lee, JS | 1 |
| Kim, J | 1 |
| Lee, YS | 1 |
| Rossio, V | 1 |
| Galati, E | 1 |
| Piatti, S | 1 |
| Wei, Y | 1 |
| Multi, S | 1 |
| Yang, CR | 1 |
| Ma, J | 1 |
| Zhang, QH | 1 |
| Wei, L | 1 |
| Ge, ZJ | 1 |
| Zhang, CH | 1 |
| Hou, Y | 2 |
| Bui, CB | 1 |
| Shin, J | 1 |
| Zhang, Y | 1 |
| van Deursen, J | 1 |
| Galardy, PJ | 1 |
| Zhu, J | 1 |
| Wang, YP | 1 |
| Díaz-Rodríguez, E | 1 |
| Álvarez-Fernández, S | 1 |
| Chen, X | 1 |
| Paiva, B | 1 |
| López-Pérez, R | 1 |
| García-Hernández, JL | 1 |
| San Miguel, JF | 1 |
| Pandiella, A | 1 |
| Huang, Y | 1 |
| Jiang, L | 1 |
| Yi, Q | 1 |
| Lv, L | 1 |
| Wang, Z | 1 |
| Zhao, X | 1 |
| Zhong, L | 1 |
| Jiang, H | 1 |
| Rasool, S | 1 |
| Hao, Q | 1 |
| Guo, Z | 1 |
| Cooke, HJ | 1 |
| Fenech, M | 1 |
| Shi, Q | 1 |
| Zacharaki, P | 1 |
| Stephanou, G | 1 |
| Demopoulos, NA | 1 |
| Lee, CG | 2 |
| Park, GY | 1 |
| Han, YK | 1 |
| Chun, SH | 1 |
| Park, HY | 1 |
| Kim, EG | 1 |
| Choi, YJ | 1 |
| Yang, K | 1 |
| Lee, CW | 1 |
| Decordier, I | 2 |
| Dillen, L | 1 |
| Cundari, E | 2 |
| Kirsch-Volders, M | 5 |
| Roumier, T | 1 |
| Valent, A | 1 |
| Perfettini, JL | 1 |
| Métivier, D | 1 |
| Castedo, M | 1 |
| Kroemer, G | 1 |
| Sun, F | 1 |
| Betzendahl, I | 1 |
| Pacchierotti, F | 1 |
| Ranaldi, R | 1 |
| Smitz, J | 1 |
| Cortvrindt, R | 1 |
| Eichenlaub-Ritter, U | 2 |
| Nguyen, HG | 1 |
| Chinnappan, D | 1 |
| Urano, T | 1 |
| Ravid, K | 1 |
| Kanda, A | 1 |
| Kawai, H | 1 |
| Suto, S | 1 |
| Kitajima, S | 1 |
| Sato, S | 1 |
| Takata, T | 1 |
| Tatsuka, M | 1 |
| Ren, J | 1 |
| Kan, A | 1 |
| Leong, SH | 1 |
| Ooi, LL | 1 |
| Jeang, KT | 1 |
| Chong, SS | 1 |
| Kon, OL | 1 |
| Boyapati, A | 1 |
| Yan, M | 1 |
| Peterson, LF | 1 |
| Biggs, JR | 1 |
| Le Beau, MM | 1 |
| Zhang, DE | 1 |
| Egli, D | 1 |
| Rosains, J | 1 |
| Birkhoff, G | 1 |
| Eggan, K | 1 |
| Attia, SM | 1 |
| Badary, OA | 1 |
| Hamada, FM | 1 |
| Hrabé de Angelis, M | 1 |
| Adler, ID | 1 |
| Zimmermann, FK | 1 |
| Mayer, VW | 6 |
| Scheel, I | 1 |
| Elhajouji, A | 2 |
| Van Hummelen, P | 1 |
| Verma, A | 1 |
| Brockman, HE | 1 |
| Andreassen, PR | 1 |
| Martineau, SN | 1 |
| Margolis, RL | 1 |
| Tibaldi, F | 1 |
| Khan, SH | 1 |
| Wahl, GM | 1 |
| Cahill, DP | 1 |
| Lengauer, C | 1 |
| Yu, J | 1 |
| Riggins, GJ | 1 |
| Willson, JK | 1 |
| Markowitz, SD | 1 |
| Kinzler, KW | 1 |
| Vogelstein, B | 1 |
| Larsen, CJ | 1 |
| Notterman, D | 1 |
| Young, S | 1 |
| Wainger, B | 1 |
| Levine, AJ | 1 |
| Burns, EM | 1 |
| Christopoulou, L | 1 |
| Corish, P | 1 |
| Tyler-Smith, C | 1 |
| Cimini, D | 2 |
| Tanzarella, C | 1 |
| Degrassi, F | 2 |
| Ghadimi, BM | 1 |
| Sackett, DL | 1 |
| Difilippantonio, MJ | 1 |
| Schröck, E | 1 |
| Neumann, T | 1 |
| Jauho, A | 1 |
| Auer, G | 1 |
| Ried, T | 1 |
| Howell, B | 1 |
| Maddox, P | 1 |
| Khodjakov, A | 1 |
| Tighe, A | 1 |
| Johnson, VL | 1 |
| Albertella, M | 1 |
| Taylor, SS | 1 |
| Purohit, A | 1 |
| Pihan, GA | 1 |
| Doxsey, SJ | 1 |
| Tinwell, H | 1 |
| Ashby, J | 1 |
| Albertini, S | 1 |
| Sheu, CW | 1 |
| Lee, JK | 1 |
| Arras, CA | 1 |
| Jones, RL | 1 |
| Lavappa, KS | 1 |
| Boll, I | 1 |
| Vanderkerken, K | 1 |
| Vanparys, P | 1 |
| Verschaeve, L | 1 |
| Generoso, WM | 1 |
| Katoh, M | 1 |
| Cain, KT | 1 |
| Hughes, LA | 1 |
| Foxworth, LB | 1 |
| Mitchell, TJ | 1 |
| Bishop, JB | 1 |
| Goin, CJ | 4 |
| Sandhu, SS | 1 |
| Gudi, R | 1 |
| Athwal, RS | 1 |
| Taylor-Mayer, RE | 1 |
| Correll, AT | 1 |
| Ford, JH | 1 |
1 review available for nocodazole and Aneuploid
| Article | Year |
|---|---|
Survival of aneuploid, micronucleated and/or polyploid cells: crosstalk between ploidy control and apoptosis.
Topics: Aneuploidy; Animals; Apoptosis; Cell Survival; Humans; Micronuclei, Chromosome-Defective; Models, Bi | 2008 |
58 other studies available for nocodazole and Aneuploid
| Article | Year |
|---|---|
Evaluation of the Spindle Assembly Checkpoint Integrity in Mouse Oocytes.
Topics: Anaphase-Promoting Complex-Cyclosome; Aneuploidy; Animals; Cell Cycle Proteins; Kinetochores; M Phas | 2022 |
Spindle assembly checkpoint competence in aneuploid canine malignant melanoma cell lines.
Topics: Aneuploidy; Animals; Cell Cycle Proteins; Cell Line, Tumor; Chromatids; Dog Diseases; Dogs; Histones | 2020 |
Non-random Mis-segregation of Human Chromosomes.
Topics: Anaphase; Aneuploidy; Carrier Proteins; Cell Line, Tumor; Chromosome Segregation; Chromosomes, Human | 2018 |
MED28 Over-Expression Shortens the Cell Cycle and Induces Genomic Instability.
Topics: Aneuploidy; Cell Cycle; Genomic Instability; HEK293 Cells; HeLa Cells; Humans; MCF-7 Cells; Mediator | 2019 |
Effects of DNA damage and short-term spindle disruption on oocyte meiotic maturation.
Topics: Aneugens; Aneuploidy; Animals; Antibiotics, Antineoplastic; Bleomycin; Chromosomes; DNA Breaks, Doub | 2014 |
Reduced ability to recover from spindle disruption and loss of kinetochore spindle assembly checkpoint proteins in oocytes from aged mice.
Topics: Aging; Aneuploidy; Animals; Aurora Kinase C; Cell Cycle Proteins; Chromosome Segregation; Female; Ki | 2014 |
The Spindle Assembly Checkpoint Safeguards Genomic Integrity of Skeletal Muscle Satellite Cells.
Topics: Aneuploidy; Animals; Cell Differentiation; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21; G | 2015 |
Cullin9 protects mouse eggs from aneuploidy by controlling microtubule dynamics via Survivin.
Topics: Aneuploidy; Animals; Chromosomes, Mammalian; Cullin Proteins; Female; Gene Expression Regulation, De | 2016 |
BRCA1 is required for meiotic spindle assembly and spindle assembly checkpoint activation in mouse oocytes.
Topics: Aneuploidy; Animals; BRCA1 Protein; Cell Cycle Proteins; Cells, Cultured; Embryo, Mammalian; Female; | 2008 |
Impaired Bub1 function in vivo compromises tension-dependent checkpoint function leading to aneuploidy and tumorigenesis.
Topics: Alleles; Aneuploidy; Animals; Cell Cycle Proteins; Cell Transformation, Neoplastic; Chromosome Segre | 2009 |
Loss of spindle assembly checkpoint-mediated inhibition of Cdc20 promotes tumorigenesis in mice.
Topics: Amino Acid Sequence; Aneuploidy; Animals; Cdc20 Proteins; Cell Cycle Proteins; Cells, Cultured; Chro | 2009 |
Evidence that a defective spindle assembly checkpoint is not the primary cause of maternal age-associated aneuploidy in mouse eggs.
Topics: Aging; Aneuploidy; Animals; Chromosomes; Female; Maternal Age; Meiosis; Mice; Nocodazole; Oocytes; S | 2009 |
Heat shock factor 1-mediated aneuploidy requires a defective function of p53.
Topics: Aneuploidy; Animals; Bone Neoplasms; Calcium-Binding Proteins; Carcinoma, Non-Small-Cell Lung; Cdc20 | 2009 |
Adapt or die: how eukaryotic cells respond to prolonged activation of the spindle assembly checkpoint.
Topics: Adaptation, Physiological; Aneuploidy; Antimitotic Agents; Cell Cycle Proteins; Eukaryotic Cells; Fu | 2010 |
Spindle assembly checkpoint regulates mitotic cell cycle progression during preimplantation embryo development.
Topics: Anaphase; Aneuploidy; Animals; Blastocyst; Chromatids; Chromosome Segregation; Chromosomes, Mammalia | 2011 |
Persistent expression of Nqo1 by p62-mediated Nrf2 activation facilitates p53-dependent mitotic catastrophe.
Topics: Adaptor Proteins, Signal Transducing; Aneuploidy; HCT116 Cells; Humans; Intracellular Signaling Pept | 2011 |
Overexpression of ubiquitin specific protease 44 (USP44) induces chromosomal instability and is frequently observed in human T-cell leukemia.
Topics: Aneuploidy; Animals; Chromosomal Instability; Chromosome Segregation; Cyclin B; Endopeptidases; Huma | 2011 |
Septin1 is required for spindle assembly and chromosome congression in mouse oocytes.
Topics: Aneuploidy; Animals; Chromosome Segregation; Chromosomes; Female; Meiosis; Mice; Nocodazole; Oocytes | 2011 |
Deficient spindle assembly checkpoint in multiple myeloma.
Topics: Aneuploidy; Calcium-Binding Proteins; Cell Cycle Proteins; Cell Line, Tumor; Gene Expression Regulat | 2011 |
Lagging chromosomes entrapped in micronuclei are not 'lost' by cells.
Topics: Aneuploidy; Cell Cycle Checkpoints; Cell Nucleus; Chromosomes; HCT116 Cells; Humans; Mitosis; Nocoda | 2012 |
Comparison of the aneugenic properties of nocodazole, paclitaxel and griseofulvin in vitro. Centrosome defects and alterations in protein expression profiles.
Topics: Aneugens; Aneuploidy; Animals; Antifungal Agents; Antineoplastic Agents; Apoptosis; Cell Cycle; Cent | 2013 |
Roles of 14-3-3η in mitotic progression and its potential use as a therapeutic target for cancers.
Topics: 14-3-3 Proteins; Aneuploidy; Apoptosis; Caspase 9; Cell Division; Forkhead Box Protein O3; Forkhead | 2013 |
Elimination of micronucleated cells by apoptosis after treatment with inhibitors of microtubules.
Topics: Adult; Aneuploidy; Apoptosis; Benzimidazoles; Carbamates; Cell Nucleus; Cells, Cultured; Chromosome | 2002 |
A cellular machine generating apoptosis-prone aneuploid cells.
Topics: Aneuploidy; Apoptosis; CD4 Antigens; Cell Cycle; Cell Fusion; Cell Survival; Chromosome Painting; DN | 2005 |
Aneuploidy in mouse metaphase II oocytes exposed in vivo and in vitro in preantral follicle culture to nocodazole.
Topics: Aneuploidy; Animals; Antineoplastic Agents; Cell Nucleus; Cytoplasm; Female; Meiosis; Metaphase; Mic | 2005 |
Mechanism of Aurora-B degradation and its dependency on intact KEN and A-boxes: identification of an aneuploidy-promoting property.
Topics: Amino Acid Motifs; Anaphase-Promoting Complex-Cyclosome; Aneuploidy; Animals; Antineoplastic Agents; | 2005 |
Aurora-B/AIM-1 kinase activity is involved in Ras-mediated cell transformation.
Topics: Aneuploidy; Animals; Antineoplastic Agents; Aurora Kinase B; Aurora Kinases; BALB 3T3 Cells; Cell Tr | 2005 |
FAT10 plays a role in the regulation of chromosomal stability.
Topics: Aneuploidy; Apoptosis; Blotting, Western; Calcium-Binding Proteins; Cell Cycle; Cell Cycle Proteins; | 2006 |
A leukemia fusion protein attenuates the spindle checkpoint and promotes aneuploidy.
Topics: Aneuploidy; Animals; Antineoplastic Agents; Cell Cycle; Cell Cycle Proteins; Chromosomes, Human, Pai | 2007 |
Developmental reprogramming after chromosome transfer into mitotic mouse zygotes.
Topics: Aneuploidy; Animals; Cell Nucleus; Chromosomes, Mammalian; Embryonic Stem Cells; Female; Interphase; | 2007 |
The chemotherapeutic agents nocodazole and amsacrine cause meiotic delay and non-disjunction in spermatocytes of mice.
Topics: Amsacrine; Aneuploidy; Animals; Antineoplastic Agents; In Situ Hybridization, Fluorescence; Injectio | 2008 |
Induction of aneuploidy by oncodazole (nocodazole), an anti-tubulin agent, and acetone.
Topics: Acetone; Aneuploidy; Benzimidazoles; Drug Resistance; Mutagenicity Tests; Mutagens; Nocodazole; Sacc | 1984 |
Indications for a threshold of chemically-induced aneuploidy in vitro in human lymphocytes.
Topics: Adult; Aneuploidy; Benzimidazoles; Carbamates; Cell Division; Cell Survival; Cells, Cultured; Centro | 1995 |
Utility of a test for chromosomal malsegregation in Saccharomyces cerevisiae strain D61.M for the detection of antianeugens: test of the model combination of chlorophyllin and nocodazole.
Topics: Aneuploidy; Antimutagenic Agents; Antineoplastic Agents; Cell Division; Chlorophyllides; Chromosome | 1996 |
Chemical induction of mitotic checkpoint override in mammalian cells results in aneuploidy following a transient tetraploid state.
Topics: 2-Aminopurine; Aneuploidy; Animals; Cell Cycle; CHO Cells; Cricetinae; Cytochalasin B; Diketopiperaz | 1996 |
Indication for thresholds of chromosome non-disjunction versus chromosome lagging induced by spindle inhibitors in vitro in human lymphocytes.
Topics: Adult; Aneuploidy; Benzimidazoles; Carbamates; Chromosomes, Human; Chromosomes, Human, Pair 1; Chrom | 1997 |
p53 and pRb prevent rereplication in response to microtubule inhibitors by mediating a reversible G1 arrest.
Topics: Aneuploidy; Antineoplastic Agents; Cell Cycle; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p1 | 1998 |
Mutations of mitotic checkpoint genes in human cancers.
Topics: Amino Acid Sequence; Aneuploidy; Antineoplastic Agents; Cell Cycle; Cloning, Molecular; Colorectal N | 1998 |
[Have they discovered the origins of aneuploidy in tumors?].
Topics: Aneuploidy; Antineoplastic Agents; Humans; Microsatellite Repeats; Microtubules; Mitosis; Mitotic In | 1998 |
Prevention of mammalian DNA reduplication, following the release from the mitotic spindle checkpoint, requires p53 protein, but not p53-mediated transcriptional activity.
Topics: Amino Acid Substitution; Aneuploidy; Animals; Cell Cycle; Cyclins; Diploidy; DNA Replication; Fibrob | 1998 |
Quantitative measurement of mammalian chromosome mitotic loss rates using the green fluorescent protein.
Topics: Aneuploidy; Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Buffers; Caffeine; Ce | 1999 |
Differences in malsegregation rates obtained by scoring ana-telophases or binucleate cells.
Topics: Anaphase; Aneuploidy; Cell Nucleus; Cells, Cultured; Chromosomes, Human, Pair 11; Chromosomes, Human | 1999 |
Centrosome amplification and instability occurs exclusively in aneuploid, but not in diploid colorectal cancer cell lines, and correlates with numerical chromosomal aberrations.
Topics: Aneuploidy; Caco-2 Cells; Cell Division; Centrosome; Chromosome Aberrations; Colorectal Neoplasms; D | 2000 |
Merotelic kinetochore orientation is a major mechanism of aneuploidy in mitotic mammalian tissue cells.
Topics: Anaphase; Aneuploidy; Animals; Calcium-Binding Proteins; Carrier Proteins; Cell Cycle Proteins; Cell | 2001 |
Aneuploid colon cancer cells have a robust spindle checkpoint.
Topics: Adenomatous Polyposis Coli Protein; Aneuploidy; Animals; Antineoplastic Agents; Cell Cycle; Chromoso | 2001 |
Methods for the study of pericentrin in centrosome assembly and function.
Topics: Aneuploidy; Animals; Antigens; Antineoplastic Agents; Cell Cycle; Centrosome; CHO Cells; Cricetinae; | 2001 |
Micronucleus morphology as a means to distinguish aneugens and clastogens in the mouse bone marrow micronucleus assay.
Topics: Aneuploidy; Animals; Bone Marrow; Bone Marrow Cells; Cell Nucleus; Dose-Response Relationship, Drug; | 1991 |
Reevaluation of the 9 compounds reported conclusive positive in yeast Saccharomyces cerevisiae aneuploidy test systems by the Gene-Tox Program using strain D61.M of Saccharomyces cerevisiae.
Topics: Acetone; Aneuploidy; Benomyl; Benzimidazoles; Biotransformation; Carbamates; Chromosomes, Fungal; Cy | 1991 |
The feasibility of using Chinese hamsters as an animal model for aneuploidy.
Topics: Aneuploidy; Animals; Benzimidazoles; Bone Marrow; Carbamates; Cricetinae; Cricetulus; Cyclophosphami | 1990 |
Nocodazole sensitivity, age-related aneuploidy, and alterations in the cell cycle during maturation of mouse oocytes.
Topics: Aging; Aneuploidy; Animals; Cell Cycle; Chromosomes; Female; Mice; Mice, Inbred Strains; Nocodazole; | 1989 |
The mouse bone marrow micronucleus assay can be used to distinguish aneugens from clastogens.
Topics: Aneuploidy; Animals; Benzimidazoles; Bone Marrow; Centromere; Chromosome Banding; Cyclophosphamide; | 1989 |
Chromosome malsegregation and embryonic lethality induced by treatment of normally ovulated mouse oocytes with nocodazole.
Topics: Aneuploidy; Animals; Benzimidazoles; Embryo Transfer; Female; Fetal Death; In Vitro Techniques; Meta | 1989 |
Investigations of aneuploidy-inducing chemical combinations in Saccharomyces cerevisiae.
Topics: Acetates; Aneuploidy; Benzimidazoles; Butanones; Drug Combinations; Drug Synergism; Nocodazole; Pyrr | 1988 |
A genetic assay for aneuploidy: quantitation of chromosome loss using a mouse/human monochromosomal hybrid cell line.
Topics: Aneuploidy; Animals; Benzimidazoles; Cell Line; Chromosome Deletion; Chromosomes, Human, Pair 2; Clo | 1988 |
Effect of treatment medium on induction of aneuploidy by nocodazole in Saccharomyces cerevisiae.
Topics: Aneuploidy; Benzimidazoles; Culture Media; Mutagens; Nocodazole; Peptones; Saccharomyces cerevisiae | 1988 |
Effects of chemical combinations on the induction of aneuploidy in Saccharomyces cerevisiae.
Topics: Acetates; Acetone; Aneuploidy; Benzimidazoles; Butanones; Carbamates; Dimethyl Sulfoxide; Dimethylfo | 1987 |
Aneuploidy induced by nocodazole or ethyl acetate is suppressed by dimethyl sulfoxide.
Topics: Acetates; Aneuploidy; Benzimidazoles; Dimethyl Sulfoxide; Drug Interactions; Mutagenicity Tests; Mut | 1987 |
Chromosome flexion: potential for assessing the state of spindle assembly.
Topics: Adult; Age Factors; Aneuploidy; Benzimidazoles; Cells, Cultured; Chromosomes; Humans; Lymphocytes; M | 1987 |