nocodazole has been researched along with Alzheimer Disease in 11 studies
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Given that Alzheimer's disease involves accumulation of aggregates of two different proteins, the potential involvement of the unfolded protein response (UPR) and endoplasmic reticulum (ER) dysfunction has been suggested to lead to cell death." | 1.33 | beta-Amyloid and endoplasmic reticulum stress responses in primary neurons: effects of drugs that interact with the cytoskeleton. ( Ansar, S; Bean, J; Michaelis, ML; Seyb, KI, 2006) |
| "Since in Alzheimer's disease tau protein is elevated and mislocalized, these observations point to a possible cause for the gradual degeneration of neurons." | 1.30 | Overexpression of tau protein inhibits kinesin-dependent trafficking of vesicles, mitochondria, and endoplasmic reticulum: implications for Alzheimer's disease. ( Ebneth, A; Godemann, R; Illenberger, S; Mandelkow, E; Stamer, K; Trinczek, B, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (27.27) | 18.2507 |
| 2000's | 5 (45.45) | 29.6817 |
| 2010's | 2 (18.18) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Ding, Y | 1 |
| Zhong, Y | 1 |
| Baldeshwiler, A | 1 |
| Abner, EL | 1 |
| Bauer, B | 1 |
| Hartz, AMS | 1 |
| Pchitskaya, EI | 1 |
| Zhemkov, VA | 1 |
| Bezprozvanny, IB | 1 |
| Penazzi, L | 1 |
| Tackenberg, C | 1 |
| Ghori, A | 1 |
| Golovyashkina, N | 1 |
| Niewidok, B | 1 |
| Selle, K | 1 |
| Ballatore, C | 1 |
| Smith, AB | 1 |
| Bakota, L | 1 |
| Brandt, R | 1 |
| Seyb, KI | 1 |
| Ansar, S | 1 |
| Bean, J | 1 |
| Michaelis, ML | 1 |
| Dewitt, DA | 1 |
| Hurd, JA | 1 |
| Fox, N | 1 |
| Townsend, BE | 1 |
| Griffioen, KJ | 1 |
| Ghribi, O | 1 |
| Savory, J | 1 |
| Li, B | 1 |
| Chohan, MO | 1 |
| Grundke-Iqbal, I | 1 |
| Iqbal, K | 1 |
| Gellermann, GP | 1 |
| Ullrich, K | 1 |
| Unger, C | 1 |
| Fändrich, M | 1 |
| Sauter, S | 1 |
| Diekmann, S | 1 |
| Mönning, U | 1 |
| Sandbrink, R | 1 |
| Weidemann, A | 1 |
| Banati, RB | 1 |
| Masters, CL | 1 |
| Beyreuther, K | 1 |
| Merrick, SE | 1 |
| Demoise, DC | 1 |
| Lee, VM | 1 |
| Ebneth, A | 1 |
| Godemann, R | 1 |
| Stamer, K | 1 |
| Illenberger, S | 1 |
| Trinczek, B | 1 |
| Mandelkow, E | 1 |
| Thorpe, JR | 1 |
| Morley, SJ | 1 |
| Rulten, SL | 1 |
1 review available for nocodazole and Alzheimer Disease
| Article | Year |
|---|---|
Dynamic Microtubules in Alzheimer's Disease: Association with Dendritic Spine Pathology.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Cytoskeleton; Dendritic Spines; Epothilones; Humans; Micro | 2018 |
10 other studies available for nocodazole and Alzheimer Disease
| Article | Year |
|---|---|
Protecting P-glycoprotein at the blood-brain barrier from degradation in an Alzheimer's disease mouse model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; ATP Binding Casse | 2021 |
Aβ-mediated spine changes in the hippocampus are microtubule-dependent and can be reversed by a subnanomolar concentration of the microtubule-stabilizing agent epothilone D.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Cells, Cultured; Dendritic Spines; Diami | 2016 |
beta-Amyloid and endoplasmic reticulum stress responses in primary neurons: effects of drugs that interact with the cytoskeleton.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antineoplastic Agents; Cells, Cultured; Cytoskele | 2006 |
Peri-nuclear clustering of mitochondria is triggered during aluminum maltolate induced apoptosis.
Topics: Alzheimer Disease; Amino Acid Chloromethyl Ketones; Animals; Antineoplastic Agents; Apoptosis; Cell | 2006 |
Disruption of microtubule network by Alzheimer abnormally hyperphosphorylated tau.
Topics: 3T3 Cells; Alzheimer Disease; Animals; Antineoplastic Agents; Brain; Cytosol; Dose-Response Relation | 2007 |
Identification of molecular compounds critical to Alzheimer's-like plaque formation.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Cells, Cultured; Chondroitin; Cytochalasin D; Dextran Sulf | 2007 |
Extracellular matrix influences the biogenesis of amyloid precursor protein in microglial cells.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Blotting, Western | 1995 |
Site-specific dephosphorylation of tau protein at Ser202/Thr205 in response to microtubule depolymerization in cultured human neurons involves protein phosphatase 2A.
Topics: Alzheimer Disease; Amino Acid Sequence; Antibodies; Autoradiography; Blotting, Western; Cells, Cultu | 1996 |
Overexpression of tau protein inhibits kinesin-dependent trafficking of vesicles, mitochondria, and endoplasmic reticulum: implications for Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Biological Transport; Cell Size; Centrosome; CHO Cells; Cricetinae; Doce | 1998 |
Utilizing the peptidyl-prolyl cis-trans isomerase pin1 as a probe of its phosphorylated target proteins. Examples of binding to nuclear proteins in a human kidney cell line and to tau in Alzheimer's diseased brain.
Topics: Alzheimer Disease; Brain; Cell Line; Cell Nucleus; Humans; Hydrogen-Ion Concentration; Immunohistoch | 2001 |