nocloprost and Gastrointestinal-Hemorrhage

nocloprost has been researched along with Gastrointestinal-Hemorrhage* in 1 studies

Trials

1 trial(s) available for nocloprost and Gastrointestinal-Hemorrhage

ArticleYear
Gastric protection by nocloprost against aspirin damage in humans. Possible role of epidermal growth factor.
    Scandinavian journal of gastroenterology, 1991, Volume: 26, Issue:3

    Ten healthy young male subjects took part in a double-blind, placebo-controlled crossover study to assess the effects of nocloprost on gastric microbleeding and endoscopic mucosal injury induced by the administration of aspirin (2.5 g). In addition, basal and pentagastrin-induced gastric acid and pepsin secretion and salivary and plasma contents of epidermal growth factor (EGF) were measured after placebo plus aspirin or nocloprost plus aspirin treatment in these subjects. Nocloprost (100 micrograms/dose) significantly reduced spontaneous gastric microbleeding and almost completely prevented gastric mucosal injury induced by aspirin. Nocloprost failed to affect basal and pentagastrin-stimulated gastric acid and pepsin secretion but increased significantly the salivary outputs and plasma concentrations of EGF. In conclusion, nocloprost is effective in preventing gastric injury by aspirin even at a non-antisecretory dose, and this protection may involve an excessive release of EGF.

    Topics: Adult; Aspirin; Double-Blind Method; Epidermal Growth Factor; Gastric Acid; Gastric Mucosa; Gastrointestinal Hemorrhage; Gastroscopy; Humans; Male; Pepsin A; Prostaglandins F, Synthetic; Saliva; Vasodilator Agents

1991