nocistatin and Alcoholism

In earlier experiments perinatal hormonal imprinting by alcohol decreased the hormone content of immune cells for life. In the present study, both a single day (15% on the third postnatal day) and a long-term treatment schedule of alcohol exposure (3% for 21 days) of dams during lactation significantly (P < 0.01) enhanced endogenous levels of nocistatin in the blood plasma as well as in the cerebrospinal fluid of the offspring, measured in 3-month-old rats. Our data suggest that alcohol consumption during lactation can cause a life-long influence on nocistatin levels in the offspring and most likely modify nocistatin-related functions such as pain tolerance.

Topics: Age Factors; Alcoholism; Animals; Animals, Newborn; Brain; Dose-Response Relationship, Drug; Ethanol; Female; Imprinting, Psychological; Lactation; Opioid Peptides; Pain Threshold; Rats; Rats, Wistar