nocathiacin-i and Disease-Models--Animal

Nocathiacin I (1) was converted to its deoxy indole analogue, nocathiacin II (2), another natural product, by a unique and facile chemical process. This process was applied to nocathiacin IV (4), generating the lactone analogue of glycothiohexide alpha (5), which was also prepared from nocathiacin II by a mild hydrolytic process. In contrast to glycothiohexide alpha (3), this lactone analogue (5) was found to exhibit in vivo antibacterial efficacy in an animal (mouse) infection model.

Topics: Animals; Anti-Bacterial Agents; Disease Models, Animal; Intercellular Signaling Peptides and Proteins; Mice; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Peptides; Peptides, Cyclic; Thiazoles