nnd-502 and Tinea-Versicolor

nnd-502 has been researched along with Tinea-Versicolor* in 1 studies

Other Studies

1 other study(ies) available for nnd-502 and Tinea-Versicolor

Article	Year
In vitro activity of novel imidazole antifungal agent NND-502 against Malassezia species. International journal of antimicrobial agents, 2003, Volume: 21, Issue:3 The in vitro activity of NND-502, a novel antifungal imidazole compound, was tested against the three major Malassezia species by an agar dilution method with modified Dixon medium and compared with the activities of three reference antifungal drugs of topical use, lanoconazole (LCZ), bifonazole (BFZ) and terbinafine (TBF). The geometric mean (GM)-MICs of NND-502 for 25 strains of M. furfur, 15 strains of M. sympodialis and ten strains of M. slooffiae were approximately 1.4, 0.1 and 1.0 mg/l, respectively, showing the greatest activity against M. sympodialis and the least against M. slooffiae. These values were similar to that of LCZ, but four to 69 times lower than that of BFZ and two to three times lower than that of TBF. The results suggest that NND-502 might be beneficial in the treatment of Malassezia-associated skin diseases. Topics: Antifungal Agents; Dermatomycoses; Dose-Response Relationship, Drug; Drug Resistance, Fungal; Heterocyclic Compounds; Humans; Imidazoles; In Vitro Techniques; Malassezia; Microbial Sensitivity Tests; Naphthalenes; Species Specificity; Terbinafine; Tinea Versicolor	2003

Article

Year

In vitro activity of novel imidazole antifungal agent NND-502 against Malassezia species.

International journal of antimicrobial agents, 2003, Volume: 21, Issue:3

The in vitro activity of NND-502, a novel antifungal imidazole compound, was tested against the three major Malassezia species by an agar dilution method with modified Dixon medium and compared with the activities of three reference antifungal drugs of topical use, lanoconazole (LCZ), bifonazole (BFZ) and terbinafine (TBF). The geometric mean (GM)-MICs of NND-502 for 25 strains of M. furfur, 15 strains of M. sympodialis and ten strains of M. slooffiae were approximately 1.4, 0.1 and 1.0 mg/l, respectively, showing the greatest activity against M. sympodialis and the least against M. slooffiae. These values were similar to that of LCZ, but four to 69 times lower than that of BFZ and two to three times lower than that of TBF. The results suggest that NND-502 might be beneficial in the treatment of Malassezia-associated skin diseases.

Topics: Antifungal Agents; Dermatomycoses; Dose-Response Relationship, Drug; Drug Resistance, Fungal; Heterocyclic Compounds; Humans; Imidazoles; In Vitro Techniques; Malassezia; Microbial Sensitivity Tests; Naphthalenes; Species Specificity; Terbinafine; Tinea Versicolor

2003