nnc-55-0396 and Ovarian-Neoplasms

nnc-55-0396 has been researched along with Ovarian-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for nnc-55-0396 and Ovarian-Neoplasms

Article	Year
Blockade of T-type Ca(2+) channels inhibits human ovarian cancer cell proliferation. Cancer investigation, 2011, Volume: 29, Issue:5 Regulation of Ca(2+) channels has been implicated in the progression of tumor cells. We report here that T-type Ca(2+) channel expression in human ovarian cancer tissues is greatly increased compared to normal ovarian tissues. Blockade of T-type Ca(2+) channel with NNC 55-0396, mibefradil, or by specifically knocking down the expression of these proteins with siRNA-Ca(v)3.1/3.2 suppressed the proliferation of two ovarian cancer cell lines and increased G0/G1 phase distribution in the cell cycle. Furthermore, NNC 55-0396 slowed ovarian cancer formation in nude mice. Therefore the function of T-type Ca(2+) channels is important for the proliferation of human ovarian cancer cells. Topics: Animals; Antineoplastic Agents; Benzimidazoles; Calcium Channel Blockers; Calcium Channels, T-Type; Cell Line, Tumor; Cell Proliferation; Chi-Square Distribution; Cyclopropanes; Female; Humans; Mibefradil; Mice; Mice, Nude; Naphthalenes; Ovarian Neoplasms; RNA Interference; Time Factors; Tumor Burden; Xenograft Model Antitumor Assays	2011

Article

Year

Blockade of T-type Ca(2+) channels inhibits human ovarian cancer cell proliferation.

Cancer investigation, 2011, Volume: 29, Issue:5

Regulation of Ca(2+) channels has been implicated in the progression of tumor cells. We report here that T-type Ca(2+) channel expression in human ovarian cancer tissues is greatly increased compared to normal ovarian tissues. Blockade of T-type Ca(2+) channel with NNC 55-0396, mibefradil, or by specifically knocking down the expression of these proteins with siRNA-Ca(v)3.1/3.2 suppressed the proliferation of two ovarian cancer cell lines and increased G0/G1 phase distribution in the cell cycle. Furthermore, NNC 55-0396 slowed ovarian cancer formation in nude mice. Therefore the function of T-type Ca(2+) channels is important for the proliferation of human ovarian cancer cells.

Topics: Animals; Antineoplastic Agents; Benzimidazoles; Calcium Channel Blockers; Calcium Channels, T-Type; Cell Line, Tumor; Cell Proliferation; Chi-Square Distribution; Cyclopropanes; Female; Humans; Mibefradil; Mice; Mice, Nude; Naphthalenes; Ovarian Neoplasms; RNA Interference; Time Factors; Tumor Burden; Xenograft Model Antitumor Assays

2011