nnc-55-0396 and Glioblastoma

Mibefradil and NNC-55-0396, tetralol derivatives with a proven -ability to block T-type calcium channels in excitable cells, reduce cancer cell viability in vitro, causing cell death. Furthermore, they reduce tumor growth in preclinical models of Glioblastoma multiforme (GBM), a brain tumor of poor prognosis. Here we found that GBM cells treated with cytotoxic concentrations of NNC-55-0396 paradoxically increased cytosolic calcium levels through the activation of inositol triphosphate receptors (IP

Topics: Apoptosis; Benzimidazoles; Calcium; Calcium Signaling; Cell Death; Cyclopropanes; Endoplasmic Reticulum Stress; Endoribonucleases; Glioblastoma; Humans; Naphthalenes; Protein Serine-Threonine Kinases; Tetralones; Unfolded Protein Response