nk-121 and Mesonephroma

nk-121 has been researched along with Mesonephroma* in 1 studies

Other Studies

1 other study(ies) available for nk-121 and Mesonephroma

Article	Year
[Effect of a newly developed platinum compound cis-1, 1-cyclobutane dicarboxylato-(2R)-2-methyl-1,4-butane diamine platinum (II), on human ovarian tumors transplanted into nude mice]. Gan to kagaku ryoho. Cancer & chemotherapy, 1988, Volume: 15, Issue:4 Pt 1 The therapeutic effect of cis-1, 1-cyclobutane dicarboxylato-(2R)-2-methyl-1,4-butane diamine platinum (II) (NK 121) on 3 human yolk sac tumors of the ovary (YST-1, YST-2 and YST-3), which were transplanted into nude mice, was compared with that of cisplatin (CDDP). While tumors YST-2 and YST-3 exhibited a broad comparable sensitivity to CDDP and NK 121, YST-1 was substantially more sensitive to CDDP than NK 121. A significant weight loss was noted in the non-tumor bearing nude mice treated with CDDP, as compared with the loss in both control and NK 121-treated groups. NK 121 showed a good antitumor activity without showing severe toxicities. Topics: Animals; Antineoplastic Agents; Carboplatin; Female; Humans; Mesonephroma; Mice; Mice, Nude; Neoplasm Transplantation; Organoplatinum Compounds; Ovarian Neoplasms	1988

Article

Year

[Effect of a newly developed platinum compound cis-1, 1-cyclobutane dicarboxylato-(2R)-2-methyl-1,4-butane diamine platinum (II), on human ovarian tumors transplanted into nude mice].

Gan to kagaku ryoho. Cancer & chemotherapy, 1988, Volume: 15, Issue:4 Pt 1

The therapeutic effect of cis-1, 1-cyclobutane dicarboxylato-(2R)-2-methyl-1,4-butane diamine platinum (II) (NK 121) on 3 human yolk sac tumors of the ovary (YST-1, YST-2 and YST-3), which were transplanted into nude mice, was compared with that of cisplatin (CDDP). While tumors YST-2 and YST-3 exhibited a broad comparable sensitivity to CDDP and NK 121, YST-1 was substantially more sensitive to CDDP than NK 121. A significant weight loss was noted in the non-tumor bearing nude mice treated with CDDP, as compared with the loss in both control and NK 121-treated groups. NK 121 showed a good antitumor activity without showing severe toxicities.

Topics: Animals; Antineoplastic Agents; Carboplatin; Female; Humans; Mesonephroma; Mice; Mice, Nude; Neoplasm Transplantation; Organoplatinum Compounds; Ovarian Neoplasms

1988