nizofenone has been researched along with Brain Ischemia in 12 studies
nizofenone: protects experimental mice & rats against cerebral anoxia
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We have previously reported that the combined administration of mannitol and perfluorochemical blood substitutes is evidently effective in protecting the brain from cerebral ischemia." | 7.67 | [Experimental study of cerebral protective effect on cerebral ischemia of various antioxidants and other agents. With special reference to the combined treatment of mannitol, vitamin E, dexamethasone and perfluorochemicals]. ( Fujimoto, S; Mizoi, K; Oba, M; Suzuki, J, 1984) |
| "Effect of nizofenone on pyramidal response (PR), electrocorticogram (ECoG) and regional cerebral blood flow (rCBF) following recirculation after complete global brain ischemia was compared with that of pentobarbital in gallamine-immobilized cats." | 7.67 | [Effect of nizofenone on pyramidal response, electrocorticogram and regional cerebral blood flow following recirculation after complete global brain ischemia in cats]. ( Nakajima, A; Shuto, S; Tsumagari, T, 1984) |
| "Using the "canine model of complete ischemic brain regulated with a perfusion method" in which it is possible to control the degree of blood flow to a cerebral hemisphere via a perfusion pump, the protective effects of nizofenone against cerebral ischemia was investigated." | 7.67 | [An experimental study on the protective effect of nizofenone in cerebral ischemia]. ( Abiko, H; Fujimoto, S; Mizoi, K; Olca, M; Suzuki, J, 1984) |
| "The effect of Nizofenone (Y-9179), a vertebral protective agent, on delayed ischemic neurological deficits following subarachnoid hemorrhage (SAH) due to aneurysmal rupture was investigated by a cooperative double-blind clinical trials." | 5.05 | A double-blind clinical evaluation of the effect of Nizofenone (Y-9179) on delayed ischemic neurological deficits following aneurysmal rupture. ( Asano, T; Ochiai, C; Saito, I; Sano, K; Takakura, K; Tamura, A, 1983) |
| "We have previously reported that the combined administration of mannitol and perfluorochemical blood substitutes is evidently effective in protecting the brain from cerebral ischemia." | 3.67 | [Experimental study of cerebral protective effect on cerebral ischemia of various antioxidants and other agents. With special reference to the combined treatment of mannitol, vitamin E, dexamethasone and perfluorochemicals]. ( Fujimoto, S; Mizoi, K; Oba, M; Suzuki, J, 1984) |
| "Effect of nizofenone on pyramidal response (PR), electrocorticogram (ECoG) and regional cerebral blood flow (rCBF) following recirculation after complete global brain ischemia was compared with that of pentobarbital in gallamine-immobilized cats." | 3.67 | [Effect of nizofenone on pyramidal response, electrocorticogram and regional cerebral blood flow following recirculation after complete global brain ischemia in cats]. ( Nakajima, A; Shuto, S; Tsumagari, T, 1984) |
| "Using the "canine model of complete ischemic brain regulated with a perfusion method" in which it is possible to control the degree of blood flow to a cerebral hemisphere via a perfusion pump, the protective effects of nizofenone against cerebral ischemia was investigated." | 3.67 | [An experimental study on the protective effect of nizofenone in cerebral ischemia]. ( Abiko, H; Fujimoto, S; Mizoi, K; Olca, M; Suzuki, J, 1984) |
| "Nizofenone is a potent neuroprotective drug which ameliorates this imbalance and also various pathophysiologic events during ischemia, such as ATP depletion, lactate accumulation, glutamate release, free fatty acid liberation, edema, and neuronal degeneration; in particular, ischemia-induced excessive glutamate release has been completely blocked by this drug." | 2.38 | Brain protection against ischemic injury by nizofenone. ( Nakajima, A; Yasuda, H, 1993) |
| "The effects of nizofenone on ischemic cerebral edema in Mongolian gerbils were compared with those of pentobarbital (PBT)." | 1.27 | [Effects of nizofenone on ischemic cerebral edema in Mongolian gerbils]. ( Fukuda, T; Morimoto, Y; Tsumagari, T, 1984) |
| " The effective dosage of the drugs were 20-40 mg/kg in pentobarbital, 10-20 mg/kg in diazepam, and 12." | 1.27 | [Treatable ischemic neuronal damage in the gerbil hippocampus]. ( Kirino, T; Sano, K; Tamura, A; Tomukai, N, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (91.67) | 18.7374 |
| 1990's | 1 (8.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Saito, I | 1 |
| Asano, T | 2 |
| Ochiai, C | 2 |
| Takakura, K | 1 |
| Tamura, A | 4 |
| Sano, K | 4 |
| Fukuda, T | 3 |
| Nakamura, T | 1 |
| Fujimoto, S | 2 |
| Mizoi, K | 2 |
| Oba, M | 1 |
| Suzuki, J | 2 |
| Morimoto, Y | 2 |
| Tsumagari, T | 3 |
| Shuto, S | 1 |
| Nakajima, A | 2 |
| Olca, M | 1 |
| Abiko, H | 1 |
| Yasuda, H | 3 |
| Kishiro, K | 1 |
| Izumi, N | 2 |
| Nakanishi, M | 2 |
| Maruyama, Y | 1 |
| Kirino, T | 1 |
| Tomukai, N | 1 |
2 reviews available for nizofenone and Brain Ischemia
| Article | Year |
|---|---|
Brain protection against ischemic injury by nizofenone.
Topics: Animals; Anti-Arrhythmia Agents; Brain Ischemia; Humans; Imidazoles | 1993 |
[Nizofenone, a cerebral protective agent].
Topics: Animals; Brain; Brain Ischemia; Cats; Cerebrovascular Circulation; Dogs; Hemodynamics; Humans; Hypox | 1985 |
1 trial available for nizofenone and Brain Ischemia
| Article | Year |
|---|---|
A double-blind clinical evaluation of the effect of Nizofenone (Y-9179) on delayed ischemic neurological deficits following aneurysmal rupture.
Topics: Adult; Aged; Brain Ischemia; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Hypoxia, | 1983 |
9 other studies available for nizofenone and Brain Ischemia
| Article | Year |
|---|---|
[An experimental study on the mechanism of the protective action of pentobarbital and Y-9179 against cerebral ischemia (author's transl)].
Topics: Animals; Blood Pressure; Brain Ischemia; Cerebrovascular Circulation; Dogs; Electroencephalography; | 1981 |
[Experimental study of cerebral protective effect on cerebral ischemia of various antioxidants and other agents. With special reference to the combined treatment of mannitol, vitamin E, dexamethasone and perfluorochemicals].
Topics: Animals; Blood Substitutes; Brain Ischemia; Cerebrovascular Circulation; Dexamethasone; Dimethyl Sul | 1984 |
[Effect of nizofenone (Y-9179) on experimental cerebral ischemia in Mongolian gerbils].
Topics: Animals; Brain Ischemia; Female; Gerbillinae; Imidazoles; Male; Pentobarbital; Time Factors | 1984 |
[Effects of nizofenone on ischemic cerebral edema in Mongolian gerbils].
Topics: Animals; Body Water; Brain Chemistry; Brain Edema; Brain Ischemia; Disease Models, Animal; Gerbillin | 1984 |
[Effect of nizofenone on pyramidal response, electrocorticogram and regional cerebral blood flow following recirculation after complete global brain ischemia in cats].
Topics: Animals; Blood Gas Analysis; Blood Pressure; Body Temperature; Brain; Brain Ischemia; Cats; Electroe | 1984 |
[An experimental study on the protective effect of nizofenone in cerebral ischemia].
Topics: Animals; Brain Ischemia; Cerebrovascular Circulation; Dogs; Dose-Response Relationship, Drug; Electr | 1984 |
Biphasic liberation of arachidonic and stearic acids during cerebral ischemia.
Topics: Adenosine Triphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Brain; Brain Ischemia; Cyclic | 1985 |
Brain protection against oxygen deficiency by nizofenone.
Topics: Animals; Anti-Arrhythmia Agents; Brain; Brain Ischemia; Energy Metabolism; Hypoxia; Imidazoles; Kine | 1988 |
[Treatable ischemic neuronal damage in the gerbil hippocampus].
Topics: Animals; Brain Ischemia; Diazepam; Gerbillinae; Hippocampus; Humans; Imidazoles; Pentobarbital | 1986 |