nitroxyl has been researched along with Cardiomegaly in 2 studies
nitroxyl: hydroxamic acid oxidized to nitroxyl free radical
nitroxyl : A nitrogen oxoacid consisting of an oxygen atom double-bonded to an NH group.
Cardiomegaly: Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Nitroxyl (HNO) is a redox congener of NO." | 1.39 | HNO/cGMP-dependent antihypertrophic actions of isopropylamine-NONOate in neonatal rat cardiomyocytes: potential therapeutic advantages of HNO over NO. ( Alexander, AE; Cao, N; Gossain, S; Horowitz, JD; Irvine, JC; Kemp-Harper, BK; Love, JE; Qin, C; Ritchie, RH, 2013) |
| "New therapeutic targets for cardiac hypertrophy, an independent risk factor for heart failure and death, are essential." | 1.38 | Nitroxyl (HNO) stimulates soluble guanylyl cyclase to suppress cardiomyocyte hypertrophy and superoxide generation. ( Alexander, AE; Cao, AH; Irvine, JC; Kaye, DM; Kemp-Harper, BK; Lin, EQ; Love, JE; McMullen, JR; Patel, R; Ritchie, RH, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Irvine, JC | 2 |
| Cao, N | 1 |
| Gossain, S | 1 |
| Alexander, AE | 2 |
| Love, JE | 2 |
| Qin, C | 1 |
| Horowitz, JD | 1 |
| Kemp-Harper, BK | 2 |
| Ritchie, RH | 2 |
| Lin, EQ | 1 |
| Cao, AH | 1 |
| Patel, R | 1 |
| McMullen, JR | 1 |
| Kaye, DM | 1 |
2 other studies available for nitroxyl and Cardiomegaly
| Article | Year |
|---|---|
HNO/cGMP-dependent antihypertrophic actions of isopropylamine-NONOate in neonatal rat cardiomyocytes: potential therapeutic advantages of HNO over NO.
Topics: Animals; Animals, Newborn; Antioxidants; Cardiomegaly; Cardiovascular Agents; Cells, Cultured; Cycli | 2013 |
Nitroxyl (HNO) stimulates soluble guanylyl cyclase to suppress cardiomyocyte hypertrophy and superoxide generation.
Topics: Angiotensin II; Animals; Cardiomegaly; Cell Adhesion Molecules; Cyclic GMP; Endothelin-1; Guanylate | 2012 |