nitroxyl has been researched along with Cardiac Hypertrophy in 2 studies
nitroxyl: hydroxamic acid oxidized to nitroxyl free radical
nitroxyl : A nitrogen oxoacid consisting of an oxygen atom double-bonded to an NH group.
Cardiac Hypertrophy: Enlargement of the HEART due to chamber HYPERTROPHY, an increase in wall thickness without an increase in the number of cells (MYOCYTES, CARDIAC). It is the result of increase in myocyte size, mitochondrial and myofibrillar mass, as well as changes in extracellular matrix.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Nitroxyl (HNO) is a redox congener of NO." | 1.39 | HNO/cGMP-dependent antihypertrophic actions of isopropylamine-NONOate in neonatal rat cardiomyocytes: potential therapeutic advantages of HNO over NO. ( Alexander, AE; Cao, N; Gossain, S; Horowitz, JD; Irvine, JC; Kemp-Harper, BK; Love, JE; Qin, C; Ritchie, RH, 2013) |
| "New therapeutic targets for cardiac hypertrophy, an independent risk factor for heart failure and death, are essential." | 1.38 | Nitroxyl (HNO) stimulates soluble guanylyl cyclase to suppress cardiomyocyte hypertrophy and superoxide generation. ( Alexander, AE; Cao, AH; Irvine, JC; Kaye, DM; Kemp-Harper, BK; Lin, EQ; Love, JE; McMullen, JR; Patel, R; Ritchie, RH, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Irvine, JC | 2 |
| Cao, N | 1 |
| Gossain, S | 1 |
| Alexander, AE | 2 |
| Love, JE | 2 |
| Qin, C | 1 |
| Horowitz, JD | 1 |
| Kemp-Harper, BK | 2 |
| Ritchie, RH | 2 |
| Lin, EQ | 1 |
| Cao, AH | 1 |
| Patel, R | 1 |
| McMullen, JR | 1 |
| Kaye, DM | 1 |
2 other studies available for nitroxyl and Cardiac Hypertrophy
| Article | Year |
|---|---|
HNO/cGMP-dependent antihypertrophic actions of isopropylamine-NONOate in neonatal rat cardiomyocytes: potential therapeutic advantages of HNO over NO.
Topics: Animals; Animals, Newborn; Antioxidants; Cardiomegaly; Cardiovascular Agents; Cells, Cultured; Cycli | 2013 |
Nitroxyl (HNO) stimulates soluble guanylyl cyclase to suppress cardiomyocyte hypertrophy and superoxide generation.
Topics: Angiotensin II; Animals; Cardiomegaly; Cell Adhesion Molecules; Cyclic GMP; Endothelin-1; Guanylate | 2012 |